Methods for treating hematological cancers and the use of biomarkers as a predictor of clinical sensitivity to immunodulatory therapies

ABSTRACT

Provided herein, in certain embodiments, are biomarkers for use in predicting the clinical sensitivity of hematologic cancers, such as non-Hodgkin&#39;s lymphoma, and a patient&#39;s response to treatment with an immunomodulatory agent, such as 3-(4-an-rino-1-oxo-3-dihydro-isoindol-2-y])-piperidine-2,6-dione, which is also known as lenalidomide or Revlimid®. Also provided herein, in certain embodiments, are methods of treating or managing non-Hodgkin&#39;s lymphomas, including but not limited to diffuse large B-cell lymphoma (DLBCL), using prognostic factors.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of priority to U.S. Ser. No.61/913,046 filed Dec. 6, 2013, which is herein incorporated by referencein its entirety.

1. FIELD

Provided herein are biomarkers for use in predicting the clinicalsensitivity of hematologic cancers, such as non-Hodgkin's lymphoma, anda patient's response to treatment with an immunomodulatory agent, suchas 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione,which is also known as lenalidomide or Revlimid®. In one aspect,provided herein are methods of treating or managing non-Hodgkin'slymphomas, including but not limited to, diffuse large B-cell lymphoma(DLBCL), using prognostic factors.

2. BACKGROUND 2.1 Pathobiology of Cancer

Cancer is characterized primarily by an increase in the number ofabnormal cells derived from a given normal tissue, invasion of adjacenttissues by these abnormal cells, or lymphatic or blood-borne spread ofmalignant cells to regional lymph nodes and to distant sites(metastasis). Clinical data and molecular biologic studies indicate thatcancer is a multistep process that begins with minor pre-neoplasticchanges, which may under certain conditions progress to neoplasia. Theneoplastic lesion may evolve clonally and develop an increasing capacityfor invasion, growth, metastasis, and heterogeneity, especially underconditions in which the neoplastic cells escape the host's immunesurveillance. Roitt, I., Brostoff, J and Kale, D., Immunology,17.1-17.12 (3rd ed., Mosby, St. Louis, Mo., 1993).

There is an enormous variety of cancers which are described in detail inthe medical literature. Examples include cancers of the lung, colon,rectum, prostate, breast, brain, blood and intestine. The incidence ofcancer continues to climb as the general population ages, as new cancersdevelop, and as susceptible populations (e.g., people infected with AIDSor excessively exposed to sunlight) grow. However, options for thetreatment of cancer are limited. For example, in the case of bloodcancers (e.g., multiple myeloma), few treatment options are available,especially when conventional chemotherapy fails and bone-marrowtransplantation is not an option. A tremendous demand therefore existsfor new methods and compositions that can be used to treat patients withcancer.

Many types of cancers are associated with new blood vessel formation, aprocess known as angiogenesis. Several of the mechanisms involved intumor-induced angiogenesis have been elucidated. The most direct ofthese mechanisms is the secretion by the tumor cells of cytokines withangiogenic properties. Examples of these cytokines include acidic andbasic fibroblastic growth factor (a,b-FGF), angiogenin, vascularendothelial growth factor (VEGF), and TNF-α. Alternatively, tumor cellscan release angiogenic peptides through the production of proteases andthe subsequent breakdown of the extracellular matrix where somecytokines are stored (e.g., b-FGF). Angiogenesis can also be inducedindirectly through the recruitment of inflammatory cells (particularlymacrophages) and their subsequent release of angiogenic cytokines (e.g.,TNF-α, b-FGF).

Lymphoma refers to cancers that originate in the lymphatic system.Lymphoma is characterized by malignant neoplasms of lymphocytes—Blymphocytes and T lymphocytes (i.e., B-cells and T-cells). Lymphomagenerally starts in lymph nodes or collections of lymphatic tissue inorgans including, but not limited to, the stomach or intestines.Lymphoma may involve the marrow and the blood in some cases. Lymphomamay spread from one site to other parts of the body.

The treatment of various forms of lymphomas are described, for example,in U.S. Pat. No. 7,468,363, the entirety of which is incorporated hereinby reference. Such lymphomas include, but are not limited to, Hodgkin'slymphoma, non-Hodgkin's lymphoma, cutaneous B-cell lymphoma, activatedB-cell lymphoma, DLBCL, mantle cell lymphoma (MCL), follicular centerlymphoma, transformed lymphoma, lymphocytic lymphoma of intermediatedifferentiation, intermediate lymphocytic lymphoma (ILL), diffuse poorlydifferentiated lymphocytic lymphoma (PDL), centrocytic lymphoma, diffusesmall-cleaved cell lymphoma (DSCCL), peripheral T-cell lymphomas (PTCL),cutaneous T-Cell lymphoma and mantle zone lymphoma and low gradefollicular lymphoma.

The non-Hodgkin lymphomas (NHLs) are a diverse group of blood cancersthat include any kind of lymphoma except Hodgkin's lymphomas. Types ofNHL vary significantly in their severity, from indolent to veryaggressive. Less aggressive non-Hodgkin lymphomas are compatible with along survival while more aggressive non-Hodgkin lymphomas can be rapidlyfatal without treatment they can be formed from either B-cells orT-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chroniclymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse largeB-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma,precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cellnon-Hodgkin lymphomas include mycosis fungoides, anaplastic large celllymphoma, and precursor T-lymphoblastic lymphoma. Prognosis andtreatment depend on the stage and type of disease.

Diffuse large B-cell lymphoma (DLBCL) accounts for approximatelyone-third of non-Hodgkin's lymphomas. While some DLBCL patients arecured with traditional chemotherapy, the remainder die from the disease.Anticancer drugs cause rapid and persistent depletion of lymphocytes,possibly by direct apoptosis induction in mature T and B cells. See K.Stahnke. et al., Blood 2001, 98:3066-3073. Absolute lymphocyte count(ALC) has been shown to be a prognostic factor in follicularnon-Hodgkin's lymphoma and recent results have suggested that ALC atdiagnosis is an important prognostic factor in diffuse large B-celllymphoma.

The diffuse large-B-cell lymphomas (DLBCL) can be divided into distinctmolecular subtypes according to their gene profiling patterns:germinal-center B-cell-like DLBCL (GCB-DLBCL), activated B-cell-likeDLBCL (ABC-DLBCL), and primary mediastinal B-cell lymphoma (PMBL) orunclassified type. These subtypes are characterized by distinctdifferences in survival, chemo-responsiveness, and signaling pathwaydependence, particularly the NF-κB pathway. See D. Kim et al., Journalof Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol25, No. 18S (June 20 Supplement), 2007: 8082. See Bea S, et al., Blood2005; 106: 3183-90; Ngo V. N. et al., Nature 2011; 470: 115-9. Suchdifferences have prompted the search for more effective andsubtype-specific treatment strategies in DLBCL.

Leukemia refers to malignant neoplasms of the blood-forming tissues.Various forms of leukemias are described, for example, in U.S. Pat. No.7,393,862 and U.S. provisional patent application No. 60/380,842, filedMay 17, 2002, the entireties of which are incorporated herein byreference. Although viruses reportedly cause several forms of leukemiain animals, causes of leukemia in humans are to a large extent unknown.The Merck Manual, 944-952 (17^(th) ed. 1999). Transformation tomalignancy typically occurs in a single cell through two or more stepswith subsequent proliferation and clonal expansion. In some leukemias,specific chromosomal translocations have been identified with consistentleukemic cell morphology and special clinical features (e.g.,translocations of 9 and 22 in chronic myelocytic leukemia, and of 15 and17 in acute promyelocytic leukemia). Acute leukemias are predominantlyundifferentiated cell populations and chronic leukemias more mature cellforms.

Acute leukemias are divided into lymphoblastic (ALL) andnon-lymphoblastic (ANLL) types. The Merck Manual, 946-949 (17^(th) ed.1999). They may be further subdivided by their morphologic andcytochemical appearance according to the French-American-British (FAB)classification or according to their type and degree of differentiation.The use of specific B- and T-cell and myeloid-antigen monoclonalantibodies are most helpful for classification. ALL is predominantly achildhood disease which is established by laboratory findings and bonemarrow examination. ANLL, also known as acute myelogenous leukemia oracute myeloid leukemia (AML), occurs at all ages and is the more commonacute leukemia among adults; it is the form usually associated withirradiation as a causative agent.

Chronic leukemias are described as being lymphocytic (CLL) or myelocytic(CML). The Merck Manual, 949-952 (17^(th) ed. 1999). CLL ischaracterized by the appearance of mature lymphocytes in blood, bonemarrow, and lymphoid organs. The hallmark of CLL is sustained, absolutelymphocytosis (>5,000/μL) and an increase of lymphocytes in the bonemarrow. Most CLL patients also have clonal expansion of lymphocytes withB-cell characteristics. CLL is a disease of middle or old age. In CML,the characteristic feature is the predominance of granulocytic cells ofall stages of differentiation in blood, bone marrow, liver, spleen, andother organs. In the symptomatic patient at diagnosis, the total whiteblood cell (WBC) count is usually about 200,000/μL, but may reach1,000,000/μL. CML is relatively easy to diagnose because of the presenceof the Philadelphia chromosome.

Bone marrow stromal cells are well known to support CLL diseaseprogression and resistance to chemotherapy. Disrupting the interactionsbetween CLL cells and stromal cells is an additional target of CLLchemotherapy.

In addition to the acute and chronic categorization, neoplasms are alsocategorized based upon the cells giving rise to such disorder intoprecursor or peripheral. See e.g., U.S. patent publication no.2008/0051379, the disclosure of which is incorporated herein byreference in its entirety. Precursor neoplasms include ALLs andlymphoblastic lymphomas and occur in lymphocytes before they havedifferentiated into either a T- or B-cell. Peripheral neoplasms arethose that occur in lymphocytes that have differentiated into either T-or B-cells. Such peripheral neoplasms include, but are not limited to,B-cell CLL, B-cell prolymphocytic leukemia, lymphoplasmacytic lymphoma,mantle cell lymphoma, follicular lymphoma, extranodal marginal zoneB-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginalzone lymphoma, splenic marginal zone lymphoma, hairy cell leukemia,plasmacytoma, diffuse large B-cell lymphoma and Burkitt lymphoma. Inover 95 percent of CLL cases, the clonal expansion is of a B celllineage. See Cancer: Principles & Practice of Oncology (3rd Edition)(1989) (pp. 1843-1847). In less than 5 percent of CLL cases, the tumorcells have a T-cell phenotype. Notwithstanding these classifications,however, the pathological impairment of normal hematopoiesis is thehallmark of all leukemias.

Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow.Normally, plasma cells produce antibodies and play a key role in immunefunction. However, uncontrolled growth of these cells leads to bone painand fractures, anemia, infections, and other complications. Multiplemyeloma is the second most common hematological malignancy, although theexact causes of multiple myeloma remain unknown. Multiple myeloma causeshigh levels of proteins in the blood, urine, and organs, including butnot limited to M-protein and other immunoglobulins (antibodies),albumin, and beta-2-microglobulin. M-protein, short for monoclonalprotein, also known as paraprotein, is a particularly abnormal proteinproduced by the myeloma plasma cells and can be found in the blood orurine of almost all patients with multiple myeloma.

Skeletal symptoms, including bone pain, are among the most clinicallysignificant symptoms of multiple myeloma. Malignant plasma cells releaseosteoclast stimulating factors (including IL-1, IL-6 and TNF) whichcause calcium to be leached from bones causing lytic lesions;hypercalcemia is another symptom. The osteoclast stimulating factors,also referred to as cytokines, may prevent apoptosis, or death ofmyeloma cells. Fifty percent of patients have radiologically detectablemyeloma-related skeletal lesions at diagnosis. Other common clinicalsymptoms for multiple myeloma include polyneuropathy, anemia,hyperviscosity, infections, and renal insufficiency.

Bone marrow stromal cells are well known to support multiple myelomadisease progression and resistance to chemotherapy. Disrupting theinteractions between multiple myeloma cells and stromal cells is anadditional target of multiple myeloma chemotherapy.

Further, rituximab is known to deplete normal host B cells. M. Aklilu etal., Annals of Oncology 15:1109-1114, 2004. The long-term immunologiceffects of B cell depletion with rituximab and the characteristics ofthe reconstituting B cell pool in lymphoma patients are not welldefined, despite the widespread usage of this therapy. See Jennifer H.Anolik et al., Clinical Immunology, vol. 122, issue 2, February 2007,pages 139-145.

The approach for patients with relapsed or refractory disease reliesheavily on experimental treatments followed by stem celltransplantation, which may not be appropriate for patients with a poorperformance status or advanced age. Therefore, a tremendous demandexists for new methods that can be used to treat patients with NHL.

The incidence of cancer continues to climb as the general populationages, as new cancers develop, and as susceptible populations (e.g.,people infected with AIDS or excessively exposed to sunlight) grow. Atremendous demand therefore exists for new methods and compositions thatcan be used to treat patients with cancer including NHL.

2.2. Methods of Treatment

Current cancer therapy may involve surgery, chemotherapy, hormonaltherapy and/or radiation treatment to eradicate neoplastic cells in apatient (see, for example, Stockdale, 1998, Medicine, vol. 3, Rubensteinand Federman, eds., Chapter 12, Section IV). Recently, cancer therapycould also involve biological therapy or immunotherapy. All of theseapproaches pose significant drawbacks for the patient. Surgery, forexample, may be contraindicated due to the health of a patient or may beunacceptable to the patient. Additionally, surgery may not completelyremove neoplastic tissue. Radiation therapy is only effective when theneoplastic tissue exhibits a higher sensitivity to radiation than normaltissue. Radiation therapy can also often elicit serious side effects.Hormonal therapy is rarely given as a single agent. Although hormonaltherapy can be effective, it is often used to prevent or delayrecurrence of cancer after other treatments have removed the majority ofcancer cells. Biological therapies and immunotherapies are limited innumber and may produce side effects such as rashes or swellings,flu-like symptoms, including fever, chills and fatigue, digestive tractproblems or allergic reactions.

With respect to chemotherapy, there are a variety of chemotherapeuticagents available for treatment of cancer. A majority of cancerchemotherapeutics act by inhibiting DNA synthesis, either directly, orindirectly by inhibiting the biosynthesis of deoxyribonucleotidetriphosphate precursors, to prevent DNA replication and concomitant celldivision. Gilman et al., Goodman and Gilman's: The Pharmacological Basisof Therapeutics, Tenth Ed. (McGraw Hill, New York).

Despite availability of a variety of chemotherapeutic agents,chemotherapy has many drawbacks. Stockdale, Medicine, vol. 3. Rubensteinand Federman, eds., ch. 12, sect. 10, 1998. Almost all chemotherapeuticagents are toxic, and chemotherapy causes significant, and oftendangerous side effects including severe nausea, bone marrow depression,and immunosuppression. Additionally, even with administration ofcombinations of chemotherapeutic agents, many tumor cells are resistantor develop resistance to the chemotherapeutic agents. In fact, thosecells resistant to the particular chemotherapeutic agents used in thetreatment protocol often prove to be resistant to other drugs, even ifthose agents act by different mechanism from those of the drugs used inthe specific treatment. This phenomenon is referred to as pleiotropicdrug or multidrug resistance. Because of the drug resistance, manycancers prove refractory to standard chemotherapeutic treatmentprotocols.

Still, there is a significant need for safe and effective methods oftreating, preventing and managing cancer, particularly for tumors thatare refractory to standard treatments, such as surgery, radiationtherapy, chemotherapy and hormonal therapy, while reducing or avoidingthe toxicities and/or side effects associated with the conventionaltherapies. Moreover, there remains a need for the ability to predict andmonitor response to cancer therapy in order to increase the quality ofcare for cancer patients, avoid unnecessary treatment and to increasethe success rate in cancer therapy in clinical practice.

3. SUMMARY

The present invention is based, in part, on the finding that certaingenes are differentially expressed in DLBCL patients responsive to theimmunomodulatory therapy lenalidomide (Revlimid®) relative to DLBCLpatients unresponsive to lenalidomide. In addition, the presentinvention is based, in part, on the finding that the cellularcomposition (e.g., immune cell composition) of the tumor of a DLBCLpatient may be indicative of whether the patient tumor will respond toan immunomodulatory therapy, such as lenalidomide, including itspharmaceutically acceptable salts, solvates or isomers.

In one aspect, provided herein are methods for predicting the clinicalsensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 3, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 3 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and wherein thedifferential expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In a specific embodiment, the hematologicalcancer is DLBCL. In certain embodiments, the DLBCL is refractory tocertain therapies, such as chemotherapy. In some embodiments, the DLBCLis relapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 4, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 4 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and wherein thedifferential expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In a specific embodiment, the hematologicalcancer is DLBCL. In certain embodiments, the DLBCL is refractory tocertain therapies, such as chemotherapy. In some embodiments, the DLBCLis relapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 1 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to the immunomodulatory therapy, and wherein ahigher level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In a specific embodiment, the hematologicalcancer is DLBCL. In certain embodiments, the DLBCL is refractory tocertain therapies, such as chemotherapy. In some embodiments, the DLBCLis refractory relapsed in a patient. In a specific embodiment, the DLBCLis an activated B-cell-like subtype. In another specific embodiment, theDLBCL is a germinal center B-cell-like subtype. The immunomodulatorytherapy can comprise the administration of an immunomodulatory compound,such as lenalidomide, or its pharmaceutically acceptable salts, solvatesor isomers. An immunomodulatory therapy of the embodiments of themethods provided herein can comprise lenalidomide as immunomodulatorycompound, or its pharmaceutically acceptable salts, solvates or isomers.In another specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 2, infra, and (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 2 in the first biological sample with the level ofexpression of the same genes in a second biological sample is from asecond patient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to the immunomodulatory therapy, and wherein alower level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In a specific embodiment, the hematologicalcancer is DLBCL. In certain embodiments, the DLBCL is refractory tocertain therapies, such as chemotherapy. In some embodiments, the DLBCLis relapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and measuring the level ofexpression one, two, three, four, five or more of the genes identifiedin Table 2, infra, and (c) comparing the level of expression of thegenes identified in Tables 1 and 2 in the first biological sample withthe level of expression of the same genes in a second biological sampleis from a second patient having the same type of hematological cancer asthe first patient, wherein the hematological cancer in the secondpatient is clinically insensitive to the immunomodulatory therapy, andwherein (i) a higher level of expression of the one, two, three, four,five or more of the genes identified in Table 1 in the first biologicalsample relative to the level of expression of the one, two, three, four,five or more of the genes in the second biological sample, and (ii) alower level of expression of the one, two, three, four, five or more ofthe genes identified in Table 2 in the first biological sample relativeto the level of expression of the one, two, three, four, five or more ofthe genes in the second biological sample, indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy. In a specific embodiment,the hematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.In another specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1, 2, 3 or 4, or any combination thereof in the first biologicalsample, and (c) comparing the gene expression profile of the genes orsubset of genes in the first biological sample to (i) the geneexpression profile of the genes or subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to an immunomodulatory therapy and (ii) the geneexpression of the genes or subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy, wherein a geneexpression profile for the genes or subset of genes in the firstbiological sample similar to the gene expression profile for the genesor subset of genes in tumor samples from patients having the same typeof hematological cancer which are clinically sensitive to theimmunomodulatory therapy indicates that the hematological cancer in thefirst patient will be clinical sensitive to treatment with theimmunomodulatory therapy, and a gene expression profile for the genes orsubset of genes in first biological sample similar to the geneexpression profile for the genes or subset of genes in tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 1, 2, 3 or 4, or anycombination thereof. In some embodiments, the subset of genes comprises2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of the genes in Table 1, 2, 3 or4, or any combination thereof. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells in the first tumor sample, and (c)comparing the proportion of dendritic cells in the first tumor samplewith the proportion of dendritic cells in a second tumor sample from asecond patient having the same type of hematological cancer, wherein thesecond patient's hematological cancer is clinically insensitive totreatment with the immunomodulatory therapy, and wherein a higherproportion of dendritic cells in the first tumor sample relative theproportion of dendritic cells in the second tumor sample indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy. In a specificembodiment, the hematological cancer is DLBCL. In certain embodiments,the DLBCL is refractory to certain therapies, such as chemotherapy. Insome embodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of plasma cells in the first tumor sample, and (c) comparingthe proportion of plasma cells in the first tumor sample with theproportion of plasma cells in a second tumor sample from a secondpatient having the same type of hematological cancer, wherein the secondpatient's hematological cancer is clinically insensitive to treatmentwith the immunomodulatory therapy, and wherein a higher proportion ofplasma cells in the first tumor sample relative the proportion of plasmacells in the second tumor sample indicates that the hematological cancerin the first patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In a specific embodiment, the hematologicalcancer is DLBCL. In certain embodiments, the DLBCL is refractory tocertain therapies, such as chemotherapy. In some embodiments, the DLBCLis relapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells and plasma cells in the first tumorsample, and (c) comparing the proportion of dendritic cells and plasmacells in the first tumor sample with the proportion of dendritic cellsand plasma cells in a second tumor sample from a second patient havingthe same type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with theimmunomodulatory therapy, and wherein a higher proportion of dendriticcells and plasma cells in the first tumor sample relative the proportionof dendritic cells and plasma cells in the second tumor sample indicatesthat the hematological cancer in the first patient will be clinicalsensitive to treatment with the immunomodulatory therapy. In a specificembodiment, the hematological cancer is DLBCL. In certain embodiments,the DLBCL is refractory to certain therapies, such as chemotherapy. Insome embodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having a hematological cancer, (b) measuring theproportion of immune cells in the tumor sample, and (c) comparing theproportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a proportion of the immune cells inthe first tumor sample similar to the proportion of the same immunecells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy indicates that the hematological cancer in thefirst patient will be clinical sensitive to treatment with theimmunomodulatory therapy, and a proportion of the immune cells in thefirst tumor sample similar to the proportion of the same immune cells intumor samples from patients having the same type of hematological cancerwhich are clinically insensitive to the immunomodulatory therapyindicates that the hematological cancer in the first patient will beclinical insensitive to treatment with the immunomodulatory therapy. Insome embodiments, the immune cells are subset of immune cells, such assubset of B cells. In certain embodiments, the immune cells aredendritic cells. In some embodiments, the immune cells are plasma cells.In certain embodiments, the immune cells are monocytes. In someembodiments, the immune cells are tumor infiltrating immune cells. Incertain embodiments, the immune cells are T cells. In some embodiments,the immune cells are B cells. In certain embodiments, the immune cellsare NK cells. In some embodiments, the immune cells are two, three ormore subsets of immune cells, such as two more types of T cells (e.g.,CD4+ and CD8+ T cells). In some embodiments, the proportion of differentpopulations of immune cells in the first tumor sample are compared to(i) the proportion of the same populations of immune cells in the tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy and (ii) theproportion of the same populations of immune cells in the tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy. In a specificembodiment, the hematological cancer is DLBCL. In certain embodiments,the DLBCL is refractory to certain therapies, such as chemotherapy. Insome embodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 3, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 3 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if theone, two, three, four, five or more of the genes in the first biologicalsample are differentially expressed relative to the level of expressionof the one, two, three, four, five or more of the genes in the secondbiological sample. In a specific embodiment, the hematological cancer isDLBCL. In certain embodiments, the DLBCL is refractory to certaintherapies, such as chemotherapy. In some embodiments, the DLBCL isrelapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 4, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 4 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if theone, two, three, four, five or more of the genes in the first biologicalsample are differentially expressed relative to the level of expressionof the one, two, three, four, five or more of the genes in the secondbiological sample. In a specific embodiment, the hematological cancer isDLBCL. In certain embodiments, the DLBCL is refractory to certaintherapies, such as chemotherapy. In some embodiments, the DLBCL isrelapsed in a patient. In a specific embodiment, the DLBCL is anactivated B-cell-like subtype. In another specific embodiment, the DLBCLis a germinal center B-cell-like subtype. The immunomodulatory therapycan comprise the administration of an immunomodulatory compound, such aslenalidomide, or its pharmaceutically acceptable salts, solvates orisomers. An immunomodulatory therapy of the embodiments of the methodsprovided herein can comprise lenalidomide as immunomodulatory compound,or its pharmaceutically acceptable salts, solvates or isomers. Inanother specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 1 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if ahigher level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample is measured relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. Theimmunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 2, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 2 in the first biological sample with the level ofexpression of the same genes in a second biological sample is from asecond patient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if alower level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample is measured relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample. In certain embodiments, theimmunomodulatory therapy is not administered or additional assays areconducted if the level of expression of one, two, three, four, five ormore of the genes are not lower in the first biological sample than inthe second biological sample. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and measuring the level ofexpression one, two, three, four, five or more of the genes identifiedin Table 2, supra, (c) comparing the level of expression of the genesidentified in Tables 1 and 2 in the first biological sample with thelevel of expression of the same genes in a second biological sample isfrom a second patient having the same type of hematological cancer asthe first patient, wherein the hematological cancer in the secondpatient is clinically insensitive to an immunomodulatory therapy, and(d) administering the immunomodulatory to the first patient if (i) ahigher level of expression of the one, two, three, four, five or more ofthe genes identified in Table 1 in the first biological sample ismeasured relative to the level of expression of the one, two, three,four, five or more of the genes in the second biological sample, and(ii) a lower level of expression of the one, two, three, four, five ormore of the genes identified in Table 2 in the first biological sampleis measured relative to the level of expression of the one, two, three,four, five or more of the genes in the second biological sample. In aspecific embodiment, the hematological cancer is DLBCL. In certainembodiments, the DLBCL is refractory to certain therapies, such aschemotherapy. In some embodiments, the DLBCL is relapsed in a patient.In a specific embodiment, the DLBCL is an activated B-cell-like subtype.In another specific embodiment, the DLBCL is a germinal centerB-cell-like subtype. The immunomodulatory therapy can comprise theadministration of an immunomodulatory compound, such as lenalidomide, orits pharmaceutically acceptable salts, solvates or isomers. Animmunomodulatory therapy of the embodiments of the methods providedherein can comprise lenalidomide as immunomodulatory compound, or itspharmaceutically acceptable salts, solvates or isomers. In anotherspecific embodiment, the immunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 1, 2, 3or 4, or any combination thereof in the first biological sample, and (c)comparing the gene expression profile of the subset of genes in thefirst biological sample to (i) the gene expression profile of the subsetof genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the subset ofgenes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if: (i) the gene expression profile for thesubset of genes in the first biological sample is similar to the geneexpression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to the immunomodulatory therapy and (ii) the geneexpression profile for the subset of genes in first biological sample isnot similar to the gene expression profile for the subset of genes intumor samples from patients having the same type of hematological cancerwhich are clinically insensitive to the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 1, 2, 3 or 4, or anycombination thereof. In some embodiments, the subset of genes comprises2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of the genes in Table 1, 2, 3 or4, or any combination thereof. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.In another specific embodiment, the immunomodulatory therapy islenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells in the first tumor sample, (c) comparingthe proportion of dendritic cells in the first tumor sample with theproportion of dendritic cells in a second tumor sample from a secondpatient having the same type of hematological cancer, wherein the secondpatient's hematological cancer is clinically insensitive to treatmentwith an immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if a higher proportion ofdendritic cells in the first tumor sample is measured relative theproportion of dendritic cells in the second tumor sample. In a specificembodiment, the hematological cancer is DLBCL. In certain embodiments,the DLBCL is refractory to certain therapies, such as chemotherapy. Insome embodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of plasma cells in the first tumor sample, (c) comparing theproportion of plasma cells in the first tumor sample with the proportionof plasma cells in a second tumor sample from a second patient havingthe same type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with animmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if a higher proportion of plasma cells inthe first tumor sample is measured relative the proportion of plasmacells in the second tumor sample. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells and plasma cells in the first tumorsample, (c) comparing the proportion of dendritic cells and plasma cellsin the first tumor sample with the proportion of dendritic cells andplasma cells in a second tumor sample from a second patient having thesame type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with animmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if a higher proportion of dendritic cellsand plasma cells in the first tumor sample is measured relative theproportion of dendritic cells and plasma cells in the second tumorsample. In a specific embodiment, the hematological cancer is DLBCL. Incertain embodiments, the DLBCL is refractory to certain therapies, suchas chemotherapy. In some embodiments, the DLBCL is relapsed in apatient. In a specific embodiment, the DLBCL is an activated B-cell-likesubtype. In another specific embodiment, the DLBCL is a germinal centerB-cell-like subtype. The immunomodulatory therapy can comprise theadministration of an immunomodulatory compound, such as lenalidomide, orits pharmaceutically acceptable salts, solvates or isomers. Animmunomodulatory therapy of the embodiments of the methods providedherein can comprise lenalidomide as immunomodulatory compound, or itspharmaceutically acceptable salts, solvates or isomers. In anotherspecific embodiment, the immunomodulatory therapy is lenalidomide.

In another aspect, provided herein are for managing or treating ahematological cancer comprising: (a) obtaining a first tumor sample froma first patient having a hematological cancer, (b) measuring theproportion of immune cells in the first tumor sample, and (c) comparingthe proportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the proportion of the immune cells inthe first tumor sample is (i) similar to the proportion of the sameimmune cells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy, and (ii) not similar to the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy. In a specific embodiment, thehematological cancer is DLBCL. In certain embodiments, the DLBCL isrefractory to certain therapies, such as chemotherapy. In someembodiments, the DLBCL is relapsed in a patient. In a specificembodiment, the DLBCL is an activated B-cell-like subtype. In anotherspecific embodiment, the DLBCL is a germinal center B-cell-like subtype.The immunomodulatory therapy can comprise the administration of animmunomodulatory compound, such as lenalidomide, or its pharmaceuticallyacceptable salts, solvates or isomers. An immunomodulatory therapy ofthe embodiments of the methods provided herein can comprise lenalidomideas immunomodulatory compound, or its pharmaceutically acceptable salts,solvates or isomers. In another specific embodiment, theimmunomodulatory therapy is lenalidomide.

In accordance with the methods described herein, the biological samplecan be any sample obtained from the patient. In certain embodiments, thebiological sample is a cell sample. In other embodiments, the biologicalsample is whole blood sample, peripheral blood mononuclear cell sample,or tissue sample. In specific embodiments, the biological sample is atumor sample. See Section 5.8, infra, regarding biological samples.

In accordance with the methods described herein, the level of expressionof one, two, three, four, five or more of the genes in Table 1 and/orTable 2 and/or Table 3 and/or Table 4, infra, can be measured at the RNAand/or protein levels. In certain embodiments, the level of expressionof the genes are measured at the RNA (e.g., mRNA) level. In otherembodiments, the level of expression of the genes are measured at theprotein level.

In another aspect, provided herein are kits useful for predicting thelikelihood of an effective patient tumor response. In certainembodiments, the kit comprises a solid support, and a means fordetecting the protein expression of at least one biomarker in abiological sample. Such a kit may employ, for example, a dipstick, amembrane, a chip, a disk, a test strip, a filter, a microsphere, aslide, a multiwell plate, or an optical fiber. The solid support of thekit can be, for example, a plastic, silicon, a metal, a resin, glass, amembrane, a particle, a precipitate, a gel, a polymer, a sheet, asphere, a polysaccharide, a capillary, a film, a plate, or a slide. Insome embodiments, the kit comprises a solid support, nucleic acidscontacting the support, where the nucleic acids are complementary to atleast 20, 50, 100, 200, 350, or more bases of mRNA, and a means fordetecting the expression of the mRNA in a biological sample.

In certain embodiments, the kits provided herein employ means fordetecting the expression of a biomarker by quantitative real-time PCR(QRT-PCR), microarray, flow cytometry or immunofluorescence. In otherembodiments, the expression of the biomarker is measured by ELISA-basedmethodologies or other similar methods known in the art.

4. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1: Hierarchical clustering (Euclidean distance; Ward linkage) ofrelative gene expression across 21 lenalidomide/Revlimid®-arm FFprofiles, as represented by A. 1018 genes deemed significantlydifferentially regulated at FDR5%, and B. A subset of those genes deemedsignificantly differentially regulated at FDR1%, between discretebest-response categories. Gene expressions standardized to zero mean andunit standard variance across all profiles. Bars below dendrogramdisplay: DLBCL cell of origin sub-type {GCB (white), ABC/Other (black),as determined by IHC at screen}; Investigator defined best response ofpatients in the Revlimid arm, {CR,PR,SD}(black) vs. {PD,Death}(white).

FIG. 2: Decomposition of 21 lenalidomide/Revlimid®-arm profiles derivedfrom FF samples. Each boxplot represents estimated proportion (y-axis)of corresponding cell phenotype (x-axis) across two discreteInvestigator defined best-response categories, {CR,PR,SD} (grey) and{PD,death}(white). Cell-types on the x-axis are: T-helper cells (Th);Activated T-helper cells (Th act); T-cells (Tc); Activated T-cells (Tcact); B-cells (B); Activated B-cells (B act); BCR-ligated B-cells (BaIgM); IgG Memory B-cells (Mem IgG); IgM Memory B-cells (Mem IgM);Plasma cells (PC); Natural Killer cells (NK); Activated Natural Killercells (NK act); Monocytes (mono); Activated Monocytes (mono act);Dendritic Cells (DC); Activated Dendritic cells (DC act); Neutrophils(neutro). Phenotypic cell types defined in (Abbas et al., PLoS One,2009).

FIG. 3: Summed estimated proportion of resting and activated dendriticcells (y-axis, left) across 21 lenalidomide/Revlimid®-arm profilesderived from FF samples (x-axis; triangles, ordered by descending PFS).PFS (y-axis, right; unit weeks) overlaid as line-connected points, withcensor events denoted by a cross.

FIG. 4: Summed estimated proportion of BCR-ligated B-cells (y-axis,left) across 21 lenalidomide/Revlimid®-arm profiles derived from FFsamples (x-axis; triangles, ordered by descending PFS). PFS (y-axis,right; unit weeks) overlaid as line-connected points, with censor eventsdenoted by a cross.

FIG. 5: Bar plot of difference in estimated proportion of BCR-ligatedB-cells and plasma cells (y-axis, left), derived fromlenalidomide/Revlimid®-arm FF profiles (one profile per bar, x-axis;sorted in order of increasing difference between BCR-ligatedB-cell/plasma-cell proportions. PFS (y-axis, right; unit weeks) overlaidas line-connected points, with censor events denoted by a cross. Dashedline represents median PFS in the two groups defined by estimatedBCR-ligated B-cell proportion being greater or less than estimatedplasma cell proportion.

5. DETAILED DESCRIPTION 5.1 Terminology

As used herein, and unless otherwise specified, the terms “treat,”“treating” and “treatment” refer to an action that occurs while apatient is suffering from the specified cancer, which includes thereduction in the severity of the cancer, reduces tumor size, or retardsor slows the progression of the cancer.

The term “sensitivity” and “sensitive” when made in reference totreatment with compound is a relative term which refers to the degree ofeffectiveness of the compound in lessening or decreasing the progress ofa tumor or the disease being treated.

As used herein, and unless otherwise specified, the term “effectiveamount” of a compound is an amount sufficient to provide a therapeuticbenefit in the treatment or management of a cancer, or to delay orminimize one or more symptoms associated with the presence of thecancer. An effective amount of a compound means an amount of therapeuticagent, alone or in combination with other therapies, which provides atherapeutic benefit in the treatment or management of the cancer. Theterm “effective amount” can encompass an amount that improves overalltherapy, reduces or avoids symptoms or causes of cancer, or enhances thetherapeutic efficacy of another therapeutic agent.

As used herein, an “effective patient tumor response” refers to anyincrease in the therapeutic benefit to the patient. An “effectivepatient tumor response” can be, for example, a 5%, 10%, 15%, 20%, 25%,30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% decrease in the rate ofprogress of the tumor. An “effective patient tumor response” can be, forexample, a 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or100% decrease in the physical symptoms of a cancer. An “effectivepatient tumor response” can be, for example, a 5%, 10%, 15%, 20%, 25%,30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% decrease in the size of atumor. An “effective patient tumor response” can be, for example, a 5%,10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% decreasein the physical symptoms of a cancer. An “effective patient tumorresponse” can also be, for example, a 5%, 10%, 15%, 20%, 25%, 30%, 40%,50%, 60%, 70%, 80%, 90%, 100%, or 200%, or more increase in the responseof the patient, as measured by any suitable means, such as geneexpression, cell counts, assay results, etc.

The term “likelihood” generally refers to an increase in the probabilityof an event. The term “likelihood” when used in reference to theeffectiveness of a patient tumor response generally contemplates anincreased probability that the rate of tumor progress or tumor cellgrowth will decrease. The term “likelihood” when used in reference tothe effectiveness of a patient tumor response can also generally meanthe increase of indicators, such as mRNA or protein expression, that mayevidence an increase in the progress in treating the tumor.

The term “predict” generally means to determine or tell in advance. Whenused to “predict” the effectiveness of a cancer treatment, for example,the term “predict” can mean that the likelihood of the outcome of thecancer treatment can be determined at the outset, before the treatmenthas begun, or before the treatment period has progressed substantially.

An improvement in the cancer or cancer-related disease can becharacterized as a complete or partial response. “Complete response”refers to an essential absence (or absence) of clinically detectabledisease with normalization of any previously abnormal radiographicstudies, bone marrow, and cerebrospinal fluid (CSF) or abnormalmonoclonal protein measurements. “Partial response” refers to at leastabout a 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%decrease in all measurable tumor burden (i.e., the number of malignantcells present in the subject, or the measured bulk of tumor masses orthe quantity of abnormal monoclonal protein) in the absence of newlesions. The term “treatment” contemplates both a complete and a partialresponse.

“Tumor,” as used herein, refers to all neoplastic cell growth andproliferation, whether malignant or benign, and all pre-cancerous andcancerous cells and tissues. “Neoplastic,” as used herein, refers to anyform of dysregulated or unregulated cell growth, whether malignant orbenign, resulting in abnormal tissue growth. Thus, “neoplastic cells”include malignant and benign cells having dysregulated or unregulatedcell growth.

The terms “cancer” and “cancerous” refer to or describe thephysiological condition in mammals that is typically characterized byunregulated cell growth. Examples of cancer include, but are not limitedto, blood-borne tumors (e.g., multiple myeloma, lymphoma and leukemia),and solid tumors.

The term “refractory or resistant” refers to a circumstance wherepatients, even after intensive treatment, have residual cancer cells(e.g., leukemia or lymphoma cells) in their lymphatic system, bloodand/or blood forming tissues (e.g., marrow).

As used herein the terms “polypeptide” and “protein” as usedinterchangeably herein, refer to a polymer of amino acids of three ormore amino acids in a serial array, linked through peptide bonds. Theterm “polypeptide” includes proteins, protein fragments, proteinanalogues, oligopeptides and the like. The term polypeptide as usedherein can also refer to a peptide. The amino acids making up thepolypeptide may be naturally derived, or may be synthetic. Thepolypeptide can be purified from a biological sample.

An mRNA that is “upregulated” is generally increased upon a giventreatment or condition. An mRNA that is “downregulated” generally refersto a decrease in the level of expression of the mRNA in response to agiven treatment or condition. In some situations, the mRNA level canremain unchanged upon a given treatment or condition.

An mRNA from a patient sample can be “upregulated” when treated with animmunomodulatory therapy, as compared to a control. This upregulationcan be, for example, an increase of about 5%, 10%, 20%, 30%, 40%, 50%,60%, 70%, 90%, 100%, 200%, 300%, 500%, 600%, 700%, 800%, 900%, 1,000%,1,500%, 2,000%, 2,500%, 3,00%, 3,500%, 4,000%, 4,500%, 5,000% or more ofthe comparative control mRNA level.

Alternatively, an mRNA can be “downregulated”, or expressed at a lowerlevel, in response to administration of certain immunomodulatorytherapies or other therapies. A downregulated mRNA can be, for example,present at a level of about 99%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%,55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, 5%, 3%, 1% or less ofthe comparative control mRNA level.

Similarly, the level of a polypeptide or protein biomarker from apatient sample can be increased when treated with an immunomodulatorytherapy, as compared to a non-treated control. This increase can beabout 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 300%,400%, 500%, 700%, 1,000%, 1,500%, 2,000%, 2,500%, 3,000%, 3,500%,4,000%, 4,500%, 5,000% or more of the comparative control protein level.

Alternatively, the level of a protein biomarker can be decreased inresponse to administration of certain immunomodulatory therapies orother agents. This decrease can be, for example, present at a level ofabout 99%, 95%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, 5%, 3%, 1%or less of the comparative control protein level.

The terms “determining”, “measuring”, “evaluating”, “assessing” and“assaying” as used herein generally refer to any form of measurement,and include determining if an element is present or not. These termsinclude both quantitative and/or qualitative determinations. Assessingmay be relative or absolute. “Assessing the presence of” can includedetermining the amount of something present, as well as determiningwhether it is present or absent.

The terms “nucleic acid” and “polynucleotide” are used interchangeablyherein to describe a polymer of any length composed of nucleotides,e.g., deoxyribonucleotides or ribonucleotides, or compounds producedsynthetically, which can hybridize with naturally occurring nucleicacids in a sequence specific manner analogous to that of two naturallyoccurring nucleic acids, e.g., can participate in Watson-Crick basepairing interactions. As used herein in the context of a polynucleotidesequence, the term “bases” (or “base”) is synonymous with “nucleotides”(or “nucleotide”), i.e., the monomer subunit of a polynucleotide. Theterms “nucleoside” and “nucleotide” are intended to include thosemoieties that contain not only the known purine and pyrimidine bases,but also other heterocyclic bases that have been modified. Suchmodifications include methylated purines or pyrimidines, acylatedpurines or pyrimidines, alkylated riboses or other heterocycles. Inaddition, the terms “nucleoside” and “nucleotide” include those moietiesthat contain not only conventional ribose and deoxyribose sugars, butother sugars as well. Modified nucleosides or nucleotides also includemodifications on the sugar moiety, e.g., wherein one or more of thehydroxyl groups are replaced with halogen atoms or aliphatic groups, orare functionalized as ethers, amines, or the like. “Analogues” refer tomolecules having structural features that are recognized in theliterature as being mimetics, derivatives, having analogous structures,or other like terms, and include, for example, polynucleotidesincorporating non-natural nucleotides, nucleotide mimetics such as2′-modified nucleosides, peptide nucleic acids, oligomeric nucleosidephosphonates, and any polynucleotide that has added substituent groups,such as protecting groups or linking moieties.

The terms “isolated” and “purified” refer to isolation of a substance(such as mRNA or protein) such that the substance comprises asubstantial portion of the sample in which it resides, i.e. greater thanthe substance is typically found in its natural or un-isolated state.Typically, a substantial portion of the sample comprises, e.g., greaterthan 1%, greater than 2%, greater than 5%, greater than 10%, greaterthan 20%, greater than 30%, greater than 50%, or more, usually up toabout 90%-100% of the sample. For example, a sample of isolated mRNA cantypically comprise at least about 1% total mRNA. Techniques forpurifying polynucleotides are well known in the art and include, forexample, gel electrophoresis, ion-exchange chromatography, affinitychromatography, flow sorting, and sedimentation according to density.

The term “sample” as used herein relates to a material or mixture ofmaterials, typically, although not necessarily, in fluid form,containing one or more components of interest.

“Biological sample” as used herein refers to a sample obtained from abiological subject, including sample of biological tissue or fluidorigin, obtained, reached, or collected in vivo or in situ. A biologicalsample also includes samples from a region of a biological subjectcontaining precancerous or cancer cells or tissues. Such samples can be,but are not limited to, organs, tissues, fractions and cells isolatedfrom a subject. Exemplary biological samples include but are not limitedto cell lysate, a cell culture, a cell line, a tissue, oral tissue,gastrointestinal tissue, an organ, an organelle, a biological fluid, ablood sample, a urine sample, a skin sample, and the like. Preferredbiological samples include but are not limited to whole blood, partiallypurified blood, PBMCs, tissue biopsies, and the like.

As used herein, the terms “patient” and “subject” refer to an animal,such as a mammal. In a specific embodiment, the patient is a human. Inother embodiments, the patient is a non-human animal, such as a dog,cat, farm animal (e.g., horse, pig, or donkey), chimpanzee, or monkey.

A biological marker or “biomarker” is a substance whose detectionindicates a particular biological state, such as, for example, thepresence of cancer. In some embodiments, biomarkers can either bedetermined individually, or several biomarkers can be measuredsimultaneously.

A “biomarker” can indicate a change in the level of mRNA expression thatmay correlate with the risk or progression of a disease, or with thesusceptibility of the disease to a given treatment. In some embodiments,the biomarker is a nucleic acid, such as a mRNA or cDNA.

A “biomarker” can also indicate a change in the level of polypeptide orprotein expression that may correlate with the risk, susceptibility totreatment, or progression of a disease. The biomarker can be apolypeptide or protein, or a fragment thereof. The relative level ofspecific proteins can be determined by methods known in the art. Forexample, antibody based methods, such as an immunoblot, enzyme-linkedimmunosorbent assay (ELISA), or other methods can be used.

As used herein and unless otherwise indicated, the term“pharmaceutically acceptable salt” encompasses non-toxic acid and baseaddition salts of the compound to which the term refers. Acceptablenon-toxic acid addition salts include those derived from organic andinorganic acids or bases know in the art, which include, for example,hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid,methanesulphonic acid, acetic acid, tartaric acid, lactic acid, succinicacid, citric acid, malic acid, maleic acid, sorbic acid, aconitic acid,salicylic acid, phthalic acid, embolic acid, enanthic acid, and thelike.

Compounds that are acidic in nature are capable of forming salts withvarious pharmaceutically acceptable bases. The bases that can be used toprepare pharmaceutically acceptable base addition salts of such acidiccompounds are those that form non-toxic base addition salts, i.e., saltscontaining pharmacologically acceptable cations such as, but not limitedto, alkali metal or alkaline earth metal salts and the calcium,magnesium, sodium or potassium salts in particular. Suitable organicbases include, but are not limited to, N,N-dibenzylethylenediamine,chloroprocaine, choline, diethanolamine, ethylenediamine, meglumaine(N-methylglucamine), lysine, and procaine.

As used herein and unless otherwise indicated, the term “solvate” meansa compound provided herein or a salt thereof, that further includes astoichiometric or non-stoichiometric amount of solvent bound bynon-covalent intermolecular forces. Where the solvent is water, thesolvate is a hydrate.

As used herein and unless otherwise indicated, the term “stereomericallypure” means a composition that comprises one stereoisomer of a compoundand is substantially free of other stereoisomers of that compound. Forexample, a stereomerically pure composition of a compound having onechiral center will be substantially free of the opposite enantiomer ofthe compound. A stereomerically pure composition of a compound havingtwo chiral centers will be substantially free of other diastereomers ofthe compound. A typical stereomerically pure compound comprises greaterthan about 80% by weight of one stereoisomer of the compound and lessthan about 20% by weight of other stereoisomers of the compound, morepreferably greater than about 90% by weight of one stereoisomer of thecompound and less than about 10% by weight of the other stereoisomers ofthe compound, even more preferably greater than about 95% by weight ofone stereoisomer of the compound and less than about 5% by weight of theother stereoisomers of the compound, and most preferably greater thanabout 97% by weight of one stereoisomer of the compound and less thanabout 3% by weight of the other stereoisomers of the compound. As usedherein and unless otherwise indicated, the term “stereomericallyenriched” means a composition that comprises greater than about 60% byweight of one stereoisomer of a compound, preferably greater than about70% by weight, more preferably greater than about 80% by weight of onestereoisomer of a compound. As used herein and unless otherwiseindicated, the term “enantiomerically pure” means a stereomerically purecomposition of a compound having one chiral center. Similarly, the term“stereomerically enriched” means a stereomerically enriched compositionof a compound having one chiral center.

It should be noted that if there is a discrepancy between a depictedstructure and a name given that structure, the depicted structure is tobe accorded more weight. In addition, if the stereochemistry of astructure or a portion of a structure is not indicated with, forexample, bold or dashed lines, the structure or portion of the structureis to be interpreted as encompassing all stereoisomers of it.

The practice of the embodiments provided herein will employ, unlessotherwise indicated, conventional techniques of molecular biology,microbiology, and immunology, which are within the skill of thoseworking in the art. Such techniques are explained fully in theliterature. Examples of particularly suitable texts for consultationinclude the following: Sambrook et al. (1989) Molecular Cloning; ALaboratory Manual (2d ed.); D. N. Glover, ed. (1985) DNA Cloning,Volumes I and II; M. J. Gait, ed. (1984) Oligonucleotide Synthesis; B.D. Hames & S J. Higgins, eds. (1984) Nucleic Acid Hybridization; B. D.Hames & S. J. Higgins, eds. (1984) Transcription and Translation; R. I.Freshney, ed. (1986) Animal Cell Culture; Immobilized Cells and Enzymes(IRL Press, 1986); Immunochemical Methods in Cell and Molecular Biology(Academic Press, London); Scopes (1987) Protein Purification: Principlesand Practice (2d ed.; Springer Verlag, N.Y.); and D. M. Weir and C. C.Blackwell, eds. (1986) Handbook of Experimental Immunology, VolumesI-IV.

5.2 Methods for Predicting Clinical Sensitivity of a HematologicalCancer by Measuring Gene Expression

In one aspect, provided herein are methods for predicting the clinicalsensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 3 or 4, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 3 or 4 in the first biological sample with the levelof expression of the same genes in a second biological sample from asecond patient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and wherein thedifferential expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 1 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to the immunomodulatory therapy, and wherein ahigher level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 2, infra, and (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 2 in the first biological sample with the level ofexpression of the same genes in a second biological sample is from asecond patient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to the immunomodulatory therapy, and wherein alower level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample indicates that the hematological cancer inthe first patient will be clinical sensitive to treatment with theimmunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and measuring the level ofexpression one, two, three, four, five or more of the genes identifiedin Table 2, infra, and (c) comparing the level of expression of thegenes identified in Tables 1 and 2 in the first biological sample withthe level of expression of the same genes in a second biological sampleis from a second patient having the same type of hematological cancer asthe first patient, wherein the hematological cancer in the secondpatient is clinically insensitive to the immunomodulatory therapy, andwherein (i) a higher level of expression of the one, two, three, four,five or more of the genes identified in Table 1 in the first biologicalsample relative to the level of expression of the one, two, three, four,five or more of the genes in the second biological sample, and (ii) alower level of expression of the one, two, three, four, five or more ofthe genes identified in Table 2 in the first biological sample relativeto the level of expression of the one, two, three, four, five or more ofthe genes in the second biological sample, indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining biological samplesfrom patients having a hematological cancer, (b) measuring the level ofexpression of one, two, three, four, five or more of the genesidentified in Table 3, infra, (c) assessing expression levels of theselected genes, either individually, conjointly, or via a functionaltransformation thereof, and (d) using of the expression levels topredict patients as sensitive or insensitive to an immunomodulatorytherapy, via similarity to expression phenotypes displayed across thesame genes by patients with the same indication and already known to besensitive or insensitive to that therapy.

In one aspect, provided herein are methods for predicting the clinicalsensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining biological samplesfrom patients having a hematological cancer, (b) measuring the level ofexpression of one, two, three, four, five or more of the genesidentified in Table 4, infra, (c) assessing expression levels of theselected genes, either individually, conjointly, or via a functionaltransformation thereof, and (d) using of the expression levels topredict patients as sensitive or insensitive to an immunomodulatorytherapy, via similarity to expression phenotypes displayed across thesame genes by patients with the same indication and already known to besensitive or insensitive to that therapy.

In one aspect, provided herein are methods for predicting the clinicalsensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining biological samplesfrom patients having a hematological cancer, (b) measuring the level ofexpression of one, two, three, four, five or more of the genesidentified in Table 1, infra, (c) assessing expression levels of theselected genes, either individually, conjointly, or via a functionaltransformation thereof, and (d) using of the expression levels topredict patients as sensitive or insensitive to an immunomodulatorytherapy, via similarity to expression phenotypes displayed across thesame genes by patients with the same indication and already known to besensitive or insensitive to that therapy.

In one aspect, provided herein are methods for predicting the clinicalsensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining biological samplesfrom patients having a hematological cancer, (b) measuring the level ofexpression of one, two, three, four, five or more of the genesidentified in Table 2, infra, (c) assessing expression levels of theselected genes, either individually, conjointly, or via a functionaltransformation thereof, and (d) using of the expression levels topredict patients as sensitive or insensitive to an immunomodulatorytherapy, via similarity to expression phenotypes displayed across thesame genes by patients with the same indication and already known to besensitive or insensitive to that therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3 in thefirst biological sample, and (c) comparing the gene expression profileof the subset of genes in the first biological sample to (i) the geneexpression profile of the subset of genes in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the gene expression ofthe subset of genes in tumor samples from patients having the same typeof hematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thesubset of genes in the first biological sample similar to the geneexpression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to the immunomodulatory therapy indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy, and a gene expressionprofile for the subset of genes in first biological sample similar tothe gene expression profile for the subset of genes in tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 3. In some embodiments,the subset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 ofthe genes in Table 3.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3 in thefirst biological sample, and (c) comparing the gene expression profileof the subset of genes in the first biological sample to (i) the geneexpression profile of the subset of genes in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the gene expression ofthe subset of genes in tumor samples from patients having the same typeof hematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thesubset of genes in the first biological sample similar to the geneexpression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to the immunomodulatory therapy indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy. In certain embodiments, thesubset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 ormore of the genes in Table 3. In some embodiments, the subset of genescomprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of the genes in Table3.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3 in thefirst biological sample, and (c) comparing the gene expression profileof the subset of genes in the first biological sample to (i) the geneexpression profile of the subset of genes in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the gene expression ofthe subset of genes in tumor samples from patients having the same typeof hematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thesubset of genes in first biological sample similar to the geneexpression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 3. In some embodiments,the subset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 ofthe genes in Table 3.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in Table 4 in tumor samples from patients having thesame type of hematological cancer which are clinically insensitive tothe immunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy, and a gene expressionprofile for the subset of genes in first biological sample similar tothe gene expression profile for the subset of genes in tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 4. In some embodiments,the subset of genes comprises 2-5, 5-10, or 10-15 of the genes in Table4.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in Table 4 in tumor samples from patients having thesame type of hematological cancer which are clinically insensitive tothe immunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy. In certain embodiments,the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 ormore of the genes in Table 4. In some embodiments, the subset of genescomprises 2-5, 5-10, or 10-15 of the genes in Table 4.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in Table 4 in tumor samples from patients having thesame type of hematological cancer which are clinically insensitive tothe immunomodulatory therapy, wherein a gene expression profile for thesubset of genes in first biological sample similar to the geneexpression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 4. In some embodiments,the subset of genes comprises 2-5, 5-10, or 10-15 of the genes in Table4.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to the immunomodulatory therapy indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy, and a gene expressionprofile for the genes or subset of genes in first biological samplesimilar to the gene expression profile for the genes or subset of genesin tumor samples from patients having the same type of hematologicalcancer which are clinically insensitive to the immunomodulatory therapyindicates that the hematological cancer of the first patient will beclinically insensitive to the treatment with the immunomodulatorytherapy. In certain embodiments, the subset of genes comprises 3, 4, 5,6, 7, 8, 9, 10, 11, 12, 14, 15 or more of the genes in Table 1. In someembodiments, the subset of genes comprises 2-5, 5-10, 10-15, 15-20,20-25 or 25-30 of the genes in Table 1.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to the immunomodulatory therapy indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy. In certain embodiments, thesubset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 ormore of the genes in Table 1. In some embodiments, the subset of genescomprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of the genes in Table1.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in first biological sample similar to the geneexpression profile for the genes or subset of genes in tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 14, 15 or more of the genes in Table 1. In some embodiments,the subset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 ofthe genes in Table 1.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy, and a gene expressionprofile for the genes or subset of genes in first biological samplesimilar to the gene expression profile for the genes or subset of genesin tumor samples from patients having the same type of hematologicalcancer which are clinically insensitive to the immunomodulatory therapyindicates that the hematological cancer of the first patient will beclinically insensitive to the treatment with the immunomodulatorytherapy. In certain embodiments, the subset of genes comprises 3, 4, 5,6, 7, 8, 9, 10, 11, 12, 14, 15 or more of the genes in Table 2. In someembodiments, the subset of genes comprises 2-5, 5-10, 10-15, 15-20,20-25 or 25-30 of the genes in Table 2.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy. In certain embodiments,the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 ormore of the genes in Table 2. In some embodiments, the subset of genescomprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of the genes in Table2.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2 in the first biological sample, and (c) comparing the geneexpression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a gene expression profile for thegenes or subset of genes in first biological sample similar to the geneexpression profile for the genes or subset of genes in tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy indicates thatthe hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. Incertain embodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9,10, 1, 12, 14, 15 or more of the genes in Table 2. In some embodiments,the subset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 ofthe genes in Table 2.

In accordance with the methods described herein, the biological samplecan be any sample obtained from the patient. In certain embodiments, thebiological sample is a cell sample. In other embodiments, the biologicalsample is whole blood sample, peripheral blood mononuclear cell sample,or tissue sample. In specific embodiments, the biological sample is atumor sample. See Section 5.8, infra, regarding biological samples.

In accordance with the methods described herein, the hematologicalcancer can be any hematological cancer. Examples of hematologicalcancers can be found in Section 5.5, infra. In a specific embodiment,the hematological cancer is a lymphoma. In another specific embodiment,the hematological cancer is a non-Hodgkin's lymphoma. In yet anotherembodiment, the hematological cancer is a diffuse large B-cell lymphoma(DLBCL). In certain embodiments, the DLBCL is a germinal centerB-cell-like DLBCL. In other embodiments, the DLBCL is an activatedB-cell-like DLBCL.

In accordance with the methods described herein, the level of expressionof one, two, three, four, five or more of the genes in Table 1, Table 2,Table 3, and/or Table 4, infra, can be measured at the RNA and/orprotein levels. In certain embodiments, the level of expression of thegenes are measured at the RNA (e.g., mRNA) level. In other embodiments,the level of expression of the genes are measured at the protein level.

Techniques known to one skilled in the art may be used to measure theamount of an RNA transcript(s). In some embodiments, the amount of one,two, three, four, five or more RNA transcripts is measured using deepsequencing, such as ILLUMINA® RNASeq, ILLUMINA® next generationsequencing (NGS), ION TORRENT™ RNA next generation sequencing, 454™pyrosequencing, or Sequencing by Oligo Ligation Detection (SOLID™). Inother embodiments, the amount of multiple RNA transcripts is measuredusing a microarray and/or gene chip, such as described in Section 6,infra. In certain embodiments, the amount of one, two, three or more RNAtranscripts is determined by RT-PCR. In other embodiments, the amount ofone, two, three or more RNA transcripts is measured by RT-qPCR.Techniques for conducting these assays are known to one skilled in theart. See Section 5.9, infra, for examples of assays to measure RNAtranscripts.

In some embodiments, a statistical analysis or other analysis isperformed on data from the assay utilized to measure an RNA transcriptor protein. In certain specific embodiments, p value of those RNAtranscripts or proteins differentially expressed is 0.1, 0.5, 0.4, 0.3,0.2, 0.01, 0.05, 0.001, 0.005, or 0.0001. In specific embodiments, afalse discovery rate (FDR) of 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1% orless is selected.

Techniques known to one skilled in the art may be used to measure theamount of a protein. For example, flow cytometry, immunofluorescence,enzyme-linked immunosorbent assay-based methodologies (ELISA) andsimilar assays known in the art. See Section 5.10, infra, for examplesof assays to measure protein.

In accordance with the methods described herein, the immunomodulatorytherapy can be any therapy that modulates the immune system or immuneresponse. Examples of immunomodulatory therapies are provided in Section5.6, infra. In a specific embodiment, the immunomodulatory therapy islenalidomide (Revlimid®).

5.3 Methods for Predicting Clinical Sensitivity of a HematologicalCancer by Measuring Proportion of Cells

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells in the first tumor sample, and (c)comparing the proportion of dendritic cells in the first tumor samplewith the proportion of dendritic cells in a second tumor sample from asecond patient having the same type of hematological cancer, wherein thesecond patient's hematological cancer is clinically insensitive totreatment with the immunomodulatory therapy, and wherein a higherproportion of dendritic cells in the first tumor sample relative theproportion of dendritic cells in the second tumor sample indicates thatthe hematological cancer in the first patient will be clinical sensitiveto treatment with the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of plasma cells in the first tumor sample, and (c) comparingthe proportion of plasma cells in the first tumor sample with theproportion of plasma cells in a second tumor sample from a secondpatient having the same type of hematological cancer, wherein the secondpatient's hematological cancer is clinically insensitive to treatmentwith the immunomodulatory therapy, and wherein a higher proportion ofplasma cells in the first tumor sample relative the proportion of plasmacells in the second tumor sample indicates that the hematological cancerin the first patient will be clinical sensitive to treatment with theimmunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells and plasma cells in the first tumorsample, and (c) comparing the proportion of dendritic cells and plasmacells in the first tumor sample with the proportion of dendritic cellsand plasma cells in a second tumor sample from a second patient havingthe same type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with theimmunomodulatory therapy, and wherein a higher proportion of dendriticcells and plasma cells in the first tumor sample relative the proportionof dendritic cells and plasma cells in the second tumor sample indicatesthat the hematological cancer in the first patient will be clinicalsensitive to treatment with the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of B cells in the first tumor sample, and (c) comparing theproportion of B cells in the first tumor sample with the proportion of Bcells in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with the immunomodulatorytherapy, and wherein a decreased proportion of B cells in the firsttumor sample relative the proportion of B cells in the second tumorsample indicates that the hematological cancer in the first patient willbe clinical sensitive to treatment with the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of Natural Killer (NK) cells in the first tumor sample, and(c) comparing the proportion of NK cells in the first tumor sample withthe proportion of NK cells in a second tumor sample from a secondpatient having the same type of hematological cancer, wherein the secondpatient's hematological cancer is clinically insensitive to treatmentwith the immunomodulatory therapy, and wherein a higher proportion of NKcells in the first tumor sample relative the proportion of NK cells inthe second tumor sample indicates that the hematological cancer in thefirst patient will be clinical sensitive to treatment with theimmunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of tumor infiltrating immune cells in the first tumor sample,and (c) comparing the proportion of tumor infiltrating immune cells inthe first tumor sample with the proportion of tumor infiltrating immunecells in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with the immunomodulatorytherapy, and wherein a higher proportion of tumor infiltrating immunecells in the first tumor sample relative the proportion of tumorinfiltrating immune cells in the second tumor sample indicates that thehematological cancer in the first patient will be clinical sensitive totreatment with the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of monocytes in the first tumor sample, and (c) comparing theproportion of NK cells in the first tumor sample with the proportion ofmonocytes in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with the immunomodulatorytherapy, and wherein a higher proportion of monocytes in the first tumorsample relative the proportion of monocytes in the second tumor sampleindicates that the hematological cancer in the first patient will beclinical sensitive to treatment with the immunomodulatory therapy.

In certain embodiments of the foregoing paragraphs in this section, thesecond patient is a single patient. In other embodiments of theforegoing paragraphs in this section, the second patient is a populationof patients. In specific embodiments, the population comprises 5, 10,15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100,125, 150, 200, 225, 250, 300 or more patients.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having a hematological cancer, (b) measuring theproportion of immune cells in the tumor sample, and (c) comparing theproportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a proportion of the immune cells inthe first tumor sample similar to the proportion of the same immunecells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy indicates that the hematological cancer in thefirst patient will be clinical sensitive to treatment with theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having a hematological cancer, (b) measuring theproportion of immune cells in the tumor sample, and (c) comparing theproportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a proportion of the immune cells inthe first tumor sample similar to the proportion of the same immunecells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy indicates that the hematological cancer of thefirst patient will be clinically insensitive to the treatment with theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy.

In another aspect, provided herein are methods for predicting theclinical sensitivity of a hematological cancer to treatment with animmunomodulatory therapy comprising: (a) obtaining a first tumor samplefrom a first patient having a hematological cancer, (b) measuring theproportion of immune cells in the tumor sample, and (c) comparing theproportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, wherein a proportion of the immune cells inthe first tumor sample similar to the proportion of the same immunecells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy indicates that the hematological cancer in thefirst patient, and a proportion of the immune cells in the first tumorsample similar to the proportion of the same immune cells in tumorsamples from patients having the same type of hematological cancer whichare clinically insensitive to the immunomodulatory therapy indicatesthat the hematological cancer of the first patient will be clinicallyinsensitive to the treatment with the immunomodulatory therapy. In someembodiments, the immune cells are subset of immune cells, such as subsetof B cells. In certain embodiments, the immune cells are dendriticcells. In some embodiments, the immune cells are plasma cells. Incertain embodiments, the immune cells are monocytes. In someembodiments, the immune cells are tumor infiltrating immune cells. Incertain embodiments, the immune cells are T cells. In some embodiments,the immune cells are B cells. In certain embodiments, the immune cellsare NK cells. In some embodiments, the immune cells are two, three ormore subsets of immune cells, such as two more types of T cells (e.g.,CD4+ and CD8+ T cells). In some embodiments, the proportion of differentpopulations of immune cells in the first tumor sample are compared to(i) the proportion of the same populations of immune cells in the tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy and (ii) theproportion of the same populations of immune cells in the tumor samplesfrom patients having the same type of hematological cancer which areclinically insensitive to the immunomodulatory therapy.

In addition to measuring the cells (e.g., dendritic cells, plasma cells,B cells, monocytes, and infiltrating immune cells) in a tumor samplefrom a patient, levels of expression of genes (e.g., one, two, three,four, five or more of the genes in Table 1 and/or Table 2) may beassessed. In specific embodiments, the methods set forth in Section 5.1,supra, are combined with the methods set forth in this Section 5.2 topredict the clinical sensitivity of a hematological cancer to treatmentwith an immunomodulatory therapy.

Techniques known to one skilled in the art may be used to measure theproportion of cells in a tumor sample. In certain embodiments, theproportion of cells is measured by flow cytometry, immunofluorescence,enzyme-linked immunosorbent assay-based methodologies (ELISA) andsimilar assays known in the art. See Section 5.8, infra, regardingtechniques for measuring and distinguishing cell types. In otherembodiments, the proportion of cells is measured by inference from geneexpression profiles.

In accordance with the methods described herein, the hematologicalcancer can be any hematological cancer. Examples of hematologicalcancers can be found in Section 5.5, infra. In a specific embodiment,the hematological cancer is a lymphoma. In another specific embodiment,the hematological cancer is a non-Hodgkin's lymphoma. In yet anotherembodiment, the hematological cancer is a diffuse large B-cell lymphoma(DLBCL). In certain embodiments, the DLBCL is a germinal centerB-cell-like DLBCL. In other embodiments, the DLBCL is an activatedB-cell-like DLBCL.

In accordance with the methods described herein, the immunomodulatorytherapy can be any therapy that modulates the immune system or immuneresponse. Examples of immunomodulatory therapies are provided in Section5.6, infra. In a specific embodiment, the immunomodulatory therapy islenalidomide (Revlimid®).

5.4 Methods for Managing and Treating Hematological Cancer

In one aspect, provided herein are methods for managing or treating ahematological cancer comprising: (a) obtaining a first biological samplefrom a first patient having a hematological cancer, (b) measuring thelevel of expression of one, two, three, four, five or more of the genesidentified in Table 3 or 4, infra, (c) comparing the level of expressionof the one, two, three, four, five or more of the genes identified inTable 3 or 4 in the first biological sample with the level of expressionof the same genes in a second biological sample from a second patienthaving the same type of hematological cancer as the first patient,wherein the hematological cancer in the second patient is clinicallyinsensitive to an immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if the one, two, three,four, five or more of the genes in the first biological sample aredifferentially expressed relative to the level of expression of the one,two, three, four, five or more of the genes in the second biologicalsample. In certain embodiments, the immunomodulatory therapy is notadministered or additional assays are conducted if the level ofexpression of one, two, three, four, five or more of the genes are nothigher in the first biological sample than in the second biologicalsample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 1 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if ahigher level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample is measured relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample. In certain embodiments, theimmunomodulatory therapy is not administered or additional assays areconducted if the level of expression of one, two, three, four, five ormore of the genes are not higher in the first biological sample than inthe second biological sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 2, infra, (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 2 in the first biological sample with the level ofexpression of the same genes in a second biological sample is from asecond patient having the same type of hematological cancer as the firstpatient, wherein the hematological cancer in the second patient isclinically insensitive to an immunomodulatory therapy, and (d)administering the immunomodulatory therapy to the first patient if alower level of expression of the one, two, three, four, five or more ofthe genes in the first biological sample is measured relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample. In certain embodiments, theimmunomodulatory therapy is not administered or additional assays areconducted if the level of expression of one, two, three, four, five ormore of the genes are not lower in the first biological sample than inthe second biological sample. In certain embodiments, theimmunomodulatory therapy is not administered or additional assays areconducted if the level of expression of one, two, three, four, five ormore of the genes are not higher in the first biological sample than inthe second biological sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe level of expression of one, two, three, four, five or more of thegenes identified in Table 1, infra, and measuring the level ofexpression one, two, three, four, five or more of the genes identifiedin Table 2, infra, (c) comparing the level of expression of the genesidentified in Tables 1 and 2 in the first biological sample with thelevel of expression of the same genes in a second biological sample isfrom a second patient having the same type of hematological cancer asthe first patient, wherein the hematological cancer in the secondpatient is clinically insensitive to an immunomodulatory therapy, and(d) administering the immunomodulatory to the first patient if (i) ahigher level of expression of the one, two, three, four, five or more ofthe genes identified in Table 1 in the first biological sample ismeasured relative to the level of expression of the one, two, three,four, five or more of the genes in the second biological sample, and(ii) a lower level of expression of the one, two, three, four, five ormore of the genes identified in Table 2 in the first biological sampleis measured relative to the level of expression of the one, two, three,four, five or more of the genes in the second biological sample. Incertain embodiments, the immunomodulatory therapy is not administered oradditional assays are conducted if the level of expression of one, two,three, four, five or more of the genes are not higher in the firstbiological sample than in the second biological sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3, infra,in the first biological sample, and (c) comparing the gene expressionprofile of the subset of genes in the first biological sample to (i) thegene expression profile of the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to an immunomodulatory therapy and (ii) the geneexpression of the subset of genes in tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if the gene expressionprofile for the subset of genes in the first biological sample issimilar to the gene expression profile for the subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 3. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 3.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3, infra,in the first biological sample, and (c) comparing the gene expressionprofile of the subset of genes in the first biological sample to (i) thegene expression profile of the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to an immunomodulatory therapy and (ii) the geneexpression of the subset of genes in tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if the gene expressionprofile for the subset of genes in the first biological sample is notsimilar to the gene expression profile for the subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically insensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 3. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 3.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of a certain subset of genes set forth in Table 3, infra,in the first biological sample, and (c) comparing the gene expressionprofile of the subset of genes in the first biological sample to (i) thegene expression profile of the subset of genes in tumor samples frompatients having the same type of hematological cancer which areclinically sensitive to an immunomodulatory therapy and (ii) the geneexpression of the subset of genes in tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if: (i) the geneexpression profile for the subset of genes in the first biologicalsample is similar to the gene expression profile for the subset of genesin tumor samples from patients having the same type of hematologicalcancer which are clinically sensitive to the immunomodulatory therapyand (ii) the gene expression profile for the subset of genes in firstbiological sample is not similar to the gene expression profile for thesubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory. In certain embodiments, the subset of genes comprises3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 or more of the genes in Table 3.In some embodiments, the subset of genes comprises 2-5, 5-10, 10-15,15-20, 20-25 or 25-30 of the genes in Table 3.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or a subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 4. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 4.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is not similarto the gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically insensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 4. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 4.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 4, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if: (i) the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy and (ii) thegene expression profile for the genes or subset of genes in firstbiological sample is not similar to the gene expression profile for thegenes or subset of genes in tumor samples from patients having the sametype of hematological cancer which are clinically insensitive to theimmunomodulatory. In certain embodiments, the subset of genes comprises3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 or more of the genes in Table 4.In some embodiments, the subset of genes comprises 2-5, 5-10, 10-15,15-20, 20-25 or 25-30 of the genes in Table 4.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or a subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 1. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 1.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes i in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is not similarto the gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically insensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 1. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 1.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 1, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if: (i) the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy and (ii) thegene expression profile for the genes or subset of genes in firstbiological sample is not similar to the gene expression profile for thegenes or subset of genes in tumor samples from patients having the sametype of hematological cancer which are clinically insensitive to theimmunomodulatory. In certain embodiments, the subset of genes comprises3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15 or more of the genes in Table 1.In some embodiments, the subset of genes comprises 2-5, 5-10, 10-15,15-20, 20-25 or 25-30 of the genes in Table 1.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or a subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 2. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 2.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes i in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the gene expression profile for thegenes or subset of genes in the first biological sample is not similarto the gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically insensitive to the immunomodulatory therapy. In certainembodiments, the subset of genes comprises 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 14, 15 or more of the genes in Table 2. In some embodiments, thesubset of genes comprises 2-5, 5-10, 10-15, 15-20, 20-25 or 25-30 of thegenes in Table 2.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first biologicalsample from a first patient having a hematological cancer, (b) measuringthe expression of the genes or a certain subset of genes set forth inTable 2, infra, in the first biological sample, and (c) comparing thegene expression profile of the genes or subset of genes in the firstbiological sample to (i) the gene expression profile of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to animmunomodulatory therapy and (ii) the gene expression of the genes orsubset of genes in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if: (i) the gene expression profile for thegenes or subset of genes in the first biological sample is similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having the same type of hematological cancer whichare clinically sensitive to the immunomodulatory therapy and (ii) thegene expression profile for the genes or subset of genes in firstbiological sample is not similar to the gene expression profile for thegenes or subset of genes in tumor samples from patients having the sametype of hematological cancer which are clinically insensitive to theimmunomodulatory. In certain embodiments, the subset of genes comprises3, 4, 5, 6, 7, 8, 9, 10, 1, 12, 14, 15 or more of the genes in Table 2.In some embodiments, the subset of genes comprises 2-5, 5-10, 10-15,15-20, 20-25 or 25-30 of the genes in Table 2.

In accordance with the methods described herein, the biological samplecan be any sample obtained from the patient. In certain embodiments, thebiological sample is a cell sample. In other embodiments, the biologicalsample is whole blood sample, peripheral blood mononuclear cell sample,or tissue sample. In specific embodiments, the biological sample is atumor sample. See Section 5.8, infra, regarding biological samples.

In accordance with the methods described herein, the level of expressionof one, two, three, four, five or more of the genes in Table 1 and/orTable 2 and/or Table 3 and/or Table 4, infra, can be measured at the RNAand/or protein levels. In certain embodiments, the level of expressionof the genes are measured at the RNA (e.g., mRNA) level. In otherembodiments, the level of expression of the genes are measured at theprotein level.

Techniques known to one skilled in the art may be used to measure theamount of an RNA transcript(s). In some embodiments, the amount of one,two, three, four, five or more RNA transcripts is measured using deepsequencing, such as ILLUMINA® RNASeq, ILLUMINA® next generationsequencing (NGS), ION TORRENT™ RNA next generation sequencing, 454™pyrosequencing, or Sequencing by Oligo Ligation Detection (SOLID™). Inother embodiments, the amount of multiple RNA transcripts is measuredusing a microarray and/or gene chip, such as described in Section 6,infra. In certain embodiments, the amount of one, two, three or more RNAtranscripts is determined by RT-PCR. In other embodiments, the amount ofone, two, three or more RNA transcripts is measured by RT-qPCR.Techniques for conducting these assays are known to one skilled in theart. See Section 5.9, infra, for examples of assays for measuring RNAtranscripts.

In some embodiments, a statistical analysis or other analysis isperformed on data from the assay utilized to measure an RNA transcriptor protein. In some specific embodiments, p value of those RNAtranscripts or proteins differentially expressed is 0.1, 0.5, 0.4, 0.3,0.2, 0.01, 0.05, 0.001, or 0.0001. In specific embodiments, a falsediscovery rate (FDR) of 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2% 1% or lessis selected.

Techniques known to one skilled in the art may be used to measure theamount of a protein. For example, flow cytometry, immunofluorescence,enzyme-linked immunosorbent assay-based methodologies (ELISA) andsimilar assays known in the art. See Section 5.9, infra, for examples ofassays for measuring RNA transcripts.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells in the first tumor sample, (c) comparingthe proportion of dendritic cells in the first tumor sample with theproportion of dendritic cells in a second tumor sample from a secondpatient having the same type of hematological cancer, wherein the secondpatient's hematological cancer is clinically insensitive to treatmentwith an immunomodulatory therapy, and (d) administering theimmunomodulatory therapy to the first patient if a higher proportion ofdendritic cells in the first tumor sample is measured relative theproportion of dendritic cells in the second tumor sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of plasma cells in the first tumor sample, (c) comparing theproportion of plasma cells in the first tumor sample with the proportionof plasma cells in a second tumor sample from a second patient havingthe same type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with animmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if a higher proportion of plasma cells inthe first tumor sample is measured relative the proportion of plasmacells in the second tumor sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of dendritic cells and plasma cells in the first tumorsample, (c) comparing the proportion of dendritic cells and plasma cellsin the first tumor sample with the proportion of dendritic cells andplasma cells in a second tumor sample from a second patient having thesame type of hematological cancer, wherein the second patient'shematological cancer is clinically insensitive to treatment with animmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if a higher proportion of dendritic cellsand plasma cells in the first tumor sample is measured relative theproportion of dendritic cells and plasma cells in the second tumorsample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of B cells in the first tumor sample, (c) comparing theproportion of B cells in the first tumor sample with the proportion of Bcells in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with an immunomodulatorytherapy, and (d) administering the immunomodulatory therapy to the firstpatient if a decreased proportion of B cells in the first tumor sampleis measured relative the proportion of B cells in the second tumorsample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of tumor infiltrating immune cells in the first tumor sample,(c) comparing the proportion of tumor infiltrating immune cells in thefirst tumor sample with the proportion of tumor infiltrating immunecells in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with an immunomodulatorytherapy, and (d) administering the immunomodulatory therapy to the firstpatient if a higher proportion of tumor infiltrating immune cells in thefirst tumor sample is measured relative the proportion of tumorinfiltrating immune cells in the second tumor sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of NK cells in the first tumor sample, (c) comparing theproportion of NK cells in the first tumor sample with the proportion ofNK cells in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with an immunomodulatorytherapy, and (d) administering the immunomodulatory therapy to the firstpatient if a higher proportion of NK cells in the first tumor sample ismeasured relative the proportion of NK cells in the second tumor sample.

In another aspect, provided herein are methods for managing or treatinga hematological cancer comprising: (a) obtaining a first tumor samplefrom a first patient having the hematological cancer, (b) measuring theproportion of monocytes in the first tumor sample, (c) comparing theproportion of monocytes in the first tumor sample with the proportion ofmonocytes in a second tumor sample from a second patient having the sametype of hematological cancer, wherein the second patient's hematologicalcancer is clinically insensitive to treatment with an immunomodulatorytherapy, and (d) administering the immunomodulatory therapy to the firstpatient if a higher proportion of monocytes in the first tumor sample ismeasured relative the proportion of monocytes in the second tumorsample.

In certain embodiments of the foregoing paragraphs in this section, thesecond patient is a single patient. In other embodiments of theforegoing paragraphs in this section, the second patient is a populationof patients. In specific embodiments, the population comprises 5, 10,15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100,125, 150, 200, 225, 250, 300 or more patients.

In another aspect, provided herein are for managing or treating ahematological cancer comprising: (a) obtaining a first tumor sample froma first patient having a hematological cancer, (b) measuring theproportion of immune cells in the first tumor sample, and (c) comparingthe proportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the proportion of the immune cells inthe first tumor sample is similar to the proportion of the same immunecells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy.

In another aspect, provided herein are for managing or treating ahematological cancer comprising: (a) obtaining a first tumor sample froma first patient having a hematological cancer, (b) measuring theproportion of immune cells in the first tumor sample, and (c) comparingthe proportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the proportion of the immune cells inthe first tumor sample is not similar to the proportion of the sameimmune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy.

In another aspect, provided herein are for managing or treating ahematological cancer comprising: (a) obtaining a first tumor sample froma first patient having a hematological cancer, (b) measuring theproportion of immune cells in the first tumor sample, and (c) comparingthe proportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving the same type of hematological cancer which are clinicallysensitive to an immunomodulatory therapy and (ii) the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy, and (d) administering the immunomodulatorytherapy to the first patient if the proportion of the immune cells inthe first tumor sample is (i) similar to the proportion of the sameimmune cells in tumor samples from patients having the same type ofhematological cancer which are clinically sensitive to theimmunomodulatory therapy, and (ii) not similar to the proportion of thesame immune cells in tumor samples from patients having the same type ofhematological cancer which are clinically insensitive to theimmunomodulatory therapy. In some embodiments, the immune cells aresubset of immune cells, such as subset of B cells. In certainembodiments, the immune cells are dendritic cells. In some embodiments,the immune cells are plasma cells. In certain embodiments, the immunecells are monocytes. In some embodiments, the immune cells are tumorinfiltrating immune cells. In certain embodiments, the immune cells areT cells. In some embodiments, the immune cells are B cells. In certainembodiments, the immune cells are NK cells. In some embodiments, theimmune cells are two, three or more subsets of immune cells, such as twomore types of T cells (e.g., CD4+ and CD8+ T cells). In someembodiments, the proportion of different populations of immune cells inthe first tumor sample are compared to (i) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically sensitive tothe immunomodulatory therapy and (ii) the proportion of the samepopulations of immune cells in the tumor samples from patients havingthe same type of hematological cancer which are clinically insensitiveto the immunomodulatory therapy.

In addition to measuring the cells (e.g., dendritic cells and plasmacells) in a tumor sample from a patient, levels of expression of genes(e.g., one, two, three, four, five or more of the genes in Table 1and/or Table 2 and/or Table 3 and/or Table 4) may be assessed. Inspecific embodiments, the methods set forth for measuring geneexpression supra, are combined with the methods set forth for measuringa proportion of cells to determine if an immunomodulatory therapy is tobe administered to a patient with a hematological cancer.

Techniques known to one skilled in the art may be used to measure theproportion of cells in a tumor sample. In certain embodiments, theproportion of cells is measured by flow cytometry, immunofluorescence,enzyme-linked immunosorbent assay-based methodologies (ELISA) andsimilar assays known in the art. In other embodiments, the proportion ofcells is measured by inference from gene expression profiles.

In accordance with the methods described herein, the immunomodulatorytherapy can be any therapy that modulates the immune system or immuneresponse. Examples of immunomodulatory therapies are provided in Section5.6, infra. In a specific embodiment, the immunomodulatory therapy islenalidomide (Revlimid®).

In specific embodiments, an immunomodulatory therapy is administered toa hematological cancer patient in the form of a pharmaceuticalcomposition. In a specific embodiment, an pharmaceutical compositionadministered to a hematological cancer patient comprising animmunomodulatory therapy and a pharmaceutically acceptable carrier orexcipient. In certain embodiments, the pharmaceutical composition maycomprise an additional therapy, such as described in Section 5.7, infra.The dosage form of the pharmaceutical composition will vary dependingupon the route of administration. The immunomodulatory therapy or apharmaceutical composition thereof may be administered by any route ofadministration, such as oral, mucosal, parenteral (e.g., subcutaneous,intravenous, bolus injection, intramuscular), topical, transdermal, ortranscutaneous. In a specific embodiment, the immunomodulatory therapyor a pharmaceutical composition thereof is orally administered to ahematological cancer patient.

In accordance with the methods described herein, the dose of animmunomodulatory therapy administered to a patient varies depending on avariety of factors, such as the health and age of the patient. Incertain embodiments, in accordance with the methods described herein thepatient is administered a dose of 0.01 mg to 1000 mg of animmunomodulatory therapy. In certain embodiments, in accordance with themethods described herein the patient is administered a dose of 0.01 mgto 500 mg of an immunomodulatory therapy. In certain embodiments, inaccordance with the methods described herein the patient is administereda dose of 0.01 mg to 100 mg of an immunomodulatory therapy. In someembodiments, in accordance with the methods described herein the patientis administered a dose of 0.1 mg to 500 mg of an immunomodulatorytherapy. In some embodiments, in accordance with the methods describedherein the patient is administered a dose of 0.01 mg to 500 mg of animmunomodulatory therapy. In some embodiments, in accordance with themethods described herein the patient is administered a dose of 1 mg to500 mg of an immunomodulatory therapy. In certain embodiments, inaccordance with the methods described herein the patient is administereda dose of 0.1 mg to 100 mg of an immunomodulatory therapy. In certainembodiments, in accordance with the methods described herein the patientis administered a dose of 1 mg to 100 mg of an immunomodulatory therapy.In some embodiments, in accordance with the methods described herein thepatient is administered a dose of 1 mg to 50 mg of an immunomodulatorytherapy. In some embodiments, in accordance with the methods describedherein the patient is administered a dose of 1 mg to 100 mg of animmunomodulatory therapy. In some embodiments, in accordance with themethods described herein the patient is administered a dose of 1 mg to500 mg of an immunomodulatory therapy. In some embodiments, inaccordance with the methods described herein the patient is administereda dose of 1 mg to 1000 mg of an immunomodulatory therapy. The dose ofthe immunomodulatory therapy can be administered once, twice or threetimes per day. The dose of the immunomodulatory therapy can beadministered every other day, every two days, every three days, everyfour days, every five days, every six days, or once per week. Specificdoses per day include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33,34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 mgper day. The dose of the immunomodulatory therapy is administered inaccordance with the label for the therapy. The immunomodulatory therapycan be lenalidomide (Revlimid®), or its pharmaceutically acceptablesalt, solvate, hydrate or stereoisomer, and it is administered at a doseof 1 to 50 mg per day, or anything in between, or 25 mg per day.

In accordance with the methods described herein, the hematologicalcancer can be any hematological cancer. Examples of hematologicalcancers can be found in Section 5.5, infra. In a specific embodiment,the hematological cancer is a lymphoma. In another specific embodiment,the hematological cancer is a non-Hodgkin's lymphoma. In yet anotherembodiment, the hematological cancer is a diffuse large B-cell lymphoma(DLBCL). In certain embodiments, the DLBCL is a germinal centerB-cell-like DLBCL. In other embodiments, the DLBCL is an activatedB-cell-like DLBCL.

In certain embodiments, the methods of managing or treating ahematological cancer involve the administration of another therapy. Insome embodiments, the other therapy is to alleviate pain or one or moreother symptoms associated with the hematological cancer. Examples ofother therapies that may be used in combination with an immunomodulatorytherapy are disclosed in Section 5.7, infra. In certain embodiments, oneor more of the following additional active ingredients are administeredin combination with an immunomodulatory therapy in accordance with themethods described herein: oblimersen, melphalan, G-CSF, GM-CSF, EPO, acox-2 inhibitor, topotecan, pentoxifylline, ciprofloxacin, taxotere,iritotecan, dexamethasone, doxorubicin, vincristine, IL 2, IFN,dacarbazine, Ara-C, vinorelbine and/or isotretinoin. In a specificembodiment, chemotherapeutic agents, such as cyclohexamide,hydroxydaunorubicin, oncovin, and prednisone (CHOP), are used incombination with an immunomodulatory therapy, such as lenalidomide, inaccordance with the methods described herein. In another specificembodiment, rituximab is used in combination with an immunomodulatorytherapy, such as lenalidomide. In another specific embodiment, CHOP andrituximab are used in combination with an immunomodulatory therapy, suchas lenalidomide.

5.5 Hematological Cancers

In some embodiments, the hematological cancer is a lymphoma. In otherembodiments, the hematological cancer is a leukemia. In one embodiment,the hematological cancer is multiple myeloma. In another embodiment, thehematological cancer is chronic lymphocytic leukemia (CLL). In anotherembodiment, the hematological cancer is myelodysplastic syndrome, anacute leukemia, e.g., acute T cell leukemia, acute myelogenous leukemia(AML), acute promyelocytic leukemia, acute myeloblastic leukemia, acutemegakaryoblastic leukemia, precursor B acute lymphoblastic leukemia,precursor T acute lymphoblastic leukemia, Burkitt's leukemia (Burkitt'slymphoma), or acute biphenotypic leukemia; a chronic leukemia, e.g.,chronic myeloid lymphoma, chronic myclogenous leukemia (CML), chronicmonocytic leukemia, small lymphocytic lymphoma, or B-cell prolymphocyticleukemia; hairy cell lymphoma; T-cell prolymphocytic leukemia; or alymphoma, e.g, histiocytic lymphoma, lymphoplasmacytic lymphoma (e.g.,Waldenström macroglobulinemia), splenic marginal zone lymphoma, plasmacell neoplasm (e.g., plasma cell myeloma, plasmacytoma, a monoclonalimmunoglobulin deposition disease, or a heavy chain disease), extranodalmarginal zone B cell lymphoma (MALT lymphoma), nodal marginal zone Bcell lymphoma (NMZL), follicular lymphoma, mantle cell lymphoma, diffuselarge B cell lymphoma, mediastinal (thymic) large B cell lymphoma,intravascular large B cell lymphoma, primary effusion lymphoma, T celllarge granular lymphocytic leukemia, aggressive NK cell leukemia, adultT cell leukemia/lymphoma, extranodal NK/T cell lymphoma, nasal type,enteropathy-type T cell lymphoma, hepatosplenic T cell lymphoma, blasticNK cell lymphoma, mycosis fungoides (Sezary syndrome), a primarycutaneous CD30-positive T cell lymphoproliferative disorder (e.g.,primary cutaneous anaplastic large cell lymphoma or lymphomatoidpapulosis), angioimmunoblastic T cell lymphoma, peripheral T celllymphoma, unspecified, anaplastic large cell lymphoma, a Hodgkin'slymphoma or a nodular lymphocyte-predominant Hodgkin's lymphoma.

In a specific embodiment, the hematological cancer is DLBCL. In anotherspecific embodiment, the hematological cancer is an activatedB-cell-like DLBCL. In another specific embodiment, the hematologicalcancer is a germinal center B-cell-like DLBCL.

5.6 Immunomodulatory Therapies

Immunomodulatory therapies described in the methods provided hereininclude compounds known as “IMiDs®” (Celgene Corporation), a group ofcompounds that can be useful to treat several types of human diseases,including certain cancers.

As used herein and unless otherwise indicated, the terms“immunomodulatory compound”, “immunomodulatory agent” and“immunomodulatory therapy” are used interchangeably, and can encompasscertain small organic molecules that inhibit LPS induced monocyte TNF-α,IL-1B, IL-12, IL-6, MIP-1α, MCP-1, GM-CSF, G-CSF, and COX-2 production.These compounds can be prepared synthetically, or can be obtainedcommercially.

Exemplary immunomodulating compounds include but are not limited toN-{[2-(2,6-dioxo(3-piperidyl)-1,3-dioxoisoindolin-4-yl]methyl}cyclopropyl-carboxamide;3-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-1,1-dimethyl-urea;(−)-3-(3,4-Dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide;(+)-3-(3,4-Dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide;(−)-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione};(+)-{2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione};Difluoro-methoxy SelCIDs; 1-phthalimido-1-(3,4-diethoxyphenyl)ethane;3-(3,4-dimethoxyphenyl)-3-(3,5-dimethoxyphenyl)acrylo nitrile;1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;4-amino-2-(3-methyl-2,6-dioxo-piperidine-3-yl)-isoindole-1,3-dione;3-(3-acetoamidophthalimido)-3-(3-ethoxy-4-methoxyphenyl)-N-hydroxypropionamide;1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline;Cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide;Substituted 2-(3-hydroxy-2,6-dioxopiperidin-5-yl) isoindoline;N-[2-(2,6-Dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-4-trifluoromethoxybenzamide;(S)-4-chloro-N-((2-(3-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)benzamide; Pyridine-2-carboxylic acid[2-[(3S)-3-methyl-2,6-dioxo-piperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-amide;(S)—N-((2-(3-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)-4-(trifluoromethyl)benzamide;3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and thelike. In a specific embodiment, the immunomodulatory compound is3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, or asalt, solvate or hydrate thereof.

Immunomodulatory compounds disclosed herein may enhance the degradationof TNF-α mRNA. Immunomodulatory compounds disclosed herein may also bepotent co-stimulators of T cells and increase cell proliferationdramatically in a dose dependent manner. Immunomodulatory compoundsdisclosed herein may also have a greater co-stimulatory effect on theCD8+ T cell subset than on the CD4+ T cell subset. Immunomodulatorycompounds disclosed herein may be capable of acting both indirectlythrough cytokine activation and directly on Natural Killer (“NK”) cellsand Natural Killer T (“NKT”) cells, and increase the NK cells' abilityto produce beneficial cytokines such as, but not limited to, IFN-γ, andto enhance NK and NKT cell cytotoxic activity.

Specific examples of immunomodulatory compounds include cyano andcarboxy derivatives of substituted styrenes such as those disclosed inU.S. Pat. No. 5,929,117; 1-oxo-2-(2,6-dioxo-3-fluoropiperidin-3yl)isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidine-3-yl)isoindolines such as those described in U.S. Pat. Nos. 5,874,448 and5,955,476; the tetra substituted2-(2,6-dioxopiperdin-3-yl)-1-oxoisoindolines described in U.S. Pat. No.5,798,368; 1-oxo and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines(e.g., 4-methyl derivatives of thalidomide), substituted2-(2,6-dioxopiperidin-3-yl) phthalimides and substituted2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoles including, but not limitedto, those disclosed in U.S. Pat. Nos. 5,635,517, 6,281,230, 6,316,471,6,403,613, 6,476,052 and 6,555,554; 1-oxo and 1,3-dioxoisoindolinessubstituted in the 4- or 5-position of the indoline ring (e.g.,4-(4-amino-1,3-dioxoisoindoline-2-yl)-4-carbamoylbutanoic acid)described in U.S. Pat. No. 6,380,239; isoindoline-1-one andisoindoline-1,3-dione substituted in the 2-position with2,6-dioxo-3-hydroxypiperidin-5-yl (e.g.,2-(2,6-dioxo-3-hydroxy-5-fluoropiperidin-5-yl)-4-aminoisoindolin-1-one)described in U.S. Pat. No. 6,458,810; a class of non-polypeptide cyclicamides disclosed in U.S. Pat. Nos. 5,698,579 and 5,877,200; andisoindole-imide compounds such as those described in U.S. patentpublication no. 2003/0045552 published on Mar. 6, 2003, U.S. patentpublication no. 2003/0096841 published on May 22, 2003, andInternational Application No. PCT/US01/50401 (International PublicationNo. WO 02/059106). US patent publication no. 2006/0205787 describes4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1,3-dionecompositions. US patent publication no. 2007/0049618 describesisoindole-imide compounds. The entireties of each of the patents andpatent applications identified herein are incorporated by reference. Inone embodiment, immunomodulatory compounds do not include thalidomide.

Various immunomodulatory compounds disclosed herein contain one or morechiral centers, and can exist as racemic mixtures of enantiomers ormixtures of diastereomers. Thus, also provided herein is the use ofstereomerically pure forms of such compounds, as well as the use ofmixtures of those forms. For example, mixtures comprising equal orunequal amounts of the enantiomers of a particular immunomodulatorycompounds may be used. These isomers may be asymmetrically synthesizedor resolved using standard techniques such as chiral columns or chiralresolving agents. See, e.g., Jacques. J., et al., Enantiomers, Racematesand Resolutions (Wiley-Interscience, New York, 1981); Wilen, S. H., etal., Tetrahedron 33:2725 (1977); Eliel, E. L., Stereochemistry of CarbonCompounds (McGraw-Hill, NY, 1962); and Wilen, S. H., Tables of ResolvingAgents and Optical Resolutions p. 268 (E. L. Eliel, Ed., Univ. of NotreDame Press, Notre Dame, Ind., 1972).

Immunomodulatory compounds provided herein include, but are not limitedto, 1-oxo- and 1,3 dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolinessubstituted with amino in the benzo ring as described in U.S. Pat. No.5,635,517 which is incorporated herein by reference.

These compounds have the structure I:

in which one of X and Y is C═O, the other of X and Y is C═O or CH₂, andR² is hydrogen or lower alkyl, in particular methyl. Specificimmunomodulatory compounds include, but are not limited to:

1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; and

1,3-dioxo-2-(3-methyl-2,6-dioxopiperidin-3-yl)-4-aminoisoindole, andoptically pure isomers thereof.

The compounds can be obtained via standard, synthetic methods (see e.g.,U.S. Pat. No. 5,635,517, incorporated herein by reference). Thecompounds are also available from Celgene Corporation, Warren, N.J.

Other specific immunomodulatory compounds belong to a class ofsubstituted 2-(2,6-dioxopiperidin-3-yl) phthalimides and substituted2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoles, such as those described inU.S. Pat. Nos. 6,281,230; 6,316,471; 6,335,349; and 6,476,052, andInternational Patent Application No. PCT/US97/13375 (InternationalPublication No. WO 98/03502), each of which is incorporated herein byreference. Representative compounds are of formula:

in which:one of X and Y is C═O and the other of X and Y is C═O or CH₂;

-   -   (i) each of R¹, R², R³, and R⁴, independently of the others, is        halo, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon        atoms or (ii) one of R¹, R², R³, and R⁴ is —NHR⁵ and the        remaining of R¹, R², R³, and R⁴ are hydrogen;    -   R⁵ is hydrogen or alkyl of 1 to 8 carbon atoms;    -   R⁶ is hydrogen, alkyl of 1 to 8 carbon atoms, benzyl, or halo;    -   provided that R⁶ is other than hydrogen if X and Y are C═O        and (i) each of R¹, R², R³, and R⁴ is fluoro or (ii) one of R¹,        R², R³, or R⁴ is amino.

Compounds representative of this class are of the formulas:

wherein R¹ is hydrogen or methyl. In a separate embodiment, providedherein is the use of enantiomerically pure forms (e.g. optically pure(R) or (S) enantiomers) of these compounds.

Still other specific immunomodulatory compounds disclosed herein belongto a class of isoindole-imides disclosed in U.S. Pat. No. 7,091,353,U.S. Patent Publication No. 2003/0045552, and International ApplicationNo. PCT/US01/50401 (International Publication No. WO 02/059106), each ofwhich are incorporated herein by reference. Representative compounds areof formula II:

and pharmaceutically acceptable salts, hydrates, solvates, clathrates,enantiomers, diastereomers, racemates, and mixtures of stereoisomersthereof, wherein:one of X and Y is C═O and the other is CH₂ or C═O;R¹ is H, (C₁-C₈)alkyl, (C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl,(C₂-C₈)alkynyl, benzyl, aryl, (C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl,(C₀-C₄)alkyl-(C₂-C₅)heteroaryl, C(O)R³, C(S)R³, C(O)OR⁴,(C₁-C₈)alkyl-N(R⁶)2, (C₁-C₈)alkyl-OR⁵, (C₁-C₈)alkyl-C(O)OR⁵, C(O)NHR³,C(S)NHR³, C(O)NR³R^(3′), C(S)NR³R^(3′) or (C₁-C₈)alkyl-O(CO)R⁵;R² is H, F, benzyl, (C₁-C₈)alkyl, (C₂-C₈)alkenyl, or (C₂-C₈)alkynyl;R³ and R^(3′) are independently (C₁-C₈)alkyl, (C₃-C₇)cycloalkyl,(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, benzyl, aryl,(C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl, (C₀-C₄)alkyl-(C₂-C₅)heteroaryl,(C₀-C₈)alkyl-N(R⁶)2, (C₁-C₈)alkyl-OR⁵, (C₁-C₈)alkyl-C(O)OR⁵,(C₁-C₈)alkyl-O(CO)R⁵, or C(O)OR⁵;R⁴ is (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, (C₁-C₄)alkyl-OR⁵,benzyl, aryl, (C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl, or(C₀-C₄)alkyl-(C₂-C₅)heteroaryl;R⁵ is (C₁-C₈)alkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, benzyl, aryl, or(C₂-C₅)heteroaryl;each occurrence of R⁶ is independently H, (C₁-C₈)alkyl, (C₂-C₈)alkenyl,(C₂-C₈)alkynyl, benzyl, aryl, (C₂-C₅)heteroaryl, or(C₀-C₈)alkyl-C(O)O—R⁵ or the R⁶ groups can join to form aheterocycloalkyl group;n is 0 or 1; and* represents a chiral-carbon center.

In specific compounds of formula II, when n is 0 then R¹ is(C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, benzyl, aryl,(C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl, (C₀-C₄)alkyl-(C₂-C₅)heteroaryl,C(O)R³, C(O)OR⁴, (C₁-C₈)alkyl-N(R⁶)₂, (C₁-C₈)alkyl-OR⁵,(C₁-C₈)alkyl-C(O)OR⁵, C(S)NHR³, or (C₁-C₈)alkyl-O(CO)R⁵;

R² is H or (C₁-C₈)alkyl; andR³ is (C₁-C₈)alkyl, (C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl,benzyl, aryl, (C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl,(C₀-C₄)alkyl-(C₂-C₅)heteroaryl, (C₅-C₈)alkyl-N(R⁶)2;(C₀-C₈)alkyl-NH—C(O)O—R⁵; (C₁-C₈)alkyl-OR⁵, (C₁-C₈)alkyl-C(O)OR⁵,(C₁-C₈)alkyl-O(CO)R⁵, or C(O)OR⁵;and the other variables have the same definitions.

In other specific compounds of formula II, R² is H or (C₁-C₄)alkyl.

In other specific compounds of formula II, R¹ is (C₁-C₈)alkyl or benzyl.

In other specific compounds of formula II, R¹ is H, (C₁-C₈)alkyl,benzyl, CH₂OCH₃, CH₂CH₂OCH₃, or

In another embodiment of the compounds of formula II, R¹ is

wherein Q is O or S, and each occurrence of R⁷ is independently H,(C₁-C₈)alkyl, (C₃-C₇)cycloalkyl, (C₂-C₈)alkenyl, (C₂-C₈)alkynyl, benzyl,aryl, halogen, (C₀-C₄)alkyl-(C₁-C₆)heterocycloalkyl,(C₀-C₄)alkyl-(C₂-C₅)heteroaryl, (C₀-C₈)alkyl-N(R⁶)2, (C₁-C₈)alkyl-OR⁵,(C₁-C₈)alkyl-C(O)OR⁵, (C₁-C₈)alkyl-O(CO)R⁵, or C(O)OR⁵, or adjacentoccurrences of R⁷ can be taken together to form a bicyclic alkyl or arylring.

In other specific compounds of formula II, R¹ is C(O)R³.

In other specific compounds of formula II, R³ is(C₀-C₄)alkyl-(C₂-C₅)heteroaryl, (C₁-C₈)alkyl, aryl, or (C₀-C₄)alkyl-OR⁵.

In other specific compounds of formula II, heteroaryl is pyridyl, furyl,or thienyl.

In other specific compounds of formula II, R¹ is C(O)OR⁴.

In other specific compounds of formula II, the H of C(O)NHC(O) can bereplaced with (C₁-C₄)alkyl, aryl, or benzyl.

Further examples of the compounds in this class include, but are notlimited to:[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-amide;(2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl)-carbamicacid tert-butyl ester;4-(aminomethyl)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione;N-(2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl)-acetamide;N-{(2-(2,6-dioxo(3-piperidyl)-1,3-dioxoisoindolin-4-yl)methyl}cyclopropyl-carboxamide;2-chloro-N-{(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)methyl}acetamide;N-(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)-3-pyridylcarboxamide;3-{1-oxo-4-(benzylamino)isoindolin-2-yl}piperidine-2,6-dione;2-(2,6-dioxo(3-piperidyl))-4-(benzylamino)isoindoline-1,3-dione;N-{(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)methyl}propanamide;N-{(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)methyl}-3-pyridylcarboxamide;N-{(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)methyl}heptanamide;N-{(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)methyl}-2-furylcarboxamide;{N-(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)carbamoyl}methylacetate;N-(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)pentanamide;N-(2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl)-2-thienylcarboxamide;N-{[2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]methyl}(butylamino)carboxamide;N-{[2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]methyl}(octylamino)carboxamide;andN-{[2-(2,6-dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]methyl}(benzylamino)carboxamide.

Still other specific immunomodulatory compounds disclosed herein belongto a class of isoindole-imides disclosed in U.S. Patent ApplicationPublication Nos. US 2002/0045643, International Publication No. WO98/54170, and U.S. Pat. No. 6,395,754, each of which is incorporatedherein by reference. Representative compounds are of formula III:

and pharmaceutically acceptable salts, hydrates, solvates, clathrates,enantiomers, diastereomers, racemates, and mixtures of stereoisomersthereof, wherein:one of X and Y is C═O and the other is CH₂ or C═O;

R is H or CH₂OCOR′;

(i) each of R¹, R², R³, or R⁴, independently of the others, is halo,alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (ii)one of R¹, R², R³, or R⁴ is nitro or —NHR⁵ and the remaining of R¹, R²,R³, or R⁴ are hydrogen;R⁵ is hydrogen or alkyl of 1 to 8 carbonsR⁶ hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro;R′ is R⁷—CHR¹⁰—N(R⁸R⁹);R⁷ is m-phenylene or p-phenylene or -(CnH2n)- in which n has a value of0 to 4;each of R⁸ and R⁹ taken independently of the other is hydrogen or alkylof 1 to 8 carbon atoms, or R⁸ and R⁹ taken together are tetramethylene,pentamethylene, hexamethylene, or —CH₂CH₂X¹CH₂CH₂— in which X¹ is —O—,—S—, or —NH—;R¹⁰ is hydrogen, alkyl of to 8 carbon atoms, or phenyl; and* represents a chiral-carbon center.

Other representative compounds are of formula:

wherein:one of X and Y is C═O and the other of X and Y is C═O or CH₂;

(i) each of R¹, R², R³, or R⁴, independently of the others, is halo,alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (ii)one of R¹, R², R³, and R⁴ is —NHR⁵ and the remaining of R¹, R², R³, andR⁴ are hydrogen;

R⁵ is hydrogen or alkyl of 1 to 8 carbon atoms;

R⁶ is hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro;

R⁷ is m-phenylene or p-phenylene or -(CnH2n)- in which n has a value of0 to 4;

each of R⁸ and R⁹ taken independently of the other is hydrogen or alkylof 1 to 8 carbon atoms, or R⁸ and R⁹ taken together are tetramethylene,pentamethylene, hexamethylene, or —CH₂CH₂X¹CH₂CH₂— in which X¹ is —O—,—S—, or —NH—; and

R¹⁰ is hydrogen, alkyl of to 8 carbon atoms, or phenyl.

Other representative compounds are of formula:

in which

one of X and Y is C═O and the other of X and Y is C═O or CH₂;

each of R¹, R², R³, and R⁴, independently of the others, is halo, alkylof 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (ii) one ofR¹, R², R³, and R⁴ is nitro or protected amino and the remaining of R¹,R², R³, and R⁴ are hydrogen; and

R⁶ is hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro.

Other representative compounds are of formula:

in which:

one of X and Y is C═O and the other of X and Y is C═O or CH₂;

(i) each of R¹, R², R³, and R⁴, independently of the others, is halo,alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (ii)one of R¹, R², R³, and R⁴ is —NHR⁵ and the remaining of R¹, R², R³, andR⁴ are hydrogen;

R⁵ is hydrogen, alkyl of 1 to 8 carbon atoms, or CO—R⁷—CH(R¹⁰)NR⁸R⁹ inwhich each of R⁷, R⁸, R⁹, and R¹⁰ is as herein defined; and

R⁶ is alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro.

Specific examples of the compounds are of formula:

in which:

one of X and Y is C═O and the other of X and Y is C═O or CH₂;

R⁶ is hydrogen, alkyl of 1 to 8 carbon atoms, benzyl, chloro, or fluoro;

R⁷ is m-phenylene, p-phenylene or -(CnH2n)- in which n has a value of 0to 4;

each of R⁸ and R⁹ taken independently of the other is hydrogen or alkylof 1 to 8 carbon atoms, or R⁸ and R⁹ taken together are tetramethylene,pentamethylene, hexamethylene, or —CH₂CH₂X¹CH₂CH₂— in which X¹ is —O—,—S— or —NH—; and

R¹⁰ is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl.

Other specific immunomodulatory compounds are1-oxo-2-(2,6-dioxo-3-fluoropiperidin-3yl) isoindolines and1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidine-3-yl) isoindolines such asthose described in U.S. Pat. Nos. 5,874,448 and 5,955,476, each of whichis incorporated herein by reference. Representative compounds are offormula:

wherein:Y is oxygen or H₂ andeach of R¹, R², R³, and R⁴, independently of the others, is hydrogen,halo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, oramino.

Other specific immunomodulatory compounds are the tetra substituted2-(2,6-dioxopiperdin-3-yl)-1-oxoisoindolines described in U.S. Pat. No.5,798,368, which is incorporated herein by reference. Representativecompounds are of formula:

wherein each of R¹, R², R³, and R⁴, independently of the others, ishalo, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms.

Other specific immunomodulatory compounds are 1-oxo and1,3-dioxo-2-(2,6-dioxopiperidin-3-yl) isoindolines disclosed in U.S.Pat. No. 6,403,613, which is incorporated herein by reference.Representative compounds are of formula:

in which

Y is oxygen or H₂,

a first of R¹ and R² is halo, alkyl, alkoxy, alkylamino, dialkylamino,cyano, or carbamoyl, the second of R¹ and R², independently of thefirst, is hydrogen, halo, alkyl, alkoxy, alkylamino, dialkylamino,cyano, or carbamoyl, and

R³ is hydrogen, alkyl, or benzyl.

Specific examples of the compounds are of formula:

whereina first of R¹ and R² is halo, alkyl of from 1 to 4 carbon atoms, alkoxyof from 1 to 4 carbon atoms, dialkylamino in which each alkyl is of from1 to 4 carbon atoms, cyano, or carbamoyl;the second of R¹ and R², independently of the first, is hydrogen, halo,alkyl of from 1 to 4 carbon atoms, alkoxy of from 1 to 4 carbon atoms,alkylamino in which alkyl is of from 1 to 4 carbon atoms, dialkylaminoin which each alkyl is of from 1 to 4 carbon atoms, cyano, or carbamoyl;and R³ is hydrogen, alkyl of from 1 to 4 carbon atoms, or benzyl.Specific examples include, but are not limited to,1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline.

Other representative compounds are of formula:

wherein:a first of R¹ and R² is halo, alkyl of from 1 to 4 carbon atoms, alkoxyof from 1 to 4 carbon atoms, dialkylamino in which each alkyl is of from1 to 4 carbon atoms, cyano, or carbamoyl;the second of R¹ and R², independently of the first, is hydrogen, halo,alkyl of from 1 to 4 carbon atoms, alkoxy of from 1 to 4 carbon atoms,alkylamino in which alkyl is of from 1 to 4 carbon atoms, dialkylaminoin which each alkyl is of from 1 to 4 carbon atoms, cyano, or carbamoyl;andR³ is hydrogen, alkyl of from 1 to 4 carbon atoms, or benzyl.

Other specific immunomodulatory compounds disclosed herein are 1-oxo and1,3-dioxoisoindolines substituted in the 4- or 5-position of theindoline ring described in U.S. Pat. No. 6,380,239 and U.S. Pat. No.7,244,759, both of which are incorporated herein by reference.Representative compounds are of formula:

in which the carbon atom designated C* constitutes a center of chirality(when n is not zero and R¹ is not the same as R²); one of X¹ and X² isamino, nitro, alkyl of one to six carbons, or NH—Z, and the other of X¹or X² is hydrogen; each of R¹ and R² independent of the other, ishydroxy or NH—Z; R³ is hydrogen, alkyl of one to six carbons, halo, orhaloalkyl; Z is hydrogen, aryl, alkyl of one to six carbons, formyl, oracyl of one to six carbons; and n has a value of 0, 1, or 2; providedthat if X¹ is amino, and n is 1 or 2, then R¹ and R² are not bothhydroxy; and the salts thereof.

Further representative compounds are of formula:

in which the carbon atom designated C* constitutes a center of chiralitywhen n is not zero and R¹ is not R²; one of X¹ and X² is amino, nitro,alkyl of one to six carbons, or NH—Z, and the other of X¹ or X² ishydrogen; each of R¹ and R² independent of the other, is hydroxy orNH—Z; R³ is alkyl of one to six carbons, halo, or hydrogen; Z ishydrogen, aryl or an alkyl or acyl of one to six carbons; and n has avalue of 0, 1, or 2.

Specific examples include, but are not limited to,2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-4-carbamoyl-butyric acid and4-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-4-cabamoyl-butyric acid,which have the following structures, respectively, and pharmaceuticallyacceptable salts, solvates, prodrugs, and stereoisomers thereof:

Other representative compounds are of formula:

in which the carbon atom designated C* constitutes a center of chiralitywhen n is not zero and R¹ is not R²; one of X¹ and X² is amino, nitro,alkyl of one to six carbons, or NH—Z, and the other of X¹ or X² ishydrogen; each of R¹ and R² independent of the other, is hydroxy orNH—Z; R³ is alkyl of one to six carbons, halo, or hydrogen; Z ishydrogen, aryl, or an alkyl or acyl of one to six carbons; and n has avalue of 0, 1, or 2; and the salts thereof.

Specific examples include, but are not limited to,4-carbamoyl-4-{4-[(furan-2-yl-methyl)-amino]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-butyricacid,4-carbamoyl-2-{4-[(furan-2-yl-methyl)-amino]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-butyricacid,2-{4-[(furan-2-yl-methyl)-amino]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-4-phenylcarbamoyl-butyricacid, and2-{4-[(furan-2-yl-methyl)-amino]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-pentanedioicacid, which have the following structures, respectively, andpharmaceutically acceptable salts, solvate, prodrugs, and stereoisomersthereof:

Other specific examples of the compounds are of formula:

wherein:

one of X¹ and X² is nitro, or NH—Z, and the other of X¹ or X² ishydrogen;

each of R¹ and R², independent of the other, is hydroxy or NH—Z;

R³ is alkyl of one to six carbons, halo, or hydrogen;

Z is hydrogen, phenyl, an acyl of one to six carbons, or an alkyl of oneto six carbons; and

n has a value of 0, 1, or 2; and

if —COR² and —(CH₂)_(n)COR¹ are different, the carbon atom designated Cconstitutes a center of chirality.

Other representative compounds are of formula:

wherein:

one of X¹ and X² is alkyl of one to six carbons;

each of R¹ and R², independent of the other, is hydroxy or NH—Z;

R³ is alkyl of one to six carbons, halo, or hydrogen;

Z is hydrogen, phenyl, an acyl of one to six carbons, or an alkyl of oneto six carbons; and

n has a value of 0, 1, or 2; and

if —COR² and —(CH₂)_(n)COR¹ are different, the carbon atom designated C*constitutes a center of chirality.

Still other specific immunomodulatory compounds are isoindoline-1-oneand isoindoline-1,3-dione substituted in the 2-position with2,6-dioxo-3-hydroxypiperidin-5-yl described in U.S. Pat. No. 6,458,810,which is incorporated herein by reference. Representative compounds areof formula:

wherein:

the carbon atoms designated constitute centers of chirality;

X is —C(O)— or —CH₂—;

R¹ is alkyl of 1 to 8 carbon atoms or —NHR³;

R² is hydrogen, alkyl of 1 to 8 carbon atoms, or halogen; and

R³ is hydrogen,

alkyl of 1 to 8 carbon atoms, unsubstituted or substituted with alkoxyof 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbonatoms,

cycloalkyl of 3 to 18 carbon atoms,

phenyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms,alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4carbon atoms,

benzyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms,alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4carbon atoms, or —COR⁴ in which

R⁴ is hydrogen,

alkyl of 1 to 8 carbon atoms, unsubstituted or substituted with alkoxyof 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4 carbonatoms,

cycloalkyl of 3 to 18 carbon atoms,

phenyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms,alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4carbon atoms, or

benzyl, unsubstituted or substituted with alkyl of 1 to 8 carbon atoms,alkoxy of 1 to 8 carbon atoms, halo, amino, or alkylamino of 1 to 4carbon atoms.

Other specific compounds provided herein are of formula:

and pharmaceutically acceptable salts, solvates, and stereoisomersthereof, wherein:

-   R¹ is: hydrogen; halo; —(CH₂)_(n)OH; (C₁-C₆)alkyl, optionally    substituted with one or more halo; (C₁-C₆)alkoxy, optionally    substituted with one or more halo; or

—(CH₂)_(n)NHR^(a), wherein R^(a) is:

-   -   hydrogen;    -   (C₁-C₆)alkyl, optionally substituted with one or more halo;    -   —(CH₂)_(n)-(6 to 10 membered aryl);    -   —C(O)—(CH₂)_(n)-(6 to 10 membered aryl) or —C(O)—(CH₂)_(n)-(6 to        10 membered heteroaryl), wherein the aryl or heteroaryl is        optionally substituted with one or more of: halo; —SCF₃;        (C₁-C₆)alkyl, itself optionally substituted with one or more        halo; or (C₁-C₆)alkoxy, itself optionally substituted with one        or more halo;    -   —C(O)—(C₁-C₈)alkyl, wherein the alkyl is optionally substituted        with one or more halo;    -   —C(O)—(CH₂)_(n)—(C₃-C₁₀-cycloalkyl);    -   —C(O)—(CH₂)_(n)—NR^(b)R^(c), wherein R^(b) and R^(c) are each        independently:        -   hydrogen;        -   (C₁-C₆)alkyl, optionally substituted with one or more halo;        -   (C₁-C₆)alkoxy, optionally substituted with one or more halo;            or        -   6 to 10 membered aryl, optionally substituted with one or            more of: halo; (C₁-C₆)alkyl, itself optionally substituted            with one or more halo;

or (C₁-C₆)alkoxy, itself optionally substituted with one or more halo;

-   -   —C(O)—(CH₂)_(n)—O—(C₁-C₆)alkyl; or    -   —C(O)—(CH₂)_(n)—O—(CH₂)_(n)-(6 to 10 membered aryl);

-   R² is: hydrogen; —(CH₂)_(n)OH; phenyl; —O—(C₁-C₆)alkyl; or    (C₁-C₆)alkyl, optionally substituted with one or more halo;

-   R³ is: hydrogen; or (C₁-C₆)alkyl, optionally substituted with one or    more halo; and

-   n is 0, 1, or 2.

Specific examples include, but are not limited to,3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione(“Compound A”), which has the following structure:

or an enantiomer or a mixture of enantiomers thereof; or apharmaceutically acceptable salt, solvate, hydrate, co-crystal,clathrate, or polymorph thereof.

Compound A can be prepared according to the methods described in theExamples provided herein or as described in U.S. Pat. No. 7,635,700, thedisclosure of which is incorporated herein by reference in its entirety.The compound can be also synthesized according to other methods apparentto those of skill in the art based upon the teaching herein. In certainembodiments, Compound A is in a crystalline form described in U.S.Provisional Pat. App. No. 61/451,806, filed Mar. 11, 2011, which isincorporated herein by reference in its entirety. In some embodiments,the hydrochloride salt of Compound A is used in the methods providedherein. Methods of treating, preventing and/or managing cancers andother diseases using Compound A are described in U.S. Provisional Pat.App. No. 61/451,995, filed Mar. 11, 2011, which is incorporated hereinby reference in its entirety.

Other specific compounds provided herein are of formula:

or a pharmaceutically acceptable salt, solvate or stereoisomer thereof,wherein:

-   X is C═O or CH₂;-   R¹ is —Y—R³;-   R² is H or (C₁-C₆)alkyl;-   Y is: 6 to 10 membered aryl, heteroaryl or heterocycle, each of    which may be optionally substituted with one or more halogen; or a    bond;-   R³ is: —(CH₂)_(n)-aryl, —O—(CH₂)_(n)-aryl or —(CH₂)_(n)—O-aryl,    wherein the aryl is optionally substituted with one or more:    (C₁-C₆)alkyl, itself optionally substituted with one or more    halogen; (C₁-C₆)alkoxy, itself substituted with one or more halogen;    oxo; amino; carboxyl; cyano; hydroxyl; halogen; deuterium; 6 to 10    membered aryl or heteroaryl, optionally substituted with one or more    -   (C₁-C₆)alkyl, (C₁-C₆)alkoxy or halogen; —CONH₂; or        —COO—(C₁-C₆)alkyl, wherein the alkyl may be optionally        substituted with one or more halogen;    -   —(CH₂)_(n)-heterocycle, —O—(CH₂)-heterocycle or        —(CH₂)_(n)—O-heterocycle, wherein the    -   heterocycle is optionally substituted with one or more:        (C₁-C₆)alkyl, itself optionally substituted with one or more        halogen; (C₁-C₆)alkoxy, itself substituted with one or more        halogen; oxo; amino; carboxyl; cyano; hydroxyl; halogen;        deuterium; 6 to 10 membered aryl or heteroaryl, optionally        substituted with one or more (C₁-C₆)alkyl, (C₁-C₆)alkoxy or        halogen; —CONH₂; or —COO—(C₁-C₆)alkyl, wherein the alkyl may be        optionally substituted with one or more halogen; or        —(CH₂)_(n)-heteroaryl, —O—(CH₂)_(n)-heteroaryl or        —(CH₂)_(n)—O-heteroaryl, wherein the    -   heteroaryl is optionally substituted with one or more:        (C₁-C₆)alkyl, itself optionally substituted with one or more        halogen; (C₁-C₆)alkoxy, itself substituted with one or more        halogen; oxo; amino; carboxyl; cyano; hydroxyl; halogen;        deuterium; 6 to 10 membered aryl or heteroaryl, optionally        substituted with one or more (C₁-C₆)alkyl, (C₁-C₆)alkoxy or        halogen; —CONH₂; or —COO—(C₁-C₆)alkyl, wherein the alkyl may be        optionally substituted with one or more halogen; and        -   n is 0, 1, 2 or 3.

Specific examples include, but are not limited to,3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione.In one embodiment, provided herein is the (S) stereoisomer of3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione(“Compound B”) e.g., for use in the methods described herein. Racemic3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dioneand methods of preparing the same have been reported in U.S. PatentPublication No. 2011/0196150, which is incorporated herein by referencein its entirety. Compound B has the following structure:

All of the compounds described can either be commercially purchased orprepared according to the methods described in the patents or patentpublications disclosed herein. Further, optically pure compounds can beasymmetrically synthesized or resolved using known resolving agents orchiral columns as well as other standard synthetic organic chemistrytechniques. Additional information on immunomodulatory compounds, theirpreparation, and use can be found, for example, in U.S. PatentApplication Publication Nos. US20060188475, US20060205787, andUS20070049618, each of which is incorporated by reference herein in itsentirety.

The immunomodulatory therapies may be small organic molecules having amolecular weight less than about 1,000 g/mol, and are not proteins,peptides, oligonucleotides, oligosaccharides or other macromolecules.

It should be noted that if there is a discrepancy between a depictedstructure and a name given that structure, the depicted structure is tobe accorded more weight. In addition, if the stereochemistry of astructure or a portion of a structure is not indicated with, forexample, bold or dashed lines, the structure or portion of the structureis to be interpreted as encompassing all stereoisomers of it.

5.7 Combination Therapy

One or more additional therapies, such as additional active ingredientsor agents, that can be used in combination with an immunomodulatorytherapy, such as described in Section 5.6, supra. In a specificembodiment, one or more additional active ingredients or agents can beused in the methods and compositions provided herein with animmunomodulatory therapy. The one or more additional therapies can beadministered prior to, concurrently with, or subsequent to theadministration of an immunomodulatory therapy. Administration of animmunomodulatory therapy and an additional active agent to a patient canoccur simultaneously or sequentially by the same or different routes ofadministration. The suitability of a particular route of administrationemployed for a particular active agent will depend on the active agentitself (e.g., whether it can be administered orally without decomposingprior to entering the blood stream) and the cancer being treated.Preferred routes of administration for the additional active agents oringredients of the invention are known to those of ordinary skill in theart. See, e.g., Physicians' Desk Reference.

In certain embodiments, an immunomodulatory therapy and an additionalactive agent are cyclically administered to a patient with ahematological cancer (e.g., DLBCL). Cycling therapy involves theadministration of an active agent for a period of time, followed by arest for a period of time, and repeating this sequential administration.Cycling therapy can reduce the development of resistance to one or moreof the therapies, avoid or reduce the side effects of one of thetherapies, and/or improves the efficacy of the treatment.

The additional active agents administered in combination with animmunomodulatory therapy can be large molecules (e.g., proteins) orsmall molecules (e.g., synthetic inorganic, organometallic, or organicmolecules). In certain embodiments, the additional active agent isanother immunomodulatory therapy. In other embodiments, the additionalactive agent is not an immunomodulatory therapy. Examples of largemolecule active agents include, but are not limited to, hematopoieticgrowth factors, cytokines, and monoclonal and polyclonal antibodies. Incertain embodiments, large molecule active agents are biologicalmolecules, such as naturally occurring or artificially made proteins.Proteins that are useful include proteins that stimulate the survivaland/or proliferation of hematopoietic precursor cells andimmunologically active poietic cells in vitro or in vivo. Othersstimulate the division and differentiation of committed erythroidprogenitors in cells in vitro or in vivo. Particular proteins include,but are not limited to: interleukins, such as IL-2 (includingrecombinant IL-I1 (“rIL2”) and canarypox IL-2), IL-10, IL-12, and IL-18;interferons, such as interferon alfa-2a, interferon alfa-2b, interferonalfa-n1, interferon alfa-n3, interferon beta-I a, and interferon gamma-Ib; GM-CF and GM-CSF; and EPO.

Particular proteins that can be used in the methods and compositions ofthe disclosure include, but are not limited to: filgrastim, which issold in the United States under the trade name NEUPOGEN® (Amgen,Thousand Oaks, Calif.); sargramostim, which is sold in the United Statesunder the trade name LEUKINE® (Immunex, Seattle, Wash.); and recombinantEPO, which is sold in the United States under the trade name EPGEN®(Amgen, Thousand Oaks, Calif.).

Inhibitors of ActRII receptors or activin-ActRII inhibitors may be usedin the methods and compositions provided herein. ActRII receptorsinclude ActRIIA inhibitors and ActRIIB inhibitors. Inhibitors of ActRIIreceptors can be polypeptides comprising activin-binding domains ofActRII. In certain embodiments, the activin-binding domain comprisingpolypeptides are linked to an Fc portion of an antibody (i.e., aconjugate comprising an activin-binding domain comprising polypeptide ofan ActRII receptor and an Fc portion of an antibody is generated). Incertain embodiments, the activin-binding domain is linked to an Fcportion of an antibody via a linker, e.g., a peptide linker. Examples ofsuch non-antibody proteins selected for activin or ActRIIA binding andmethods for design and selection of the same are found inWO/2002/088171, WO/2006/055689, WO/2002/032925, WO/2005/037989, US2003/0133939, and US 2005/0238646, each of which is incorporated hereinby reference in its entirety.

Recombinant and mutated forms of GM-CSF can be prepared as described inU.S. Pat. Nos. 5,391,485; 5,393,870; and 5,229,496; the disclosure ofeach of which is incorporated herein by reference in its entirety.Recombinant and mutated forms of G-CSF can be prepared as described inU.S. Pat. Nos. 4,810,643; 4,999,291; 5,528,823; and 5,580,755; thedisclosure of each of which is incorporated herein by reference in itsentirety.

This disclosure encompasses the use of native, naturally occurring, andrecombinant proteins. The disclosure further encompasses mutants andderivatives (e.g., modified forms) of naturally occurring proteins thatexhibit, in vivo, at least some of the pharmacological activity of theproteins upon which they are based. Examples of mutants include, but arenot limited to, proteins that have one or more amino acid residues thatdiffer from the corresponding residues in the naturally occurring formsof the proteins. Also encompassed by the term “mutants” are proteinsthat lack carbohydrate moieties normally present in their naturallyoccurring forms (e.g., nonglycosylated forms). Examples of derivativesinclude, but are not limited to, pegylated derivatives and fusionproteins, such as proteins formed by fusing IgG1 or IgG3 to the proteinor active portion of the protein of interest. See, e.g., Penichet, M. L.and Morrison, S. L., J. Immunol. Methods 248:91-101 (2001).

Antibodies that can be used in combination with an immunomodulatorytherapy include monoclonal and polyclonal antibodies. Examples ofantibodies include, but are not limited to, trastuzumab (HERCEPTIN®),rituximab (RITUXAN®), bevacizumab (AVASTIN®), pertuzumab (OMNITARG™),tositumomab (BEXXAR®), edrecolomab (PANOREX®), panitumumab and G250. Animmunomodulatory therapy provided herein can also be combined with orused in combination with anti-TNF-alpha antibodies.

Large molecule active agents may be administered in the form ofanti-cancer vaccines.

For example, vaccines that secrete, or cause the secretion of, cytokinessuch as IL-2, SCF, CXC14 (platelet factor 4), G-CSF, and GM-CSF can beused in the methods, pharmaceutical compositions, and kits of thedisclosure. See, e.g., Emens, L. A., et al., Curr. Opinion Mol. Ther.3(1):77-84 (2001).

Additional active agents that are small molecules can also be used toalleviate adverse effects associated with the administration of animmunomodulatory therapy. However, like some large molecules, many arebelieved to be capable of providing a synergistic effect whenadministered with (e.g., before, after or simultaneously) theimmunomodulatory therapy. Examples of small molecule additional activeagents include, but are not limited to, anti-cancer agents, antibiotics,immunosuppressive agents, and steroids.

Examples of anti-cancer agents include, but are not limited to:abraxane; ace-11; acivicin; aclarubicin; acodazole hydrochloride;acronine; adozelesin; aldesleukin; altretamine; ambomycin; ametantroneacetate; amrubicin; amsacrine; anastrozole; anthramycin; asparaginase;asperlin; azacitidine; azetepa; azotomycin; batimastat; benzodepa;bicalutamide; bisantrene hydrochloride; bisnafide dimesylate; bizelesin;bleomycin sulfate; brequinar sodium; bropirimine; busulfan;cactinomycin; calusterone; caracemide; carbetimer, carboplatin;carmustine; carubicin hydrochloride; carzelesin; cedefingol; celecoxib(COX-2 inhibitor); chlorambucil; cirolemycin; cisplatin; cladribine;crisnatol mesylate; cyclophosphamide; cytarabine; dacarbazine;dactinomycin; daunorubicin hydrochloride; decitabine; dexormaplatin;dezaguanine; dezaguanine mesylate; diaziquone; docetaxel; doxorubicin;doxorubicin hydrochloride; droloxifene; droloxifene citrate;dromostanolone propionate; duazomycin; edatrexate; eflornithinehydrochloride; elsamitrucin; enloplatin; enpromate; epipropidine;epirubicin hydrochloride; erbulozole; esorubicin hydrochloride;estramustine; estramustine phosphate sodium; etanidazole; etoposide;etoposide phosphate; etoprine; fadrozole hydrochloride; fazarabine;fenretinide; floxuridine; fludarabine phosphate; fluorouracil;fluorocitabine; fosquidone; fostriecin sodium; gemcitabine; gemcitabinehydrochloride; herceptin; hydroxyurea; idarubicin hydrochloride;ifosfamide; ilmofosine; iproplatin; irinotecan; irinotecanhydrochloride; lanreotide acetate; lapatinib; letrozole; leuprolideacetate; liarozole hydrochloride; lometrexol sodium; lomustine;losoxantrone hydrochloride; masoprocol; maytansine; mechlorethaminehydrochloride; megestrol acetate; melengestrol acetate; melphalan;menogaril; mercaptopurine; methotrexate; methotrexate sodium; metoprine;meturedepa; mitindomide; mitocarcin; mitocromin; mitogillin; mitomalcin;mitomycin; mitosper, mitotane; mitoxantrone hydrochloride; mycophenolicacid; nocodazole; nogalamycin; ormaplatin; oxisuran; paclitaxel;pegaspargase; peliomycin; pentamustine; peplomycin sulfate;perfosfamide; pipobroman; piposulfan; piroxantrone hydrochloride;plicamycin; plomestane; porflmer sodium; porfiromycin; prednimustine;procarbazine hydrochloride; puromycin; puromycin hydrochloride;pyrazofurin; riboprine; romidepsin; safingol; safingol hydrochloride;semustine; simtrazene; sparfosate sodium; sparsomycin; spirogermaniumhydrochloride; spiromustine; spiroplatin; stem cell treatments such asPDA-001; streptonigrin; streptozocin; sulofenur; talisomycin; tecogalansodium; taxotere; tegafur; teloxantrone hydrochloride; temoporfin;teniposide; teroxirone; testolactone; thiamiprine; thioguanine;thiotepa; tiazofurin; tirapazamine; toremifene citrate; trestoloneacetate; triciribine phosphate; trimetrexate; trimetrexate glucuronate;triptorelin; tubulozole hydrochloride; uracil mustard; uredepa;vapreotide; verteporfin; vinblastine sulfate; vincristine sulfate;vindesine; vindesine sulfate; vinepidine sulfate; vinglycinate sulfate;vinleurosine sulfate; vinorelbine tartrate; vinrosidine sulfate;vinzolidine sulfate; vorozole; zeniplatin; zinostatin; and zorubicinhydrochloride.

Other anti-cancer drugs include, but are not limited to: 20-epi-1,25dihydroxyvitamin D3; 5-ethynyluracil; abiraterone; aclarubicin;acylfulvene; adecypenol; adozelesin; aldesleukin; ALL-TK antagonists;altretamine; ambamustine; amidox; amifostine; aminolevulinic acid;amrubicin; amsacrine; anagrelide; anastrozole; andrographolide;angiogenesis inhibitors; antagonist D; antagonist G; antarelix;anti-dorsalizing morphogenetic protein-1; antiandrogen, prostaticcarcinoma; antiestrogen; antineoplaston; antisense oligonucleotides;aphidicolin glycinate; apoptosis gene modulators; apoptosis regulators;apurinic acid; ara-CDP-DL-PTBA; arginine deaminase; asulacrine;atamestane; atrimustine; axinastatin 1; axinastatin 2; axinastatin 3;azasetron; azatoxin; azatyrosine; baccatin III derivatives; balanol;batimastat; BCR/ABL antagonists; benzochlorins; benzoylstaurosporine;beta lactam derivatives; beta-alethine; betaclamycin B; betulinic acid;b-FGF inhibitor; bicalutamide; bisantrene; bisaziridinylspermine;bisnafide; bistratene A; bizelesin; breflate; bropirimine; budotitane;buthionine sulfoximine; calcipotriol; calphostin C; camptothecinderivatives; capecitabine; carboxamide-amino-triazole;carboxyamidotriazole; CaRest M3; CARN 700; cartilage derived inhibitor,carzelesin; casein kinase inhibitors (ICOS); castanospermine; cecropinB; cetrorelix; chlorins; chloroquinoxaline sulfonamide; cicaprost;cis-porphyrin; cladribine; clomifene analogues; clotrimazole;collismycin A; collismycin B; combretastatin A4; combretastatinanalogue; conagenin; crambescidin 816; crisnatol; cryptophycin 8;cryptophycin A derivatives; curacin A; cyclopentanthraquinones;cycloplatam; cypemycin; cytarabine ocfosfate; cytolytic factor;cytostatin; dacliximab; decitabine; dehydrodidemnin B; deslorelin;dexamethasone; dexifosfamide; dexrazoxane; dexverapamil; diaziquone;didemnin B; didox; diethylnorspermine; dihydro-5-azacytidine;dihydrotaxol, 9-; dioxamycin; diphenyl spiromustine; docetaxel;docosanol; dolasetron; doxifluridine; doxorubicin; droloxifene;dronabinol; duocarmycin SA; ebselen; ecomustine; edelfosine;edrecolomab; eflornithine; elemene; emitefur; epirubicin; epristeride;estramustine analogue; estrogen agonists; estrogen antagonists;etanidazole; etoposide phosphate exemestane; fadrozole; fazarabine;fenretinide; filgrastim; finasteride; flavopiridol; flezelastine;fluasterone; fludarabine; fluorodaunorunicin hydrochloride; forfenimex;formestane; fostriecin; fotemustine; gadolinium texaphyrin; galliumnitrate; galocitabine; ganirelix; gelatinase inhibitors; gemcitabine;glutathione inhibitors; hepsulfam; heregulin; hexamethylenebisacetamide; hypericin; ibandronic acid; idarubicin; idoxifene;idramantone; ilmofosine; ilomastat; imatinib (e.g., GLEEVEC®),imiquimod; immunostimulant peptides; insulin-like growth factor-1receptor inhibitor; interferon agonists; interferons; interleukins;iobenguane; iododoxorubicin; ipomeanol, 4-; iroplact; irsogladine;isobengazole; isohomohalicondrin B; itasetron; jasplakinolide;kahalalide F; lamellarin-N triacetate; lanreotide; leinamycin;lenograstim; lentinan sulfate; leptolstatin; letrozole; leukemiainhibiting factor; leukocyte alpha interferon;leuprolide+estrogen+progesterone; leuprorelin; levamisole; liarozole;linear polyamine analogue; lipophilic disaccharide peptide; lipophilicplatinum compounds; lissoclinamide 7; lobaplatin; lombricine;lometrexol; lonidamine; losoxantrone; loxoribine; lurtotecan; lutetiumtexaphyrin; lysofylline; lytic peptides; maitansine; mannostatin A;marimastat; masoprocol; maspin; matrilysin inhibitors; matrixmetalloproteinase inhibitors; menogaril; merbarone; meterelin;methioninase; metoclopramide; MIF inhibitor; mifepristone; miltefosine;mirimostim; mitoguazone; mitolactol; mitomycin analogues; mitonafide;mitotoxin fibroblast growth factor-saporin; mitoxantrone; mofarotene;molgramostim; Erbitux, human chorionic gonadotrophin; monophosphoryllipid A+myobacterium cell wall sk; mopidamol; mustard anticancer agent;mycaperoxide B; mycobacterial cell wall extract; myriaporone;N-acetyldinaline; N-substituted benzamides; nafarelin; nagrestip;naloxone+pentazocine; napavin; naphterpin; nartograstim; nedaplatin;nemorubicin; neridronic acid; nilutamide; nisamycin; nitric oxidemodulators; nitroxide antioxidant; nitrullyn; oblimersen (GENASENSE®);O.sup.6-benzylguanine; octreotide; okicenone; oligonucleotides;onapristone; ondansetron; ondansetron; oracin; oral cytokine inducer;ormaplatin; osaterone; oxaliplatin; oxaunomycin; paclitaxel; paclitaxelanalogues; paclitaxel derivatives; palauamine; palmitoylrhizoxin;pamidronic acid; panaxytriol; panomifene; parabactin; pazelliptine;pegaspargase; peldesine; pentosan polysulfate sodium; pentostatin;pentrozole; perflubron; perfosfamide; perillyl alcohol; phenazinomycin;phenylacetate; phosphatase inhibitors; picibanil; pilocarpinehydrochloride; pirarubicin; piritrexim; placetin A; placetin B;plasminogen activator inhibitor, platinum complex; platinum compounds;platinum-triamine complex; porfimer sodium; porfiromycin; prednisone;propyl bis-acridone; prostaglandin J2; proteasome inhibitors; proteinA-based immune modulator; protein kinase C inhibitor, protein kinase Cinhibitors, microalgal; protein tyrosine phosphatase inhibitors; purinenucleoside phosphorylase inhibitors; purpurins; pyrazoloacridine;pyridoxylated hemoglobin polyoxyethylene conjugate; raf antagonists;raltitrexed; ramosetron; ras farnesyl protein transferase inhibitors;ras inhibitors; ras-GAP inhibitor; retelliptine demethylated; rhenium Re186 etidronate; rhizoxin; ribozymes; RII retinamide; rohitukine;romurtide; roquinimex; rubiginone B1; ruboxyl; safingol; saintopin;SarCNU; sarcophytol A; sargramostim; Sdi 1 mimetics; semustine;senescence derived inhibitor 1; sense oligonucleotides; signaltransduction inhibitors; sizofuran; sobuzoxane; sodium borocaptate;sodium phenylacetate; solverol; somatomedin binding protein; sonermin;sparfosic acid; spicamycin D; spiromustine; splenopentin; spongistatin1; squalamine; stipiamide; stromelysin inhibitors; sulfinosine;superactive vasoactive intestinal peptide antagonist; suradista;suramin; swainsonine; tallimustine; tamoxifen methiodide; tauromustine;tazarotene; tecogalan sodium; tegafur; tellurapyrylium; telomeraseinhibitors; temoporfin; teniposide; tetrachlorodecaoxide; tetrazomine;thaliblastine; thiocoraline; thrombopoietin; thrombopoietin mimetic;thymalfasin; thymopoietin receptor agonist; thymotrinan; thyroidstimulating hormone; tin ethyl etiopurpurin; tirapazamine; titanocenebichloride; topsentin; toremifene; translation inhibitors; tretinoin;triacetyluridine; triciribine; trimetrexate; triptorelin; tropisetron;turosteride; tyrosine kinase inhibitors; tyrphostins; UBC inhibitors;ubenimex; urogenital sinus-derived growth inhibitory factor urokinasereceptor antagonists; vapreotide; variolin B; velaresol; veramine;verdins; verteporfin; vinorelbine; vinxaltine; vitaxin; vorozole;zanoterone; zeniplatin; zilascorb; and zinostatin stimalamer.

Specific additional active agents include, but are not limited to,oblimersen (GENASENSE®), remicade, docetaxel, celecoxib, melphalan,dexamethasone (DECADRON®), steroids, gemcitabine, cisplatinum,temozolomide, etoposide, cyclophosphamide, temodar, carboplatin,procarbazine, gliadel, tamoxifen, topotecan, methotrexate, ARISA®,taxol, taxotere, fluorouracil, leucovorin, irinotecan, xeloda, CPT-11,interferon alpha, pegylated interferon alpha (e.g., PEG INTRON-A),capecitabine, cisplatin, thiotepa, fludarabine, carboplatin, liposomaldaunorubicin, cytarabine, doxetaxol, pacilitaxel, vinblastine, IL-2,GM-CSF, dacarbazine, vinorelbine, zoledronic acid, palmitronate, biaxin,busulphan, prednisone, bisphosphonate, arsenic trioxide, vincristine,doxorubicin (DOXIL®), paclitaxel, ganciclovir, adriamycin, estramustinesodium phosphate) (EMCYT.degree.), sulindac, and etoposide.

5.8 Biological Samples

In certain embodiments, the various methods provided herein use samples(e.g., biological samples) from subjects or individuals (e.g.,patients). In a specific embodiment, the subject is a patient with ahematological cancer, such as multiple myeloma, leukemia or a lymphoma.The subject can be a mammal, for example, a human. The subject can bemale or female, and can be an adult, child or infant. Samples can beanalyzed at a time during an active phase of a disease or disorder, orwhen a disease or disorder is inactive. In a specific embodiment, asample is obtained from a subject prior, concurrently with and/orsubsequent to administration of an immunomodulatory therapy. In certainembodiments, more than one sample from a subject can be obtained.

In certain embodiments, the sample used in the methods provided hereincomprises body fluids from a subject. Non-limiting examples of bodyfluids include blood (e.g., peripheral whole blood, peripheral blood),blood plasma, amniotic fluid, aqueous humor, bile, cerumen, cowper'sfluid, pre-ejaculatory fluid, chyle, chyme, female ejaculate,interstitial fluid, lymph, menses, breast milk, mucus, pleural fluid,pus, saliva, sebum, semen, serum, sweat, tears, urine, vaginallubrication, vomit, water, feces, internal body fluids, includingcerebrospinal fluid surrounding the brain and the spinal cord, synovialfluid surrounding bone joints, intracellular fluid is the fluid insidecells, and vitreous humour the fluids in the eyeball. In someembodiments, the sample is a blood sample. The blood sample can beobtained using conventional techniques as described in, e.g. Innis etal, editors, PCR Protocols (Academic Press, 1990). White blood cells canbe separated from blood samples using convention techniques orcommercially available kits, e.g. RosetteSep™ kit (Stein CellTechnologies, Vancouver, Canada). Sub-populations of white blood cells,e.g. mononuclear cells, B cells, T cells, monocytes, granulocytes orlymphocytes, can be further isolated using conventional techniques, e.g.magnetically activated cell sorting (MACS) (Miltenyi Biotec. Auburn,Calif.) or fluorescently activated cell sorting (FACS) (BectonDickinson, San Jose, Calif.).

In one embodiment, the blood sample is from about 0.1 mL to about 10.0mL, from about 0.2 mL to about 7 mL, from about 0.3 mL to about 5 mL,from about 0.4 mL to about 3.5 mL, or from about 0.5 mL to about 3 mL.In another embodiment, the blood sample is about 0.3, 0.4, 0.5, 0.6,0.7, 0.8, 0.9, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 6.0, 7.0,8.0, 9.0 or 10.0 mL.

In some embodiments, the sample used in the present methods comprises abiopsy (e.g., a tumor biopsy). The biopsy can be from any organ ortissue, for example, skin, liver, lung, heart, colon, kidney, bonemarrow, teeth, lymph node, hair, spleen, brain, breast, or other organs.Any biopsy technique known by those skilled in the art can be used forisolating a sample from a subject, for instance, open biopsy, closebiopsy, core biopsy, incisional biopsy, excisional biopsy, or fineneedle aspiration biopsy.

In one embodiment, the sample used in the methods provided herein isobtained from the subject prior to the subject receiving a treatment forthe hematological cancer. In another embodiment, the sample is obtainedfrom the subject during the subject receiving a treatment for thehematological cancer. In another embodiment, the sample is obtained fromthe subject after the subject receiving a treatment for thehematological cancer. In various embodiments, the treatment comprisesadministering an immunomodulatory therapy (e.g., a compound provided inSection 5.6) to the subject.

In certain embodiments, the sample used in the methods provided hereincomprises a plurality of cells. Such cells can include any type ofcells, e.g., stem cells, blood cells (e.g., peripheral blood mononuclearcells), lymphocytes, B cells, T cells, monocytes, granulocytes, immunecells, or tumor or cancer cells. The tumor or cancer cells or a tumortissue, such as a tumor biopsy or a tumor explants. T cells (Tlymphocytes) include, for example, helper T cells (effector T cells orTh cells), cytotoxic T cells (CTLs), memory T cells, and regulatory Tcells. In one embodiment, the cells used in the methods provided hereinare CD3⁺ T cells, e.g., as detected by flow cytometry. The number of Tcells used in the methods can range from a single cell to about 10⁹cells. B cells (B lymphocytes) include, for example, plasma B cells,dendritic cells, memory B cells, B1 cells, B2 cells, marginal-zone Bcells, and follicular B cells. B cells can express immunoglobulins(antibodies, B cell receptor).

Specific cell populations can be obtained using a combination ofcommercially available antibodies (e.g., Quest Diagnostic (San JuanCapistrano, Calif.); Dako (Denmark)).

In some embodiments, the cancer is a hematological cancer. In oneembodiment, the blood cancer is multiple myeloma. In another embodiment,the blood cancer is chronic lymphocytic leukemia (CLL). In anotherembodiment, the blood cancer is DLBCL. In another embodiment, the bloodcancer is myelodysplastic syndrome, an acute leukemia, e.g., acute Tcell leukemia, acute myelogenous leukemia (AML), acute promyelocyticleukemia, acute myeloblastic leukemia, acute megakaryoblastic leukemia,precursor B acute lymphoblastic leukemia, precursor T acutelymphoblastic leukemia, Burkitt's leukemia (Burkitt's lymphoma), oracute biphenotypic leukemia; a chronic leukemia, e.g., chronic myeloidlymphoma, chronic myelogenous leukemia (CML), chronic monocyticleukemia, Small lymphocytic lymphoma, or B-cell prolymphocytic leukemia;hairy cell lymphoma; T-cell prolymphocytic leukemia, or a lymphoma, e.g,histiocytic lymphoma, lymphoplasmacytic lymphoma (e.g., Waldenströmmacroglobulinemia), splenic marginal zone lymphoma, plasma cell neoplasm(e.g., plasma cell myeloma, plasmacytoma, a monoclonal immunoglobulindeposition disease, or a heavy chain disease), extranodal marginal zoneB cell lymphoma (MALT lymphoma), nodal marginal zone B cell lymphoma(NMZL), follicular lymphoma, mantle cell lymphoma, diffuse large B celllymphoma, mediastinal (thymic) large B cell lymphoma, intravascularlarge B cell lymphoma, primary effusion lymphoma, T cell large granularlymphocytic leukemia, aggressive NK cell leukemia, adult T cellleukemia/lymphoma, extranodal NK/T cell lymphoma, nasal type,enteropathy-type T cell lymphoma, hepatosplenic T cell lymphoma, blasticNK cell lymphoma, mycosis fungoides (Sezary syndrome), a primarycutaneous CD30-positive T cell lymphoproliferative disorder (e.g.,primary cutaneous anaplastic large cell lymphoma or lymphomatoidpapulosis), angioimmunoblastic T cell lymphoma, peripheral T celllymphoma, unspecified, anaplastic large cell lymphoma, a Hodgkin'slymphoma or a nodular lymphocyte-predominant Hodgkin's lymphoma.

In certain embodiments, the sample used in the methods provided hereinis from a diseased tissue, e.g., from an individual having ahematological cancer. In certain embodiments, the number of cells usedin the methods provided herein can range from a single cell to about 10⁹cells. In some embodiments, the number of cells used in the methodsprovided herein is about 1×10⁴, 5×10⁴, 1×10⁵, 5×10⁵, 1×10⁶, 5×10⁶,1×10⁷, 5×10⁷, 1×10⁸, or 5×10⁸.

The number and type of cells collected from a subject can be monitored,for example, by measuring changes in morphology and cell surface markersusing standard cell detection techniques such as flow cytometry, cellsorting, immunocytochemistry (e.g., staining with tissue specific orcell-marker specific antibodies) fluorescence activated cell sorting(FACS), magnetic activated cell sorting (MACS), by examination of themorphology of cells using light or confocal microscopy, and/or bymeasuring changes in gene expression using techniques well known in theart, such as PCR and gene expression profiling. These techniques can beused, too, to identify cells that are positive for one or moreparticular markers. Fluorescence activated cell sorting (FACS) is awell-known method for separating particles, including cells, based onthe fluorescent properties of the particles (Kamarch, 1987, MethodsEnzymol, 151:150-165). Laser excitation of fluorescent moieties in theindividual particles results in a small electrical charge allowingelectromagnetic separation of positive and negative particles from amixture. In one embodiment, cell surface marker-specific antibodies orligands are labeled with distinct fluorescent labels. Cells areprocessed through the cell sorter, allowing separation of cells based ontheir ability to bind to the antibodies used. FACS sorted particles maybe directly deposited into individual wells of 96-well or 384-wellplates to facilitate separation and cloning.

In certain embodiments, subsets of cells are used in the methodsprovided herein. Methods to sort and isolate specific populations ofcells are well-known in the art and can be based on cell size,morphology, or intracellular or extracellular markers. Such methodsinclude, but are not limited to, flow cytometry, flow sorting, FACS,bead based separation such as magnetic cell sorting, size-basedseparation (e.g., a sieve, an array of obstacles, or a filter), sortingin a microfluidics device, antibody-based separation, sedimentation,affinity adsorption, affinity extraction, density gradientcentrifugation, laser capture microdissection, etc.

5.9 Methods for Detecting RNA Expression

Several methods of detecting or quantitating mRNA levels are known inthe art. Exemplary methods include but are not limited to northernblots, ribonuclease protection assays, PCR-based methods, and the like.The mRNA sequence can be used to prepare a probe that is at leastpartially complementary. The probe can then be used to detect the mRNAsequence in a sample, using any suitable assay, such as PCR-basedmethods. Northern blotting, a dipstick assay, and the like.

In other embodiments, a nucleic acid assay for testing forimmunomodulatory activity in a biological sample can be prepared. Anassay typically contains a solid support and at least one nucleic acidcontacting the support, where the nucleic acid corresponds to at least aportion of an mRNA encoded by a gene listed in Table 1, 2, 3 or 4. Theassay can also have a means for detecting the altered expression of themRNA in the sample.

The assay method can be varied depending on the type of mRNA informationdesired. Exemplary methods include but are not limited to Northern blotsand PCR-based methods (e.g., qRT-PCR). Methods such as qRT-PCR can alsoaccurately quantitate the amount of the mRNA in a sample.

Any suitable assay platform can be used to determine the presence of themRNA in a sample. For example, an assay may be in the form of adipstick, a membrane, a chip, a disk, a test strip, a filter, amicrosphere, a slide, a multiwell plate, or an optical fiber. An assaysystem may have a solid support on which a nucleic acid corresponding tothe mRNA is attached. The solid support may comprise, for example, aplastic, silicon, a metal, a resin, glass, a membrane, a particle, aprecipitate, a gel, a polymer, a sheet, a sphere, a polysaccharide, acapillary, a film a plate, or a slide. The assay components can beprepared and packaged together as a kit for detecting an mRNA.

The nucleic acid can be labeled, if desired, to make a population oflabeled mRNAs. In general, a sample can be labeled using methods thatare well known in the art (e.g., using DNA ligase, terminal transferase,or by labeling the RNA backbone, etc.; see, e.g., Ausubel, et al., ShortProtocols in Molecular Biology, 3rd ed., Wiley & Sons 1995 and Sambrooket al., Molecular Cloning: A Laboratory Manual, Third Edition, 2001 ColdSpring Harbor, N.Y.). In some embodiments, the sample is labeled withfluorescent label. Exemplary fluorescent dyes include but are notlimited to xanthene dyes, fluorescein dyes, rhodamine dyes, fluoresceinisothiocyanate (FITC), 6 carboxyfluorescein (FAM), 6carboxy-2′,4′,7′,4,7-hexachlorofluorescein (HEX), 6 carboxy 4′, 5′dichloro 2′, 7′ dimethoxyfluorescein (JOE or J), N,N,N′,N′ tetramethyl 6carboxyrhodamine (TAMRA or T), 6 carboxy X rhodamine (ROX or R), 5carboxyrhodamine 6G (R6G5 or G5), 6 carboxyrhodamine 6G (R6G6 or G6),and rhodamine 110; cyanine dyes, e.g. Cy3, Cy5 and Cy7 dyes; Alexa dyes,e.g. Alexa-fluor-555; coumarin, Diethylaminocoumarin, umbelliferone;benzimide dyes, e.g. Hoechst 33258; phenanthridine dyes, e.g. Texas Red;ethidium dyes; acridine dyes; carbazole dyes; phenoxazine dyes;porphyrin dyes; polymethine dyes, BODIPY dyes, quinoline dyes, Pyrene,Fluorescein Chlorotriazinyl, R110, Eosin, JOE, R6G,Tetramethylrhodamine, Lissamine, ROX, Napthofluorescein, and the like.

In some embodiments, the mRNA sequences comprise at least one mRNAselected from the mRNAs encoded by the genes listed in Table 3, or afragment thereof. The nucleic acids may be present in specific,addressable locations on a solid support; each corresponding to at leasta portion of mRNA sequences that are differentially expressed upontreatment of an immunomodulatory compound in a cell or a patient.

A typical mRNA assay method can contain the steps of 1) obtainingsurface-bound subject probes; 2) hybridization of a population of mRNAsto the surface-bound probes under conditions sufficient to provide forspecific binding (3) post-hybridization washes to remove nucleic acidsnot bound in the hybridization; and (4) detection of the hybridizedmRNAs. The reagents used in each of these steps and their conditions foruse may vary depending on the particular application.

Hybridization can be carried out under suitable hybridizationconditions, which may vary in stringency as desired. Typical conditionsare sufficient to produce probe/target complexes on a solid surfacebetween complementary binding members, i.e., between surface-boundsubject probes and complementary mRNAs in a sample. In certainembodiments, stringent hybridization conditions may be employed.

Hybridization is typically performed under stringent hybridizationconditions. Standard hybridization techniques (e.g. under conditionssufficient to provide for specific binding of target mRNAs in the sampleto the probes) are described in Kallioniemi et al., Science 258:818-821(1992) and WO 93/18186. Several guides to general techniques areavailable, e.g., Tijssen, Hybridization with Nucleic Acid Probes, PartsI and II (Elsevier, Amsterdam 1993). For descriptions of techniquessuitable for in situ hybridizations, see Gall et al. Meth. Enzymol.,21:470-480 (1981); and Angerer et al. in Genetic Engineering: Principlesand Methods (Setlow and Hollaender, Eds.) Vol 7, pgs 43-65 (PlenumPress, New York 1985). Selection of appropriate conditions, includingtemperature, salt concentration, polynucleotide concentration,hybridization time, stringency of washing conditions, and the like willdepend on experimental design, including source of sample, identity ofcapture agents, degree of complementarity expected, etc., and may bedetermined as a matter of routine experimentation for those of ordinaryskill in the art.

Those of ordinary skill will readily recognize that alternative butcomparable hybridization and wash conditions can be utilized to provideconditions of similar stringency.

After the mRNA hybridization procedure, the surface boundpolynucleotides are typically washed to remove unbound nucleic acids.Washing may be performed using any convenient washing protocol, wherethe washing conditions are typically stringent, as described above. Thehybridization of the target mRNAs to the probes is then detected usingstandard techniques.

Other methods, such as PCR-based methods, can also be used to follow theexpression of the genes in Table 1, 2, or 3. Examples of PCR methods canbe found in the literature. Examples of PCR assays can be found in U.S.Pat. No. 6,927,024, which is incorporated by reference herein in itsentirety. Examples of RT-PCR methods can be found in U.S. Pat. No.7,122,799, which is incorporated by reference herein in its entirety. Amethod of fluorescent in situ PCR is described in U.S. Pat. No.7,186,507, which is incorporated by reference herein in its entirety.

In some embodiments, Real-Time Reverse Transcription-PCR (qRT-PCR) canbe used for both the detection and quantification of RNA targets(Bustin, et al., 2005, Clin. Sci., 109:365-379). Quantitative resultsobtained by qRT-PCR are generally more informative than qualitativedata. Thus, in some embodiments, qRT-PCR-based assays can be useful tomeasure mRNA levels during cell-based assays. The qRT-PCR method is alsouseful to monitor patient therapy. Examples of qRT-PCR-based methods canbe found, for example, in U.S. Pat. No. 7,101,663, which is incorporatedby reference herein in its entirety.

In contrast to regular reverse transcriptase-PCR and analysis by agarosegels, real-time PCR gives quantitative results. An additional advantageof real-time PCR is the relative ease and convenience of use.Instruments for real-time PCR, such as the Applied Biosystems 7500, areavailable commercially, as are the reagents, such as TaqMan SequenceDetection chemistry. For example, TaqMan® Gene Expression Assays can beused, following the manufacturer's instructions. These kits arepre-formulated gene expression assays for rapid, reliable detection andquantification of human, mouse and rat mRNA transcripts. An exemplaryPCR program, for example, is 50° C. for 2 minutes, 95° C. for 10minutes, 40 cycles of 95° C. for 15 seconds, then 60° C. for 1 minute.

To determine the cycle number at which the fluorescence signalassociated with a particular amplicon accumulation crosses the threshold(referred to as the CT), the data can be analyzed, for example, using a7500 Real-Time PCR System Sequence Detection software v1.3 using thecomparative CT relative quantification calculation method. Using thismethod, the output is expressed as a fold-change of expression levels.In some embodiments, the threshold level can be selected to beautomatically determined by the software. In some embodiments, thethreshold level is set to be above the baseline but sufficiently low tobe within the exponential growth region of an amplification curve.

5.10 Methods for Detecting Protein Expression

Several protein detection and quantitation methods can be used tomeasure the level of proteins. Any suitable protein quantitation methodcan be used. In some embodiments, antibody-based methods are used.Exemplary methods that can be used include but are not limited toimmunoblotting (western blot), enzyme-linked immunosorbent assay(ELISA), immunohistochemistry, flow cytometry, cytometric bead array,mass spectroscopy, and the like. Several types of ELISA are commonlyused, including direct ELISA, indirect ELISA, and sandwich ELISA.

5.11 Kits

In one aspect, provided herein are pharmaceutical or assay kitscomprising an immunomodulatory therapy or a pharmaceutical compositionthereof, in one or more containers, and instructions for use. In certainembodiments, the kits useful for predicting the likelihood of aneffective patient tumor response. In further embodiments, theimmunomodulatory therapy, in a container, is accompanied by an apparatusor apparati necessary for administering the compound or compositionthereof to a subject.

In certain embodiments, a kit comprises an immunomodulatory therapy orpharmaceutical composition thereof, in a container, and a reagent orreagents necessary for carrying out an assay(s) described herein, in oneor more other containers. In certain embodiments, the kit comprises asolid support, and a means for detecting the RNA or protein expressionof at least one biomarker (e.g., a differentially expressed geneidentified in Table 1, 2, 3, or 4) in a biological sample. Such a kitmay employ, for example, a dipstick, a membrane, a chip, a disk, a teststrip, a filter, a microsphere, a slide, a multiwell plate, or anoptical fiber. The solid support of the kit can be, for example, aplastic, silicon, a metal, a resin, glass, a membrane, a particle, aprecipitate, a gel, a polymer, a sheet, a sphere, a polysaccharide, acapillary, a film, a plate, or a slide.

In a specific embodiment, the pharmaceutical or assay kit comprises, ina container, an immunomodulatory therapy or a pharmaceutical compositionthereof, and further comprises, in one or more containers, componentsfor isolating RNA. In another specific embodiment, the pharmaceutical orassay kit comprises, in a container, an immunomodulatory therapy or apharmaceutical composition, and further comprises, in one or morecontainers, components for conducting RT-PCR, RT-qPCR, deep sequencingor a microarray. In some embodiments, the kit comprises a solid support,nucleic acids contacting the support, where the nucleic acids arecomplementary to at least 20, 50, 100, 200, 350, or more bases of mRNA,and a means for detecting the expression of the mRNA in a biologicalsample.

In another specific embodiment, the pharmaceutical or assay kitcomprises, in a container, an immunomodulatory therapy or apharmaceutical composition thereof, and further comprises, in one ormore containers, components for isolating protein In another specificembodiment, the pharmaceutical or assay kit comprises, in a container,an immunomodulatory therapy or a pharmaceutical composition, and furthercomprises, in one or more containers, components for conducting flowcytometry or an ELISA.

In another aspect, provided herein are kits for measuring biomarkersproviding the materials necessary to measure the abundance of one ormore of the gene products of the genes or a subset of genes (e.g., one,two, three, four, five or more genes) in Table 1, 2, 3 or 4, or anycombination thereof. Such kits may comprise materials and reagentsrequired for measuring RNA or protein. In some embodiments, such kitsinclude microarrays, wherein the microarray is comprised ofoligonucleotides and/or DNA and/or RNA fragments which hybridize to oneor more of the products of one or more of the genes or a subset of genesin Table 1, 2, 3 or 4, or any combination thereof. In some embodiments,such kits may include primers for PCR of either the RNA product or thecDNA copy of the RNA product of the genes or subset of genes, or both.In some embodiments, such kits may include primers for PCR as well asprobes for Quantitative PCR. In some embodiments, such kits may includemultiple primers and multiple probes wherein some of said probes havedifferent fluorophores so as to permit multiplexing of multiple productsof a gene product or multiple gene products. In some embodiments, suchkits may further include materials and reagents for creating cDNA fromRNA. In some embodiments, such kits may include antibodies specific forthe protein products of a gene or subset of genes in Table 1, 2, 3, or4, or any combination thereof. Such kits may additionally comprisematerials and reagents for isolating RNA and/or proteins from abiological sample. In addition such kits may include materials andreagents for synthesizing cDNA from RNA isolated from a biologicalsample. In some embodiments, such kits may include, a computer programproduct embedded on computer readable media for predicting whether apatient is clinically sensitive to an immunomodulatory therapy. In someembodiments, the kits may include a computer program product embedded ona computer readable media along with instructions.

In some embodiments, kits for measuring the expression of one or morenucleic acid sequences of a gene or a subset of genes in Table 1, 2, 3or 4 or a combination thereof. In a specific embodiment, such kitsmeasure the expression of one or more nucleic acid sequences associatedwith a gene or a subset of genes in Table 1, 2, 3 or 4, or a combinationthereof. In accordance with this embodiment, the kits may comprisematerials and reagents that are necessary for measuring the expressionof particular nucleic acid sequence products of genes or a subset ofgenes in Table 1, 2, 3 or 4, or a combination thereof. For example, amicroarray or RT-PCR kit may be produced for a specific condition andcontain only those reagents and materials necessary for measuring thelevels of specific RNA transcript products of the genes or a subset ofgenes in Table 1, 2, 3 or 4, or a combination thereof to predict whethera hematological cancer in a patient is clinically sensitive to animmunomodulatory therapy. Alternatively, in some embodiments, the kitscan comprise materials and reagents that are not limited to thoserequired to measure the expression of particular nucleic acid sequencesof any particular gene in Table 1, 2, 3, or 4, or a combination thereof.For example, in certain embodiments, the kits comprise materials andreagents necessary for measuring the levels of expression of 1, 2, 3, 4,5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50 or more of the genesin Table 1, 2, 3 or 4, in addition to reagents and materials necessaryfor measuring the levels of the expression of at least 1, at least 2, atleast 3, at least 4, at least 5, at least 6, at least 7, at least 8, atleast 9, at least 10, at least 15, at least 20, at least 25, at least30, at least 35, at least 40, at least 45, at least 50 or more genesother than those in Table 1, 2, 3 or 4. In other embodiments, the kitscontain reagents and materials necessary for measuring the levels ofexpression of at least 1, at least 2, at least 3, at least 4, at least5, at least 6, at least 7, at least 8, at least 9, at least 10, at least15, at least 20, at least 25, at least 30, at least 35, at least 40, atleast 45, at least 50 or more of the genes in Table 1, 2, 3 or 4, and 1,2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80,85, 90, 95, 100, 125, 150, 175, 200, 225, 250, 300, 350, 400, 450, ormore genes that are genes not in Table 1, 2, 3 or 4, or 1-10, 1-100,1-150, 1-200, 1-300, 1-400, 1-500, 1-1000, 25-100, 25-200, 25-300,25-400, 25-500, 25-1000, 100-150, 100-200, 100-300, 100-400, 100-500,100-1000 or 500-1000 genes that are genes not in Table 1, 2, 3 or 4.

For nucleic acid microarray kits, the kits generally comprise probesattached to a solid support surface. In one such embodiment, probes canbe either oligonucleotides or longer length probes including probesranging from 150 nucleotides in length to 800 nucleotides in length. Theprobes may be labeled with a detectable label. In a specific embodiment,the probes are specific for one or more of the gene products in Table 1,2, 3 or 4. The microarray kits may comprise instructions for performingthe assay and methods for interpreting and analyzing the data resultingfrom the performance of the assay. In a specific embodiment, the kitscomprise instructions for predicting whether a hematological cancer in apatient is clinically sensitive to an immunomodulatory therapy. The kitsmay also comprise hybridization reagents and/or reagents necessary fordetecting a signal produced when a probe hybridizes to a target nucleicacid sequence. Generally, the materials and reagents for the microarraykits are in one or more containers. Each component of the kit isgenerally in its own a suitable container.

In certain embodiments, a nucleic acid microarray kit comprisesmaterials and reagents necessary for measuring the levels of expressionof 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50 or moreof the genes identified in Table 1, 2, 3 or 4, or a combination thereof,in addition to reagents and materials necessary for measuring the levelsof the expression of at least 1, at least 2, at least 3, at least 4, atleast 5, at least 6, at least 7, at least 8, at least 9, at least 10, atleast 15, at least 20, at least 25, at least 30, at least 35, at least40, at least 45, at least 50 or more genes other than those in Tables 1,2, 3 or 4. In other embodiments, a nucleic acid microarray kit containsreagents and materials necessary for measuring the levels of expressionof at least 1, at least 2, at least 3, at least 4, at least 5, at least6, at least 7, at least 8, at least 9, at least 10, at least 15, atleast 20, at least 25, at least 30, at least 35, at least 40, at least45, at least 50 or more of the genes in Table 1, 2, 3 or 4, or anycombination thereof, and 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45,50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 125, 150, 175, 200, 225,250, 300, 350, 400, 450, or more genes that are not in Table 1, 2, 3 or4, or 1-10, 1-100, 1-150, 1-200, 1-300, 1-400, 1-500, 1-1000, 25-100,25-200, 25-300, 25-400, 25-500, 25-1000, 100-150, 100-200, 100-300,100-400, 100-500, 100-1000 or 500-1000 genes that are not in Table 1, 2,3 or 4.

For Quantitative PCR, the kits generally comprise pre-selected primersspecific for particular nucleic acid sequences. The Quantitative PCRkits may also comprise enzymes suitable for amplifying nucleic acids(e.g., polymerases such as Taq), and deoxynucleotides and buffers neededfor the reaction mixture for amplification. The Quantitative PCR kitsmay also comprise probes specific for the nucleic acid sequencesassociated with or indicative of a condition. The probes may or may notbe labeled with a fluorophore. The probes may or may not be labeled witha quencher molecule. In some embodiments the Quantitative PCR kits alsocomprise components suitable for reverse-transcribing RNA includingenzymes (e.g., reverse transcriptases such as AMV, MMLV and the like)and primers for reverse transcription along with deoxynucleotides andbuffers needed for the reverse transcription reaction. Each component ofthe quantitative PCR kit is generally in its own suitable container.Thus, these kits generally comprise distinct containers suitable foreach individual reagent, enzyme, primer and probe. Further, thequantitative PCR kits may comprise instructions for performing the assayand methods for interpreting and analyzing the data resulting from theperformance of the assay. In a specific embodiment, the kits containinstructions for predicting whether a hematological cancer in a patientis clinically sensitive to an immunomodulatory therapy.

For antibody based kits, the kit can comprise, for example: (1) a firstantibody (which may or may not be attached to a solid support) whichbinds to a peptide, polypeptide or protein of interest; and, optionally,(2) a second, different antibody which binds to either the peptide,polypeptide or protein, or the first antibody and is conjugated to adetectable label (e.g., a fluorescent label, radioactive isotope orenzyme). In a specific embodiment, the peptide, polypeptide or proteinof interest is associated with or indicative of a condition (e.g., adisease). The antibody-based kits may also comprise beads for conductingan immunoprecipitation. Each component of the antibody-based kits isgenerally in its own suitable container. Thus, these kits generallycomprise distinct containers suitable for each antibody. Further, theantibody-based kits may comprise instructions for performing the assayand methods for interpreting and analyzing the data resulting from theperformance of the assay. In a specific embodiment, the kits containinstructions for predicting whether a hematological cancer in a patientis clinically sensitive to an immunomodulatory therapy.

6. EXAMPLES

Certain embodiments of the invention are illustrated by the followingnon-limiting examples.

Gene expression differences between the baseline transcriptionalprofiles of refractory or relapsed diffuse large B-Cell lymphoma (DLBCL)patients who display response subsequent to lenalidomide treatment andthose of patients who do not respond were investigated. A clinical trialwas formed with four arms, each arm containing 25 patients. One armcontained patients classified as presenting germinal center B-cell-likeDLBCL subtypes receiving lenalidomide, a second arm contained patientsclassified as presenting germinal center B-cell-like DLBCL subtypesreceiving another therapy selected by the investigator, a third armcontained patients classified as presenting activated B-cell-like DLBCLsubtypes receiving lenalidomide, and a fourth arm contained patientsclassified as presenting activated B-cell-like DLBCL subtypes receivinganother therapy selected by the investigator. The patients in the fourarms of the clinical trial received treatment until disease progression.

For purposes of this exploratory analysis, a subset of the clinical dataassociated to each patient comprised the therapy arm, Revlimid (REV) orcontrol drug (CON), and their corresponding response to the drug in bothcategorical variable {complete response (CR), partial response (PR),establish disease (SD), progression disease (PD) and Death} andcontinuous variables as progression free survival (PFS) and overall(OS), unit weeks. It also includes the predicted DLBCL sub-type(ABC/GCB) and other demographic data.

Samples from patient biopsies taken prior to receiving therapy werehybridized to Affymetrix HG-U 133 Plus 2.0 GeneChip™ microarrays(www.afymetrix.com/) at the Molecular Characterization & Clinical AssayDevelopment Laboratory, SAIC Frederick National Laboratory for CancerResearch, SAIC-Frederick, Frederick, Md. Biopsy samples wereflash-frozen at screen (FF), archived having been formalin-fixed andparaffin embedded (FFPE archive), or FFPE treated at screen. Allpatients are associated with at least one gene expression profileobtained from one of the three sample types, some are associated withmore than one profile. The results described in this Section 6 wereobtained from analysis of only those profiles relating to FF samples andwhich passed QC.

Microarray Data QC

Raw Affymetrix image (.cel) files were imported into the R statisticalprogramming environment v3.0.0 (r-project.org) using functionality ofthe Affy package of the related Bioconductor suite of open-sourcebioinformatics software (bioconductor.org). Transcriptional profile QCwas performed using the NUSE algorithm, implemented in the Bioconductorpackage arrayQualityMetrics (Kauffmann et al., 2009), applied to a log 2transformation of raw signal.

The RMA (Irizarry et al., 2003) algorithm was applied tobackground-correct, quantile normalize and summarize profiles thatpassed QC. Annotation of probe-sets to genes was performed using the Rpackages annotate (Gentleman, 2013) and genefilter (Gentleman et al.,2013) selecting only one probeset per gene (Entrez Gene ID) and choosingthe most variable across profiles according to inter-quartile range incases wherein multiple probe-sets map to a single gene.

Clustering & Visualization

Data visualization via clustering and heatmap graphics was implementedin the R statistical programming environment. Either Euclidean distanceand correlation (1—Pearson correlation) were used to representinter-profile dissimilarity and (1—pearson correlation) to representdissimilarity between genes across profiles. In both cases, hierarchicalclustering using Ward's algorithm was applied. Comparative geneexpression heatmaps were implemented using gplots (Warnes et al., 2013)and heatmap.plus (Day, 2012) packages from the Bioconductor suite, withcolours generated using palettes from the RColorBrewer™ package(Neuwirth, 2011). Prior to clustering and visualization, individual geneexpression across profiles was standardized to have zero mean and unitvariance.

Differential Expression

The SAM algorithm (Tusher et al., 2001), as implemented in theR/Bioconductor package siggenes (Schwender, 2012), was applied to assessstatistical significance of differential gene expression across discreteprofile groups. Significance values obtained from multiple hypothesistests were corrected for false-discovery by permutation as implementedin the SAM algorithm.

The Enrichr (Chen et al., 2013) tool (available atamp.pharm.mssm.eduEnrichr/) was used to assess statisticalover-representation of gene categories among genes deemed differentiallyregulated. The tool combines 35 gene set libraries sorted by categoriesincluding transcription, pathways, ontologies, diseases, etc. andtotaling 31,026 gene-sets.

Survival Analysis

The BioNet algorithm (Beisser et al., 2010), as implemented in therelated Bioconductor package, was applied to the combined output ofstatistical tests for differential expression between refractory versusnon-refractory best response groups and gene expression correlation withPFS and used the Human Interactome obtained from HINT (Das and Yu,2012). Optimal response-related sub-networks were visualized via theCytoscape platform (Saito et al., 2012; Shannon et al., 2003; Smoot etal., 2011).

The Reactome FI package (Wu and Stein, 2012) was implemented viaCytoscape and applied to Reactome annotation (Croft et al., 2011)imported with the software. The “microarray data analysis” option wasapplied, with database version 2012, absolute value for Pearsoncorrelation, and an inflation parameter of 5.0 for the Markov ClusterAlgorithm. After network generation, Biological Process and Pathwayenrichment and survival analyses were generated using associatedfunctionality of the package. Survival analyses were calculated permodule upon import of corresponding PFS and censor information.

Cox regression models and Kaplan-Meier curves were performed using the Rpackage survival (Terry M. Therneau, 2013; Terry M. Therneau andPatricia M. Grambsch, 2000).

Decomposition

Microarray gene expression profiles were decomposed using defaultfunctionality of the CellMix R/Bioconductor package (Gaujoux andSeoighe, 2013), which also provided collections of reference data usedfor decomposition. The decomposition method and reference collection of(Abbas et al., 2009) were applied to REV-DLC-001 profiles. Results werevisualized and associated statistics calculated using nativefunctionality of the R environment.

Results

Tables 3 and 4 provide lists of genes deemed significantlydifferentially regulated (empirical FDR 5%) pre-treatment, betweenpatient groups determined as refractory and non-refractory further toRevlimid/lenalidomide therapy. Table 1 provides a list of genes deemedsignificantly upregulated (empirical FDR 5%) pre-treatment in patientsnon-refractory to further therapy relative to patients refractory tofurther Revlimid/lenalidomide therapy. Table 2 provides a list of genesdeemed significantly downregulated (empirical FDR 5%) pre-treatment inpatients non-refractory to further therapy relative to patientsrefractory to further Revlimid/lenalidomide therapy.

Analysis was performed on the FF sample profiles from thelenalidomide-arm and estimated relative proportions of the referenceimmune cell types were compared between profiles associated with binarylenalidomide response vs. non-response categories (see FIG. 2). Thedistinction between lenalidomide response profiles and thenon-responding profiles is characterized by lower estimated B-cellproportions and clear increases in estimated proportions of plasmacells, dendritic cells, and, in a smaller subset of responding patients,NK cells.

It is of note that estimated proportions of monocytes and cytotoxicT-cells do not correlate strongly with Revlimid response, despiteinterpretations of the preceding analyses having suggested theirpresence. Rather, the patterns displayed appear more related to anearlier ‘host response’ (Monti et al., 2005) or immune infiltrate incombination with a corresponding reduction in particular B-cellpopulations—as in earlier interpretation of the combined THRLBCL (VanLoo et al., 2010)/host response (Monti et al., 2005) gene signatures.

FIG. 4 displays estimated proportion of BCR-ligated B-cells (B aIgM) inbaseline patient profiles plotted alongside corresponding progressionfree survival (PFS) further to lenalidomide treatment. The associationbetween low estimated B aIgM proportion and relatively high PFS isstriking, in particular in the knowledge that one patient with both lowB aIgM proportion and low PFS (<3 weeks) died shortly after startingtreatment.

The estimated proportion of plasma cells displays the opposite tendency.This observation lends relevance to the decomposition data, as the twocell types are directly linked (Caven et al., 2007) and strongup-regulation of plasma cell marker differentiation marker PRDM1(BLIMP1)is observed in profiles associated with response to treatment. Thispattern persists to the extent that the sign of a simple subtracteddifference between estimated proportions of BCR-ligated B-cells andplasma cells across Revlimid arm profile decompositions (see FIG. 5(lenalidomide-arm)) provides a statistically significant difference inPFS between two patient groups thus defined (Wilcoxon rank sum, p=0.04).

The response-related decomposition values for resting NK-cellproportions are interesting. Only four profiles are associated withnon-zero estimated proportion of NK-cells, but these profiles areassociated with PFS of 27, 31.9, 32.4 & 85.3 weeks. Clearly, were theseestimations to bear out in practice (they include two very smallestimated proportions, 0.114, 0.158, 0.004 & 0.002 respectively), thepresence of NK cells in the tumor sample may provide a good indicatorfor Revlimid response enrichment.

Finally, relative estimated proportions of dendritic cells are higherand more stable than for NK cells, although they lack the binary‘on/off’ nature of BCR-ligated B-cell and plasma cell proportions inrelation to best response categories. FIG. 3 displays the relationshipbetween estimated DC proportion (resting+activated) and PFS. Takentogether with the partially response-discriminant populations above, theresults suggest potential for, for example, a focused flow cytometryscreen for future patients more likely to respond to Revlimid treatment.

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Table 1, Table, 2, Table 3 and Table 4 are provided below.

TABLE 1 mean_ mean_ Chro- chrom_ probeset gene_symbol ensembl_id q.valuelogFC nonRef Ref mosome band gene_description 228754_at SLC6A6ENSG00000131389 0 0.9754805 8.981006 8.005526 3 p25.1 solute carrierfamily 6 (neurotransmitter transporter, taurine), member 6 [Source: HGNCSymbol; Acc: 11052] 238327_at ODF3B ENSG00000177989 0.00273 1.03041178.897771 7.86736 22 q13.33 outer dense fiber of sperm tails 3B [Source:HGNC Symbol; Acc: 34388] 208683_at CAPN2 ENSG00000162909 0.002732.0591386 9.820198 7.761059 1 q41 calpain 2, (m/ll) large subunit[Source: HGNC Symbol; Acc: 1479] 218648_at CRTC3 ENSG00000140577 0.002731.3932573 9.008044 7.614786 15 q26.1 CREB regulated transcriptioncoactivator 3 [Source: HGNC Symbol; Acc: 26148] 225146_at FAM219AENSG00000164970 0.00273 0.7957467 8.091946 7.296199 9 p13.3 family withsequence similarity 219, member A [Source: HGNC Symbol; Acc: 19920]218589_at LPAR6 ENSG00000139679 0.00273 2.4225735 9.179664 6.75709 13q14.2 lysophosphatidic acid receptor 6 [Source: HGNC Symbol; Acc: 15520]217762_s_at RAB31 ENSG00000168461 0.00273 1.7495761 10.13227 8.382693 18p11.22 RAB31, member RAS oncogene family [Source: HGNC Symbol; Acc:9771] 201506_at TGFBI ENSG00000120708 0.00273 1.8055477 11.4844 9.6788525 q31.1 transforming growth factor, beta-induced, 68 kDa [Source: HGNCSymbol; Acc: 11771] 224862_at GNAQ ENSG00000156052 0.00273 2.02536346.97061 4.945246 9 q21.2 guanine nucleotide binding protein (G protein),q polypeptide [Source: HGNC Symbol; Acc: 4390] 201425_at ALDH2ENSG00000111275 0.00273 1.9293787 10.60165 8.672267 12 q24.12 aldehydedehydrogenase 2 family (mitochondrial) [Source: HGNC Symbol; Acc,: 404]1555851_s_at SEPW1 ENSG00000178980 0.00312 1.5331244 10.54942 9.01629219 q13.33 selenoprotein W, 1 [Source: HGNC Symbol; Acc: 10752] 205241_atSCO2 ENSG00000130489 0.00312 0.8920118 9.145278 8.253267 22 q13.33 SCO2cytochrome c oxidase assembly protein [Source: HGNC Symbol; Acc: 10604]218552_at ECHDC2 ENSG00000121310 0.00312 1.3353136 9.234133 7.89882 1p32.3 enoyl CoA hydratase domain containing 2 [Source: HGNC Symbol; Acc:23408] 55662_at C10orf76 ENSG00000120029 0.00312 0.7212711 8.2121537.490882 10 q24.32 chromosome 10 open reading frame 76 [Source: HGNCSymbol; Acc: 257881 204773_at IL11RA ENSG00000137070 0.004437 0.91739027.610983 6.693593 9 p13.3 interleukin 11 receptor, alpha [Source: HGNCSymbol; Acc: 5967] 202600_s_at NRIP1 ENSG00000180530 0.004437 1.6623667.562455 5.900089 21 q21.1 nuclear receptor interacting protein 1[Source: HGNC Symbol; Acc: 8001] 221802_s_at KIAA1598 ENSG000001871640.004818 1.8894563 8.343765 6.454309 10 q25.3 KIAA1598 [Source: HGNCSymbol; Acc: 29319] 226000_at CTTNBP2NL ENSG00000143079 0.0051571.4672863 7.674825 6.207539 1 p13.2 CTTNBP2 N-terminal like [Source:HGNC Symbol; Acc: 25330] 222484_s_at CXCL14 ENSG00000145824 0.0051733.4617357 11.01983 7.558095 5 q31.1 chemokine (C-X-C motif) ligand 14[Source: HGNC Symbol; Acc: 10640] 201012_at ANXA1 ENSG000001350460.005188 1.8681422 10.78464 8.916494 9 q21.13 annexin A1 [Source: HGNCSymbol; Acc: 533] 218854_at DSE ENSG00000111817 0.006453 1.63213439.397392 7.765258 6 q22.1 dermatan sulfate epimerase [Source: HGNCSymbol; Acc: 21144] 214040_s_at GSN ENSG00000148180 0.006453 1.345118410.2628 8.917685 9 q33.2 gelsolin [Source: HGNC Symbol; Acc: 4620]201302_at ANXA4 ENSG00000196975 0.006598 1.7017558 9.377174 7.675418 2p13.3 annexin A4 [Source: HGNC Symbol; Acc: 542] 208923_at CYFIP1ENSG00000068793 0.006598 1.4183371 9.308029 7.889692 15 q11.2cytoplasmic FMR1 interacting protein 1 [Source: HGNC Symbol; Acc: 13759]224414_s_at CARD6 ENSG00000132357 0.007208 1.298678 8.497051 7.198373 5p13.1 caspase recruitment domain family, member 6 [Source: HGNC Symbol;Acc: 16394] 205945_at IL6R ENSG00000160712 0.008097 1.7659924 8.8741177.108125 1 q21.3 interleukin 6 receptor [Source: HGNC Symbol; Acc: 6019]200765_x_at CTNNA1 ENSG00000044115 0.008097 1.1179416 9.63084 8.512898 5q31.2 catenin (cadherin-associated protein), alpha 1, 102 kDa [Source:HGNC Symbol; Acc: 2509] 223228_at LDOC1L ENSG00000188636 0.0080971.239346 8.444984 7.205638 22 q13.31 leucine zipper, down-regulated incancer 1-like [Source: HGNC Symbol; Acc: 13343] 225842_at PHLDA1ENSG00000139289 0.008191 1.472676 8.29771 6.825034 12 q21.2 pleckstrinhomology-like domain, family A, member 1 [Source: HGNC Symbol; Acc:8933] 201348_at GPX3 ENSG00000211445 0.008351 2.1699179 11.324229.154304 5 q33.1 glutathione peroxidase 3 (plasma) [Source: HGNC Symbol;Acc: 4555] 219885_at SLFN12 ENSG00000172123 0.008351 1.2351533 6.0977894.862636 17 q12 schlafen family member 12 [Source: HGNC Symbol; Acc:25500] 212830_at MEGF9 ENSG00000106780 0.008351 1.2431752 6.7340855.490909 9 q33.2 multiple EFG-like-domains 9 [Source: HGNC Symbol; Acc:3234] 202687_s_at TNFSF10 ENSG00000121858 0.008425 1.5293527 11.105279.57592 3 q26.31 tumor necrosis factor (ligand) superfamily, member 10[Source: HGNC Symbol; Acc: 11925] 217731_s_at ITM2B ENSG000001361560.009101 1.4493355 10.05153 8.602193 13 q14.2 integral membrane protein28 [Source: HGNC Symbol; Acc: 6174] 218694_at ARMCX1 ENSG000001269470.009456 1.4991554 7.418732 5.919576 X q22.1 armadillo repeatcontaining, X-linked 1 [Source: HGNC Symbol; Acc: 18073] 202944_at NAGAENSG00000198951 0.009456 0.9946444 8.604684 7.61004 22 q13.2N-acetylgalactosaminidase, alpha- [Source: HGNC Symbol; Acc: 7631]212522_at PDE8A ENSG00000073417 0.009456 1.2124713 8.751053 7.538532 15q25.3 phosphodiesterase 8A [Source: HGNC Symbol; Acc: 8793] 226247_atPLEKHA1 ENSG00000107679 0.009456 1.762189 8.231589 6.4694 10 q26.13pleckstrin homology domain containing, family A (phosphoinositidebinding specific) member 1 [Source: HGNC Symbol; Acc: 14335] 243423_atTNIP1 ENSG00000145901 0.009621 1.0393627 6.139027 5.099664 5 q33.1TNFAIP3 interacting protein 1 [Source: HGNC Symbol; Acc: 16903]229074_at EHD4 ENSG00000103966 0.00995 1.116796 8.728409 7.611613 15q15.1 EH-domain containing 4 [Source: HGNC Symbol; Acc: 3245]222154_s_at SPATS2L ENSG00000196141 0.00995 1.2398395 9.909155 8.6693162 q33.1 spermatogenesis associated, serine-rich 2-like [Source: HGNCSymbol; Acc: 24574] 200710_at ACADVL ENSG00000072778 0.011037 0.87200849.456312 8.584304 17 p13.1 acyl-CoA dehydrogenase, very long chain[Source: HGNC Symbol; Acc: 92] 228791_at LOC100129502 NA 0.0110371.7938919 8.411267 6.617375 NA NA NA 208634_s_at MACF1 ENSG000001276030.011768 1.2346253 10.26299 9.028368 1 p34.3 microtubule-actincrosslinking factor 1 [Source: HGNC Symbol; Acc: 13664] 242487_at CC2D1BENSG00000154222 0.011768 0.5238144 6.843606 6.319792 1 p32.3 coiled-coiland C2 domain containing 1B [Source: HGNC Symbol; Acc: 29336]218559_s_at MAFB ENSG00000204103 0.011768 1.8491222 11.31545 9.466329 20q12 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B[Source: HGNC Symbol; Acc: 6408] 201360_at CST3 ENSG00000101439 0.0117681.3533248 11.64386 10.29054 20 p11.21 cystatin C [Source: HGNC Symbol;Acc: 2475] 206101_at ECM2 ENSG00000106823 0.011768 1.7286086 7.1565115.427902 9 q22.31 extracellular matrix protein 2, female organ andadipocyte specific [Source: HGNC Symbol; Acc: 3154] 218004_at BSDC1ENSG00000160058 0.011768 0.5416922 8.948162 8.40647 1 p35.1 BSD domaincontaining 1 [Source: HGNC Symbol; Acc: 25501] 36129_at SGSM2ENSG00000141258 0.011768 0.89385 9.48007 8.58622 17 p13.3 small Gprotein signaling modulator 2 [Source: HGNC Symbol; Acc: 29026]227889_at LPCAT2 ENSG00000087253 0.011768 1.9822482 7.953706 5.971458 16q12.2 lysophosphatidylcholine acyltransferase 2 [Source: HGNC Symbol;Acc: 26032] 218043_s_at AZI2 ENSG00000163512 0.011768 0.8638989 6.6442855.780336 3 p24.1 5-azacytidine induced 2 [Source: HGNC Symbol; Acc:24002] 218066_at SLC12A7 ENSG00000113504 0.011768 1.0053443 8.9127227.907378 5 p15.33 solute carrier family 12 (potassium/chloridetransporters), member 7 [Source: HGNC Symbol; Acc: 10915] 58780_s_atARHGEF40 ENSG00000165801 0.011847 1.4859821 7.235422 5.74944 14 q11.2Rho guanine nucleotide exchange factor (GEF) 40 [Source: HGNC Symbol;Acc: 25516] 200660_at S100A11 ENSG00000163191 0.01233 1.3882864 11.6106610.22237 1 q21.3 S100 calcium binding protein A11 [Source: HGNC Symbol;Acc: 10488] 212907_at SLC30A1 ENSG00000170385 0.01233 1.1713121 9.3504678.179154 1 q32.3 solute carrier family 30 (zinc transporter), member 1[Source: HGNC Symbol; Acc: 11012] 208999_at SEPT8 ENSG000001644020.012828 1.1133968 8.412743 7.299346 5 q31.1 septin 8 [Source: HGNCSymbol; Acc: 16511] 208949_s_at LGALS3 ENSG00000131981 0.0129371.4663704 11.76909 10.30272 14 q22.3 lectin, galactoside-binding,soluble, 3 [Source: HGNC Symbol; Acc: 6563] 218311_at MAP4K3ENSG00000011566 0.012937 1.467988 7.560719 6.092731 2 p22.1mitogen-activated protein kinase kinase kinase kinase 3 [Source: HGNCSymbol; Acc: 6865] 203518_at LYST ENSG00000143669 0.013774 1.78138928.315307 6.533918 1 q42.3 lysosomal trafficking regulator [Source: HGNCSymbol; Acc: 19681 204137_at GPR137B ENSG00000077585 0.01568 2.08875069.969767 7.881016 1 q42.3 G protein-coupled receptor 137B [Source: HGNCSymbol; Acc: 11862] 222217_s_at SLC27A3 ENSG00000143554 0.015680.9016644 8.45229 7.550626 1 q21.3 solute carrier family 27 (fatty acidtransporter), member 3 [Source: HGNC Symbol; Acc: 10997] 201505_at LAMB1ENSG00000091136 0.015689 1.8347161 9.325408 7.490692 7 q31.1 laminin,beta 1 [Source: HGNC Symbol; Acc: 6486] 217728_at S100A6 ENSG000001979560.016157 0.9618026 11.17652 10.21472 1 q21.3 S100 calcium bindingprotein A6 [Source: HGNC Symbol; Acc: 10496] 225483_at VPS26BENSG00000151502 0.01616 0.7314643 8.008599 7.277135 11 q25 vacuolarprotein sorting 26 homolog B (S. pombe) [Source: HGNC Symbol; Acc:28119] 202686_s_at AXL ENSG00000167601 0.016163 2.1648837 9.7491767.584292 19 q13.2 AXL receptor tyrosine kinase [Source: HGNC Symbol;Acc: 905] 227276_at PLXDC2 ENSG00000120594 0.016167 1.9691918 9.8579347.888742 10 p12.31 plexin domain containing 2 [Source: HGNC Symbol; Acc:2013] 228185_at ZNF25 ENSG00000175395 0.016167 0.9293975 6.5108395.581442 10 p11.1 zinc finger protein 25 [Source: HGNC Symbol; Acc:13043] 217892_s_at LIMA1 ENSG00000050405 0.016167 1.8593217 9.9683668.109044 12 q13.12 LIM domain and actin binding 1 [Source: HGNC Symbol;Acc: 24636] 202727_s_at IFNGR1 ENSG00000027697 0.016167 1.20332259.855228 8.651905 6 q23.3 interferon gamma receptor 1 [Source: HGNCSymbol; Acc: 5439] 212112_s_at STX12 ENSG00000117758 0.016167 0.81158948.768046 7.956457 1 p35.3 syntaxin 12 [Source: HGNC Symbol; Acc: 11430]203789_s_at SEMA3C ENSG00000075223 0.016167 1.8263518 6.851145 5.0247937 q21.11 sema domain, immunoglobulin domain (lg), short basic domain,secreted, (semaphorin) 3C [Source: HGNC Symbol; Acc: 10725] 200677_atPTTG1IP ENSG00000183255 0.016167 0.9443082 10.81552 9.871214 21 q22.3pituitary tumor-transforming 1 interacting protein [Source: HGNC Symbol;Acc: 13524] 222876_s_at ADAP2 ENSG00000184060 0.016167 1.230284 9.9479098.717625 17 q11.2 ArfGAP with dual PH domains 2 [Source: HGNC Symbol;Acc; 16487] 210145_at PLA2G4A ENSG00000116711 0.016167 1.018587 5.597694.579103 1 q31.1 phospholipase A2, group IVA (cytosolic,calcium-dependent) [Source: HGNC Symbol; Acc: 9035] 208109_s_atLINC00597 NA 0.016167 1.2522138 6.056933 4.804719 NA NA NA 209651_atTGFB1I1 ENSG00000140682 0.016167 1.6390689 8.383831 6.744762 16 p11.2transforming growth factor beta 1 induced transcript 1 [Source: HGNCSymbol; Acc: 11767] 212698_s_at SEPT10 ENSG00000186522 0.0161672.0293866 6.787502 4.758115 2 q13 septin 10 [Source: HGNC Symbol; Acc:14349] 212526_at SPG20 ENSG00000133104 0.016167 1.308041 6.9744735.666432 13 q13.3 spastic paraplegia 20 (Troyer syndrome) [Source: HGNCSymbol; Acc: 18514] 209684_at RIN2 ENSG00000132669 0.016167 1.94849879.25026 7.301761 20 p11.23 Ras and Rab interactor 2 [Source: HGNCSymbol; Acc: 18750] 223204_at FAM198B ENSG00000164125 0.016167 1.55670477.718117 6.161412 4 q32.1 family with sequence similarity 198, member B[Source: HGNC Symbol; Acc: 25312] 200673_at LAPTM4A ENSG000000686970.016167 1.052583 10.80128 9.748695 2 p24.1 lysosomal proteintransmembrane 4 alpha [Source: HGNC Symbol; Acc: 6924] 225384_at DOCK7ENSG00000116641 0.016167 0.820345 7.335351 6.515006 1 p31.3 dedicator ofcytokinesis 7 [Source: HGNC Symbol,Acc: 19190] 209210_s_at FERMT2ENSG00000073712 0.016167 1.600225 8.650583 7.050358 14 q22.1 fermitinfamily member 2 [Source: HGNC Symbol; Acc: 15767] 201798_s_at MYOFENSG00000138119 0.016167 1.9337214 9.90089 7.967169 10 q23.33 myoferlin[Source: HGNC Symbol; Acc: 3656] 225949_at NRBP2 ENSG000001851890.016167 1.1978158 8.229623 7.031807 8 q24.3 nuclear receptor bindingprotein 2 (Source: HGNC Symbol; Acc: 19339] 208924_at RNF11ENSG00000123091 0.016167 1.3126563 7.905885 6.593229 1 p32.3 ring fingerprotein 11 [Source: HGNC Symbol; Acc: 10056] 209004_s_at FBXL5ENSG00000118564 0.016167 1.0838058 10.00546 8.921656 4 p15.32 F-box andleucine-rich repeat protein 5 [Source: HGNC Symbol; Acc: 13602]226743_at SLFN11 ENSG00000172716 0.016167 1.6530276 8.752878 7.099851 17q12 schlafen family member 11 [Source: HGNC Symbol; Acc: 26633]228573_at ANTXR2 ENSG00000163297 0.016167 1.2231191 6.502217 5.279098 4q21.21 anthrax toxin receptor 2 [Source: HGNC Symbol; Acc: 21732]222065_s_at FLII ENSG00000177731 0.016167 0.7794236 9.687503 8.90808 17p11.2 flightless I homolog (Drosophila) [Source: HGNC Symbol; Acc: 3750]212989_at SGMS1 ENSG00000198964 0.016167 1.1804345 5.341958 4.161523 10q11.23 sphingomyelin synthase 1 [Source: HGNC Symbol; Acc: 29799]202228_s_at NPTN ENSG00000156642 0.016167 1.1313461 9.703866 8.57252 15q24.1 neuroplastin [Source: HGNC Symbol; Acc: 17867] 227761_at MYO5AENSG00000197535 0.016167 1.4777088 8.28231 6.804601 15 q21.2 myosin VA(heavy chain 12, myoxin) [Source: HGNC Symbol; Acc: 7602] 202133_atWWTR1 ENSG00000018408 0.016167 1.9825407 8.759155 6.776615 3 q25.1 WWdomain containing transcription regulator 1 [Source: HGNC Symbol; Acc:24042] 209960_at HGF ENSG00000019991 0.016167 1.2162213 4.7389853.522763 7 q21.11 hepatocyte growth factor (hepapoietin A; scatterfactor) [Source: HGNC Symbol; Acc: 4893] 212203_x_at IFITM3ENSG00000142089 0.016167 0.9994654 12.83133 11.83186 11 p15.5 interferoninduced transmembrane protein 3 [Source: HGNC Symbol; Acc: 5414]212158_at SDC2 ENSG00000169439 0.016167 1.6948793 8.399184 6.704305 8q22.1 syndecan 2 [Source: HGNC Symbol; Acc: 10659] 224797_at ARRDC3ENSG00000113369 0.016167 1.2808966 7.04992 5.769023 5 q14.3 arrestindomain containing 3 [Source: HGNC Symbol; Acc: 29263] 203124_s_atSLC11A2 ENSG00000110911 0.016167 1.3149816 8.210637 6.895655 12 q13.12solute carrier family 11 (proton-coupled divalent metal iontransporters), member 2 [Source: HGNC Symbol; Acc: 10908] 1553034_atSDCCAG8 ENSG00000054282 0.016167 0.6479854 7.598444 6.950458 1 q43serologically defined colon cancer antigen 8 [Source: HGNC Symbol; Acc:10671] 226111_s_at ZNF385A ENSG00000161642 0.016167 1.0612964 9.5298228.46525 12 q13.13 zinc finger protein 385A [Source: HGNC Symbol; Acc:17521] 231579_s_at TIMP2 ENSG00000035862 0.016167 1.9509024 11.290349.339442 17 q25.3 TIMP metallopeptidase inhibitor 2 [Source: HGNCSymbol; Acc: 11821] 202007_at NID1 ENSG00000116962 0.016167 1.61713847.967908 6.350769 1 q42.3 nidogen 1 [Source: HGNC Symbol; Acc: 7821]201681_s_at DLG5 ENSG00000151208 0.016382 1.584355 7.680377 6.096022 10q22.3 discs, large homolog 5 (Drosophila) [Source: HGNC Symbol; Acc:2904] 212761_at ICF7L2 ENSG00000148737 0.016678 1.5655854 7.5953066.02972 10 q25.2 transcription factor 7-like 2 (T-cell specific,HMG-box) [Source: HGNC Symbol; Acc: 11641] 224983_at SCARB2ENSG00000138760 0.016923 1.3192641 9.808333 8.489069 4 q21.1 scavengerreceptor class B, member 2 [Source: HGNC Symbol; Acc: 1665] 218706_s_atGRAMD3 ENSG00000155324 0.016923 1.1289944 6.584781 5.455786 5 q23.2 GRAMdomain containing 3 [Source: HGNC Symbol; Acc: 24911] 203595_s_at IFIT5ENSG00000152778 0.017039 1.3141225 8.100951 6.786828 10 q23.31interferon-induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol; Acc: 13328] 225133_at KLF3 ENSG00000109787 0.0172711.8771599 7.744133 5.866973 4 p14 Kruppel-like factor 3 (basic) [Source:HGNC Symbol; Acc: 16516] 204396_s_at GRK5 ENSG00000198873 0.0174580.9777677 8.134717 7.156949 10 q26.11 G protein-coupled receptor kinase5 [Source: HGNC Symbol; Acc: 4544] 210105_s_at FYN ENSG000000108100.017653 1.6156589 10.56934 8.953681 6 q21 FYN oncogene related to SRC,FGR, YES [Source: HGNC Symbol; Acc: 4037] 201218_at CTBP2ENSG00000175029 0.017653 1.464242 7.445366 5.981124 10 q26.13 C-terminalbinding protein 2 [Source: HGNC Symbol; Acc: 2495] 203973_s_at CEBPDENSG00000221869 0.017653 1.6141966 10.46813 8.85393 8 q11.21CCAAT/enhancer binding protein (C/EBP), delta [Source: HGNC Symbol; Acc:1835] 243038_at RBM43 ENSG00000184898 0.017653 0.9687316 7.015396.046658 2 q23.3 RNA binding motif protein 43 [Source: HGNC Symbol; Acc:24790] 212667_at SPARC ENSG00000113140 0.017553 2.0387778 9.7601587.72138 5 q33.1 secreted protein, acidic, cysteine-rich (osteonectin)[Source: HGNC Symbol; Acc: 11219] 209341_s_at IKBKB ENSG000001043650.017653 0.9809497 8.789651 7.808701 8 p11.21 inhibitor of kappa lightpolypeptide gene enhancer in B-cells, kinase beta [Source: HGNC Symbol;Acc: 5960] 202336_s_at PAM ENSG00000145730 0.017653 1.3185154 9.2890217.970505 5 q21.1 peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol; Acc: 8596] 212298_at NRP1 ENSG00000099250 0.0180671.7793457 9.257538 7.478193 10 p11.22 neuropilin 1 [Source: HGNC Symbol;Acc: 8004] 221773_at ELK3 ENSG00000111145 0.018896 1.6207184 8.1754216.554703 12 q23.1 ELK3, ETS-domain protein (SRF accessory protein 2)[Source: HGNC Symbol; Acc: 3325] 208816_x_at ANXA2P2 ENSG000002319910.018902 0.8785493 10.01166 9.13311 9 p13.3 annexin A2 pseudogene 2[Source: HGNC Symbol; Acc: 539] 225188_at RAPH1 ENSG00000173166 0.0189022.0051889 7.673175 5.667987 2 q33.2 Ras association (RaiGDS/AF-6) andpleckstrin homology domains 1 [Source: HGNC Symbol; Acc: 14436]212779_at KIAA1109 ENSG00000138688 0.018902 0.9900719 8.187159 7.1970874 q27 KIAA1109 [Source: HGNC Symbol; Acc: 26953] 221748_s_at TNS1ENSG00000079308 0.018902 2.0203509 8.86943 6.84908 2 q35 tensin 1[Source: HGNC Symbol; Acc: 11973] 213379_at COQ2 ENSG000001730850.018902 0.5237323 8.028911 7.505178 4 q21.23 coenzyme Q24-hydroxybenzoete polyprenyltransferase [Source: HGNC Symbol; Acc:25223] 211684_s_at DYNC1I2 ENSG00000077380 0.018902 0.8229036 8.9106238.08772 2 q31.1 dynein, cytoplasmic 1, intermediate chain 2 [Source:HGNC Symbol; Acc: 2964] 201739_at SGK1 ENSG00000118515 0.0189021.4797614 10.75365 9.273888 6 q23.2 serum/glucocorticoid regulatedkinase 1 [Source: HGNC Symbol; Acc: 10810] 209090_s_at SH3GLB1ENSG00000097033 0.018902 0.9614008 9.962485 9.001085 1 p22.3 SH3-domainGRB2-like endophilin B1 [Source: HGNC Symbol; Acc: 10833] 225171_atARHGAP18 ENSG00000146376 0.018902 1.5370749 8.677922 7.140848 6 q22.33Rho GTPase activating protein 18 [Source: HGNC Symbol; Acc: 21035]204517_at PPIC ENSG00000168938 0.018902 1.4583399 7.874059 6.415719 5q23.2 peptidylprolyl isomerase C (cyclophilin C) [Source: HGNC Symbol;Acc: 9256] 213923_at RAP2B ENSG00000181467 0.018902 1.241375 10.185148.943765 3 q25.2 RAP2B, member of RAS oncogene family [Source: HGNCSymbol; Acc: 9862] 201590_x_at ANXA2 ENSG00000182718 0.018902 1.222362712.76742 11.54506 15 q22.2 annexin A2 [Source: HGNC Symbol; Acc: 537]202202_s_at LAMA4 ENSG00000112769 0.018902 1.0953018 9.350315 8.255013 6q21 laminin, alpha 4 [Source: HGNC Symbol; Acc: 6484] 218718_at PDGFCENSG00000145431 0.018921 2.1063846 7.633895 5.52751 4 q32.1 plateletderived growth factor C [Source: HGNC Symbol; Acc: 8801] 206414_s_atASAP2 ENSG00000151693 0.018921 1.4747717 6.713855 5.239084 2 p25.1ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [Source: HGNCSymbol; Acc: 2721] 212169_at FKBP9 ENSG00000122642 0.019065 1.11075248.896737 7.785985 7 p14.3 FK506 binding protein 9, 63 kDa [Source: HGNCSymbol; Acc: 3725] 209348_s_at MAF ENSG00000178573 0.019065 2.1557868.892164 6.736378 16 q23.2 v-maf avian musculoaponeurotic fibrosarcomaoncogene homolog [Source: HGNC Symbol; Acc: 6776] 202011_at TJP1ENSG00000104067 0.019267 2.0936522 8.408239 6.314587 15 q13.1 tightjunction protein 1 [Source: HGNC Symbol; Acc: 11827] 226823_at PHACTR4ENSG00000204138 0.019506 0.7884982 7.613814 6.825316 1 p35.3 phosphataseand actin regulator 4 [Source: HGNC Symbol; Acc: 25793] 201375_s_atPPP2CB ENSG00000104695 0.019506 0.8835548 10.00679 9.123237 8 p12protein phosphatase 2, catalytic subunit, beta isozyme [Source: HGNCSymbol; Acc: 9300] 202808_at WBP1L ENSG00000166272 0.019506 0.66727929.547031 8.879752 10 q24.32 WW domain binding protein 1-like [Source:HGNC Symbol; Acc: 23510] 227911_at ARHGAP28 ENSG00000088756 0.019881.6321361 5.975404 4.343267 18 p11.31 Rho GTPase activating protein 28[Source: HGNC Symbol; Acc: 25509] 206049_at SELP ENSG00000174175 0.019881.7100903 7.227627 5.517537 1 q24.2 selectin P (granule membrane protein140 kDa, antigen CD62) [Source: HGNC Symbol; Acc: 10721] 202357_s_at CFBENSG00000243649 0.01988 1.1573646 8.626327 7.468963 6 p21.33 complementfactor B [Source: HGNC Symbol; Acc: 1037] 217497_at TYMP ENSG000000257080.01988 0.8516144 8.694769 7.843155 22 q13.33 thymidine phosphorylase[Source: HGNC Symbol; Acc: 3148] 204034_at ETHE1 ENSG00000105755 0.019880.5289265 8.283721 7.754794 19 q13.31 ethylmalonic encephalopathy 1[Source: HGNC Symbol; Acc: 23287] 210139_s_at PMP22 ENSG000001090990.01988 1.7494057 9.219437 7.470032 17 p12 peripheral myelin protein 22[Source: HGNC Symbol; Acc: 9118] 204114_at NID2 ENSG00000087303 0.019881.6354339 7.748453 6.113019 14 q22.1 nidogen 2 (osteonidogen) [Source:HGNC Symbol; Acc: 13389] 200878_at EPAS1 ENSG00000116016 0.0201341.6643506 10.74529 9.080936 2 p21 endothelial PAS domain protein 1[Source: HGNC Symbol; Acc: 3374] 202446_s_at PLSCR1 ENSG000001883130.020139 1.410605 9.74777 8.337165 3 q24 phospholipid scramblase 1[Source: HGNC Symbol; Acc: 9092] 221139_s_at CSAD ENSG000001396310.020139 1.1033652 6.32666 5.223294 12 q13.13 cysteine sulfinic aciddecarboxylase [Source: HGNC Symbol; Acc 18966] 221012_s_at TRIM8ENSG00000171206 0.020139 0.9021545 9.733515 8.831361 10 q24.32tripartite motif containing 8 [Source: HGNC Symbol; Acc: 15579]1555832_s_at KLF6 ENSG00000067082 0.020139 1.5050907 10.49276 8.98766610 p15.1 Kruppel-like factor 6 [Source: HGNC Symbol; Acc: 2235] 212859x_at MT1E ENSG00000169715 0.020139 1.3116378 11.29222 9.98058 16 q12.2metallothionein 1E [Source: HGNC Symbol; Acc: 7397] 203729_at EMP3ENSG00000142227 0.020691 1.2426119 10.80073 9.558169 19 q13.33epithelial membrane protein 3 [Source: HGNC Symbol; Acc: 3335] 209238_atSTX3 ENSG00000166900 0.021317 1.0475218 7.816754 6.769232 11 q12.1syntaxin 3 [Source: HGNC Symbol; Acc: 11438] 228617_at XAF1ENSG00000132530 0.02132 1.8591633 9.784426 7.925263 17 p13.1 XIAPassociated factor 1 [Source: HGNC Symbol; Acc: 30932] 204436_at PLEKHO2ENSG00000241839 0.021661 0.8149093 9.412795 8.597885 15 q22.31pleckstrin homology domain containing, family O member 2 [Source: HGNCSymbol; Acc: 30026] 1555756_a_at CLEC7A ENSG00000172243 0.0217391.9487017 9.541407 7.592705 12 p13.2 C-type lectin domain family 7,member A [Source: HGNC Symbol; Acc: 14558] 202381_at ADAM9ENSG00000168615 0.022252 1.5225689 9.387992 7.865423 8 p11.22 ADAMmetallopeptidase domain 9 [Source: HGNC Symbol; Acc: 216] 202291_s_atMGP ENSG00000111341 0.022612 2.1289603 11.06084 8.931878 12 p12.3 matrixGla protein [Source: HGNC Symbol; Acc: 7060] 213056_at FRMD4BENSG00000114541 0.022612 1.7413741 6.023278 4.281904 3 p14.1 FERM domaincontaining 4B [Source: HGNC Symbol; Acc: 24886] 218162_at OLFML3ENSG00000116774 0.022612 1.5508457 8.32843 6.777584 1 p13.2olfactomedin-like 3 [Source: HGNC Symbol; Acc: 24956] 212845_at SAMD4AENSG00000020577 0.022612 1.2467155 6.634447 5.387731 14 q22.2 sterilealpha motif domain containing 4A [Source: HGNC Symbol; Acc: 23023]218541_s_at C8orf4 ENSC00000176907 0.022732 1.9762953 6.693744 4.7174498 p11.21 chromosome 8 open reading frame 4 [Source: HGNC Symbol; Acc:1357] 1559005_s_at CNTLN ENSG00000044459 0.022732 1.3908169 6.5128955.122078 9 p22.2 centlein, centrosomal protein [Source: HGNC Symbol;Acc: 23432] 218909_at RPS6KC1 ENSG00000136643 0.022732 0.75215788.355674 7.603516 1 q32.3 ribosomal protein 56 kinase, 52 kDa,polypeptide 1 [Source: HGNC Symbol; Acc: 10439] 226384_at PPAPDC1BENSG00000147535 0.022732 1.2111184 8.159726 6.948608 8 p11.23phosphatidic acid phosphatase type 2 domain containing 1B [Source: HGNCSymbol; Acc: 25026] 212509_s_at MXRA7 ENSG00000182534 0.022732 1.46747599.764658 8.297182 17 q25.1 matrix-remodelling associated 7 [Source: HGNCSymbol; Acc: 7541] 225975_at PCDH18 ENSG00000189184 0.023159 1.77902387.236967 5.457943 4 q28.3 protocadherin 18 [Source: HGNC Symbol; Acc:14268] 201341_at ENC1 ENSG00000171617 0.023416 1.4443337 8.0666086.622274 5 q13.3 ectodermal-neural cortex 1 (with BTB domain) [Source:HGNC Symbol; Acc: 3345] 203324_s_at CAV2 ENSG00000105971 0.0235061.952201 8.152024 6.199823 7 q31.2 caveolin 2 [Source: HGNC Symbol; Acc:1528] 212230_at PPAP2B ENSC00000162407 0.023506 1.8165102 9.0716987.255187 1 p32.2 phosphatidic acid phosphatase type 2B [Source: HGNCSymbol; Acc: 9229] 218632_at HECTD3 ENSG00000126107 0.023506 0.73690049.627648 8.890747 1 p34.1 HECT domain containing E3 ubiquitin proteinligase 3 [Source: HGNC Symbol; Acc: 26117] 212204_at TMEM87AENSG00000103978 0.023515 0.8984928 9.007547 8.109054 15 q15.1transmembrane protein 87A [Source: HGNC Symbol; Acc: 24522] 226022_atSASH1 ENSG00000111961 0.023515 2.0027112 7.610796 5.608085 6 q24.3 SAMand SH3 domain containing 1 [Source: HGNC Symbol; Acc: 19182] 242800_atNHS ENSG00000188158 0.023677 1.1627115 6.713331 5.550619 X p22.13Nance-Horan syndrome (congenital cataracts and dental anomalies)[Source: HGNC Symbol; Acc: 7820] 203477_at COL15A1 ENSG000002042910.023677 1.6143067 8.436883 6.822576 9 q22.33 collagen, type XV, alpha 1[Source: HGNC Symbol; Acc: 2192] 200857_s_at NCOR1 ENSG000001410270.023677 0.7091943 8.662953 7.953759 17 p11.2 nuclear receptorcorepressor 1 [Source: HGNC Symbol; Acc: 7672] 224996_at ASPHENSG00000198363 0.0237 1.5230174 7.874016 6.350998 8 q12.3 aspartatebeta-hydroxylase [Source: HGNC Symbol; Acc: 757] 223562_at PARVGENSG00000138964 0.0237 1.5009148 9.669889 8.168975 22 q13.31 parvin,gamma [Source: HGNC Symbol; Acc: 14654]. 213353_at ABCA5 ENSG000001542650.0237 0.9962432 8.332971 7.336728 17 q24.3 ATP-binding cassette,sub-family A (ABC1), member 5 [Source: HGNC Symbol; Acc: 35] 209593_s_atTOR1B ENSG00000136816 0.0238 0.4661131 7.855148 7.389035 9 q34.11 torsinfamily 1, member B (torsin B) [Source: HGNC Symbol; Acc: 11995] 35626_atSGSH ENSG00000181523 0.0238 0.7817095 9.79381 9.0121 17 g25.3N-sulfoglucosamine sulfohydrolase [Source: HGNC Symbol; Acc: 10818]234994_at TMEM200A ENSG00000164484 0.0238 1.6120474 6.524548 4.9125 6q23.1 transmembrane protein 200A [Source: HGNC Symbol; Acc: 21075]211456_x_at MT1P2 NA 0.0238 1.0267142 11.33702 10.3103 NA NA NA203501_at CPQ ENSC00000104324 0.024112 0.9862063 7.824448 6.838241 8q22.1 carboxypeptidase Q [Source: HGNC Symbol; Acc: 16910] 226155_atFAM160B1 ENSG00000151553 0.024112 0.9499152 8.161808 7.211893 10 q25.3family with sequence similarity 160, member B1 [Source: HGNC Symbol;Acc: 29320] 1552258_at LINC00152 ENSG00000222041 0.024124 1.12452588.139435 7.014909 2 p11.2 long intergenic non-protein coding RNA 152[Source: HGNC Symbol; Acc: 28717] 238025_at MLKL ENSG000001684040.024866 1.2159905 8.756993 7.541002 16 q23.1 mixed lineage kinasedomain-like [Source: HGNC Symbol; Acc: 26617] 219460_s_at TMEM127ENSG00000135956 0.024866 0.4546254 8.629221 8.174596 2 q11.2transmembrane protein 127 [Source: HGNC Symbol; Acc: 26038] 225522_atAAK1 ENSG00000115977 0.024866 1.1728016 8.652908 7.480107 2 p13.3 AP2associated kinase 1 [Source: HGNC Symbol; Acc: 19679] 217757_at A2MENSG00000175899 0.02498 1.5764623 12.02894 10.45243 12 p13.31alpha-2-macroglobulin [Source: HGNC Symbol; Acc: 7] 223168_at RHOUENSG00000116574 0.025427 1.5603849 7.215569 5.655184 1 q42.13 rashomolog family member U [Source: HGNC Symbol; Acc: 17794] 1561615_s_atSLC8A1 ENSG00000183023 0.025808 1.5650362 8.855137 7.290101 2 p22.1solute carrier family 8 (sodium/calcium exchanger), member 1 [Source:HGNC Symbol; Acc: 11068] 203758_at CTSO ENSG00000256043 0.0260661.1560559 9.311624 8.155568 4 q32.1 cathepsin O [Source: HGNC Symbol;Acc: 2542] 226552_at IER5L ENSG00000133483 0.026467 0.936727 7.6119416.675214 9 q34.11 immediate early response 5-like [Source: HGNC Symbol;Acc: 23679] 202766_s_at FBN1 ENSG00000166147 0.027121 1.374538 7.7453626.370824 15 q21.1 fibrillin 1 [Source: HGNC Symbol; Acc: 3603]225629_s_at ZBTB4 ENSG00000174282 0.027121 1.019746 9.543581 8.523835 17p13.1 zinc finger and BTB domain containing 4 [Source: HGNC Symbol; Acc:23847] 212136_at ATP284 ENSG00000058668 0.027283 1.5266923 8.8332197.306527 1 q32.1 ATPase, Ca  

 transporting, plasma membrane 4 [Source: HGNC Symbol; Acc: 817]1555881_s_at LZTS2 ENSG00000107816 0.027517 0.4402212 7.841075 7.40085410 q24.31 leucine zipper, putative tumor suppressor 2 [Source: HGNCSymbol; Acc: 29381] 57715_at CALHM2 ENSG00000138172 0.027517 0.69600748.099815 7.403808 10 q24.33 calcium homeostasis modulator 2 [Source:HGNC Symbol; Acc: 23493] 226601_at SLC30A7 ENSG00000162695 0.0275170.9372185 8.338968 7.401749 1 p21.2 solute carrier family 30 (zinctransporter), member 7 [Source: HGNC Symbol; Acc: 19306] 217890_s_atPARVA ENSG00000197702 0.027517 1.5638318 9.160286 7.596454 11 p15.3parvin, alpha [Source: HGNC Symbol; Acc: 14652] 207624_s_at RPGRENSG00000156313 0.027572 0.5262896 7.293504 6.767215 X p11.4 retinitispigmentosa GTPase regulator [Source: HGNC Symbol; Acc: 10295] 212372_atMYH10 ENSG00000133026 0.027572 1.0557138 8.323251 7.267537 17 p13.1myosin, heavy chain 10, non-muscle [Source: HGNC Symbol; Acc: 7568]226820_at ZNF362 ENSG00000160094 0.027572 0.8062413 8.807479 8.001238 1p35.1 zinc finger protein 362 [Source: HGNC Symbol; Acc: 18079]202551_s_at CRIM1 ENSG00000150938 0.027572 1.4256957 8.947674 7.521978 2p22.3 cysteine rich transmembrane BMP regulator 1 (chordin-like)[Source: HGNC Symbol; Acc: 2359] 208030_s_at ADD1 ENSG000000872740.027643 0.584655 9.931156 9.346501 4 p16.3 adducin 1 (alpha) [Source:HGNC Symbol; Acc: 243] 206618_at IL18R1 ENSG00000115604 0.0276431.4815374 7.518533 6.036996 2 q12.1 interleukin 18 receptor 1 [Source:HGNC Symbol; Acc: 5988] 201212_at LGMN ENSG00000100600 0.027659 2.06681210.16982 8.103011 14 q32.12 legumain [Source: HGNC Symbol; Acc: 9472]208782_at FSTL1 ENSG00000163430 0.027737 1.3252445 10.08689 8.761649 3q13.33 follistatin-like 1 [Source: HGNC Symbol; Acc: 3972] 209191_atTUBB6 ENSG00000175014 0.027737 1.6575274 9.832241 8.174714 18 p11.21tubulin, beta 6 class V [Source: HGNC Symbol; Acc: 20776] 206375_s_atSLK ENSG00000065613 0.027737 1.0643734 8.057717 6.993344 10 q24.33STE20-like kinase [Source: HGNC Symbol; Acc: 11088] 212990_at SYNJ1ENSG00000159082 0.027737 1.0442604 7.114954 6.070694 21 q22.11synaptojanin 1 [Source: HGNC Symbol; Acc: 11503] 204193_at CHKBENSG00000100283 0.027737 0.8998133 9.518634 8.618821 22 q13.33 cholinekinase beta [Source: HGNC Symbol; Acc: 1938] 203243_s_at PDLIM5ENSG00000163110 0.02803 1.1428446 7.842659 6.699815 4 q22.3 PDZ and LIMdomain 5 [Source: HGNC Symbol; Acc: 17468] 227554_at MAGI2-AS3ENSG00000234456 0.02803 1.5835165 7.049678 5.466162 7 q21.11 MAGI2antisense RNA 3 [Source: HGNC Symbol; Acc: 40862] 224616_at DYNC1LI2ENSG00000135720 0.02803 0.7957119 10.00718 9.211464 16 q22.1 dynein,cytoplasmic 1, light intermediate chain 2 [Source: HGNC Symbol; Acc:2966] 218901_at PLSCR4 ENSG00000114698 0.028186 1.6412008 5.9386074.297406 3 q24 phospholipid scramblase 4 [Source: HGNC Symbol; Acc:16497] 209050_s_at RALGDS ENSC00000160271 0.028199 0.8301435 9.5097988.679655 9 q34.2 ral guanine nucleotide dissociation stimulator [Source:HGNC Symbol; Acc: 9842] 209472_at CCBL2 ENSG00000137944 0.0281990.791466 9.348802 8.557336 1 p22.2 cysteine conjugate-beta lyase 2[Source: HGNC Symbol; Acc: 33238] 227542_at SOCS6 ENSG000001706770.028199 1.310032 6.680389 5.370357 18 q22.2 suppressor of cytokinesignaling 6 [Source: HGNC Symbol; Acc: 16833] 204039_at CEBPAENSG00000245848 0.028199 0.9298719 8.572793 7.642921 19 q13.11CCAA/enhancer binding protein (C/EBP), alpha [Source: HGNC Symbol; Acc:1833] 212586_at CAST ENSG00000153113 0.028199 0.7412945 9.2047748.463479 5 q15 calpastatin [Source: HGNC Symbol; Acc: 1515] 201280_s_atDAB2 ENSG00000153071 0.028199 1.7797808 8.603167 6.823386 5 p13.1 Dab,mitogen-responsive phosphoprotein, homolog 2 (Drosophila) [Source: HGNCSymbol; Acc: 2662] 201599_at OAT ENSG00000065154 0.028199 0.88998149.474237 8.584256 10 q26.13 ornithine aminotransferase [Source: HGNCSymbol; Acc: 8091] 225334_at C10orf32 ENSG00000166275 0.028199 0.78143888.253485 7.472047 10 q24.32 chromosome 10 open reading frame 32 [Source:HGNC Symbol; Acc: 23516] 201334_s_at ARHGEF12 ENSG00000196914 0.0282271.1207523 9.211231 8.090479 11 q23.3 Rho guanine nucleotide exchangefactor (GEF) 12 [Source: HGNC Symbol; Acc: 14193] 229041_s_at ITGB2-AS1ENSG00000227039 0.02892 1.8343051 9.515398 7.681093 21 q22.3 ITGB2antisense RNA 1 [Source: HGNC Symbol; Acc: 44304] 212124_at ZMIZ1ENSG00000108175 0.02892 1.4720018 10.25153 8.779525 10 q22.3 zincfinger, MIZ-type containing 1 [Source: HGNC Symbol; Acc: 16493]204863_s_at IL6ST ENSG00000134352 0.02892 1.1450808 9.161299 8.016219 5q11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor)[Source: HGNC Symbol; Acc: 6021] 215235_at SPTAN1 ENSG000001976940.02892 0.6877124 10.61621 9.928495 9 q34.11 spectrin, alpha,non-erythrocytic 1 [Source: HGNC Symbol; Acc: 11273] 212606_at WDFY3ENSG00000163625 0.02892 1.6875876 6.840272 5.152685 4 q21.23 WD repeatand FYVE domain containing 3 [Source: HGNC Symbol; Acc: 20751] 212601_atZZEF1 ENSG00000074755 0.02892 0.4622513 8.027308 7.565057 17 p13.2 zincfinger, ZZ-type with EF-hand domain 1 [Source: HGNC Symbol; Acc: 29027]228577_x_at ODF2L ENSG00000122417 0.02892 0.9283355 7.13428 6.205945 1p22.3 outer dense fiber of sperm tails 2-like [Source: HGNC Symbol; Acc:29225] 227776_at ACER3 ENSG00000078124 0.02892 1.1794217 7.5214376.342016 11 q13.5 alkaline ceramidase 3 [Source: HGNC Symbol; Acc:16066] 201146_at NFE2L2 ENSG00000116044 0.02892 0.9705592 10.202379.231807 2 q31.2 nuclear factor (erythroid-derived 2)-like 2 [Source:HGNC Symbol; Acc: 7782] 214807_at LOC100509635 NA 0.02892 1.83989248.320893 6.481 NA NA NA 201185_at HTRA1 ENSG00000166033 0.02892 1.8150729.750466 7.935394 10 q26.13 HtrA serine peptidase 1 [Source: HGNCSymbol; Acc: 9476] 209120_at NR2F2 ENSG00000185551 0.029112 2.19143568.372705 6.181269 15 q26.2 nuclear receptor subfamily 2, group F, member2 [Source: HGNC Symbol; Acc: 7976] 226021_at RDH10 ENSG000001210390.029112 1.1810757 6.837597 5.656521 8 q21.11 retinol dehydrogenase 10(all-trans) [Source: HGNC Symbol; Acc: 19975] 224480_s_at AGPAT9ENSG00000138678 0.029341 1.110371 4.910358 3.799487 4 q21.231-acylglycerol-3-phosphate O-acyltransferase 9 [Source: HGNC Symbol;Acc: 28157] 212077_at CALD1 ENSG00000122786 0.029341 1.7247901 10.17928.454405 7 q33 caldesmon 1 [Source: HGNC Symbol; Acc: 1441] 204745_x_atMT1G ENSG00000125144 0.029341 1.0418968 10.90301 9.861108 16 q13metallothionein 1G [Source: HGNC Symbol; Acc: 7399] 227930_at AGO4ENSG00000134698 0.029586 1.1053521 6.925534 5.820132 1 p34.3 argonauteRISC catalytic component 4 [Source: HGNC Symbol; Acc: 18424] 212636_atQKI ENSG00000112531 0.029711 1.3783407 3.509471 7.13113 6 q26 QKI, KHdomain containing, RNA binding [Source: HGNC Symbol; Acc: 21100]202609_at EPS8 ENSG00000151491 0.029743 2.016396 8.302003 6.285607 12p12.3 epidermal growth factor receptor pathway substrate 8 [Source: HGNCSymbol; Acc: 3420] 207791_s_at RAB1A ENSG00000138069 0.029761 0.83424279.926541 9.092298 2 p14 RAB1A, member RAS oncogene family [Source: HGNCSymbol; Acc: 9758] 226377_at NFIC ENSG00000141905 0.029761 1.71249358.785641 7.660706 19 p13.3 nuclear factor I/C (CCAAT-bindingtranscription factor) [Source: HGNC Symbol; Acc: 7786] 212607_at AKT3ENSG00000117020 0.029761 1.2861363 8.867901 7.581765 1 q44 v-akt murinethymorna viral oncogene homolog 3 [Source: HGNC Symbol; Acc: 393]220122_at MCTP1 ENSG00000175471 0.029808 1.5794589 7.121595 5.542136 5q15 multiple C2 domains, transmembrane 1 [Source: HGNC Symbol; Acc:26183] 225941_at EIF4E3 ENSG00000163412 0.029808 1.3642413 7.7908186.426577 3 p13 eukaryotic translation initiation factor 4E family member3 [Source: HGNC Symbol; Acc: 31837] 65635_at ENGASE ENSG000001672800.029836 0.5491265 9.240447 8.69132 17 q25.3endo-beta-N-acetylglucosaminiciase [Source: HGNC Symbol; Acc: 24622]202897_at SIRPA ENSG00000198053 0.029836 1.0792131 9.722842 8.643629 20p13 signal-regulatory protein alpha [Source: HGNC Symbol; Acc: 9662]213817_at IRAK3 ENSG00000090376 0.029836 1.4320001 6.594781 5.162731 12q14.3 interleukin-1 receptor-associated kinase 3 [Source: HGNC Symbol;Acc: 17020] 204703_at IFT88 ENSG00000032742 0.029836 0.5556265 7.9140957.358469 13 q12.11 intraflagellar transport 88 homolog (Chlamyclomonas)[Source: HGNC Symbol; Acc: 20606] 201029_s_at CD99 ENSG000000025860.029836 1.1795508 11.79489 10.61534 X p22.33 CD99 molecule [Source:HGNC Symbol; Acc: 7082] 201105_at LGALS1 ENSG00000100097 0.0298361.0679695 12.55396 11.48599 22 q13.1 lectin, galactoside-binding,soluble, 1 [Source: HGNC Symbol; Acc: 6561] 228666_at C15orf38ENSG00000242498 0.029836 0.9655288 8.632863 7.667335 15 q26.1 chromosome15 open reading frame 38 [Source: HGNC Symbol; Acc: 28782] 213733_atMYO1F ENSG00000142347 0.029836 1.2120209 9.047983 7.835962 19 p13.2myosin IF [Source: HGNC Symbol; Acc: 7600] 225162_at SH3D19ENSG00000109686 0.029836 1.6977199 6.304496 4.606776 4 q31.3 SH3 domaincontaining 19 [Source: HGNC Symbol; Acc: 30418] 221766_s_at FAM46AENSG00000112773 0.030026 1.3074382 9.102394 7.794956 6 q14.1 family withsequence similarity 46, member A [Source: HGNC Symbol; Acc: 18345]235256_s_at GALM ENSG00000143891 0.030026 1.3208648 7.939207 6.618342 2p22.1 galactose mutarotase (aldose 1-epimerase) [Source: HGNC Symbol;Acc: 24063] 201417_at SOX4 ENSG00000124766 0.030026 1.0943539 7.3145556.220202 6 p22.3 SRY (sex determining region Y)-box 4 [Source: HGNCSymbol; Acc: 11200] 201963_at ACSL1 ENSG00000151726 0.030026 1.02625759.481285 8.455027 4 q35.1 acyl-CoA synthetase long-chain family member 1[Source: HGNC Symbol; Acc: 3569] 218983_at C1RL ENSG00000139178 0.0300261.0535412 6.970689 5.917148 12 p13.31 complement component 1, rsubcomponent-like [Source: HGNC Symbol; Acc: 21265] 225442_at DDR2ENSG00000162733 0.030026 1.204158 8.120903 6.916745 1 q23.3 discoidindomain receptor tyrosine kinase 2 [Source: HGNC Symbol; Acc: 2731]225128_at KDELC2 ENSG00000178202 0.030089 0.839869 7.886197 7.046328 11q22.3 KDEL (Lys-Asp-Glu-Leu) containing 2 [Source: HGNC Symbol; Acc:28496] 225913_at PEAK1 NA 0.030089 0.8774813 8.926048 8.048566 NA NA NA238477_at KIF1C ENSG00000129250 0.030089 0.5143139 6.616652 6.102338 17p13.2 kinesin family member 1C [Source: HGNC Symbol; Acc: 6317]1557236_at APOL6 ENSG00000221963 0.030333 1.3530187 6.588335 5.235316 22q12.3 apolipoprotein L, 6 [Source: HGNC Symbol; Acc: 14870] 224764_atARHGAP21 ENSG00000107863 0.030504 0.7262548 8.341028 7.614773 10 p12.1Rho GTPase activating protein 21 [Source: HGNC Symbol; Acc: 23725]204568_at ATG14 ENSG00000126775 0.030504 0.6825568 7.833225 7.150668 14q22.3 autophagy related 14 [Source: HGNC Symbol; Acc: 19962] 202598_atS100A13 ENSG00000189171 0.030504 0.9054696 10.25863 9.353158 1 q21.3S100 calcium binding protein A13 [Source: HGNC Symbol; Acc: 10490]218315_s_at TMEM51 ENSG00000171729 0.03053 0.8211201 9.101394 3.280274 1p36.21 transmembrane protein 51 [Source: HGNC Symbol; Acc: 25488]204214_s_at RAB32 ENSG00000118508 0.03053 0.9747791 8.206092 7.231313 6q24.3 RAB32, member RAS oncogene family [Source: HGNC Symbol; Acc: 9772]226152_at TTC7B ENSG00000165914 0.030555 1.2253262 7.058997 5.833171 14q32.11 tetratricopeptide repeat domain 7B [Source: HGNC Symbol; Acc:19858] 205590_at RASGRP1 ENSG00000172575 0.030555 1.8115112 10.058018.2465 15 q14 RAS guanyl releasing protein 1 (calcium and DAG-regulated)[Source: HGNC Symbol; Acc: 9878] 1555579_s_at PTPRM ENSG000001734820.030555 1.1333216 7.834017 6.700695 18 p11.23 protein tyrosinephosphatase, receptor type, M [Source: HGNC Symbol; Acc: 9675] 218486_atKLF11 ENSG00000172059 0.030555 1.2762837 7.737116 6.460832 2 p25.1Kruppel-like factor 11 [Source: HGNC Symbol; Acc: 11811] 204451_at FZD1ENSG00000157240 0.030555 1.2800529 7.241574 5.961521 7 q21.13 frizzledfamily receptor 1 [Source: HGNC Symbol; Acc: 4038] 226186_at TMOD2ENSG00000128872 0.030555 1.3625462 6.784226 5.42168 15 q21.2tropomodulin 2 (neuronal) [Source: HGNC Symbol; Acc: 11872] 225288_atCOL27A1 ENSG00000196739 0.030691 1.4054422 7.835002 6.429559 9 q32collagen, type XXVII, alpha 1 [Source: HGNC Symbol; Acc: 22986]225163_at FRMD4A ENSG00000151474 0.030947 1.1375317 7.411625 6.274094 10p13 FERM domain containing 4A [Source: HGNC Symbol; Acc: 25491]221541_at CRISPLD2 ENSG00000103196 0.030947 1.7573923 8.718881 6.96148916 q24.1 cysteine-rich secretory protein LCCL domain containing 2[Source: HGNC Symbol; Acc: 25248] 230480_at PIWIL4 ENSG000001346270.030947 0.6575147 6.112214 5.4547 11 q21 piwi-like RNA-mediated genesilencing 4 [Source: HGNC Symbol; Acc: 18444] 227444_at ARMCX4ENSG00000196440 0.030947 0.97698 6.08167 5.051187 X q22.1 armadillorepeat containing, X-linked 4 [Source: HGNC Symbol; Acc: 28615]218285_s_at BDH2 ENSG00000164039 0.030947 0.7247672 8.942667 8.2179 4q24 3-hydroxybutyrate dehydrogenase, type 2 [Source: HGNC Symbol; Acc:32389] 209687_at CXCL12 ENSG00000107562 0.030947 2.2250584 9.7161347.491076 10 q11.21 chemokine (C-X-C motif) ligand 12 [Source: HGNCSymbol; Acc: 10672] 203261_at DCTN6 ENSG00000104671 0.030947 0.806565310.35688 9.550316 8 p12 dynactin 6 [Source: HGNC Symbol; Acc: 16964]227001_at NIPAL2 ENSG00000104361 0.030947 1.3854199 8.211606 6.826186 8q22.2 NIPA-like domain containing 2 [Source: HGNC Symbol; Acc: 25854]213119_at SLC36A1 ENSG00000123643 0.030947 0.527649 8.18839 7.660741 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1[Source: HGNC Symbol; Acc: 18761] 201089_at ATP6V1B2 ENSG000001474160.030947 0.979669 10.05201 9.072342 8 p21.3 ATPase, H transporting,lysosomal 56/58 kDa, V1 subunit B2 [Source: HGNC Symbol; Acc: 854]228937_at LACC1 ENSG00000179630 0.030947 1.4347724 7.370869 6.436096 13q14.11 laccase (multicopper oxidoreductase) domain containing 1 [Source:HGNC Symbol; Acc: 26789] 219666_at MS4A6A ENSG00000110077 0.0310112.1589072 10.17583 8.016976 11 q12.2 membrane-spanning 4-domains,subfamily A, member 6A [Source: HGNC Symbol; Acc: 13375] 209160_atAKR1C3 ENSG00000196139 0.031011 1.5583408 6.70255 5.144209 10 p15.1aldo-keto reductase family 1, member C3 [Source: HGNC Symbol; Acc: 386]203688_at PKD2 ENSG00000118762 0.031011 1.224664 8.101781 6.877117 4q22.1 polycystic kidney disease 2 (autosomal dominant) [Source: HGNCSymbol; Acc: 9009] 209379_s_at CCSER2 ENSG00000107771 0.031011 0.8953036.749215 5.853912 10 q23.1 coiled-coil serine-rich protein 2 [Source:HGNC Symbol; Acc: 29197] 202973_x_at FAM13A ENSG00000138640 0.0310111.5090759 6.614676 5.1056 4 q22.1 family with sequence similarity 13,member A [Source: HGNC Symbol; Acc: 19367] 222999_s_at CCNL2ENSG00000221978 0.031011 0.5863072 9.418618 8.832311 1 p36.33 cyclin L2[Source: HGNC Symbol; Acc: 20570] 32811_at MYO1C ENSG000001978790.031088 0.6404769 9.336457 8.69598 17 p13.3 myosin IC [Source: HGNCSymbol; Acc: 7597] 213737_x_at GOLGA8I ENSG00000153666 0.0311141.2841014 9.220786 7.936684 15 q11.2 golgin A8 family, member I [Source:HGNC Symbol; Acc: 26660] 202351_at ITGAV ENSG00000138443 0.0311691.360409 9.310597 7.950188 2 q32.1 integrin, alpha V [Source: HGNCSymbol; Acc: 6150] 226066_at MITF ENSG00000187098 0.031203 1.39460248.259922 6.86532 3 p14.1 microphthalmia-associated transcription factor[Source: HGNC Symbol; Acc: 7105] 212453_at KIAA1279 ENSG000001989540.031375 0.7010336 7.669603 6.96857 10 q22.1 KIAA1279 [Source: HGNCSymbol; Acc: 23419] 223276_at SMIM3 ENSG00000256235 0.031482 1.05719587.313512 6.256316 5 q33.1 small integral membrane protein 3 [Source:HGNC Symbol; Acc: 30248] 63825_at ABHD2 ENSG00000140526 0.0314821.0510036 8.787775 7.736771 15 q26.1 abhydrolase domain containing 2[Source: HGNC Symbol; Acc: 18717] 203817_at GUCY1B3 ENSG000000619380.031482 1.3742528 7.677666 6.303413 4 q32.1 guanylate cyclase 1,soluble, beta 3 [Source: HGNC Symbol; Acc: 4687] 232090_at DNM3OSENSG00000230630 0.031482 1.8766379 6.73819 4.861552 1 q24.3 DNM3opposite strand/antisense RNA [Source: HGNC Symbol; Acc: 41228]218292_s_at PRKAG2 ENSG00000106617 0.03163 0.7377637 7.332145 6.594381 7q36.1 protein kinase, AMP-activated, gamma 2 non-catalytic subunit[Source: HGNC Symbol; Acc: 9386] 1558173_a_at LUZP1 ENSG000001696410.03163 0.7965467 9.005566 8.20902 1 p36.12 leucine zipper protein 1[Source: HGNC Symbol; Acc: 14985] 201438_at COL6A3 ENSG000001633590.03163 1.6730976 11.52 9.846906 2 q37.3 collagen, type VI, alpha 3[Source: HGNC Symbol; Acc: 2213] 235458_at HAVCR2 ENSG000001350770.03163 1.5671406 9.031225 7.464085 5 q33.3 hepatitis A virus cellularreceptor 2 [Source: HGNC Symbol; Acc: 18437] 223393_s_at TSHZ3ENSG00000121297 0.03163 1.3239929 7.607905 6.283912 19 q12 teashirt zincfinger homeobox 3 [Source: HGNC Symbol; Acc: 30700] 215706_x_at ZYXENSG00000159840 0.031657 0.8773626 10.71626 9.838895 7 q34 zyxin[Source: HGNC Symbol; Acc: 13200] 219315_s_at TMEM204 ENSG000001316340.0318 0.9451335 7.656937 6.711803 16 p13.3 transmembrane protein 204[Source: HGNC: Symbol; Acc: 14158] 201296_s_at WSB1 ENSG000001090460.0318 1.2622427 10.19944 8.937196 17 q11.1 WD repeat and SOCS boxcontaining 1 [Source: HGNC Symbol; Acc: 19221] 232231_at RUNX2ENSG00000124813 0.0318 2.284395 8.680094 6.395699 6 p21.1 runt-relatedtranscription factor 2 [Source: HGNC Symbol; Acc: 10472] 226225_at MCCENSG00000171444 0.0318 1.7962144 5.490905 3.69469 5 q22.2 mutated incolorectal cancers [Source: HGNC Symbol; Acc: 6935] 214660_at ITGA1ENSG00000213949 0.0318 0.9359119 4.662647 3.726735 5 q11.2 integrin,alpha 1 [Source: HGNC Symbol; Acc: 6134] 216903_s_at MICU1ENSG00000107745 0.0318 0.5179458 8.825263 8.307317 10 q22.1mitochondrial calcium uptake 1 [Source: HGNC Symbol; Acc: 1530]215111_s_at TSC22D1 ENSG00000102804 0.0318 1.4896493 9.321974 7.83232513 q14.11 TSC22 domain family, member 1 [Source: HGNC Symbol; Acc:16826] 200782_at ANXA5 ENSG00000164111 0.0318 0.9613548 10.843059.881696 4 q27 annexin A5 [Source: HGNC Svmbol; Acc: 543] 226771_atATP8B2 ENSG00000143515 0.0318 1.0911816 8.208904 7.117722 1 q21.3ATPase, aminophospholipid transporter, class I, type 8B, member 2[Source: HGNC Symbol; Acc: 13534] 212185_x_at MT2A ENSG000001251480.0318 1.0146409 12.36689 11.35225 16 q12.2 metallothionein 2A [Source:HGNC Symbol; Acc: 7406] 200986_at SERPING1 ENSG00000149131 0.0319711.2398359 10.45704 9.217209 11 q12.1 serpin peptidase inhibitor, clade G(C1 inhibitor), member 1 [Source: HGNC Symbol; Acc: 1228] 221269_s_atSH3BGRL3 ENSG00000142669 0.031971 0.5644103 11.47106 10.90665 1 p36.11SH3 domain binding glutamic acid-rich protein like 3 [Source: HGNCSymbol; Acc: 15568] 202081_at IER2 ENSG00000160888 0.031971 1.223949710.27327 9.049318 19 p13.2 immediate early response 2 [Source: HGNC:Symbol; Acc: 23871] 206995_x_at SCARF1 ENSG00000074660 0.0324390.7313947 6.493193 5.761798 17 p13.3 scavenger receptor class F, member1 [Source: HGNC Symbol; Acc: 16820] 204963_at SSPN ENSG000001230960.032493 1.9774021 7.971609 5.994207 12 p12.1 sarcospan [Source: HGNCSymbol; Acc: 11322] 202192_s_at GAS7 ENSG00000007237 0.032689 1.05540659.145391 8.089984 17 p13.1 growth arrest-specific 7 [Source: HGNCSymbol; Acc: 4169] 224747_at UBE2Q2 ENSG00000140367 0.032689 1.00443458.252427 7.247992 15 q24.2 ubiquitin-conjugating enzyme E2Q familymember 2 [Source: HGNC Symbol; Acc: 19248] 202136_at ZMYND11ENSG00000015171 0.032689 1.0017022 9.77863 8.776928 10 p15.3 zincfinger, MYND-type containing 11 [Source: HGNC Symbol; Acc: 16966]209970_x_at CASP1 ENSG00000137752 0.03271 1.2604855 9.149475 7.888989 11q22.3 caspase 1, apoptosis-related cysteine peptidase [Source: HGNCSymbol; Acc: 1499] 234987_at SAMHD1 ENS600000101347 0.032727 1.41650419.200321 7.783817 20 q11.23 SAM domain and HD domain 1 [Source: HGNCSymbol; Acc: 15925] 205173_x_at CD58 ENSG00000116815 0.032727 1.60454459.9085 8.303956 1 p13.1 CD58 molecule [Source: HGNC Symbol; Acc: 1688]229732_at ZNF823 ENSG00000197933 0.032727 0.5212517 4.981581 4.460329 19p13.2 zinc finger protein 823 [Source: HGNC Symbol; Acc: 30936] 37408_atMRC2 ENSG00000011028 0.032727 0.9769173 9.11946 8.142542 17 q23.2mannose receptor, C type 2 [Source: HGNC Symbol; Acc: 16875] 208922_s_atNXF1 ENSG00000162231 0.032727 0.7165582 10.10897 9.392408 11 q12.3nuclear RNA export factor 1 [Source: HGNC Symbol; Acc: 8071] 200766_atCTSD ENSG00000117984 0.032727 1.0316494 11.05559 10.02395 11 p15.5cathepsin D [Source: HGNC Symbol; Acc: 2529] 209129_at TRIP6ENSG00000087077 0.032727 0.6143954 8.270125 7.655729 7 q22.1 thyroidhormone receptor in e tor 6 [Source: HGNC Symbol; Acc: 12311] 228728_atCPED1 ENSG00000106034 0.032727 1.3257067 6.216333 4.890626 7 q31.31cadharin-like and PC-esterase domain containing 1 [Source: HGNC Symbol;Acc: 26159] 223028_s_at SNX9 ENSG00000130340 0.032727 1.5469591 9.6008978.053938 6 q25.3 sorting nexin 9 [Source: HGNC Symbol; Acc: 14973]214464_at CDC42BPA ENSG00000143776 0.032727 1.5903569 8.711909 7.1215531 q42.13 CDC42 binding protein kinase alpha (DMPK-like) [Source: HGNCSymbol; Acc: 1737] 204059_s_at ME1 ENSG00000065833 0.032727 2.13095387.883911 5.752957 6 q14.2 malic enzyme 1, NADP( )-dependant, cytosolic[Source: HGNC Symbol; Acc: 6983] 202481_at DHRS3 ENSG000001624960.032727 1.3557175 9.3739 8.018183 1 p36.22 dehydrogenase/reductase (SDRfamily) member 3 [Source: HGNC Symbol; Acc: 17693] 201426_s_at VIMENSG00000026025 0.032727 0.86197 13.16644 12.30447 10 p13 vimentin[Source: HGNC Symbol; Acc: 12692] 214177_s_at PBXIP1 ENSG000001633460.032727 0.6439449 8.558974 7.915029 1 q21.3 pre-B-cell leukemiahomeobox interacting protein 1 [Source: HGNC Symbol; Acc: 21199]218793_s_at SCML1 ENSG00000047634 0.032727 1.7949304 7.348371 5.553441 Xp22.13 sex comb on midleg-like 1 (Drosophila) [Source: HGNC Symbol; Acc:10580] 201163_s_at IGEBP7 ENSG00000163453 0.032727 1.2772891 11.021799.744497 4 q12 insulin-like growth factor binding protein 7 [Source:HGNC Symbol; Acc: 5476] 225406_at TWSG1 ENSG00000128791 0.0327271.0154958 8.499218 7.483723 18 p11.22 twisted gastrulation homolog 1(Drosophila) [Source: HGNC Symbol; Acc: 12429] 209071_s_at RGS5ENSG00000143248 0.032727 1.9992561 9.334306 7.33505 1 q23.3 regulator ofG-protein signaling 5 [Source: HGNC. Symbol; Acc: 10001] 204206_at MNTENSG00000070444 0.032727 0.4543166 8.03428 7.579963 17 p13.3 MNT, MAXdimerization protein [Source: HGNC Symbol; Acc: 7188] 226026_at DIRC2ENSG00000138463 0.032727 1.2125934 8.349561 7.136968 3 q21.1 disruptedin renal carcinoma 2 [Source: HGNC Symbol; Acc: 16623] 214683_s_at CLK1ENSG00000013441 0.032727 0.9215093 10.05348 9.131974 2 q33.1 CDC-likekinase 1 [Source: HGNC Symbol; Acc: 2068] 218095_s_at TMEM165ENSG00000131851 0.032727 0.7881717 10.38715 9.598976 4 q12 transmembraneprotein 165 [Source: HGNC Symbol; Acc: 30760] 219316_s_at FLVCR2ENSG00000119686 0.032727 0.8558016 7.371184 6.515383 14 q24.3 felineleukemia virus subgroup C cellular receptor family, member 2 [Source:HGNC Symbol; Acc: 20105] 226763_at SESTD1 ENSG00000187231 0.0327271.0596477 9.549725 3.490077 2 q31.2 SEC14 and spectrin domains 1[Source: HGNC Symbol; Acc: 18379] 227361_at HS3ST3B1 ENSG000001254300.032727 1.5227184 7.752502 6.229784 17 p12 heparan sulfate(glucosamine) 3-O-sulfotransterase 3B1 [Source: HGNC Symbol; Acc: 5198]205248 _at DOPEY2 ENSG00000142197 0.032727 0.619808 7.178375 6.558567 21q22.12 dopey family member 2 [Source: HGNC Symbol; Acc: 1291]211026_s_at MGLL ENSG00000074416 0.032727 1.3462606 9.704251 8.35799 3q21.3 monoglyceride lipase [Source: HGNC Symbol; Acc: 17038] 212224_atALDH1A1 ENSG00000165092 0.032727 2.3279366 9.644013 7.316031 9 q21.13aldehyde dehydrogenase 1 family, member A1 [Source: HGNC Symbol; Acc:402] 201215_at PLS3 ENSG00000102024 0.032727 1.846069 7.9037 6.057631 Xq23 plastin 3 [Source: HGNC Symbol; Acc: 9091] 218432_at FBXO3ENSG00000110429 0.032727 0.9692028 6.759587 5.7903841 11 p13 F-boxprotein 3 [Source: HGNC Symbol; Acc: 13532] 212428_at KIAA0368ENSG00000136813 0.032727 0.5027122 8.88096 8.378248 9 q31.3 KIAA0368[Source: HGNC Symbol; Acc: 29020] 203394_s_at HES1 ENSG000001143150.032727 1.1805255 9.074966 7.894441 3 q29 hairy and enhancer of split1, (Drosophila) [Source: HGNC Symbol; Acc: 5192] 235125_x_at FAM73AENSG00000180488 0.032727 0.7890075 6.551391 5.762383 1 p31.1 family withsequence similarity 73, member A [Source: HGNC Symbol; Acc: 24741]224690_at FAM210B ENSG00000124098 0.032727 1.2185977 8.947456 7.72885820 q13.2 family with sequence similarity 210, member B [Source: HGNCSymbol; Acc: 16102] 219991_at SLC2A9 ENSG00000109667 0.032727 0.74520657.42728 6.682073 4 p16.1 solute carrier family 2 (facilitated glucosetransporter), member 9 [Source: HGNC Symbol; Acc: 13446] 214560_at FPR3ENSG00000187474 0.032727 1.5525474 10.11159 8.55904 19 q13.41 formylpeptide receptor 3 [Source: HGNC Symbol; Acc: 3828] 210946_at PPAP2AENSG00000067113 0.032727 0.8694264 8.48212 7.612694 5 q11.2 phosphatidicacid phosphatase type 2A [Source: HGNC Symbol; Acc: 9228] 210817_s_atCALCOCO2 ENSG00000136436 0.032727 0.9010721 10.04862 9.147547 17 q21.32calcium binding and coiled-coil domain 2 [Source: HGNC Symbol; Acc:29912] 208636_at ACTN1 ENSG00000072110 0.032727 1.4921308 9.0599677.567836 14 q24.1 actinin, alpha 1 [Source: HGNC Symbol; Acc: 163]1561226_at XCR1 ENSG00000173578 0.032727 0.9280383 4.980618 4.05258 3p21.31 chemokine (C motif) receptor 1 [Source: HGNC Symbol; Acc: 1625]229256_at PGM2L1 ENSG00000165434 0.032727 0.9502539 6.806744 5.85649 11q13.4 phosphoglucomutase 2-like 1 [Source: HGNC Symbol; Acc: 20898]228131_at ERCC1 ENSG00000012061 0.032727 0.6986806 8.644378 7.945697 19q13.32 excision repair cross-complementing rodent repair deficiency,complementation group 1 (includes overlapping antisense sequence)[Source: HGNC Symbol; Acc: 3433] 209310_s_at CASP4 ENSG000001969540.032736 0.9103894 10.59028 9.679891 11 q22.3 caspase 4,apoptosis-related cysteine peptidase [Source: HGNC Symbol; Acc: 1505]218729_at LXN ENSG00000079257 0.032736 1.3734357 9.362978 7.989542 3q25.32 latexin [Source: HGNC Symbol; Acc: 13347] 227274_at SYNJ2BPENSG00000213463 0.032835 0.9456553 8.969654 8.023999 14 q24.2synaptojanin 2 binding protein [Source: HGNC Symbol; Acc: 18955]219147_s_at NMRK1 ENSG00000106733 0.032835 1.031303 8.134786 7.103483 9q21.13 nicotinamide riboside kinase 1 [Source: HGNC Symbol; Acc: 26057]205083_at AOX1 ENSG00000138356 0.032835 1.3447575 6.346469 5.001711 2q33.1 aldehyde oxidase 1 [Source: HGNC Symbol; Acc: 553] 209109_s_atTSPAN6 ENSG00000000003 0.03287 1.3163026 7.197532 5.88123 X q22.1tetraspanin 6 [Source: HGNC Symbol; Acc: 11858] 225303_at KIRRELENSG00000183853 0.03287 1.2844668 7.658036 6.373569 1 q23.1 kin of IRRElike (Drosophila) [Source: HGNC Symbol; Acc: 15734] 226185_at MRASENSG00000158186 0.03287 1.0377007 7.834459 6.796758 3 q22.3 muscle RASoncogene homolog [Source: HGNC Symbol; Acc: 7227] 203716_s_at DPP4ENSG00000197635 0.03287 1.5099205 8.788772 7.278851 2 q24.2dipeptidyl-peptidase 4 [Source: HGNC Symbol; Acc: 3009] 204342_atSLC25A24 ENSG00000085491 0.03287 0.9998009 8.623813 7.624012 1 p13.3solute carrier family 25 (mitochondrial carrier; phosphate carrier),member 24 [Source: HGNC Symbol; Acc: 20662] 202948_at IL1R1ENSG00000115594 0.033188 1.7497853 8.584053 6.834267 2 q11.2 interleukin1 receptor, type I [Source: HGNC Symbol; Acc: 5993] 212511_at PICALMENSG00000073921 0.033188 0.7422533 6.915631 6.173378 11 q14.2phosphatidylinositol binding clathrin assembly protein [Source: HGNCSymbol; Acc: 15514] 214429_at MTMR6 ENSG00000139505 0.033466 0.76973048.954555 8.184824 13 q12.13 myotubularin related protein 6 [Source: HGNCSymbol; Acc: 745.3] 214021_x_at ITGB5 ENSG00000082781 0.033488 1.43597726.631669 5.195692 3 q21.2 integrin, beta 5 [Source: HGNC Symbol; Acc:6160] 227624_at TET2 ENSG00000168769 0.033488 1.0769098 7.5588466.481937 4 q24 tet methylcytosine dioxygenase 2 [Source: HGNC Symbol;Acc: 25941] 225093_at UTRN ENSG00000152818 0.033488 1.5657154 10.041298.415572 6 q24.2 utrophin [Source: HGNC Symbol; Acc: 12635] 227379_atMBOAT1 ENSG00000172197 0.033637 1.2267144 7.197727 5.971012 6 p22.3membrane bound O-acyltransferase domain containing 1 [Source: HGNCSymbol; Acc: 21579] 213139_at SNAI2 ENSG00000019549 0.033801 1.54958176.95332 5.403738 8 q11.21 snail family zinc finger 2 [Source: HGNCSymbol; Acc: 11094] 212099_at RHOB ENSG00000143878 0.033801 1.56319779.851473 8.288275 2 p24.1 ras homolog family member B [Source: HGNCSymbol; Acc: 668] 204894_s_at AOC3 ENSG00000131471 0.033801 1.48871526.950874 5.462159 17 q21.31 amine oxidase, copper containing 3 [Source:HGNC: Symbol; Acc: 550] 219432_at EVC ENSG00000072840 0.033801 0.97349547.657381 6.683835 4 p16.2 Ellis van Creveld syndrome [Source: HGNCSymbol; Acc: 3497] 55065_at MARK4 ENSG00000007047 0.033801 0.45013187.655069 7.204937 19 q13.32 MAP/microtubule affinity-regulating kinase 4[Source: HGNC Symbol; Acc: 13538] 226353_at SPPL2A ENSG000001386000.034001 1.0860363 9.824238 8.738201 15 q21.2 signal peptide peptidaselike 2A [Source: HGNC Symbol; Acc: 30227] 216598_s_at CCL2ENSG00000108691 0.034001 1.5741003 11.80437 10.23027 17 q12 chemokine(C-C motif) ligand 2 [Source: HGNC Symbol; Acc: 10618] 226568_at FAM102BENSG00000162636 0.034001 1.1949347 7.320321 6.125386 1 p13.3 family withsequence similarity 102, member B [Source: HGNC Symbol; Acc: 27637]218764_at PRKCH ENSG00000027075 0.034091 1.3242248 8.842467 7.53.8243 14q23.1 protein kinase C, eta [Source: HGNC Symbol; Acc: 9403] 225984_atPRKAA1 ENSG00000132356 0.034118 0.7616255 6.863442 6.101816 5 p13.1protein kinase, AMP-activated, alpha 1 catalytic. subunit [Source: HGNCSymbol; Acc: 9376] 201542_at SAR1A ENSG00000079332 0.034118 0.73564579.772431 9.036785 10 q22.1 SAR1 homolog A (S. cerevisiae) [Source: HGNCSymbol; Acc: 10534] 203455_s_at SAT1 ENSG00000130066 0.034118 1.3165211.13299 9.816473 X p22.11 spermidine/spermine N1-acetyltransferase 1[Source: HGNC Symbol; Acc: 10540] 225922_at FNIP2 ENSG000000527950.034118 1.5195275 8.166224 6.646697 4 q32.1 folliculin interactingprotein 2 [Source: HGNC Symbol; Acc: 29280] 218665_at FZD4ENSG00000174804 0.034118 1.0211632 7.416231 6.395068 11 q14.2 frizzledfamily receptor 4 [Source: HGNC Symbol; Acc: 4042] 221666_s_at PYCARDENSG00000103490 0.034191 0.6061082 9.397236 8.791128 16 p11.2 PYD andCARD domain containing [Source: HGNC Symbol; Acc: 16608] 201058_s_atMYL9 ENSG00000101335 0.034191 1.2676991 10.37627 9.108573 20 q11.23myosin, light chain 9, regulatory [Source: HGNC Symbol; Acc: 15754]203397_s_at GALNT3 ENSG00000115339 0.034191 1.3066403 5.451049 4.1444092 q24.3 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) [Source: HGNC Symbol; Acc:4125] 222453_at CYBRD1 ENSG00000071967 0.034191 1.3157278 9.0013927.685664 2 q31.1 cytochrome b reductase 1 [Source: HGNC Symbol; Acc:20797] 208146_s_at CPVL ENSG00000106066 0.034191 1.9432647 9.5349377.591672 7 p14.3 carboxypeptidase, vitellogenic-like [Source: HGNCSymbol; Acc: 14399] 227334_at USP54 ENSG00000166348 0.034191 0.59500487.632457 7.037452 10 q22.2 ubiquitin specific peptidase 54 [Source: HGNCSymbol; Acc: 23513] 226534_at KITLG ENSG00000049130 0.034191 1.68712036.504808 4.817688 12 q21.32 KIT ligand [Source: HGNC Symbol; Acc: 6343]229120_s_at CDC42SE1 ENSG00000197522 0.034191 1.0261208 9.0397428.013621 1 q21.3 CDC42 small effector 1 [Source: HGNC Symbol; Acc:17719] 225066_at PPP2R2D ENSG00000175470 0.034191 0.4100232 6.5151256.105102 10 q26.3 protein phosphatase 2, regulatory subunit B, delta[Source: HGNC Symbol; Acc: 23732] 211977_at GPR107 ENSG000001483580.034191 0.4150635 7.32333 6.908267 9 q34.11 G protein-coupled receptor107 [Source: HGNC Symbol; Acc: 17830) 217967_s_at FAM129AENSG00000135842 0.034191 1.6316176 9.361852 7.730234 1 q25.3 family withsequence similarity 129, member A [Source: HGNC Symbol; Acc: 16784]207705_s_at NINL ENSG00000101004 0.034191 0.4580325 7.469272 7.011239 20p11.21 ninein-like [Source: HGNC Symbol; Acc: 29163] 230029_x_at UBR3ENSG00000144357 0.034212 0.7132327 7.406814 6.693581 2 q31.1 ubiquitinprotein ligase E3 component n-recognin 3 (putative) [Source: HGNCSymbol; Acc: 30467] 227236_at TSPAN2 ENSG00000134198 0.03424 1.16052596.827258 5.666732 1 p13.2 tetraspanin 2 [Source: HGNC Symbol; Acc:20659] 202510_s_at TNFAIP2 ENSG00000185215 0.03424 1.6113115 10.986959.375641 14 q32.32 tumor necrosis factor, alpha-induced protein 2[Source: HGNC Symbol; Acc: 11895] 202450_s_at CTSK ENSG000001433870.034334 2.0587683 10.3433 8.284534 1 q21.3 cathepsin K [Source: HGNCSymbol; Acc: 2536] 226395_at HOOK3 ENSG00000168172 0.034361 0.90738429.099733 8.192349 8 p11.21 hook homolog 3 (Drosophila) [Source: HGNCSymbol; Acc: 23576] 219403_s_at HPSE ENSG00000173083 0.034374 1.27337757.073411 5.800034 4 q21.23 heparanase [Source: HGNC Symbol; Acc: 5164]227623_at CACNA2D1 ENSG00000153956 0.034401 1.5093742 5.523191 4.0138177 q21.11 calcium channel, voltage-dependent, alpha 2/delta subunit 1[Source: HGNC Symbol; Acc: 1399] 202239_at PARP4 ENSG000001026990.034401 0.9202135 9.568361 8.648148 13 q12.12 poly (ADP-ribose)polymerase family, member 4 [Source: HGNC Symbol; Acc: 271] 204646_atDPYD ENSG00000188641 0.034481 1.7165381 8.184742 6.468204 1 p21.3dihydropyrimidine dehydrogenase [Source: HGNC Symbol; Acc: 3012]209335_at DCN ENSG00000011465 0.034607 2.0562205 8.106748 6.050528 12q21.33 decorin [Source: HGNC Symbol; Acc: 2705] 202341_s_at TRIM2ENSG00000109654 0.034607 1.1549983 7.682678 6.52768 4 q31.3 tripartitemotif containing 2 [Source: HGNC Symbol; Acc: 15974] 203386_at TBC1D4ENSG00000136111 0.034612 1.5986356 9.927925 8.329289 13 q22.2 TBC1domain family, member [Source: HGNC Symbol; Acc: 19165] 202465_at PCOLCEENSG00000106333 0.034687 1.1107939 9.858341 8.747547 7 q22.1 procollagenC-endopeptidase enhancer [Source: HGNC Symbol; Acc: 8738] 218501_atARHGEF3 ENSG00000153947 0.03471 1.211901 9.645779 8.433878 3 p14.3 Rhoguanine nucleotide exchange factor (GEF) 3 [Source: HGNC Symbol; Acc:683] 203935_at ACVR1 ENSG00000115170 0.03471 0.9297485 7.59294 6.6631912 q24.1 activin A receptor, type I [Source: HGNC Symbol; Acc: 171]227726_at RNF166 ENSG00000158717 0.034778 0.7652554 6.490242 5.724987 16q24.3 ring finger protein 166 [Source: HGNC Symbol; Acc: 23856]225351_at FAM45A ENSG00000119979 0.034778 0.712687 7.985558 7.272871 10q26.11 family with sequence similarity 45, member A [Source: HGNCSymbol; Acc: 31793] 209967_s_at CREM ENSG00000095794 0.034778 1.49870828.008163 6.509455 10 p11.21 cAMP responsive element modulator [Source:HGNC Symbol; Acc: 2352] 217767_at C3 ENSG00000125730 0.034902 1.63030311.06256 9.452253 19 p13.3 complement component 3 [Source: HGNC Symbol;Acc: 1318] 202377_at LEPROT ENSG00000213625 0.034902 0.9587583 8.9277187.96896 1 p31.3 leptin receptor overlapping transcript [Source: HGNCSymbol; Acc: 29477] 212067_s_at C1R ENSG00000159403 0.034902 1.095883810.9773 9.881414 12 p13.31 complement component 1, r subcomponent[Source: HGNC Symbol; Acc: 1246] 206461_x_at MT1H ENSG000002053580.034907 0.9374798 10.9411 10.00362 16 q13 metallothionein 1H [Source:HGNC Symbol; Acc: 7400] 212651_at RHOBTB1 ENSG00000072422 0.034921.2780518 5.303259 4.025208 10 q21.2 Rho-related BTB domain containing 1[Source: HGNC Symbol; Acc: 18738] 213077_at YTHDC2 ENSG000000471880.03492 1.0822747 7.160913 6.078638 5 q22.2 YTH domain containing 2[Source: HGNC Symbol; Acc: 24721] 238617_at KIF26B ENSG000001628490.03492 1.8167267 7.548087 5.73136 1 q44 kinesin family member 26B[Source: HGNC Symbol; Acc: 25484] 201540_at FHL1 ENSG00000022267 0.034922.0909145 8.481468 6.390554 X q26.3 four and a half LIM domains 1[Source: HGNC Symbol; Acc: 3702] 227325_at PRR24 ENSG00000257704 0.034920.5900983 7.823938 7.23384 19 q13.32 proline rich 24 [Source: HGNCSymbol; Acc: 27406] 208093_s_at NDEL1 ENSG00000166579 0.034947 0.74103488.576081 7.835046 17 p13.1 nudE nuclear distribution E homolog (A.nidulans)-like 1 [Source: HGNC Symbol; Acc: 17620] 202006_at PTPN12ENSG00000127947 0.035089 1.0182628 9.540274 8.522011 7 q11.23 proteintyrosine phosphatase, non-receptor type 12 [Source: HGNC Symbol; Acc:9645] 209216_at WDR45 ENSG00000196998 0.035089 0.696795 8.8268888.130093 X q11.23 WD repeat domain 45 [Source: HGNC Symbol; Acc: 28912]225782_at MSRB3 ENSG00000174099 0.035089 1.4443755 6.51473.6 5.07034 12q14.3 methionine sulfoxide reductase B3 [Source: HGNC Symbol; Acc:27375] 200602_at APP ENSG00000142192 0.035089 1.32593 9.055535 7.72960521 q21.3 amyloid beta (A4) precursor protein [Source: HGNC Symbol; Acc:620] 226939_at CPEB2 ENSG00000137449 0.035264 1.2264987 7.6116246.385126 4 p15.33 cytoplasmic polyadenylation element binding protein 2[Source: HGNC Symbol; Acc: 21745] 218986_5_at DDX60 ENSG000001376280.035316 1.4860214 8.318531 6.83251 4 q32.3 DEAD (Asp-Glu-Ala-Asp) boxpolypeptide 60 [Source: HGNC Symbol; Acc: 25942] 203139_at DAPK1ENSG00000196730 0.035316 1.7079489 8.912548 7.204599 9 q21.33death-associated protein kinase 1 [Source: HGNC Symbol; Acc: 2674]213764_s_at MFAP5 ENSG00000197614 0.035435 1.2979822 5.790529 4.49254712 p13.31 microfibrillar associated protein 5 [Source: HGNC Symbol; Acc:29673] 202565_s_at SVIL ENSG00000197321 0.035639 1.3890512 8.6354457.246394 10 p11.23 supervillin [Source: HGNC Symbol; Acc: 11480]210968_s_at RTN4 ENSG00000115310 0.03577 0.8295931 10.69653 9.866939 2p16.1 reticulon 4 [Source: HGNC Symbol; Acc: 14085] 225562_at RASA3ENSG00000185989 0.03578 0.9721275 9.062085 8.089957 13 q34 RAS p21protein activator 3 [Source: HGNC Symbol; Acc: 20331] 218454_at PLBD1ENSG00000121316 0.035786 1.4419824 10.25392 8.811935 12 p13.1phospholipase B domain containing 1 [Source: HGNC Symbol; Acc: 26215]209467_s_at MKNK1 ENSG00000079277 0.035868 0.7832944 8.294847 7.511553 1p33 MAP kinase interacting serine/threonine kinase 1 [Source: HGNCSymbol; Acc: 7110] 226869_at MEGF6 ENSG00000162591 0.03595 1.26504347.859101 6.594058 1 p36.32 multiple EGF-like-domains 6 [Source: HGNCSymbol; Acc: 3232] 221569_at AHI1 ENSG00000135541 0.03595 1.07614067.793652 6.717512 6 q23.3 Abelson helper integration site 1 [Source:HGNC Symbol; Acc: 21575] 1569157_s_at ZNF846 ENSG00000196605 0.035950.7746233 6.057018 5.282395 19 p13.2 zinc finger protein 846 [Source:HGNC Symbol; Acc: 27260] 218132_s_at TSEN34 ENSG00000170892 0.035950.4388666 8.237399 7.798532 19 q13.42 tRNA splicing endonuclease 34homolog (S. cerevisiae) [Source: HGNC Symbol; Acc: 15506] 201591_s_atNISCH ENSG00000010322 0.036284 0.4056482 8.996513 8.590865 3 p21.1nischarin [Source: HGNC Symbol; Acc: 18006] 227098_at DUSP18ENSG00000167065 0.036417 0.4821536 7.203923 6.721759 22 q12.2 dualspecificity phosphatase 18 [Source: HGNC Symbol; Acc: 18484] 203910_atARHGAP29 ENSG00000137962 0.036417 1.5131699 7.336341 5.823171 1 p21.3Rho GTPase activating protein 29 [Source: HGNC Symbol; Acc: 30207]1555847_a_at LOC2844540 NA 0.036417 0.9290134 9.021958 8.092945 NA NA NA241353_s_at LOC1005075 NA 0.036417 0.563124 6.938192 6.375068 NA NA NA07 202225_at CRK ENSG00000167193 0.036417 0.7660484 9.380488 8.614439 17p13.3 v-crk avian sarcoma virus CT10 oncogene homolog [Source: HGNCSymbol; Acc: 2362] 212915_at PDZRN3 ENSG00000121440 0.036491 1.31257936.719045 5.406466 3 p13 PDZ domain containing ring finger 3 [Source:HGNC Symbol; Acc: 17704] 202920_at ANK2 ENSG00000145362 0.0364911.4633941 8.124628 6.661234 4 q25 ankyrin 2, neuronal [Source: HGNCSymbol; Acc: 493] 235391_at FAM92A1 ENSG00000188343 0.036548 0.62113627.223439 6.602303 8 q22.1 family with sequence similarity 92, member A1[Source: HGNC Symbol; Acc: 30452] 224906_at ANO6 ENSG000001771190.036675 0.8771124 8.664683 7.787571 12 q12 anoctamin 6 [Source: HGNCSymbol; Acc: 25240] 227087_at INPP4A ENSG00000040933 0.036675 1.02678948.031874 7.005085 2 q11.2 inositol polyphosphate-4-phosphatase, type I,107 kDa [Source: HGNC Symbol; Acc: 6074] 225931_s_at RNF213ENSG00000173821 0.036802 1.1072523 9.749178 8.641926 17 q25.3 ringfinger protein 213 [Source: HGNC Symbol; Acc: 14539] 212690_at DDHD2ENSG00000085788 0.036831 0.8783562 9.176867 8.298511 8 p11.23 DDHDdomain containing 2 [Source: HGNC Symbol; Acc: 29106] 209003_at SLC25A11ENSG00000108528 0.036891 0.4377232 7.954667 7.516944 17 p13.2 solutecarrier family 25 (mitochondrial carrier; oxoglutarate carrier), member11 [Source: HGNC Symbol; Acc: 10981] 202206_at ARL4C ENSG000001880420.036891 1.3898051 9.321387 7.931582 2 q37.1 ADP-ribosylationfactor-like 4C [Source: HGNC Symbol; Acc: 698] 232000_at ITC39BENSG00000155158 0.037068 1.3565126 4.978733 3.62222 9 p22.3tetrathcopeptide repeat domain 39B [Source: HGNC Symbol; Acc: 23704]225386_s_at HNRPLL NA 0.037068 1.4593954 9.121602 7.662206 NA NA NA2264092_at TBC1D20 ENSG00000125875 0.037068 0.5055858 8.965324 3.45973820 p13 TBC1 domain family, member 20 [Source: HGNC Symbol; Acc: 16133]204066_s_at AGAP1 ENSG00000157985 0.037088 1.0789416 6.07508 4.996139 2q37.2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol; Acc: 16922] 212441_at KIAA0232 ENSG00000170871 0.0370880.5902105 8.606786 8.016575 4 p16.1 KIAA0232 [Source: HGNC Symbol; Acc:28992] 225726_s_at PLEKHH1 ENSG00000054690 0.037088 0.9526951 5.9649585.012263 14 q24.1 pleckstrin homology domain containing, family H (withMyTH4 domain) member 1 [Source: HGNC Symbol; Acc: 17733] 232094_atKATNBL1 ENSG00000134152 0.037088 0.5971703 7.264443 6.667273 15 q14katenin p80 subunit B-like 1 [Source: HGNC Symbol; Acc: 26199]225604_s_at GLIPR2 ENSG00000122694 0.037324 0.8539107 7.844159 6.9902489 p13.3 GLI pathogenesis-related 2 [Source: HGNC Symbol; Acc: 18007]205225_at ESR1 ENSG00000091831 0.037324 1.3824683 6.467921 5.085453 6q25.1 estrogen receptor [Source: HGNC Symbol; Acc: 3467] 218838_s_atTTC31 ENSG00000115282 0.037324 0.6726502 8.524158 7.851508 2 p13.1 tetratricopeptirle repeat domain 31 [Source: HGNC Symbol; Acc: 25759]227961_at CTSB ENSG00000164733 0.037324 1.3381396 10.24117 8.903035 8p23.1 cathepsin B [Source: HGNC Symbol; Acc: 2527] 1558041_a_atKIAA0895L ENSG00000196123 0.037413 0.8767425 7.925107 7.048364 16 q22.1KIAA0395-like [Source: HGNC Symbol; Acc: 34408] 209540_at IGF1ENSG00000017427 0.037413 1.5225095 8.256633 6.734124 12 q23.2insulin-like growth factor 1 (somatomedin C) [Source: HGNC Symbol; Acc:5464] 203651_at ZFYVE16 ENSG00000039319 0.037413 1.0251416 8.5274847.502343 5 q14.1 zinc finger, FYVE domain containing 16 [Source: HGNCSymbol; Acc: 20756] 224900_at ANKFY1 ENSG00000185722 0.037546 0.5329538.58147 8.048518 17 p13.2 ankyrin repeat and FYVE domain containing 1[Source: HGNC Symbol; Acc: 20763] 223441_at SLC17A5 ENSG000001198990.037627 0.645006 6.824616 6.17961 6 q13 solute carrier family 17(anion/sugar transporter), member 5 [Source: HGNC Symbol; Acc: 10933]204294_at AMT ENSG00000145020 0.037627 0.3994342 8.335214 7.935779 3p21.31 aminomethyltransferase [Source: HGNC Symbol; Acc: 473] 204040_atRNF144A ENSG00000151692 0.037682 1.4813478 6.933004 5.451656 2 p25.2ring finger protein 144A [Source: HGNC: Symbol; Acc: 20457] 225272_atSAT2 ENSG00000141504 0.037706 0.6186121 9.078151 8.459538 17 p13.1spermidine/spermine N1-acetyltransferase family member 2 [Source: HGNCSymbol; Acc: 23160] 204464_s_at EDNRA ENSG00000151617 0.037706 1.42483417.17677 5.751936 4 q31.22 endothelin receptor type A [Source: HGNCSymbol; Acc: 3179] 205011_at VWA5A ENSG00000110002 0.037706 1.50106888.178127 6.677058 11 q24.2 von Willebrand factor A domain containing 5A[Source: HGNC Symbol; Acc: 6658] 212765_at CAMSAP2 ENSG000001182000.037714 1.0702776 7.585165 6.514887 1 q32.1 calmodulin regulatedspectrin-associated protein family, member 2 [Source: HGNC Symbol; Acc:29188] 212624_s_at CHN1 ENSG00000128656 0.037755 1.1993666 8.339427.140053 2 q31.1 chimerin 1 [Source: HGNC Symbol; Acc: 1943] 209213_atCBR1 ENSG00000159228 0.037828 0.71634 9.378176 8.661836 21 q22.12carbonyl reductase 1 [Source: HGNC Symbol; Acc: 1548] 207738_s_at NCKAP1ENSG00000061676 0.037828 1.7420168 5.909032 4.167015 2 q32.1NCK-associated protein 1 [Source: HGNC Symbol; Acc: 7666] 206856_atLILRB5 ENSG00000105609 0.03795 1.5873193 8.757092 7.169773 19 q13.42leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIMdomains), member 5 [Source: HGNC: Symbol; Acc: 6609] 200697_at HK1ENSG00000156515 0.037989 0.4970804 10.98017 10.48308 10 q22.1 hexokinase1 [Source: HGNC Symbol; Acc: 4922] 219134_at ELTD1 ENSG000001626180.03804 1.633117 7.997273 6.364156 1 p31.1 EGF, latrophilin and seventransmembrane domain containing 1 [Source: HGNC Symbol; Acc: 20822]222294_s_at RAB27A ENSG00000069974 0.038154 1.5128756 7.227373 5.71449715 q21.3 RAB27A, member RAS oncogene family [Source: HGNC Symbol; Acc:9766] 201057_s_at GOLGB1 ENSG00000173230 0.03845 0.6396181 9.2208348.581216 3 q13.33 golgin 51 [Source: HGNC Symbol; Acc: 4429] 218017_s_atHGSNAT ENSG00000165102 0.038567 1.101893 8.583363 7.48147 8 p11.21heparan-alpha-glucosamninide N-acetyltransferase [Source: HGNC Symbol;Acc: 26527] 226905_at FAM101B ENSG00000183688 0.03866 1.3556387 8.8323827.476743 17 p13.3 family with sequence similarity 101, member B [Source:HGNC Symbol; Acc: 28705] 226616_s_at NDUFV3 ENSG00000160194 0.0385720.6620698 10.466 9.803934 21 q22.3 NADH dehydrogenase (ubiquinone)flavoprotein 3, 10 kDa [Source: HGNC Symbol; Acc: 7719] 215127_s_atRBMS1 ENSG00000153250 0.038708 0.9857614 9.060146 8.074385 2 q24.2 RNAbinding motif, single stranded interacting protein 1 [Source: HGNCSymbol; Acc: 9907] 212373_at FEM1B ENSG00000169018 0.038897 0.96186878.428165 7.466297 15 q23 fern-1 homolog b (C. elegans) [Source: HGNCSymbol; Acc: 3649] 222750_s_at SRD5A3 ENSG00000128039 0.038897 0.76260548.251817 7.489212 4 q12 steroid 5 alpha-reductase 3 [Source: HGNCSymbol; Acc: 25812] 236006_s_at AKAP10 ENSG00000108599 0.0390070.6550377 7.328287 7.173249 17 p11.2 A kinase (PRKA) anchor protein 10[Source: HGNC Symbol; Acc: 68] 224733_at CMTM3 ENSG00000140931 0.0391820.6902697 9.982739 9.292469 16 q21 CKLF-like MARVEL transmembrane domaincontaining 3 [Source: HGNC Symbol; Acc: 19174] 204981_at SLC22A18ENSG00000110628 0.039182 0.5611839 7.58994 7.028756 11 p15.4 solutecarrier family 22, member 18 [Source: HGNC Symbol; Acc: 10964] 223077_atTMOD3 ENSG00000138594 0.03924 1.0922066 7.964721 6.872514 15 q21.2tropornodulin 3 (ubiquitous) [Source: HGNC Symbol; Acc: 11873] 209686_atS100B ENSG00000160307 0.039241 0.9012906 6.761868 5.860578 21 q22.3 S100calcium binding protein B [Source: HGNC Symbol; Acc: 10500] 225325_atMFSD6 ENSG00000151690 0.039241 0.8394079 8.69193 7.852522 2 q32.2 majorfacilitator superfamily domain containing 6 [Source: HGNC Symbol; Acc:24711] 205236_x_at SOD3 ENSG00000109610 0.03958 0.8919006 8.4516337.559732 4 p15.2 superoxide dismutase 3, extracellular [Source: HGNCSymbol; Acc: 11181] 228220_at FCHO2 ENSG00000157107 0.03958 1.56376258.795856 7.232094 5 q13.2 FCH domain only 2 [Source: HGNC Symbol; Acc:25180] 205904_at MICA ENSG00000204520 0.03958 0.4272285 7.6847547.257525 6 p21.33 MHC class I polypeptide-related sequence A [Source:HGNC Symbol; Acc: 7090] 226777_at ADAM12 ENSG00000148848 0.039581.9432471 7.771445 5.828198 10 q26.2 ADAM metallopeptidase domain 12[Source: HGNC Symbol; Acc: 190] 213618_at ARAP2 ENSG00000047365 0.039581.0280821 7.620559 6.592477 4 p14 ArfGAP with RhoGAP domain, ankyrinrepeat and PH dorna 2 [Source: HGNC Symbol; Acc: 16924] 205624_at CPA3ENSG00000163751 0.03958 2.1511989 6.492962 4.341763 3 q24carboxypeptidase A3 (mast cell) [Source: HGNC Symbol; Acc: 2298]215268_at KIAA0754 ENSG00000255103 0.03958 0.8091048 6.285141 5.476036 1p34.3 KIAA0754 [Source: HGNC Symbol; Acc: 29111] 203672_x_at TPMTENSG00000137364 0.03958 0.5543757 9.62339 9.069015 6 p22.3 thiopurineS-methyltransferase [Source: HGNC Symbol; Acc: 12014] 1555229_a_at C1SENSG00000182326 0.03958 1.5628333 10.46271 8.899877 12 p13.31 complementcomponent 1, s subcomponent [Source: HGNC Symbol; Acc: 1247] 203855_atWDR47 ENSG00000085433 0.03958 0.3150022 7.128001 6.412998 1 p13.3 WDrepeat domain 47 [Source: HGNC Symbol; Acc: 29141] 207072_at IL18RAPENSG00000115607 0.03958 0.9816906 7.548943 6.567253 2 q12.1 interleukin18 receptor accessory protein [Source: HGNC Symbol; Acc: 5989]221935_s_at EOGT ENSG00000163378 0.039608 0.8358766 7.127104 6.291227 3p14.1 EGF domain-specific O-linked N-acetylglucosamine (GlcNAc)transferase [Source: HGNC Symbol; Acc: 23526] 203232_s_at ATXN1ENSG00000124788 0.039608 1.4864727 8.293823 6.80735 6 p22.3 ataxin 1[Source: HGNC Symbol; Acc: 10548] 202096_s_at TSPO ENSG000001003000.03977 0.6186136 9.561586 8.942973 22 q13.2 translocator protein (18kDa) [Source: HGNC Symbol; Acc: 1158] 224813_at WASL ENSG000001062990.03977 0.8102345 8.822272 8.012038 7 q31.32 Wiskott-Aldrichsyndrome-like [Source: HGNC Symbol; Acc: 12735] 213455_at FAM114A1ENSG00000197712 0.039797 0.841538 7.947072 7.105434 4 p14 family withsequence similarity 114, member A1 [Source: HGNC Symbol; Acc: 25087]226873_at FAM63B ENSG00000128923 0.039878 0.7816817 7.054056 6.272374 15q21.3 family with sequence similarity 53, member B [Source: HGNC Symbol;Acc: 26954] 1554503_a_at OSCAR ENSG00000170909 0.040083 0.48159446.652983 6.171388 19 q13.42 osteoclast associated, immunoglobulin-likereceptor [Source: HGNC Symbol; Acc: 29960] 206118_at STAT4ENSG00000138378 0.040381 1.5428433 7.763744 6.120901 2 q32.3 signaltransducer and activator of transcription 4 [Source: HGNC Symbol; Acc:11365] 210970_s_at IBTK ENSG00000005700 0.040543 0.7538865 8.2608727.506986 6 q14.1 inhibitor of Bruton agammaglobulinernia tyrosine kinase[Source: HGNC Symbol; Acc: 17853] 227113_at ADHFE1 ENSG000001475760.040543 0.7061362 8.382822 7.676586 8 q13.1 alcohol dehydrogenase, ironcontaining, 1 [Source: HGNC Symbol; Acc: 16354] 202949_s_at FHL2ENSG00000115641 0.040594 1.4031826 7.613598 5.210416 2 q12.2 four and ahalf LIM domains 2 [Source: HGNC Symbol; Acc: 3703] 225579_at PQLC3ENSG00000162976 0.040597 1.1136678 9.537873 8.424205 2 p25.1 PQ looprepeat containing 3 [Source: HGNC Symbol; Acc: 28503] 235291_s_atFLJ32255 NA 0.040716 1.1196959 7.867314 6.747618 NA NA NA 203939_at NT5EENSG00000135318 0.040733 0.8061792 7.425231 6.619052 6 q14.35′-nucleotidase, ecto (CD73) [Source: HGNC Symbol; Acc: 8021]214274_s_at ACAA1 ENSG00000060971 0.040794 0.5024191 9.455452 8.963033 3p22.2 acetyl-CoA acyltransferase 1 [Source: HGNC Symbol; Acc: 32]204046_at PLCB2 ENSG00000137841 0.040802 0.5337836 8.533797 8.000014 15q15.1 phospholipase C, beta 2 [Source: HGNC Symbol; Acc: 9055]202392_s_at PISD ENSG00000241878 0.041073 0.3563542 8.566583 8.210219 22q12.2 phosphatidylserine decarboxylase [Source: HGNC Symbol; Acc: 8999]218326_s_at LGR4 ENSG00000205213 0.041073 1.2551214 5.02211 3.766988 11p14.1 leucine-rich repeat containing G protein-coupled receptor 4[Source: HGNC Symbol; Acc: 13299] 229119_s_at ZSWIM7 ENSG000002149410.041073 1.0247863 7.91053 6.885744 17 p12 zinc finger, SWIM-typecontaining 7 [Source: HGNC Symbol; Acc: 26993] 206491_s_at NAPAENSG00000105402 0.041415 0.4954364 9.333764 8.838328 19 q13.33N-ethylmaleimide-sensitive factor attachment protein, alpha [Source:HGNC Symbol; Acc: 7641] 227450_at ERP27 ENSG00000139055 0.0414150.9661967 6.328914 5.362718 12 p12.3 endoplasmic reticulum protein 27[Source: HGNC Symbol; Acc: 26495] 200866_s_at PSAP ENSG000001977460.041415 1.0853598 11.69849 10.61313 10 q22.1 prosaposin [Source: HGNCSymbol; Acc: 9498] 200720_s_at ACTR1A ENSG00000138107 0.041415 0.49675348.824862 8.328108 10 q24.32 ARP1 actin-related protein 1 homolog A,centractin alpha (yeast) [Source: HGNC Symbol; Acc: 167] 232064_at FERENSG00000151422 0.041415 0.6560546 7.136386 6.480331 5 q21.3 fer(fps/fes related) tyrosine kinase [Source: HGNC Symbol; Acc: 3655]217922_at MAN1A2 ENSG00000198162 0.041445 0.6973684 8.202283 7.504915 1p12 mannosidase, alpha, class 1A, member 2 [Source: HGNC Symbol; Acc:822] 201944_at HEXB ENSG00000049860 0.04157 1.0109447 11.5932 10.58226 5q13.3 hexosaminidase B (beta polypeptide) [Source: HGNC Symbol; Acc:4879] 210986_s_at TPM1 ENSG00000140416 0.04157 1.6503375 9.9446088.294271 15 q22.2 tropomyosin 1 (alpha) [Source: HGNC Symbol; Acc:12010] 227568_at HECTD2 ENSG00000165338 0.04157 1.1199318 6.6850615.565129 10 q23.32 HECT domain containing E3 ubiquitin protein ligase 2[Source: HGNC Symbol; Acc: 26736] 200645_at GABARAP ENSG000001702960.04157 0.6317473 11.38104 10.7493 17 p13.1 GABA(A) receptor-associatedprotein [Source: HGNC Symbol; Acc: 4067] 219892_at TM6SF1ENSG00000136404 0.04157 1.5187197 7.818959 6.300239 15 q25.2transmembrane 6 superfamily member 1 [Source: HGNC Symbol; Acc: 11860]222431_at SPIN1 ENSG00000106723 0.04157 0.7028249 9.18628 8.483455 9q22.1 spindlin 1 [Source: HGNC Symbol; Acc: 11243] 203665_at HMOX1ENSG00000100292 0.04157 1.0199085 9.506814 8.486905 22 q12.3 hemeoxygenate (decycling) 1 [Source: HGNC Symbol; Acc: 5013] 202506_at SSFA2ENSG00000138434 0.04157 0.9475539 8.018471 7.070918 2 q31.3 spermspecific antigen 2 [Source: HGNC Symbol; Acc: 11319] 221899_at N4BP2L2ENSG00000244754 0.04157 0.8653353 9.046774 8.181439 13 q13.1 NEDD4binding protein 2-like 2 [Source: HGNC Symbol; Acc: 26916] 203668_atMAN2C1 ENSG00000140400 0.04169 0.6339166 8.66367 8.029753 15 q24.2mannosidase, alpha, class 2C, member 1 [Source: HGNC Symbol; Acc: 6827]206295_at IL18 ENSG00000150782 0.041917 1.2921744 9.298736 8.006561 11q23.1 interleukin 18 (interferon-gamma-inducing factor) [Source: HGNCSymbol; Acc: 5986] 228152_s_at DDX60L ENSG00000181381 0.041917 1.42134367.853792 6.432448 4 q32.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like[Source: HGNC Symbol; Acc: 26429] 228341_at NUDT16 ENSG000001985850.041917 0.8132856 6.707602 5.894316 3 q22.1 nudix (nucleosidediphosphate linked moiety X)-type motif 16 [Source: HGNC Symbol; Acc:26442] 218164_at SPATA20 ENSG00000006282 0.041917 0.5879296 9.0233348.435404 17 q21.33 spermatogenesis associated 20 [Source: HGNC Symbol;Acc: 26125] 227070_at GLT8D2 ENSG00000120820 0.041917 1.7573511 5.8403184.082966 12 q23.3 glycosyltransferase 8 domain containing 2 [Source:HGNC Symbol; Acc: 24890] 213083_at SLC35D2 ENSG00000130958 0.0419170.8293654 7.315854 6.486489 9 q22.32 solute carrier family 35(UDP-GlcNAc/UDP-glucose transporter), member D2 [Source: HGNC Symbol;Acc: 20799] 224772_at NAV1 ENSG00000134369 0.041917 1.0514789 7.6021466.550667 1 q32.1 neuron navigator 1 [Source: HGNC Symbol; Acc: 15989]229287_at PCNX ENSG00000100731 0.041917 0.9439305 7.156202 6.622271 14q24.2 pecanex homolog (Drosophila) [Source: HGNC Symbol; Acc: 19740]201200_at CREG1 ENSG00000143162 0.041917 1.0581554 11.10069 10.04253 1q24.2 cellular repressor of E1A-stimulated genes 1 [Source: HGNC Symbol;Acc: 2351] 229450_at IFIT3 ENSG00000119917 0.041917 1.6631975 9.0842357.421037 10 q23.31 interferon-induced protein with tetratricopeptiderepeats 3 [Source: HGNC Symbol; Acc: 5411] 228249_at C11orf74ENSG00000166352 0.041917 0.8487982 5.174339 4.325541 11 p12 chromosome11 open reading frame 74 [Source: HGNC Symbol; Acc: 25142] 38487_atSTAB1 ENSG00000010327 0.042059 1.0905804 9.31099 8.22041 3 p21.1stabilin 1 [Source: HGNC Symbol; Acc: 18628] 202974_at MPP1ENSG00000130830 0.042059 1.0629761 9.61456 8.551584 X q28 membraneprotein, palmitoylated 1, 55 kDa [Source: HGNC Symbol; Acc: 7219]226510_at HEATR5A ENSG00000129493 0.042059 0.7510398 7.259761 6.50872114 q12 HEAT repeat containing 5A [Source: HGNC Symbol; Acc: 20276]228282_at MFSD8 ENSG00000164073 0.042059 0.8192732 7.582661 6.763388 4q28.2 major facilitator superfamily domain containing 8 [Source: HGNCSymbol; Acc: 284,86] 203675_at NUCB2 ENSG00000070081 0.042059 0.90577479.751698 8.845924 11 p15.1 nucleobindin 2 [Source: HGNC Symbol; Acc:8044] 228384_s_at PYROXD2 ENSG00000119943 0.042059 0.3040111 6.3858916.08188 10 q24.2 pyridine nucleotide-disulphide oxidoreductase domain 2[Source: HGNC Symbol; Acc: 23517] 229367_s_at GIMAP6 ENSG000001335610.042059 1.4090136 8.888668 7.479654 7 q36.1 GTPase, IMAP family member6 [Source: HGNC Symbol; Acc: 21918] 218309_at CAMK2N1 ENSG000001625450.042059 1.2605333 7.868837 6.608303 1 p36.12calcium/calmodulin-dependent protein kinase H inhibitor 1 [Source: HGNCSymbol; Acc: 24190] 34726_at CACNB3 ENSG00000167535 0.042059 0.41363086.934617 6.520986 12 q13.12 calcium channel, voltage-dependent, beta 3subunit [Source: HGNC Symbol; Acc: 1403] 212670_at ELN ENSG000000495400.042059 1.2311529 8.8137 7.582547 7 q11.23 elastin [Source: HGNCSymbol; Acc: 3327] 229800_at DCLK1 ENSG00000133083 0.042059 1.49859246.412071 4.913479 13 q13.3 doublecortin-like kinase 1 [Source: HGNCSymbol; Acc: 2700] 201975_at CLIP1 ENSG00000130779 0.042246 1.02851128.482483 7.453972 12 q24.31 CAP-GLY domain containing linker protein 1[Source: HGNC Symbol; Acc: 10461] 224413_s_at TM2D2 ENSG000001694900.042248 0.6130057 9.024042 8.411037 8 p11.22 TM2 domain containing 2[Source: HGNC Symbol; Acc: 24127] 204011_at SPRY2 ENSG000001361580.042332 1.3188526 7.198128 5.879276 13 q31.1 sprouty homolog 2(Drosophila) [Source: HGNC Symbol; Acc: 11270] 235033_at NPEPL1ENSG00000215440 0.042332 0.7632057 5.890585 5.12738 20 q13.32aminopeptidase-like 1 [Source: HGNC Symbol; Acc: 16244] 228348_at LINSENSG00000140471 0.042351 0.8898302 8.824668 7.934838 15 q26.3 lineshomolog (Drosophila] [Source: HGNC. Symbol; Acc: 30922] 227628_at GPX8ENSG00000164294 0.042351 1.180448 6.970795 5.790347 5 q11.2 glutathioneperoxidase 8 (putative) (Source: HGNC Symbol; Acc: 33100] 1557112_a_atVPS53 ENSG00000141252 0.042351 0.5180325 7.975808 7.457775 17 p13.3vacuolar protein sorting 53 homolog (S. cerevisiae) [Source: HGNCSymbol; Acc: 25608] 228071_at GIMAP7 ENSG00000179144 0.042351 1.6473648.992109 7.344745 7 q36.1 GTPase, IMAP family member 7 [Source: HGNCSymbol; Acc: 22404] 209264_s_at TSPAN4 ENSG00000214063 0.0423510.6817548 9.0067 8.324945 11 p15.5 tetraspanin 4 [Source: HGNC Symbol;Acc: 11859] 208892_s_at DUSP6 ENSG00000139318 0.042351 1.2289738 7.992046.763066 12 q21.33 dual specificity phosphatase 6 [Source: HGNC Symbol;Acc: 3072] 201315_x_at IFITM2 ENSG00000185201 0.042351 0.739392211.67358 10.93419 11 p15.5 interferon induced transmembrane protein 2[Source: HGNC Symbol; Acc: 5413] 222802_at EDN1 ENSG00000078401 0.0423511.4605418 6.322746 4.862204 6 p24.1 endothelin 1 [Source: HGNC Symbol;Acc: 3176] 1553395_a_at CD200R1 ENSG00000163606 0.042351 1.25691036.464779 5.207868 3 q13.2 CD200 receptor 1 [Source: HGNC,Symbol; Acc:24235] 226399_at DNAJB14 ENSG00000164031 0.042351 0.8499477 8.1628847.312937 4 q23 DnaJ (Hsp40) homolog, subfamily B, member 14 [Source:HGNC Symbol; Acc: 25881] 226490_at NHSL1 ENSG00000135540 0.0423511.1946659 7.117631 5.922965 6 q24.1 NHS-like 1 [Source: HGNC Symbol;Acc: 21021] 222513_s_at SORBS1 ENSG00000095637 0.042351 1.3254618.112293 6.786832 10 q24.1 sorbin and SH3 domain containing 1 [Source:HGNC Symbol; Acc: 14565] 218705_s_at SNX24 ENSG00000064652 0.0423510.9094316 7.531422 6.62199 5 q23.2 sorting nexin 24 [Source: HGNCSymbol; Acc: 21533] 226837_at SPRED1 ENSG00000166068 0.042351 1.21287127.561562 6.34869 15 q14 sprouty-related, EVH1 domain containing 1[Source: HGNC Symbol; Acc: 20249] 225338_at ZYG11B ENSG000001623780.042351 0.6244781 7.31379 6.689312 7 p32.3 zyg-11 family member B, cellcycle regulator [Source: HGNC Symbol; Acc: 25820] 204955_at SRPXENSG00000101955 0.042351 1.7691767 7.330012 5.560835 X p11.4sushi-repeat containing protein, X-linked [Source: HGNC Symbol; Acc:11309] 210840_s_at IQGAP1 ENSG00000140575 0.042351 0.8156678 10.603819.788142 15 q26.1 IQ motif containing GTPase activating protein 1[Source: HGNC Symbol; Acc: 6110] 201494_at PRCP ENSG00000137509 0.0423510.8806117 10.84225 9.961639 11 q14.1 prolylcarboxypeptidase(angiotensinase C) [Source: HGNC Symbol; Acc: 9344] 204415_at IFI6ENSG00000126709 0.042351 1.1130836 9.366478 8.253394 1 p36.11interferon, alpha-inducible protein 6 [Source: HGNC Symbol; Acc: 4054]209290_s_at NFIB ENSG00000147862 0.042351 1.6557745 8.409196 6.753422 9p22.3 nuclear factor 1/13 [Source: HGNC Symbol; Acc: 7785] 221474_atMYL12B ENSG00000118680 0.04242 0.5861311 10.97279 10.38666 18 p11.31myosin, light chain 12B, regulatory [Source: HGNC Symbol; Acc: 29827]235747_at SLC25A16 ENSG00000122912 0.04242 0.5460494 7.042745 6.49669610 q21.3 solute carrier family 25 (mitochondrial carrier; Graves diseaseautoantigen), member 16 [Source: HGNC Symbol; Acc: 10986] 201924_at AFF1ENSG00000172493 0.04242 0.9520638 10.24162 9.289557 4 q21.3 AF4/FMR2family, member 1 [Source: HGNC Symbol; Acc: 7135] 218045_x_at PTMSENSG00000159335 0.042596 0.6071624 9.924388 9.317226 12 p13.31parathymosin [Source: HGNC Symbol; Acc: 9629] 213943_at TWIST1ENSG00000122691 0.042596 1.1687342 7.271938 6.103204 7 p21.1 twist basichelix-loop-helix transcription factor 1 [Source: HGNC Symbol; Acc:12428] 226752_at FAM174A ENSG00000174132 0.042596 0.9287163 5.7764494.847732 5 q21.1 family with sequence similarity 174, member A [Source:HGNC Symbol; Acc: 24943] 201876_at PON2 ENSG00000105854 0.042721.1875711 9.054738 7.867167 7 q21.3 paraoxonase 2 [Source: HGNC Symbol;Acc: 9205] 1554240_a_at ITGAL ENSG00000005844 0.042882 1.30250549.317163 8.014657 16 p11.2 integrin, alpha L (antigen CD11A (p180),lymphocyte function-associated antigen 1; alpha polypeptide) [Source:HGNC Symbol; Acc: 6148] 203989_x_at F2R ENSG00000181104 0.0428911.2465199 7.440039 6.193519 5 q13.3 coagulation factor II (thrombin)receptor [Source: HGNC Symbol; Acc: 3537] 226425_at CLIP4ENSG00000115295 0.042891 1.4998601 7.783328 6.283468 2 p23.2 CAP-GLYdomain containing linker protein family, member 4 [Source: HGNC Symbol;Acc: 26108] 200762_at DPYSL2 ENSG00000092964 0.042891 1.1591718 9.3281248.168952 8 p21.2 dihydropyrimidinase-like 2 [Source: HGNC Symbol; Acc:3014] 223681_s_at INADL ENSG00000132849 0.042891 1.2509988 6.1818774.930378 1 p31.3 InaD-like (Drosophila) [Source: HGNC Symbol; Acc:28881] 211986_at AHNAK ENSG00000124942 0.042891 1.3341466 11.4785610.14441 11 q12.3 AHNAK nucleoprotein [Source: HGNC Symbol; Acc: 347]204112_s_at HNMT ENSG00000150540 0.042891 1.303475 8.681933 7.378458 2q22.1 histamine N-methyltransferase [Source: HGNC Symbol; Acc: 5028]235360_at PLEKHM3 ENSG00000178385 0.042891 0.4363264 7.481078 7.044751 2q33.3 pleckstrin homology domain containinng, family M, member 3[Source: HGNC Symbol; Acc: 34006] 209276_s_at GLRX ENSG000001732210.04294 1.1533528 10.46513 9.31178 5 q15 glutaredoxin (thioltransferase)[Source: HGNC Symbol; Acc: 4330] 226113_at ZNF436 ENSG000001259450.042951 0.9676351 7.934453 6.966818 1 p36.12 zinc finger protein 436[Source: HGNC Symbol; Acc: 20814] 201694_s_at EGR1 ENSG000001207380.043033 2.3562082 9.680723 7.324515 5 q31.2 early growth response 1[Source: HGNC: Symbol; Acc: 3238] 204417_at GALC ENSG000000549830.043091 1.1819717 9.186049 8.004078 14 q31.3 galactosylceramidase[Source: HGNC Symbol; Acc: 4115] 211178_s_at PSTPIP1 ENSG000001403680.043103 0.5580401 8.764375 8.206335 15 q24.3 proline-serine-threoninephosphatase interacting protein 1 [Source: HGNC Symbol; Acc: 9580]203088_at FBLN5 ENSG00000140092 0.043103 1.5746104 8.128332 6.553721 14q32.12 fibulin 5 [Source: HGNC Symbol; Acc: 3602] 218450_at HEBP1ENSG00000013583 0.043103 0.7563211 8.459513 7.703192 12 p13.1 hemebinding protein 1 [Source: HGNC Symbol; Acc: 17176] 210113_s_at NLRP1ENSG00000091592 0.043123 0.6544652 7.398937 6.744472 17 p13.2 NLRfamily, pyrin domain containing 1 [Source: HGNC Symbol; Acc: 14374]225673_at MYADM ENSG00000179820 0.043128 1.1859735 9.60657 8.274684 19q13.42 myeloid-associated differentiation marker [Source: HGNC Symbol;Acc: 7544] 31874_at GAS2L1 ENSG00000185340 0.043128 0.9591258 7.0636286.104502 22 q12.2 growth arrest-specific 2 like 1 [Source: HGNC Symbol;Acc: 16955] 222597_at SNAP29 ENSG00000099940 0.043128 0.523138 8.6822698.159131 22 q11.21 synantosomal-associated protein, 29 kDa [Source: HGNCSymbol; Acc: 11133] 226279_at PRSS23 ENSG00000150687 0.043153 1.36043677.675135 6.314698 11 q14.2 protease, serine, 23 [Source: HGNC. Symbol;Acc: 14370] 235570_at RSMS3 ENSG00000144642 0.043153 1.7823279 7.3356335.553305 3 p24.1 RNA binding motif, single stranded interacting protein3 [Source: HGNC Symbol; Acc: 134271 214830_at SLC38A6 ENSG000001399740.04325 1.2769308 7.341343 6.064412 14 q23.1 solute carrier family 38,member 6 [Source: HGNC Symbol; Acc: 19863] 201366_at ANXA7ENSG00000138279 0.04326 0.7630117 8.850377 8.087365 10 q22.2 annexin A7[Source: HGNC Symbol; Acc: 545] 203179_at GALT ENSG00000213930 0.0433160.4101715 8.833284 8.423113 9 p13.3 galactose-1-phosphateuridyltransferase Source: HGNC Symbol; Acc: 4135] 225919_s_at C9orf72ENSG00000147894 0.043475 0.8552519 8.18141 7.326158 9 p21.2 chromosome 9open reading frame 72 Source: HGNC Symbol; Acc: 28337] 36711_at MAFFENSG00000185022 0.043475 1.042386 5.605979 4.563593 22 q13.1 v-maf avianmusculoaponeurotic fibrosarcoma oncogene homolog F [Source: HGNC Symbol;Acc: 6780] 205174_s_at QPCT ENSG00000115828 0.043531 1.2617245 8.4185997.156874 2 p22.2 glutaminyl-peptide cyclotransferase Source: HGNCSymbol; Acc: 97531 225032_at FNDC3B ENSG00000075420 0.043657 1.14811179.690617 8.542506 3 q26.31 fibronectin type III domain containing 3B[Source: HGNC Symbol; Acc: 46701 225283_at ARRDC4 ENSG000001404500.043675 1.2632774 6.919418 5.656141 15 q26.6 arrestin domain containing4 Source: HGNC Symbol; Acc: 28087] 212820_at DMXL2 ENSG000001040930.043693 1.7237553 9.098754 7.374999 15 q21.2 Dmx-like 2 [Source: HGNCSymbol; Acc: 2938] 202411_at IFI27 ENSG00000165949 0.043693 1.419904510.65301 9.233109 14 q32.12 interferon, alpha-inducible protein 27[Source: HGNC Symbol; Acc: 5397] 201444_s_at ATP6AP2 ENSG000001822200.043693 0.8481282 9.927791 9.079663 X p11.4 ATPase, H transporting,lysosomal accessory protein 2 [Source: HGNC Symbol; Acc: 18305]212209_at MED13L ENSG00000123066 0.043693 0.718689 7.683203 6.964514 12q24.21 mediator complex subunit 13-like[Source: HGNC Symbol; Acc: 22962]228082_at CLMP ENSG00000166250 0.043693 0.811086 8.019361 7.208275 11q24.1 CXADR-like membrane protein Source: HGNC Symbol; Acc: 24039]201579_at FAT1 ENSG00000083857 0.043693 1.1996966 6.984438 5.784741 4q35.2 FAT atypical cadherin 1 [Source: HGNC Symbol; Acc: 3595] 201050_atPLD3 ENSG00000105223 0.043739 0.872713 11.22151 10.34879 19 q13.2phospholipase D family, member 3 [Source: HGNC Symbol; Acc: 17158]205726_at DIAPH2 ENSG00000147202 0.043865 0.8243238 7.524442 6.700118 Xq21.33 diaphanous-related formin 2 [Source: HGNC Symbol; Acc: 2877]212717_at PLEKHM1 ENSG00000225190 0.043869 0.3500827 8.468551 8.11846917 q21.31 pleckstrin homology domain containing, family M (with RUNdomain) member 1 [Source: HGNC Symbol; Acc: 29017] 202827_s_at MMP14ENSG00000157227 0.04395 1.0934303 9.702738 8.609308 14 q11.2 matrixmetallopepticiase 14 (membrane-inserted) [Source: HGNC Symbol; Acc:7160] 201594_s_at PPP4R1 ENSG00000154845 0.04395 0.8180394 9.2741198.456079 18 p11.22 protein phosphatase 4, regulatory subunit 1 [Source:HGNC Symbol; Acc: 9320] 203460_s_at PSEN1 ENSG00000080815 0.043950.8139024 8.845797 8.031895 14 q24.2 presenilin 1[Source: HGNC Symbol;Acc: 95081 221840_at PTPRE ENSG00000132334 0.044017 1.2948506 8.8856387.590787 10 q26.2 protein tyrosine phosphatase, receptor type, E[Source: HGNC Symbol; Acc: 9669] 203410_at AP3M2 ENSG000000707180.044043 0.7683391 7.036583 6.268244 8 p11.21 adaptor-related proteincomplex 3, mu 2 subunit [Source: HGNC Symbol; Acc: 570] 226582_atLOC400043 NA 0.044043 0.8694792 6.734431 5.864952 NA NA NA 209600_s_atACOX1 ENSG00000161533 0.044043 0.6483325 8.512058 7.863726 17 q25.1acyl-CoA oxidase 1, palmitoyl [Source: HGNC Symbol; Acc: 119] 221814_atGPR124 ENSG00000020181 0.044043 1.0958806 8.488648 7.392767 8 p11.23 Gprotein-coupled receptor 124 [Source: HGNC Symbol; Acc: 17849] 230836_atST8SIA4 ENSG00000113532 0.044043 1.0174978 7.57919 6.561693 5 q21.1 ST8alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [Source: HGNCSymbol; Acc: 10871] 204270_at SKI ENSG00000157933 0.044043 0.89603519.220481 8.324446 1 p36.33 v-ski avian sarcoma viral oncogene homolog[Source: HGNC Symbol; Acc: 10896] 200872_at S100A10 ENSG000001977470.044043 0.8622314 12.14558 11.28335 1 q21.3 S100 calcium bindingprotein A10 [Source: HGNC Symbol; Acc: 10487] 219761_at CLEC1AENSG00000150048 0.044043 1.2912893 6.704346 5.413057 12 p13.2 C-typelectin domain family 1, member A [Source: HGNC Symbol; Acc: 24355]212708_at MSL1 ENSG00000188895 0.044043 0.8560698 9.529726 8.673656 17q21.1 male-specific lethal 1 homolog (Drosophila) [Source: HGNC Symbol;Acc: 27905] 204326_x_at MT1X ENSG00000187193 0.04407 1.0017293 10.864859.863125 16 q13 metallothionein 1X [Source: HGNC Symbol; Acc: 7405]241392_at TMEM39A ENSG00000176142 0.04407 0.341471 6.928602 6.587131 3q13.33 transmembrane protein 39A [Source: HGNC Symbol; Acc: D600]205771_s_at AKAP7 ENSG00000118507 0.04407 0.7319958 6.526725 5.794729 6q23.2 A kinase (PRKA) anchor protein 7 [Source: HGNC Symbol; Acc: 377]206227_at CILP ENSG00000138615 0.04407 2.2575028 8.735998 6.478495 15q22.31 cartilage intermediate layer protein, nucleotidepyrophosphohydrolase [Source: HGNC Symbol; Acc: 1980] 204158_s_at TORG1ENSG00000110719 0.04407 0.5930798 9.597157 9.004077 11 q13.2 T-cell,immune regulator 1, ATPase, H transporting, lysosomal V0 subunit A3[Source: HGNC Symbol; Acc: 11647] 212948_at CAMTA2 ENSG000001085090.04407 0.5383882 9.486336 8.947948 17 p13.2 calmodulin bindingtranscription activator 2 [Source: HGNC Symbol; Acc: 18807] 218241_atGOLGA5 ENSG00000066455 0.044078 0.5034783 7.912464 7.408985 14 q32.12golgin A5 [Source: HGNC Symbol; Acc: 4428] 203042_at LAMP2ENSG00000005893 0.044078 1.3866138 9.189891 7.803278 X q24lysosomal-associated membrane protein 2 [Source: HGNC Symbol; Acc: 6501]223264_at MESDC1 ENSG00000140406 0.044215 0.6585783 8.668695 8.010116 15q25.1 mesoderm development candidate 1 [Source: HGNC Symbol; Acc: 13519]243141_at SGMS2 ENSG00000164023 0.044313 1.0856346 5.816519 4.730885 4q25 sphingomyelin synthase 2 [Source: HGNC Symbol; Acc: 28395]212513_s_at USP33 ENSG00000077254 0.044313 0.8692058 8.910601 8.041395 1p31.1 ubiquitin specific peptidase 33 [Source: HGNC Symbol; Acc: 20059]44111_at VPS33B ENSG00000184056 0.044313 0.7185294 7.769682 7.051153 15q26.1 vacuolar protein sorting 33 homolog B (yeast) [Source: HGNCSymbol; Acc: 12712] 203044_at CHSY1 ENSG00000131873 0.044778 0.86031299.374891 8.514578 15 q26.3 chondroitin sulfate synthase 1 [Source: HGNCSymbol; Acc: 17198] 201133_s_at PJA2 ENSG00000198961 0.045063 0.92885148.789327 7.860476 5 q21.3 praja ring finger 2, E3 ubiquitin proteinligase [Source: HGNC Symbol; Acc: 17481] 238478_at BNC2 ENSG000001730680.045109 1.5819289 6.500666 4.918737 9 p22.2 basonuclin 2 [Source: HGNCSymbol; Acc: 30988] 207121_s_at MAPK6 ENSG00000069956 0.045217 0.97196149.250325 8.278364 15 q21.2 mitogen-activated protein kinase 6 [Source:HGNC Symbol; Acc: 6879] 226757_at IFIT2 ENSG00000119922 0.0452171.2581633 7.398381 6.140218 10 q23.31 interferon-induced protein withtetratricopeptide repeats 2 [Source: HGNC Symbol; Acc: 5409] 224929_atTMEM173 ENSG00000184584 0.045217 0.9769018 8.795662 7.81876 5 q31.2transmembrane protein 173 [Source: HGNC Symbol; Acc: 27962] 219013_atGALNT11 ENSG00000178234 0.045217 0.6247652 8.111616 7.486851 7 q22.31UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) [Source: HGNC Symbol;Acc: 19875] 203732_at TRIP4 ENSG00000103671 0.045217 0.5349917 8.2827647.747772 15 q22.31 thyroid hormone receptor interactor 4 [Source: HGNCSymbol; Acc: 12310] 206991_s_at CCR5 ENSG00000160791 0.045321 1.49889988.807196 7.308296 3 p21.31 chemokine (C-C motif) receptor 5(gene/pseudogene) [Source: HGNC Symbol; Acc: 1606] 212192_at KCTD12ENSG00000178695 0.045321 1.241112 11.04262 9.801504 13 q22.3 potassiumchannel tetramerization domain containing 12 [Source: HGNC Symbol; Acc:14678] 212071_s_at SPTBN1 ENSG00000115306 0.045389 1.1482987 10.508399.360088 2 p16.2 spectrin, beta, non-erythrocytic 1 [Source: HGNCSymbol; Acc: 11275] 204194_at BACH1 ENSG00000156273 0.045389 0.68449547.33134 6.646344 21 q21.3 BTB and CNC homology 1, basic leucine zippertranscription factor 1 [Source: HGNC Symbol; Acc: 935] 213469_at PGAP1ENSG00000197121 0.045389 0.8013379 4.677932 3.876544 2 q33.1 post-GPIattachment to proteins 1 [Source: HGNC Symbol; Acc: 25712] 207173_x_atCDH11 ENSG00000140937 0.045389 1.855492 9.112093 7.256601 16 q21cadherin 11, type 2, OB-cadherin (osteoblast) [Source: HGNC Symbol; Acc:1750] 202020_s_at LANCL1 ENSG00000115365 0.045389 0.7225894 9.1849468.462357 2 q34 LanC lantibiotic synthetase component C- like 1(bacterial) [Source: HGNC Symbol; Acc: 6508] 201384_s_at NBR1ENSG00000188554 0.045622 0.6971938 9.452834 8.75564 17 q21.31 neighborof BRCA1 gene 1 [Source: HGNC Symbol; Acc: 6746] 213004_at ANGPTL2ENSG00000136859 0.04565 1.4882714 9.435206 7.946935 9 q33.3angiopoietin-like 2 [Source: HGNC Symbol; Acc: 490] 203310_at STXBP3ENSG00000116266 0.045775 0.7707987 7.721639 6.950841 1 p13.3 syntaxinbinding protein 3 [Source: HGNC Symbol; Acc: 11446] 212239_at PIK3R1ENSG00000145675 0.045775 0.7377508 9.025386 8.287636 5 q13.1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source: HGNCSymbol; Acc: 8979] 225864_at FAM84B ENSG00000168672 0.045775 1.67791476.194231 4.516317 8 q24.21 family with sequence similarity 84, member B[Source: HGNC Symbol; Acc: 24166] 218679_s_at VPS28 ENSG000001609480.04581 0.3909079 9.69126 9.300352 8 q24.3 vacuolar protein sorting 28homolog (S. cerevisiae) [Source: HGNC Symbol; Acc: 18178] 211964_atCOL4A2 ENSG00000134871 0.045857 1.2328119 10.70556 9.472749 13 q34collagen, type IV, alpha 2 [Source: HGNC Symbol; Acc: 2203] 212501_atCEBPB ENSG00000172216 0.045857 0.7382385 10.55473 9.816494 20 q13.13CCAAT/enhancer binding protein (C/EBP), beta [Source: HGNC Symbol; Acc:1834] 215596_s_at LTN1 ENSG00000198862 0.045857 0.6006951 9.1231468.522451 21 q21.3 listerin E3 ubiquitin protein ligase 1 [Source: HGNCSymbol; Acc: 13032] 235306_at GIMAP8 ENSG00000171115 0.045949 1.14152327.866982 6.725458 7 q36.1 GTPase, IMAP family member 8 [Source: HGNCSymbol; Acc: 21792] 213746_s_at FLNA ENSG00000196924 0.045983 0.670976410.55453 9.883554 X q28 filamin A, alpha [Source: HGNC Symbol; Acc:3754] 200982_s_at ANXA6 ENSG00000197043 0.045983 0.9677565 9.8523058.884549 5 q33.1 annexin A6 [Source: HGNC Symbol; Acc: 544] 227029_atFAM177A1 ENSG00000151327 0.046043 0.8330088 6.455042 5.622033 14 q13.2family with sequence similarity 177 member A1 [Source: HGNC Symbol; Acc:19829] 225695_at SLC35F6 ENSG00000213699 0.046225 0.7246104 9.0244138.299803 2 p23.3 solute carrier family 35, member F6 [Source: HGNCSymbol; Acc: 26055] 230263_s_at DOCK5 ENSG00000147459 0.046636 0.98416855.975225 4.991057 8 p21.2 dedicator of cytokinesis 5 [Source: HGNCSymbol; Acc: 23476] 219860_at LY6G5C ENSG00000204428 0.04666 0.49883696.319773 5.820936 6 p21.33 lymphocyte antigen 6 complex, locus G5C[Source: HGNC Symbol; Acc: 13932] 216620_s_at ARHGEF10 ENSG000001047280.04666 1.0059164 8.015577 7.009661 8 p23.3 Rho guanine nucleotideexchange factor (GEF) 10 [Source: HGNC Symbol; Acc: 14103] 209298_s_atITSN1 ENSG00000205726 0.046712 1.2772025 5.880818 4.603616 21 q22.11intersectin 1 (SH3 domain protein) [Source: HGNC Symbol; Acc: 6183]219383_at PRR5L ENSG00000135362 0.046712 0.8741436 4.47531 3.601166 11p13 proline rich 5 like [Source: HGNC Symbol; Acc: 25878] 218204_s_atFYCO1 ENSG00000163820 0.046712 0.4753249 7.84106 7.365735 3 p21.31 FYVEand coiled-coil domain containing 1 [Source: HGNC Symbol; Acc: 14673]212637_s_at WWP1 ENSG00000123124 0.046712 0.9223494 7.411309 6.48896 8q21.3 WW domain containing E3 ubiquitin protein ligase 1, [Source: HGNCSymbol; Acc: 17004] 200784_s_at LRP1 ENSG00000123384 0.046712 0.835469410.71172 9.876255 12 q13.3 low density lipoprotein receptor-relatedprotein 1 [Source: HGNC Symbol; Acc: 6692] 202668_at EFN82ENSG00000125266 0.046712 1.3006186 7.729295 6.428677 13 q33.3 ephrin-B2[Source: HGNC Symbol; Acc: 3227] 211926_s_at MYH9 ENSG000001003450.046851 0.5140278 10.37284 9.858809 22 q12.3 myosin, heavy chain 9,non-muscle [Source: HGNC Symbol; Acc: 7579] 207181_s_at CASP7ENSG00000165806 0.046856 0.8773186 8.172928 7.295609 10 q25.3 caspase 7,apoptosis-related cysteine peptidase (Source: HGNC Symbol; Acc: 1508]203940_s_at VASH1 ENSG00000071246 0.046904 0.759053 8.993567 8.234514 14q24.3 vasohibin 1 [Source: HGNC Symbol; Acc: 19964] 225046_at LOC389831NA 0.046904 1.209299 9.502744 8.293445 NA NA NA 229699_at LOC1001295 NA0.046904 0.7875228 7.252125 6.464602 NA NA NA 50 1555997_s_at IGFBP5ENSG00000115461 0.046904 2.0893027 9.039541 6.950238 2 q36 insulin-likegrowth factor binding protein 5 [Source: HGNC Symbol; Acc: 5474]221858_at TBC1D12 ENSG00000108239 0.046904 0.9754493 6.730089 5.75464 10q23.33 TBC1 domain family, member 12 [Source: HGNC Symbol; Acc: 29082]202123_s_at ABL1 ENSG00000097007 0.046904 0.5359328 8.956464 8.420531 9q34.12 c-abl oncogene 1, non-receptor tyrosine kinase (Source: HGNCSymbol; Acc: 76] 209189_at FOS ENSG00000170345 0.046904 2.31139538.928569 6.617174 14 q24.3 FBJ murine osteosarcoma viral oncogenehomolog (Source: HGNC Symbol; Acc: 3796] 231697_s_at VMP1ENSG00000062716 0.046904 1.3376767 9.338249 8.000572 17 q23.1 vacuolemembrane protein 1 [Source: HGNC Symbol; Acc: 29559] 231823_s_atSH3PXD28 ENSG00000174705 0.046907 1.3421906 8.749657 7.407467 5 q35.1SH3 and PX domains 2B [Source: HGNC Symbol; Acc: 29242] 226917_s_atANAPC4 ENSG00000053900 0.046907 0.7157989 9.420943 8.705144 4 p15.2anaphase promoting complex subunit 4 [Source: HGNC Symbol; Acc: 19990]213135_at TIAM1 ENSG00000156299 0.04696 1.432496 8.128731 6.696235 21q22.11 T-cell lymphoma invasion and metastasis 1 [Source: HGNC Symbol;Acc: 11805] 222793_at DDX58 ENSG00000107201 0.046977 0.7930309 6.8970656.104034 9 p21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [Source: HGNCSymbol; Acc: 19102] 235059_at RAB12 ENSG00000206418 0.047161 0.73616978.288455 7.552285 18 p11.22 RAB12, member RAS oncogene family [Source:HGNC Symbol; Acc: 31332] 213364_s_at SNX1 ENSG00000028528 0.0473580.9413216 7.632326 6.691004 15 q22.31 sorting nexin 1 [Source: HGNCSymbol,Acc: 11172] 213194_at ROBO1 ENSG00000169855 0.047358 1.20236488.299204 7.09684 3 p12.2 roundabout, axon guidance receptor, homolog 1(Drosophila) [Source: HGNC Symbol; Acc: 10249] 223434_at G6P3ENSG00000117226 0.047368 1.7670063 8.155929 6.388923 1 p22.2 guanylatebinding protein 3 (Source: HGNC Symbol; Acc: 4184] 201464_x_at JUNENSG00000177606 0.047577 1.4116477 9.379206 7.967558 1 p32.1 junproto-oncogene [Source: HGNC Symbol; Acc: 6204] 228325_at KIAA0146 NA0.047577 1.6371158 6.878768 5.241652 NA NA NA 226639_at SFT2D3ENSG00000173349 0.04777 0.4029701 7.472242 7.069272 2 q14.3 SFT2 domaincontaining 3 [Source: HGNC Symbol; Acc: 28767] 204204_at SLC31A2ENSG00000136867 0.047785 1.078147 7.858562 6.780415 9 q32 solute carrierfamily 31 (copper transporter), member 2 [Source: HGNC Symbol; Acc:11017] 213659_at ZNF75D ENSG00000186376 0.047785 0.6654956 7.8596047.194108 X q26.3 zinc finger protein 75D [Source: HGNC Symbol; Acc:13145] 219165_at PDLIM2 ENSG00000120913 0.047738 0.5378302 8.6598298.121999 8 p21.3 PDZ and LIM domain 2 (mystique) [Source: HGNC Symbol;Acc: 13992] 202704_at TOB1 ENSG00000141232 0.047841 1.1577332 7.8648736.707139 17 q21.33 transducer of EREB2, 1 [Source: HGNC Symbol; Acc:11979] 201059_at CTTN ENSG00000085733 0.047841 1.13298 8.126829 6.99384911 q13.3 cortactin [Source: HGNC Symbol; Acc: 3338] 208626_s_at VAT1ENSG00000108828 0.047843 0.9455257 10.23981 9.294287 17 q21.31 vesicleamine transport protein 1 homolog (T. californica) [Source: HGNC Symbol;Acc: 16919] 224285_at GPR174 ENSG00000147138 0.047886 1.197457 7.9617166.764259 X 821.1 G protein-coupled receptor 174 [Source: HGNC Symbol;Acc: 30245] 202746_at ITM2A ENSG00000078596 0.047974 1.7562969 8.5556596.799362 X q21.1 integral membrane protein 2A [Source: HGNC Symbol; Acc:6173] 1557749_at EHBP1L1 ENSG00000173442 0.047976 1.3008188 7.3760986.075279 11 q13.1 EH domain binding protein 1-like 1 [Source: HGNCSymbol; Acc: 30682] 208671_at SERINC1 ENSG00000111897 0.047976 0.97260958.57887 7.606261 6 q22.31 serine incorporator 1 [Source: HGNC Symbol;Acc: 13464] 235199_at RNF125 ENSG00000101695 0.048039 1.0642075 7.0656926.001485 18 q12.1 ring finger protein 125, E3 ubiquitin protein ligase[Source: HGNC Symbol; Acc: 21150] 236565_s_dt LARP6 ENSG000001661730.048103 0.6843004 5.230392 4.546092 15 q23 La ribonucleoprotein domainfamily, member 5 [Source: HGNC Symbol; Acc: 24012] 204575_s_at MMP19ENSG00000123342 0.048165 0.946556 7.578627 6.632071 12 q13.2 matrixmetallopeptidase 19 [Source: HGNC Symbol; Acc: 7165] 221653_x_at APOL2ENSG00000128335 0.048165 0.5885832 10.11617 9.527585 22 q12.3apolipoprotein L, 2 [Source: HGNC Symbol; Acc: 619] 224804_s_at FAM219BENSG00000178761 0.048165 0.6515628 8.895176 8.243613 15 q24.1 familywith sequence similarity 219, member B [Source: HGNC Symbol; Acc: 24695]202820_at AHR ENSG00000106546 0.048165 1.1914252 8.43326 7.241835 7p21.1 aryl hydrocarbon receptor [Source: HGNC Symbol; Acc: 348]204082_at PBX3 ENSG00000167081 0.048165 0.6358091 8.576776 7.940967 9q33.3 pre-B-cell leukemia homeobox 3 [Sourc.e: HGNC Symbol; Acc: 8634]218109_s_at MFSD1 ENSG00000118855 0.048305 1.1396733 10.13941 8.999736 3q25.32 major facilitator superfamily domain containing 1 [Source: HGNCSymbol; Acc: 25874] 231897_at PTGR1 ENSG00000106853 0.048305 1.15489127.789451 6.63456 9 q31.3 prostaglandin reductase 1 [Source: HGNC Symbol;Acc: 18429] 205786_s_at ITGAM ENSG00000169896 0.048306 1.13780788.121972 6.984164 16 p11.2 integrin, alpha M (complement component 3receptor 3 subunit) [Source: HGNC Symbol; Acc: 6149] 203510_at METENSG00000105976 0.048306 1.6502092 7.842579 6.19237 7 q31.2 metproto-oncogene [Source: HGNC Symbol; Acc: 7029] 224896_s_at TTLENSG00000114999 0.048306 0.5603672 8.810442 8.250075 2 q13 tubulintyrosine ligase [Source: HGNC Symbol; Acc: 21586] 232645_at LOC153684 NA0.048306 0.888957 7.159878 6.270921 NA NA NA 226576_at ARHGAP26ENSG00000145819 0.048306 0.8225882 6.112706 5.290117 5 q31.3 Rho GTPaseactivating protein 26 [Source: HGNC Symbol; Acc: 17073] 219191_s_at BIN2ENSG00000110934 0.048306 1.0978185 9.340657 8.242838 12 q13.13 bridgingintegrator 2 [Source: HGNC Symbol; Acc: 1053] 214853_s_at SHC1ENSG00000160691 0.048306 0.5806619 10.02587 9.445211 1 q21.3 SHC (Srchomology 2 domain containing) transforming protein 1 [Source: HGNCSymbol; Acc: 10840] 224358_s_at MS4A7 ENSG00000166927 0.048314 2.0668818.506524 6.439643 11 q12.2 membrane-spanning 4-domains, subfamily A,member 7 [Source: HGNC Symbol; Acc: 13378] 209164_s_at CYB561ENSG00000008283 0.04856 0.8626733 8.334774 7.472101 17 q23.3 cytochromeb561 [Source: HGNC Symbol; Acc: 2571] 222175_s_at MED15 ENSG000000999170.04856 0.4451901 9.6034 9.15821 22 q11.21 mediator complex subunit 15[Source: HGNC Symbol; Acc: 14248] 219469_at DYNC2H1 ENSG000001872400.04857 0.6595986 6.55585 5.896251 11 q22.3 dynein, cytoplasmic 2, heavychain 1 [Source: HGNC Symbol; Acc: 2962] 226143_at RAI1 ENSG000001085570.04857 1.2083934 8.541448 7.333054 17 p11.2 retinoic acid induced 1[Source: HGNC Symbol; Acc: 9834] 212681_at EPB41L3 ENSG000000823970.048619 1.3472919 8.071549 6.724257 18 p11.31 erythrocyte membraneprotein band 4.1-like 3 [Source: HGNC Symbol; Acc: 3380] 215784_at CD1EENSG00000158488 0.04871 1.1453683 5.448261 4.302893 1 q23.1 CD1emolecule [Source: HGNC Symbol; Acc: 1638] 211161_s_at COL3A1ENSG00000168542 0.04871 2.0294663 11.58326 9.553789 2 q32.2 collagen,type III, alpha 1 [Source: HGNC Symbol; Acc: 2201] 209906_at C3AR1ENSG00000171860 0.04881 1.1815832 9.984971 8.803387 12 p13.31 complementcomponent 3a receptor 1 [Source: HGNC Symbol; Acc: 1319] 200625_s_atCAP1 ENSG00000131236 0.048952 0.8385932 11.78723 10.94863 1 p34.2 CAP,adenylate cyclase-associated protein 1 (yeast) [Source: HGNC Symbol;Acc: 20040] 209550_at NDN ENSG00000182636 0.048952 0.8892051 8.5859217.696716 15 q11.2 necdin, melanoma antigen (MAGE) family member [Source:HGNC Symbol; Acc: 7675] 214039_s_at LAPTM4B ENSG00000104341 0.0489741.6628259 7.882224 6.219398 8 q22.1 lysosomal protein transmembrane 4beta [Source: HGNC Symbol; Acc: 13646] 209356_x_at EFEMP2ENSG00000172638 0.049064 0.7587052 8.007888 7.249183 11 q13.1 EGFcontaining fibulin-like extracellular matrix protein 2 [Source: HGNCSymbol; Acc: 3219] 207276_at CDR1 ENSG00000181258 0.049178 1.89259469.606612 7.714017 X q27.1 cerebellar degeneration-related protein 1, 34kDa [Source: HGNC Symbol; Acc: 1798] 209955_s_at FAP ENSG000000780980.049178 1.4777063 8.251596 6.77389 2 q24.2 fibroblast activationprotein, alpha [Source: HGNC Symbol; Acc: 3590] 226844_at MOB38ENSG00000120162 0.049203 1.1637648 6.92211 5.758345 9 p21.2 MOB kinaseactivator 3B [Source: HGNC Symbol; Acc: 23825] 222468_at KIAA0319LENSG00000142687 0.049203 0.3011724 8.203036 7.901864 1 p34.3KIAA0319-like [Source: HGNC Symbol; Acc: 30071] 226056_at ARHGAP31ENSG00000031081 0.049247 0.7875162 8.433132 7.645616 3 q13.33 Rho GTPaseactivating protein 31 [Source: HGNC Symbol; Acc: 29216] 226695_at PRRX1ENSG00000116132 0.049316 1.7627347 9.80378 8.041045 1 q24.2 pairedrelated homeobox 1 [Source: HGNC Symbol; Acc: 9142] 204844_at ENPEPENSG00000138792 0.049442 0.6595157 4.491515 3.831999 4 q25 glutamylaminopeptidase(aminopeptidase A) [Source: HGNC Symbol; Acc: 3355]200612_s_at AP2B1 ENSG00000006125 0.049442 0.5957471 8.555796 7.96004917 q12 adaptor-related protein complex 2, beta 1 subunit [Source: HGNCSymbol; Acc: 563] 200923_at LGALS3BP ENSG00000108679 0.049442 0.921133410.07362 9.152489 17 q25.3 lectin, galactoside-binding, soluble, 3binding protein [Source: HGNC Symbol; Acc: 6564] 208074_s_at AP2S1ENSG00000042753 0.049593 0.5957933 10.51239 9.916594 19 q13.32adaptor-related protein complex 2, sigma 1 subunit [Source: HGNC Symbol;Acc: 565] 200897_s_at PALLD ENSG00000129116 0.049599 1.6018945 9.5261297.924234 4 q32.3 palladin, cytoskeletal associated protein [Source: HGNCSymbol; Acc: 17068] 209667_at CES2 ENSG00000172831 0.049599 0.51279098.055154 7.542363 16 q22.1 carboxylesterase 2 [Source: HGNC. Symbol;Acc: 1864] 225785_at REEP3 ENSG00000165476 0.049649 1.1129933 7.2496496.136656 10 q21.3 receptor accessory protein 3 [Source: HGNC Symbol;Acc: 23711] 227265_at FGL2 ENSG00000127951 0.049649 1.7680217 9.4642037.696181 7 q11.23 fibrinogen-like 2 [Source: HGNC Symbol; Acc: 3696]226679_at SLC26A11 ENSG00000181045 0.049649 1.3774827 8.62206 7.24457717 q25.3 solute carrier family 26, member 11 [Source: HGNC Symbol; Acc:14471] 202441_at ERLIN1 ENSG00000107566 0.049691 0.5854142 8.6192488.033834 10 q24.31 ER lipid raft associated 1 [Source: HGNC Symbol; Acc:16947] 227758_at RERG ENSG00000134533 0.049698 1.1309377 5.7898534.658915 12 p12.3 RAS-like, estrogen-regulated, growth inhibitor[Source: HGNC Symbol; Acc: 15980] 204036_at LPAR1 ENSG000001981210.049814 1.4440394 6.674595 5.230556 9 q31.3 lysophosphatidic acidreceptor 1 [Source: HGNC Symbol; Acc: 3166] 225755_at KLHDC8BENSG00000185909 0.049849 0.8512009 8.005692 7.154491 3 p21.31 kelchdomain containing 8B [Source: HGNC Symbol; Acc: 28557] 209571_at CIR1ENSG00000138433 0.049849 0.3762687 8.299113 7.922845 2 q31.1 corepressorinteracting with RBPJ, 1 [Source: HGNC Symbol; Acc: 24217] 210184_atITGAX ENSG00000140678 0.049853 1.1127795 8.872884 7.760104 16 p11.2integrin, alpha X (complement component 3 receptor 4 subunit) [Source:HGNC Symbol; Acc: 6152] 217940_s_at CARKD ENSG00000213995 0.0498530.4806867 8.908728 8.428041 13 q34 carbohydrate kinase domain containing[Source: HGNC Symbol; Acc: 25576] 212993_at NACC2 ENSG000001484110.050115 1.1149639 7.888032 6.773068 9 q34.3 NACC family member 2, BENand BTB (POZ) domain containing [Source: HGNC Symbol; Acc: 23846]1562876_s_at LOC541471 NA 0.050218 0.6825624 3.603678 2.921115 NA NA NA242268_at CELF2 ENSG00000048740 0.050218 1.5536681 7.210053 5.656385 10p14 CNC: BP, Elav-like family member 2 [Source: HGNC Symbol; Acc: 2550]213125_at OLFML2B ENSG00000162745 0.050218 0.7874654 8.741576 7.95411 1q23.3 olfactomedin-like 2B [Source: HGNC Symbol; Acc: 24558] 221257_x_atFBXO38 ENSG00000145868 0.050301 0.5976252 7.698195 7.10057 5 q32 F-boxprotein 38 [Source: HGNC Symbol; Acc: 28844] 236782_at SAMD3ENSG00000164483 0.0504 1.0727407 7.59099 6.51825 6 q23.1 sterile alphamotif domain containing 3 [Source: HGNC Symbol; Acc: 21574] 1554690_a_atTACC1 ENSG00000147526 0.050506 1.079368 9.700335 8.620967 8 p11.22transforming, acidic coiled-coil containing protein 1 [Source: HGNCSymbol; Acc: 11522] 203431_s_at ARHGAP32 ENSG00000134909 0.0505191.2383399 6.793821 5.555481 11 q24.3 Rho GTPase activating protein 32[Source: HGNC Symbol; Acc: 17399] 226711_at FOXN2 ENSG000001708020.050636 0.9371015 9.838676 8.901574 2 p16.3 forkhead box N2 [Source:HGNC SymbOL; Acc: 5281] 203562_at FEZ1 ENSG00000149557 0.0506361.4246364 7.169091 5.744454 11 q24.2 fasciculation and elongationprotein zeta 1 (zygin I) [Source: HGNC Symbol; Acc: 36591 201508_atIGFBP4 ENSG00000141753 0.050636 1.2181533 10.95048 9.732328 17 q21.2insulin-like growth factor binding protein 4 [Source: HGNC Symbol; Acc:5473] 209933_s_at CD300A ENSG00000167851 0.050888 1.0639508 8.65367.589649 17 q25.1 CD300a molecule [Source: HGNC Symbol; Acc: 19319]226751_at CNRIP1 ENSG00000119865 0.050983 1.0463666 7.446207 6.39984 2p14 cannabinoid receptor interacting protein 1 [Source: HGNC Symbol;Acc: 24546] 203303_at DYNLT3 ENSG00000165169 0.050983 0.8389781 9.4797028.640724 X p11.4 dynein, light chain, Tctex-type 3 [Source: HGNC Symbol;Acc: 11694] 1556698_a_at GPRIN3 ENSG00000185477 0.050983 1.21533766.331782 5.116444 4 q22.1 GPRIN family member 3 [Source: HGNC Symbol;Acc: 27733] 223454_at CXCL16 ENSG00000161921 0.050983 0.9870947 9.7550653.76797 17 p13.2 chemokine (C-X-C motif) ligand 16 [Source: HGNC Symbol;Acc: 16642] 20203_s_at MAN2A2 ENSG00000196547 0.050983 0.88589199.564687 8.678795 15 q26.1 mannosidase, alpha, class 2A, member 2[Source: HGNC Symbol Acc: 6825] 205779_at RAMP2 ENSG00000131477 0.0511560.9338225 8.483655 7.549832 17 q21.31 receptor (G protein-coupled)activity modifying protein 2 [Source: HGNC Symbol; Acc: 9844]209110_s_at RGL2 ENSG00000237441 0.051156 0.6625429 8.743822 8.081279 6p21.32 ral guanine nucleotide dissociation stimulator-like 2 [Source:HGNC Symbol; Acc: 9769] 209935_at ATP2C1 ENSG00000017260 0.0511560.6570157 6.368275 5.71126 3 q22.1 ATPase, Ca 

  transporting, type 2C, member 1 [Source: HGNC Symbol; Acc: 13211]214453_s_at IFI44 ENSG00000137965 0.051156 1.6331853 9.486684 7.853498 1p31.1 interferon-induced protein 44 [Source: HGNC Symbol; Acc: 16938]201063_at RCN1 ENSG00000049449 0.051233 0.7028097 9.216223 8.513413 11p13 reticulocalbin 1, EF-hand calcium binding domain [Source: HGNCSymbol; Acc: 9934] 213222_at PLCB1 ENSG00000182621 0.051361 0.70047544.53598 3.835504 20 p12.3 phospholipase C, beta 1(phosphoinositide-specific) [Source: HGNC Symbol; Acc: 15917] 201069_atMMP2 ENSG00000087245 0.051361 1.6913538 10.01928 8.32793 16 q12.2 matrixmatallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IVcollagenase) [Source: HGNC Symbol; Acc: 7166] 200661_at CTSAENSG00000064601 0.051361 0.720607 10.64337 9.922764 20 q13.12 cathepsinA [Source: HGNC Symbol; Acc: 9251] 213258_at TFPI ENSG000000034360.051379 1.4194378 8.02985 6.610412 2 q32.1 tissue factor pathwayinhibitor (lipoprotein-associated coagulation inhibitor) [Source: HGNCSymbol; Acc: 11760] 225414_at RNF149 ENSG00000163162 0.051422 0.80467219.11227 8.307597 2 q11.2 ring finger protein 149 [Source: HGNC Symbol;Acc: 23137] 219397_at COQ10B ENSG00000115520 0.051422 0.6544798 7.3599526.705472 2 q33.1 coenzyme Q10 homolog B (S. cerevisiae) [Source: HGNCSymbol; Acc: 25819] 222127_s_at EXOC1 ENSG00000090989 0.051603 0.75436359.746304 8.99194 4 q12 exocyst complex component 1 [Source: HGNC Symbol;Acc: 30380] 223220_s_at PARP9 ENSG00000138496 0.051603 0.97994939.260982 8.281032 3 q21.1 poly (ADP-ribose) polymerase family, member 9[Source: HGNC Symbol; Acc: 24118] 213422_s_at MXRA8 ENSG000001625760.051603 1.2422437 8.999253 7.75701 1 p36.33 matrix-remodellingassociated 8 [Source: HGNC Symbol; Acc: 7542] 203153_at IFIT1ENSG00000185745 0.051753 1.5289266 7.719972 6.191046 10 q23.31interferon-induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol; Acc: 5407] 202100_at RALB ENSG00000144118 0.0518430.6714025 8.880756 8.209353 2 q14.2 v-ral simian leukemia viral oncogenehomolog B [Source: HGNC Symbol; Acc: 9840] 224895_at VAP1ENSG00000137693 0.051946 1.4909459 7.474063 5.983117 11 q22.1Yes-associated protein 1 [Source: HGNC Symbol; Acc: 16262] 201368_atZFP36L2 ENSG00000152518 0.052319 0.9647118 10.56869 9.603976 2 p21 ZFP36ring finger protein-like 2 [Source: HGNC Symbol; Acc: 1108] 212027_atRBM25 ENSG00000119707 0.052384 0.6781906 9.494824 8.816633 14 q24.2 RNAbinding motif protein 25 [Source: HGNC Symbol; Acc: 23244] 221942_s_atGUCY1A3 ENSG00000164116 0.05244 1.3677707 7.987539 6.619768 4 q32.1guanylate cyclase 1, soluble, alpha 3 [Source: HGNC Symbol; Acc: 46 ]213800_at CFH ENSG00000000971 0.05244 1.2322861 7.757237 6.524951 1q31.3 complement factor H [Source: HGNC Symbol; Acc: 4883] 1554999_atRASGEF1B ENSG00000138670 0.052614 1.4173975 6.341497 4.9241 4 q21.22RasGEF domain family, member 1B [Source: HGNC Symbol; Acc: 24881]218606_at ZDHHC7 ENSG00000153786 0.052737 0.3905379 8.928964 8.538426 16q24.1 zinc finger, DHHC-type containing 7 [Source: HGNC Symbol; Acc:18459] 204083_s_at TPM2 ENSG00000198467 0.052794 1.005641 10.065049.059402 9 p13.3 tropomyosin 2 (beta) [Source: HGNC Symbol; Acc: 12011]1553955_at PPP1R21 ENSG00000162869 0.052933 0.8388302 8.37991 7.54108 2p16.3 protein phosphatase 1, regulatory subunit 21 [Source: HGNC Symbol;Acc: 30595] 228083_at CACNA2D4 ENSG00000151062 0.052933 0.8330997.252949 6.41985 12 p13.33 calcium channel, voltage-dependent, alpha2/delta subunit 4 [Source: HGNC Symbol; Acc: 20202] 227304_at SMCR8ENSG00000176994 0.052933 0.7999914 8.377827 7.577836 17 p11.2Smith-Magenis syndrome chromosome region, candidate 8 [Source: HGNCSymbol; Acc: 17921] 225710_at GNB4 ENSG00000114450 0.052933 1.08754048.393035 7.305494 3 q26.33 guanine nucleotide binding protein (Gprotein), beta polypeptide 4 [Source: HGNC Symbol; Acc: 20731] 204154_atCDO1 ENSG00000129596 0.052989 1.1929186 5.120926 3.928008 5 q22.3cysteine dioxygenase type 1 [Source: HGNC Symbol; Acc: 1795] 228318_s_atCRIPAK ENSG00000179979 0.053008 0.5311063 6.682491 6.151384 4 p16.3cysteine-rich PAK1 inhibitor [Source: HGNC Symbol; Acc: 26619] 227013_atLATS2 ENSG00000150457 0.053008 1.1010683 7.793207 6.692139 13 q12.11large tumor suppressor kinase 2 [Source: HGNC Symbol; Acc: 6515]1558692_at C1orf85 ENSG00000198715 0.05311 0.572439 5.400512 4.828073 1q22 chromosome 1 open reading frame 85 [Source: HGNC Symbol; Acc: 29436]213238_at ATP10D ENSG00000145246 0.05311 1.0510381 8.61573 7.564692 4p12 ATPase, class V, type 10D [Source: HGNC Symbol; Acc: 13549]201850_at CAPG ENSG00000042493 0.053135 0.8093839 10.7541 9.944719 2p11.2 capping protein (actin filament), gelsolin-like [Source: HGNCSymbol; Acc: 1474] 209717_at EVIS ENSG00000067208 0.05314 0.71144967.081763 6.370314 1 p22.1 ecotropic viral integration site 5 [Source:HGNC Symbol; Acc: 3501] 227388_at TUSC1 ENSG00000198680 0.0532611.5643673 8.139273 6.574905 9 p21.2 tumor suppressor candidate 1[Source: HGNC Symbol; Acc: 31010] 200771_at LAMC1 ENSG000001358620.053546 0.8858041 8.418292 7.532487 1 q25.3 laminin, gamma 1 (formerlyLAMB2) [Source: HGNC Symbol; Acc: 6492] 229055_at GPR68 ENSG000001197140.053546 0.8377005 9.226091 8.38839 14 q32.11 G protein-coupled receptor68 [Source: HGNC Symbol; Acc: 4519] 200927_s_at RAB14 ENSG000001193960.053624 0.5226401 8.220466 7.697826 9 q33.2 RAB14, member RAS oncogenefamily [Source: HGNC Symbol; Acc: 16524] 225447_at GPD2 ENSG000001151590.053524 0.9677597 8.485215 7.517456 2 q24.1 glycerol-3-phosphatedehydrogenase 2 (mitochondrial) [Source: HGNC Symbol; Acc: 4456]225525_at KIAA1671 ENSG00000197077 0.0538 1.4467482 7.312948 5.866199 22q11.23 KIAA1671 [Source: HGNC Symbol; Acc: 29345] 209649_at STAM2ENSG00000115145 0.053804 0.7574983 7.629712 6.872214 2 q23.3 signaltransducing adaptor molecule (SH3 domain and ITAM motif) 2 [Source: HGNCSymbol; Acc: 11358] 219492_at CHIC2 ENSG00000109220 0.054092 0.67290258.386462 7.713559 4 q12 cysteine-rich hydrophobic domain 2 [Source: HGNCSymbol; Acc: 1935] 1560060_s_at VPS37C ENSG00000167987 0.0541330.5575703 8.463034 7.905464 11 q12.2 vacuolar protein sorting 37 homologC (S. cerevisiae) [Source: HGNC Symbol; Acc: 26097] 217947_at CMTM6ENSG00000091317 0.054172 0.7023048 10.47748 9.775178 3 p22.3 CKLF-likeMARVEL transmembrane domain containing 6 [Source: HGNC Symbol; Acc:19177] 219078_at GPATCH2 ENSG00000092978 0.054197 0.9518562 7.0457366.09388 1 q41 G patch domain containing 2 [Source: HGNC Symbol; Acc:25499] 203854_at CFI ENSG00000205403 0.054292 1.2057395 6.704059 5.498324 q25 complement factor 1 [Source: HGNC Symbol; Acc: 5394] 209637_s_atRGS12 ENSG00000159788 0.054328 0.5021003 7.515978 7.013877 4 p16.3regulator of G-protein signaling 12 [Source: HGNC Symbol; Acc: 9994]202252_at RAB13 ENSG00000143545 0.05435 0.9137575 9.579586 8.665828 1q21.3 RAB13, member RAS oncogene family [Source: HGNC Symbol; Acc: 9762]227373_at ATXN1L ENSG00000224470 0.05435 0.7597165 8.404084 7.644368 16q22.2 ataxin 1-like [Source: HGNC Symbol; Acc: 33279] 207469_s_at PIRENSG00000087842 0.05446 0.663779 6.265059 5.60128 X p22.2 pirin(iron-binding nuclear protein) [Source: HGNC Symbol; Acc: 30048]212543_at AIM1 ENSG00000112297 0.054464 0.7881191 9.68228 8.894161 6 q21absent in melanoma 1 [Source: HGNC Symbol; Acc: 356] 208983_s_at PECAM1NA 0.054524 1.305077 10.69254 9.387459 NA NA NA 226438_at SNTB1ENSG00000172164 0.054649 0.8096096 6.953942 6.144333 8 q24.12syntrophin, beta 1 (dystrophin-associated protein A1, 59 kDa, basiccomponent 1) [Source: HGNC Symbol; Acc: 11168] 201567_s_at GOLGA4ENSG00000144674 0.054737 0.5440613 8.834092 8.29003 3 p22.2 golgin A4[Source: HGNC Symbol; Acc: 4427] 204520_x_at BRD1 ENSG000001004250.054846 0.4383699 9.00874 8.57037 22 q13.33 bromodomain containing 1[Source: HGNC Symbol; Acc: 1102] 217828_at SLTM ENSG00000137776 0.0548460.8307026 8.864809 8.034107 15 q22.1 SAFB-like; transcription modulator[Source: HGNC Symbol; Acc: 20709] 224689_at MANBAL ENSG000001013630.054846 0.3402156 9.457076 9.11686 20 q11.23 mannosidese, beta A,lysosomal-like [Source: HGNC Symbol; Acc: 15799] 219157_at KLHL2ENSG00000109466 0.054893 0.6367528 8.271661 7.634908 4 q32.3 kelch-likefamily member 2 [Source: HGNC Symbol; Acc: 6353] 232024_at GIMAP2ENSG00000105560 0.05502 1.1621322 7.593743 6.431611 7 q36.1 GTPase, IMAPfamily member 2 [Source: HGNC Symbol; Acc: 21789] 219037_at ASPNENSG00000106819 0.055081 1.8444311 7.912112 6.067681 9 q22.31 asporin[Source: HGNC Symbol; Acc: 14872] 213010_at PRKCDBP ENSG000001709550.055081 0.6667374 7.157466 6.490729 11 p15.4 protein kinase C, deltabinding protein [Source: HGNC Symbol; Acc: 9400] 219570_at KIF16BENSG00000089177 0.055081 0.9395247 6.792996 5.853471 20 p12.1 kinesinfamily member 16B [Source: HGNC Symbol; Acc.15869] 214066_x_at NPR2ENSG00000159899 0.055081 0.4995605 7.871515 7.371954 9 p13.3 natriureticpeptide receptor B/guanylate cyclase B (atrionatriuretic peptidereceptor B) [Source: HGNC Symbol; Acc: 7944] 228372_at C10orf128ENSG00000204161 0.055081 1.2282534 8.331788 7.103535 10 q11.23chromosome 10 open reading frame 128 [Source: HGNC Symbol; Acc: 27274]230276_at FAM49A ENSG00000197872 0.055081 1.2864889 6.31294 5.026451 2p24.2 family with sequence similarity 49, member A [Source: HGNC Symbol;Acc: 25373] 203002_at AMOTL2 ENSG00000114019 0.055081 1.3811705 7.6070536.225883 3 q22.2 angiomotin like 2 [Source: HGNC Symbol; Acc: 17812]225688_s_at PHLDB2 ENSG00000144824 0.055081 1.6421107 7.415402 5.7732913 q13.2 pleckstrin homology-like domain, family B, member 2 [Source:HGNC Symbol; Acc: 29573] 1553678_a_at ITGB1 ENSG00000150093 0.0550810.7623281 9.604847 8.842519 10 p11.22 integrin, beta 1 (fibronectinreceptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [Source:HGNC Symbol; Acc: 6153] 203476_at TPBG ENSG00000145242 0.0550811.4028702 8.397859 6.994989 6 q14.1 trophoblast glycoprotein [Source:HGNC Symbol; Acc: 12004] 201180_s_at GNAI3 ENSG00000065135 0.0550810.7164849 9.753543 9.037058 1 p13.3 guanine nucleotide binding protein(G protein), alpha nhibiting activity polypeptide 3 [Source: HGNCSymbol; Acc: 4387] 220141_at C11orf63 ENSG00000109944 0.055081 0.53028915.631726 5.101437 11 q24.1 chromosome 11 open reading frame 63 [Source:HGNC Symbol; Acc: 26283] 227923_at SHANK3 ENSG00000251322 0.0550811.1756261 7.738818 6.563191 22 q13.33 SH3 and multiple ankyrin repeatdomains 3 [Source: HGNC Symbol; Acc: 14294] 235334_at ST6GALNAC3ENSG00000184005 0.055081 0.8325709 5.744061 4.91149 1 p31.1 ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminidealpha-2,6-sialyltransferase 3 [Source: HGNC Symbol; Acc: 19343]235411_at PGBD1 ENSG00000137338 0.055081 0.4549063 5.741778 5.286872 6p22.1 piggyBac transposable element derived 1 [Source: HGNC Symbol; Acc:19398] 216689_x_at ARHGAP1 ENSG00000175220 0.055086 0.5210108 9.7475269.226515 11 p11.2 Rho GTPase activating protein 1 [Source: HGNC Symbol;Acc: 673] 202932_at YES1 ENSG00000176105 0.055086 1.2124045 6.259735.047325 18 p11.32 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1[Source: HGNC Symbol; Acc: 12841] 212293_at HIPK1 ENSG000001633490.055095 0.6908166 7.914422 7.223606 1 p13.2 homeodomain interactingprotein kinase 1 [Source: HGNC Symbol; Acc: 19006] 225618_at ARHGAP27ENSG00000159314 0.055334 0.4730209 7.935837 7.462816 17 q21.31 RhoGTPase activating protein 27 [Source: HGNC Symbol; Acc: 31813]201242_s_at ATP1B1 ENSG00000143153 0.055334 1.2831495 7.126474 5.8433251 q24.2 ATPase, Na>w 

  transporting, beta 1 polypeptide [Source: HGNC Symbol; Acc: 804]203583_at UNC50 ENSG00000115446 0.055334 0.4527831 8.989706 8.536923 2q11.2 unc-50 homolog (C. elegans) [Source: HGNC Symbol; Acc: 16046]1557938_s_at PTRF ENSG00000177469 0.055334 0.8943521 8.2614 7.367048 17q21.2 polymerase land transcript release factor [Source: HGNC Symbol;Acc: 9688] 242321_at PTPN14 ENSG00000152104 0.055342 1.3269817 5.7879954.461014 1 q41 protein tyrosine phosphatase, non-receptor type 14[Source: HGNC Symbol; Acc: 9647] 212950_at GPR116 ENSG000000691220.055342 1.4662875 6.762014 5.295727 6 p12.3 G protein-coupled receptor116 [Source: HGNC Symbol; Acc: 19030] 205639_at AOAH ENSG000001362500.055342 0.6545201 9.612123 8.957603 7 p14.2 acyloxyacyl hydrolase(neutrophil) [Source: HGNC Symbol; Acc: 543] 223209_s_at VIMPENSG00000131871 0.055342 0.8381324 9.523564 8.685432 15 q26.3VCP-interacting membrane protein [Source: HGNC Symbol; Acc: 30396]208131_s_at PTGIS ENSG00000124212 0.055389 1.3212 7.49094 6.16974 20q13.13 prostaglandin 12 (prostacyclin) synthase [Source: HGNC Symbol;Acc: 9603] 227833_s_at MBD6 ENSG00000166987 0.055397 0.7519226 10.51829.766277 12 q13.3 methyl-CpG binding domain protein 6 [Source: HGNCSymbol; Acc: 20445] 208991_at STAT3 ENSG00000168610 0.055397 0.9465879.530425 8.583838 17 q21.2 signal transducer and activator oftranscription 3 (acute-phase response factor) [Source: HGNC Symbol; Acc:11364] 216361_s_at KAT6A ENSG00000083168 0.055397 0.6517457 7.9278727.276126 8 p11.21 K(lysine) acetyltransferase 6A [Source: HGNC Symbol;Acc: 13013] 1554106_at NBEAL1 ENSG00000144426 0.055397 0.66191617.462248 6.800332 2 q33.2 neurobeachin-like 1 [Source: HGNC Symbol; Acc:20631] 209357_at CITED2 ENSG00000164442 0.055397 1.2323825 9.3034958.071112 6 q24.1 Cbp/p300-interacting transactivator, with Glu/Asp-richcarboxy-terminal domain, 2 [Source: HGNC Symbol; Acc: 1987] 53720_atC19orf66 ENSG00000130813 0.055432 0.9673751 9.679982 8.712607 19 p13.2chromosome 19 open reading frame 66 [Source: HGNC Symbol; Acc: 25649]228964_at PRDM1 ENSG00000057657 0.055432 1.9550529 9.250668 7.295615 6q21 PR domain containing 1, with ZNF domain [Source: HGNC Symbol; Acc:9346] 228624_at TMEM144 ENSG00000164124 0.055512 0.8881157 6.8205135.932397 4 q32.1 transmembrane protein 144 [Source: HGNC Symbol; Acc:25633] 225626_at PAG1 ENSG00000076641 0.055625 1.6483207 9.7264928.078172 8 q21.13 phosphoprotein associated with glycosphingolipidmicrodomains 1 [Source: HGNC Symbol; Acc: 30043] 225885_at EEA1ENSG00000102189 0.055625 0.7278215 7.739963 7.012141 12 q22 earlyendosome antigen 1 [Source: HGNC Symbol; Acc: 3135] 236172_at LTB4RENSG00000213903 0.055654 1.0840457 7.387481 6.303435 14 q12 leukotrieneB4 receptor [Source: HGNC Symbol; Acc: 6713] 201953_at CIB1ENSG00000185043 0.055677 0.7092542 9.414667 8.705413 15 q26.1 calciumand integrin binding 1 (calmyrin) [Source: HGNC Symbol; Acc: 16920]213069_at HEG1 ENSG00000173706 0.055677 1.0582971 9.011754 7.953457 3q21.2 heart development protein with EGF-like domains 1 [Source: HGNCSymbol; Acc: 29227] 226885_at RNF217 ENSG00000146373 0.055688 1.50795175.917911 4.409959 6 q22.31 ring finger protein 217 [Source: HGNC Symbol;Acc: 21487] 203038_at PTPRK ENSG00000152894 0.055688 1.5495332 8.0297036.48017 6 q22.33 protein tyrosine phosphatase, receptor type, K [Source:HGNC Symbol; Acc: 9674] 240703_s_at HERC1 ENSG00000103657 0.05570.9617872 6.445278 5.483491 15 q22.31 HECT and RED domain containing E3ubiquitin protein ligase family member 1 [Source: HGNC Symbol; Acc:4867] 221641_s_at ACOT9 ENSG00000123130 0.055792 0.5924097 9.0370418.444631 X p22.11 acyl-CoA thioesterase 9 [Source: HGNC Symbol; Acc:17152] 210845_s_at PLAUR ENSG00000011422 0.055813 0.9963797 8.8660717.869692 19 q13.31 plasminogen activator urokinase receptor [Source:HGNC Symbol; Acc: 9053] 212097_at CAV1 ENSG00000105974 0.0558131.7271465 8.888796 7.16165 7 q31.2 caveolin 1, caveolae protein, 22 kDa[Source: HGNC Symbol; Acc: 1527] 243198_at TEX9 ENSG00000151575 0.0558131.5584665 6.115528 4.557062 15 q21.3 testis expressed 9 [Source: HGNCSymbol; Acc: 29585] 204122_at TYROBP ENSG00000011600 0.055813 1.153345511.48996 10.33661 19 q13.12 TYRO protein tyrosine kinase binding protein[Source: HGNC Symbol; Acc: 12449] 226343_at DPP8 ENSG000000746030.055813 0.6675677 8.292782 7.625214 15 q22.31 dipeptidyl-peptidase 8[Source: HGNC Symbol; Acc: 16490] 205715_at BST1 ENSG000001097430.056096 0.3449558 7.186266 6.84131 4 p15.32 bone marrow stromal cellantigen 1 [Source: HGNC Symbol; Acc: 1118] 211980_at COL4A1ENSG00000187498 0.056096 1.2236466 10.90018 9.676529 13 q34 collagen,type IV, alpha 1 [Source: HGNC Symbol; Acc: 2202] 213572_s_at SERPINB1ENSG00000021355 0.056096 0.8525835 9.44718 8.594597 6 p25.2 serpinpeptidase inhibitor, clade B (ovalbumin), member 1 [Source: HGNC Symbol;Acc: 3311] 209047_at AQP1 ENSG00000240583 0.056096 1.7116894 8.7671817.055491 7 p14.3 aquaporin 1 (Colton blood group) [Source: HGNC Symbol;Acc: 633] 214077_x_at MEIS3P1 ENSG00000179277 0.056096 0.92458648.655448 7.730862 17 p12 Meis homeobox 3 pseudogene 1 [Source: HGNCSymbol; Acc: 7002] 202946_s_at BTBD3 ENSG00000132640 0.056282 1.00816455.025902 4.017738 20 p12.2 BTB (POZ) domain containing 3 [Source: HGNCSymbol; Acc: 15854] 242953_at ZNF234 ENSG00000263002 0.056316 0.86364236.410969 5.547327 19 q13.31 zinc finger protein 234 [Source: HGNCSymbol; Acc: 13027] 218380_at LOC728392 NA 0.056643 0.6598628 8.0502967.390433 NA NA NA 215000_s_at FEZ2 ENSG00000171055 0.056643 0.89552199.749837 8.854315 2 p22.2 fasciculation and elongation protein zeta 2(zygin II) [Source: HGNC Symbol; Acc: 3660] 229238_at C17orf97ENSG00000187624 0.056643 0.7936262 7.026858 6.233231 17 p13.3 chromosome17 open reading frame 97 [Source: HGNC Symbol; Acc: 33800] 219700_atPLXDC1 ENSG00000161381 0.056643 1.3037293 7.282377 5.978648 17 q12plexin domain containing 1 [Source: HGNC Symbol; Acc: 20945] 202432_atPPP3CB ENSG00000107758 0.056855 0.5946658 8.65429 8.059624 10 q22.2protein phosphatase 3, catalytic subunit, beta isozyme [Source: HGNCSymbol; Acc: 9315] 1558711_at FAM13A-AS1 ENSG00000248019 0.0568580.6634859 6.443456 5.77997 4 q22.1 FAM13A antisense RNA 1 [Source: HGNCSymbol; Acc: 19370] 202304_at FNDC3A ENSG00000102531 0.056858 0.95827768.951197 7.992919 13 q14.2 fibronectin type III domain containing 3A[Source: HGNC Symbol; Acc: 20296] 213429_at BICC1 ENSG000001228700.056858 1.4554356 5.911437 4.456001 10 q21.1 bicaudal C homolog 1(Drosophila) [Source: HGNC Symbol; Acc: 19351] 203388_at ARRB2ENSG00000141480 0.056858 0.7900371 8.830551 8.040514 17 p13.2 arrestin,beta 2 (Source: HGNC Symbol; Acc: 712] 205140_at FPGT ENSG000002546850.056863 0.7461301 7.424392 6.678262 1 p31.1 fucose-1-phosphateguanylyltransferase [Source: HGNC Symbol; Acc: 3825] 226594_at ENTPD5ENSG00000187097 0.056942 0.5571412 7.324717 6.767575 14 q24.3ectonucleoside triphosphate diphosphohydrolase 5 (Source: HGNC Symbol;Acc: 3367] 219506_at C1orf54 ENSG00000118292 0.056942 1.1443229 10.502829.358498 1 q21.2 chromosome 1 open reading frame 54 [Source: HGNCSymbol; Acc: 26258] 209230_s_at NUPR1 ENSG00000176046 0.056997 1.108100611.12844 10.02034 16 p11.2 nuclear protein, transcriptional regulator, 1[Source: HGNC Symbol; Acc: 29990] 205498_at GHR ENSG00000112964 0.0570951.3991555 5.181886 3.782731 5 p13.1 growth hormone receptor [Source:HGNC Symbol; Acc: 4263]

TABLE 2 probeset gene_symbol esnsembl_id q. value logFC mean_nonRefmean_Ref 230325_at LOC100133985 NA 0.00809665 −0.911640912 5.8385058216.750146733 231463_at CNTD1 ENSG00000176563 0.008351401 −0.5389734453.84343028 4.382403725 1558844_at LOC100506127 NA 0.009456042−0.617533967 6.109066414 6.726600381 1559507_at LOC100130357 NA0.009950302 −0.519619931 5.450658035 5.970277966 229378_at STOX1ENSG00000165730 0.011768387 −0.593708902 3.913537756 4.507246657207965_at NEUROG3 ENSG00000122859 0.012330232 −0.438710752 7.8694701018.308180853 1552349_a_at PRSS33 ENSG00000103355 0.013773579 −0.5381888585.578662199 6.116851057 1566134_at CARHSP1 ENSG00000153048 0.014454348−0.5.56432401 6.9668382 7.523270601 206602_s_at HOXD3 ENSG000001286520.016154072 −0.644932774 6.906842818 7.551775592 236374_at CTXN3ENSG00000205279 0.016166047 −0.525752287 4.906041398 5.4317936861560963_a_at LOC100506379 NA 0.016166613 −0.647132124 5.4464954216.093627545 1553837_at PGAM5 ENSG00000247077 0.016166613 −0.4660151936.896008593 7.362023785 1554763_at UBE2DNL ENSG00000229547 0.016166613−0.423010772 5.56336289 5.986373662 219840_s_at TCL6 ENSG000001876210.016166613 −1.34245305 4.185464373 5.527917423 222896_at TMEM38AENSG00000072954 0.016166613 −0.778177457 6.257085542 7.035262999205688_at TFAP4 ENSG00000090447 0.016166613 −0.616680115 7.995730168.612410275 1557021_s_at LOC100507250 NA 0.016166613 −0.7674247636.40032636 7.167751123 237880_at LOC100506457 NA 0.016166613−0.776375557 6.296009341 7.072384898 210450_at IGHV5-78 ENSG000002119780.016166613 −0.929279909 5.444682435 6.373962344 1570336_at BDH1ENSG00000161267 0.016166613 −0.600927396 5.439307091 6.040234486219076_s_at PXMP2 ENSG00000176894 0.016166613 −0.603766933 7.7465234078.35029034 230467_at TMEM52 ENSG00000178821 0.016166613 −0.5477050245.782176283 6.329881307 207689_at TBX10 ENSG00000167800 0.016166613−0.58354262 5.120413125 5.703955745 210165_at DNASE1 ENSG000002139180.0170385 −0.638225732 6.797117147 7.435342379 1558431_at NHLRC4ENSG00000257108 0.017271459 −0.440024521 7.110293049 7.55031757210122_at PRM2 ENSG00000122304 0.017305066 −0.594945443 6.2976048556.892550298 1569270_at LOC100134368 NA 0.017653225 −0.5240956794.998433733 5.522529412 232781_at LHX4 ENSG00000121454 0.017653225−0.471163014 6.387893416 6.859056431 206151_x_at CELA3B ENSG000002190730.0179046 −0.389566615 6.698451608 7.088018223 1553780_at LINC00638ENSG00000258701 0.0179681 −0.442959091 5.985279128 6.4282382191564386_at TXNDC8 ENSG00000204193 0.018383789 −0.402808114 4.5698878954.972696009 207116_s_at GAPDHS ENSG00000105679 0.018896313 −0.4393958936.265814968 6.705210861 1552564_at NUDT9P1 NA 0.018901839 −0.6270974795.209804097 5.836901576 1552811_at WFIKKN1 ENSG00000127578 0.018901839−0.407943586 7.383936771 7.791880357 244543_s_at BCDIN3D-AS1ENSG00000258057 0.018901839 −0.517606933 6.104813842 6.6224207751555124_at LOC100129726 NA 0.018901839 −0.737667282 6.319280067.056947342 1553541_at LMX1A ENSG00000162761 0.018921376 −0.4777457644.729705201 5.207450965 1553178_a_at SSTR3 ENSG00000183473 0.019065055−0.49695403 6.605956381 7.10291041 1558289_at RFT1 ENSG000001639330.019506232 −0356946278 6.437355142 6.794301421 208034_s_at PROZENSG00000126231 0.019879747 −0.413177596 7.086538428 7.4997160241553444_a_at C1orf127 ENSG00000175262 0.019879747 −0.4561616997.310783447 7.766945146 220077_at CCDC134 ENSG00000100147 0.019879747−0.431568198 7.194190518 7.625758716 215756_at LOC730227 NA 0.019879747−0.466760373 5.640296789 6.107057162 242226_at LOC100288079 NA0.019879747 −0.466011928 4.501905981 4.967917909 207159_x_at CRTC1ENSG00000105662 0.019974794 −0.342848645 8.582700549 8.9255491941564072_at MYH16 ENSG00000002079 0.020133959 −0.513849511 5.1179856445.631835155 206112_at ANKRD7 ENSG00000106013 0.020139089 −0.5840077673.631160633 4.2151684 244488_at LSM14B ENSG00000149657 0.020139089−0.471204404 5.404535566 5.87573997 243022_at LOC100506631 NA0.020691131 −0.472548595 6.586231468 7.058780063 223630_at C7orf13ENSG00000244291 0.021317074 −0.621418392 6.683076994 7.304495386207366_at KCNS1 ENSG00000124134 0.021317074 −0.522556921 5.7344532966.257010217 1569532_a_at LCN15 ENSG00000177984 0.021317074 −0.4633608766.730953106 7.194313982 208291_s_at TH ENSG00000180176 0.02166097−0.435400549 5.849357981 6.284758531 239119_at DNAJC3-AS1ENSG00000247400 0.022611564 −0.889794242 6.485868079 7.375662321240185_at LOC100147773 NA 0.022611564 −0.498977477 7.3706970977.869674574 233843_at ZBTB12 ENSG00000204366 0.022611564 −0.5197427527.218271617 7.738014369 1555722_at SCAMPER NA 0.022732168 −0.3343082553.6043183 3.938626555 1553067_a_at GNRHR2 ENSG00000211451 0.022732168−0.649001368 7.399753955 8.048755323 238898_at LOC101060264 NA0.023506064 −1.193505286 5.871655735 7.065161021 224166_at SLC25A2ENSG00000120329 0.023531188 −0.439944142 4.676270398 5.11621454238239_at WDR27 ENSG00000184465 0.023577408 −0.865515668 5.4756506286.341276295 1562039_at GLYATL1 ENSG00000166840 0.023677408 −0.4941915793.390583969 3.884775548 207649_at KRT37 EN5G00000108417 0.023800085−0.376179216 5.023733968 5.399918134 1559272_at EXOC3L1 ENSG000001790440.023800085 −0.4129202 8.165645994 8.578566194 1556822_s_at ZNF837ENSG00000152475 0.023800085 −0.480490017 6.346952069 6.827442036215323_at EFR38 ENSG00000084710 0.023922328 −0.703597987 6.5562035677.259801553 1552932_at NLRP6 ENSG00000174885 0.024111993 −0.4526198846.55831599 7.010935374 probeset Chromosome chrom_band gene_description230325_at NA NA NA 231463_at 17 q21.31 cyclin N-terminal domaincontaining 1 [Source: HGNC Symbol; Acc: 26847] 1558844_at NA NA NA1559507_at NA NA NA 229378_at 10 q21.3 storkhead box 1 [Source: HGNCSymbol; Acc: 23508] 207965_at 10 q22.1 neurogenin 3 [Source: HGNCSymbol; Acc: 13806] 1552349_a_at 16 p13.3 protease, serine, 33 [Source:HGNC Symbol Acc: 30405] 1566134_at 16 p13.2 calcium regulated heatstable protein 1, 24 kDa [Source: HGNC Symbol; Acc: 17150] 206602_s_at 2q31.1 homeobox D3 [Source: HGNC Symbol; Acc: 5137] 236374_at 5 q23.2cortexin 3 [Source: HGNC Symbol; Acc: 31110] 1560963_a_at NA NA NA1553837_at 12 q24.33 phosphoglycerate mutase family member 5 [Source:HGNC Symbol; Acc: 28763] 1554763_at X q21.1 ubiquitin-conjugating enzymeE2D N-terminal like (pseudogene) [Source: HGNC Symbol; Acc: 28656]219840_s_at 14 q32.13 T-cell leukemia/lymphoma 6 (non-protein coding)[Source: HGNC Symbol; Acc: 13463] 222896_at 19 p13.11 transmembraneprotein 38A [Source: HGNC Symbol; Acc: 28462] 205688_at 16 p13.3transcription factor AP-4 (activating enhancer binding protein 4)[Source: HGNC Symbol; Acc: 11745] 1557021_s_at NA NA NA 237880_at NA NANA 210450_at 14 q32.33 immunoglobulin heavy variable 5-78 (pseudogene)[Source: HGNC Symbol; Acc: 5660] 1570336_at 3 q29 3-hydroxybutyratedehydrogenase, type 1 [Source: HGNC Symbol; Acc: 1027] 219076_s_at 12q24.33 peroxisomal membrane protein 2, 22 kDa [Source: HGNC Symbol; Acc:9716] 230467_at 1 p36.33 transmembrane protein 52 [Source: HGNC Symbol;Acc: 27916] 207689_at 11 q13.2 T-box 10 [Source: HGNC Symbol; Acc:11593] 210165_at 16 p13.3 deoxyribonuclease I [Source: HGNC Symbol; Acc:2956] 1558431_at 16 p13.3 NHL repeat containing 4 [Source: HGNC Symbol;Acc: 26700] 210122_at 16 p13.13 protamine 2 [Source: HGNC Symbol; Acc:9448] 1569270_at NA NA NA 232781_at 1 q25.2 LIM homeobox 4 [Source: HGNCSymbol; Acc: 21734] 206151_x_at 1 p36.12 chymotrypsin-like elastasefamily, member 36 [Source: HGNC Symbol; Acc: 15945] 1553780_at 14 q32.33long intergenic non-protein coding RNA 638 [Source: HGNC Symbol; Acc:28325] 1564386_at 9 q31.3 thioredoxin domain containing 8 (spermatozoa)[Source: HGNC Symbol; Acc: 31454] 207116_s_at 19 q13.12glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source: HGNCSymbol; Acc: 24864] 1552564_at NA NA NA 1552811_at 16 p13.3 WAP,follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1[Source: HGNC Symbol; Acc: 30912] 244543_s_at 12 q13.12 BCDIN3Dantisense RNA 1 [Source: HGNC Symbol; Acc: 44113] 1555124_at NA NA NA1553541_at 1 q23.3 LIM homeobox transcription factor 1, alpha [Source:HGNC Symbol; Acc: 6653] 1553178_a_at 22 q13.1 somatostatin receptor 3[Source: HGNC Symbol; Acc: 11332] 1558289_at 3 p21.1 RFT1 homolog (S.cerevisiae) [Source: HGNC Symbol; Acc: 30220] 208034_s_at 13 q34 proteinZ, vitamin K-dependent plasma glycoprotein [Source: HGNC Symbol; Acc:9460] 1553444_a_at 1 p36.22 chromosome 1 open reading frame 127 [Source:HGNC Symbol; Acc: 26730] 220077_at 22 q13.2 coiled-coil domaincontaining 134 [Source: HGNC Symbol; Acc: 26185] 215756_at NA NA NA242226_at NA NA NA 207159_x_at 19 p13.11 CREB regulated transcriptioncoactivator 1 [Source: HGNC Symbol; Acc: 16062] 1564072_at 7 q22.1myosin, heavy chain 16 pseudogene [Source: HGNC Symbol; Acc: 31038]206112_at 7 q31.31 ankyrin repeat domain 7 [Source: HGNC Symbol; Acc:18588] 244488_at 20 q13.33 LSM14B, SCD6 homolog B (S. cerevisiae)[Source: HGNC Symbol; Acc: 15887] 243022_at NA NA NA 223630_at 7 q36.3chromosome 7 open reading frame 13 [Source: HGNC Symbol; Acc: 17126]207366_at 20 q13.12 potassium voltage-gated channel, delayed-rectifier,subfamily S, member 1 [Source: HGNC Symbol; Acc: 6300] 1569532_a_at 9q34.3 lipocalin 15 [Source: HGNC Symbol; Acc: 33777] 208291_s_at 11p15.5 tyrosine hydroxylase [Source: HGNC Symbol; Acc: 11782] 239119_at13 q32.1 DNAJC3 antisense RNA 1 (head to head) [Source: HGNC Symbol;Acc: 39308] 240185_at NA NA NA 233843_at 6 p21.33 zinc finger and BTBdomain containing 12 [Source: HGNC Symbol; Acc: 19066] 1555722_at NA NANA 1553067_a_at 1 q21.1 gonadotropin-releasing hormone (type 2) receptor2 [Source: HGNC Symbol; Acc: 16341] 238898_at NA NA NA 224166_at 5 q31.3solute carrier family 25 (mitochondrial carrier; ornithine transporter)member 2 [Source: HGNC Symbol; Acc: 22921] 238239_at 6 q27 WD repeatdomain 27 [Source: HGNC Symbol; Acc: 21248] 1562039_at 11 q12.1glycine-N-acyltransferase-like 1 [Source: HGNC Symbol; Acc: 30519]207649_at 17 q21.2 keratin 37 [Source: HGNC Symbol; Acc: 6455]1559272_at 16 q22.1 exocyst complex component 3-like 1 [Source: HGNCSymbol; Acc: 27540] 1556822_s_at 19 q13.43 zinc finger protein 837[Source: HGNC Symbol; Acc: 25164] 215328_at 2 p23.3 EFR3 homolog B (S.cerevisiae) [Source: HGNC Symbol; Acc: 29155] 1552932_at 11 p15.5 NLRfamily, pyrin domain containing 6 [Source: HGNC Symbol; Acc: 22944]

TABLE 3 probeset gene_symbol esnsembl_id q. value logFC mean_nonRefmean_Ref 228754_at SLC6A6 ENSG00000131389 0 0.975480525 8.9810063338.005525809 238327_at ODF3B ENSG00000177989 0.002730266 1.0304116968.897771439 7.867359743 208683_at CAPN2 ENSG00000162909 0.0027302662.05913862 9.820197872 7.761059252 218648_at CRTC3 ENSG000001405770.002730266 1.393257272 9.008043592 7.614786319 225146_at FAM219AENSG00000164970 0.002730266 0.795746694 8.091945884 7.29619919 218589_atLPAR6 ENSG00000139679 0.002730266 2.422573482 9.17966374 6.757090257217762_s_at RAB31 ENSG00000168461 0.002730266 1.749576112 10.132268938.382692819 201506_at TGFBI ENSG00000120708 0.002730266 1.80554772711.48439996 9.67885223 224862_at GNAQ ENSG00000156052 0.0027302662.025363394 6.970609713 4.945246318 201425_at ALDH2 ENSG000001112750.002730266 1.929378657 10.6016455 8.672266847 1555851_s_at SEPW1ENSG00000178980 0.003120304 1.533124384 10.54941655 9.016292166205241_at SCO2 ENSG00000130489 0.003120304 0.892011788 9.1452783698.25326658 218552_at ECHDC2 ENSG00000121310 0.003120304 1.3353135649.234133085 7.89881952 55662_at C10orf76 ENSG00000120029 0.0031203040.721271142 8.212153422 7.49088228 204773_at IL11RA ENSG000001370700.004436682 0.917390241 7.610982979 6.693592738 202600_s_at NRIP1ENSG00000180530 0.004436682 1.662365975 7.56245491 5.900088935221802_s_at KIAA1598 ENSG00000187164 0.004818116 1.88945627 8.3437654696.454309199 226000_at CTTNBP2NL ENSG00000143079 0.005157169 1.4672862917.674825326 6.207539034 222484_s_at CXCL14 ENSG00000145824 0.0051731353.461735657 11.01983085 7.55809519 201012_at ANXA1 ENSG000001350460.005187505 1.868142161 10.78463604 8.916493883 218854_at DSEENSG00000111817 0.006453355 1.632134259 9.397392236 7.765257977214040_s_at GSN ENSG00000148180 0.006453355 1.345118377 10.262802968.917684579 201302_at ANXA4 ENSG00000196975 0.006598142 1.7017558259.377173828 7.675418003 208923_at CYFIP1 ENSG00000068793 0.0065981421.418337073 9.308029118 7.889692045 224414_s_at CARD6 ENSG000001323570.007207901 1.29867797 8.497051244 7.198373274 205945_at IL6RENSG00000160712 0.00809665 1.765992405 8.874117498 7.108125092200765_x_at CTNNA1 ENSG00000044115 0.00809665 1.117941552 9.6308398988.512898346 230325_at LOC100133985 NA 0.00809665 −0.9116409125.838505821 6.750146733 223228_at LDOC1L ENSG00000188636 0.008096651.239345994 8.444983654 7.20563766 225842_at PHLDA1 ENSG000001392890.008190797 1.472675991 8.297710351 6.825034361 201348_at GPX3ENSG00000211445 0.008351401 2.169917885 11.32422224 9.154304357219885_at SLFN12 ENSG00000172123 0.008351401 1.235153278 6.0977893824.862636104 212830_at MEGF9 ENSG00000106780 0.008351401 1.2431751616.734084575 5.490909414 231463_at CTND1 ENSG00000176563 0.008351401−0.538973445 3.84343028 4.382403725 202687_s_at TNFSF10 ENSG000001218580.00842482 1.529352742 11.10527322 9.575920476 217731_s_at ITM2BENSG00000136156 0.009100886 1.449335477 10.05152822 8.602192738218694_at ARMCX1 ENSG00000126947 0.009456042 1.499155444 7.4187317575.919576313 1558844_at LOC100506127 NA 0.009456042 −0.6175339676.109066414 6.726600381 202944_at NAGA ENSG00000198951 0.0094560420.994644426 8.304684413 7.610039987 212522_at PDE8A ENSG000000734170.009456042 1.212471343 8.751053401 7.538582058 226247_at PLEKHA1ENSG00000107679 0.009456042 1.762189016 8.231589342 6.469400327243423_at TNIP1 ENSG00000145901 0.009620936 1.039362698 6.1390270115.099664313 229074_at EHD4 ENSG00000103966 0.009950302 1.1167960298.728408949 7.61161292 1559507_at LOC100130357 NA 0.009950302−0.519619931 5.450658035 5.970277966 222154_s_at SPATS2L ENSG000001961410.009950302 1.239839493 9.90915525 8.569315758 200710_at ACADVLENSG00000072778 0.011037244 0.872008393 9.456312268 8.584303875228791_at LOC100129502 NA 0.011037244 1.793891949 8.4112666036.617374654 208634_s_at MACF1 ENSG00000127603 0.011768387 1.23462527410.26299281 9.028367538 242487_at CC2D1B ENSG00000154222 0.0117683870.523814355 6.843606374 6.319792019 218559_s_at MAFB ENSG000002041030.011768387 1.849122185 11.31545077 9.466328588 201360_at CST3ENSG00000101439 0.011768387 1.353324788 11.64386355 10.29053876206101_at ECM2 ENSG00000106823 0.011768387 1.728608593 7.1565108255.427902231 218004_at BSDC1 ENSG00000160058 0.011768387 0.5416922488.948162166 8.406469918 36129_at SGSM2 ENSG00000141258 0.0117683870.893849973 9.480069571 8.586219598 227889_at LPCAT2 ENSG000000872530.011768387 1.982248155 7.953706021 5.971457866 229378_at STOX1ENSG00000165730 0.011768387 −0.593708902 3.913537756 4.507246657218043_s_at AZI2 ENSG00000163512 0.011768387 0.863898887 6.6442845155.780385627 218066_at SLC12A7 ENSG00000113504 0.011768387 1.0053443368.912722012 7.907377676 58780_s_at ARHGEF40 ENSG00000165801 0.0118465771.485982141 7.235422011 5.74943987 200660_at S100A11 ENSG000001631910.012330232 1.388286368 11.61065539 10.22236902 207965_at NEUROG3ENSG00000122859 0.012330232 −0.438710752 7.869470101 8.308180853212907_at SLC30A1 ENSG00000170385 0.012330232 1.171312069 9.3504665148.179154445 208999_at SEPT8 ENSG00000164402 0.012827915 1.113396818.412742626 7.299345816 208949_s_at LGALS3 ENSG00000131981 0.0129372591.466370381 11.76909335 10.30272297 218311_at MAP4K3 ENSG000000115660.012937259 1.467987958 7.560719009 6.092731052 203518_at LYSTENSG00000143669 0.013773579 1.781389247 8.315307394 6.5339181471552349_a_at PRSS33 ENSG00000103355 0.013773579 −0.538188858 5.5786621996.116851057 1566134_at CARHSP1 ENSG00000153048 0.014454348 −0.5564324016.9668382 7.523270601 204137_at GPR137B ENSG00000077585 0.0156795262.08875061 9.969766837 7.881016227 222217_s_at SLC27A3 ENSG000001435540.015679526 0.901664373 8.452290275 7.550625902 201505_at LAMB1ENSG00000091136 0.015689414 1.834716085 9.325407825 7.490691739206602_s_at HOXD3 ENSG00000128652 0.016154072 −0.644932774 6.9068428187.551775592 217728_at S100A6 ENSG00000197956 0.016157189 0.96180259211.17652114 10.21471854 225483_at VPS26B ENSG00000151502 0.0161602210.731464309 8.008598811 7.277134503 202686_s_at AXL ENSG000001676010.016163173 2.164883727 9.749176136 7.584292409 236374_at CTXN3ENSG00000205279 0.016166047 −0.525752287 4.906041398 5.431793686227276_at PLXDC2 ENSG00000120594 0.016166613 1.969191816 9.8579941837.888742368 228185_at ZNF25 ENSG00000175395 0.016166613 1.9293975236.510839476 5.581441953 217892_s_at LIMA1 ENSG00000050405 0.0161666131.859321745 9.968366162 8.109044417 202727_s_at IFNGR1 ENSG000000276970.016166613 1.203322531 9.855227569 8.651905038 1560963_a_atLOC100506379 NA 0.016166613 −0.647132124 5.446495421 6.0936275451553837_at PGAM5 ENSG00000247077 0.016166613 −0.466015193 6.8960085937.362023785 1554763_at UBE2DNL ENSG00000229547 0.016166613 −0.4230107725.56336289 5.986373662 212112_s_at STX12 ENSG00000117758 0.0161666130.81158935 8.768046401 7.956457051 203789_s_at SEMA3C ENSG000000752230.016166613 1.826351818 6.85114482 5.024793002 200677_at PTTG1IPENSG00000183255 0.016166613 0.944308232 10.81552238 9.871214144222876_s_at ADAP2 ENSG00000184060 0.016166613 1.230284047 9.9479093858.717625338 210145_at PLA2G4A ENSG00000116711 0.016166613 1.0185869615.59768987 4.579102909 208109_s_at LINC00597 NA 0.016166613 1.2522137866.056932621 4.804718835 209651_at TGFB1I1 ENSG00000140682 0.0161666131.639068946 8.383831001 6.744762056 212698_s_at SEPT10 ENSG000001865220.016166613 2.029386612 6.787501727 4.758115114 212526_at SPG20ENSG00000133104 0.016166613 1.308040982 6.974473237 5.666432255209684_at RIN2 ENSG00000132669 0.016166613 1.948498746 9.2502598547.301761108 223204_at FAM198B ENSG00000164125 0.016166613 1.5567046997.718116717 6.161412018 200673_at LAPTM4A ENSG00000068697 0.0161666131.052582957 10.80127759 9.748694636 219840_s_at TCL6 ENSG000001876210.016166613 −1.34245305 4.185464373 5.527917423 222896_at TMEM38AENSG00000072954 0.016166613 −0.778177457 6.257085542 7.035262999205688_at TFAP4 ENSG00000090447 0.016166613 −0.616680115 7.995730168.612410275 225384_at DOCK7 ENSG00000116641 0.016166613 0.8203450367.335350684 6.515005648 1557021_s_at LOC100507250 NA 0.016166613−0.767424763 6.40032636 7.167151123 209210_s_at FERMT2 ENSG000000737120.016166613 1.600225002 8.650583066 7.050358064 201798_s_at MYOFENSG00000138119 0.016166613 1.933721388 9.900889993 7.967168605225949_at NRBP2 ENSG00000185189 0.016166613 1.197815793 8.2296226187.031806824 208924_at RNF11 ENSG00000123091 0.016166613 1.312656287.905885024 6.593228744 209004_s_at FBXL5 ENSG00000118564 0.0161666131.083805753 10.00546225 8.921656499 237880_at LOC100506457 NA0.016166613 −0.776375557 6.296009341 7.072384898 226743_at SLFN11ENSG00000172716 0.016166613 1.653027622 8.752878393 7.09985077 228573_atANTXR2 ENSG00000163297 0.016166613 1.223119076 6.502216851 5.279097776222065_s_at FLII ENSG00000177731 0.016166613 0.779423611 9.6875031378.908079526 210450_at IGHV5-78 ENSG00000211978 0.016166613 −0.9292799095.444682435 6.373962344 212989_at SGMS1 ENSG00000198964 0.0161666131.180434511 5.341958 4.161523489 202228_s_at NPTN ENSG000001566420.016166613 1.131346073 9.703866415 8.572520342 227761_at MYO5AENSG00000197535 0.016166613 1.47770878 8.28230981 6.80460103 202133_atWWTR1 ENSG00000018408 0.016166613 1.982540678 8.759155252 6.776614574209960_at HGF ENSG00000019991 0.016166613 1.216221253 4.7389847113.522763458 212203_x_at IFITM3 ENSG00000142089 0.016166613 0.99946536612.83133036 11.83186499 212158_at SDC2 ENSG00000169439 0.0161666131.694879284 8.399184386 6.704305102 224797_at ARRDC3 ENSG000001133690.016166613 1.280896615 7.049919874 5.769023259 203124_s_at SLC11A2ENSG00000110911 0.016166613 1.314981642 8.210636812 6.8956551711570336_at BDH1 ENSG00000161267 0.016166613 −0.600927396 5.4393070916.040234486 1553034_at SDCCAG8 ENSG00000054282 0.016166613 0.6479853977.598443667 6.95045827 219076_s_at PXMP2 ENSG00000176894 0.016166613−0.603766933 7.746523407 8.35029034 230467_at TMEM52 ENSG000001788210.016166613 −0.547705024 5.782176283 6.329881307 226111_s_at ZNF385AENSG00000161642 0.016166613 1.061296407 9.529821659 8.468525252231579_s_at TIMP2 ENSG00000035862 0.016166613 1.950902389 11.290344029.339441627 202007_at NID1 ENSG00000116962 0.016166613 1.617138417.967907666 6.350769257 207689_at TBX10 ENSG00000167800 0.016166613−0.58354262 5.120413125 5.703955745 201681_s_at DLG5 ENSG000001512080.016381594 1.584354968 7.6803766 6.096021632 212761_at TCF7L2ENSG00000148737 0.016677902 1.565585438 7.595305509 6.029720072224983_at SCARB2 ENSG00000138760 0.016923479 1.31926409 9.8083328758.489068785 218706_s_at GRAMD3 ENSG00000155324 0.016923479 1.128994386.584780567 5.455786187 210165_at DNASE1 ENSG00000213918 0.0170385−0.638225732 6.797117147 7.435342879 203595_s_at IFIT5 ENSG000001527780.0170385 1.314122515 8.100950556 6.786828041 1558431_at NHLRC4ENSG00000257108 0.017271459 −0.440024521 7.110293049 7.55031757225133_at KLF3 ENSG00000109787 0.017271459 1.877159888 7.7441326545.866972766 210122_at PRM2 ENSG00000122304 0.017305066 −0.5949454436.297604855 6.892550298 204396_s_at GRK5 ENSG00000198873 0.0174577570.977767737 8.13471677 7.156949033 1569270_at LOC100134368 NA0.017653225 −0.524095679 4.998433733 5.522529412 210105_s_at FYNENSG00000010810 0.017653225 1.615658944 10.56933985 8.953680911201218_at CTBP2 ENSG00000175029 0.017653225 1.464241977 7.4453659955.981124019 203973_s_at CEBPD ENSG00000221869 0.017653225 1.61419656710.46812679 8.853930222 243038_at RBM43 ENSG00000184898 0.0176532250.968731593 7.015389524 6.046657931 212667_at SPARC ENSG000001131400.017653225 2.038777809 9.760157874 7.721380065 209341_s_at IKBKBENSG00000104365 0.017653225 0.980949734 8.789651207 7.808701473232781_at LHX4 ENSG00000121454 0.017653225 −0.471163014 6.3878634166.859056431 202336_s_at PAM ENSG00000145730 0.017653225 1.3185153999.289020714 7.970505314 216151_x_at CELA3B ENSG00000219073 0.0179046−0.389566615 6.698451608 7.088018223 1553780_at LINC00638ENSG00000258701 0.0179681 −0.442959091 5.985279128 6.428238219 212298_atNRP1 ENSG00000099250 0.018067396 1.779345664 9.257538424 7.478192761564386_at TXNDC8 ENSG00000204193 0.018383789 −0.402808114 4.5698878954.972696009 221773_at ELK3 ENSG00000111145 0.018896313 1.620718398.175421184 6.554702794 207116_s_at GAPDHS ENSG00000105679 0.018896313−0.439395893 6.265814968 6.705210861 208816_x_at ANXA2P2 ENSG000002319910.018901839 0.878549333 10.01165886 9.133109525 225188_at RAPH1ENSG00000173166 0.018901839 2.005188858 7.673175419 5.6679865611552564_at NUDT9P1 NA 0.018901839 −0.627097479 5.209804097 5.836901576212779_at KIAA1109 ENSG00000138688 0.018901839 0.990071878 8.1871587767.197086899 221748_s_at TNS1 ENSG00000079308 0.018901839 2.0203508838.869430402 6.84907952 1552811_at WFIKKN1 ENSG00000127578 0.018901839−0.407943586 7.383936771 7.791880357 244543_s_at BCDIN3D-AS1ENSG00000258057 0.018901839 −0.517606933 6.104813842 6.6224207751555124_at LOC100129726 NA 0.018901839 −0.737667282 6.319280067.056947342 213379_at COQ2 ENSG00000173085 0.018901839 0.523732268.028910727 7.505178467 211684_s_at DYNC1I2 ENSG00000077380 0.0189018390.822903615 8.910623393 8.087719778 201739_at SGK1 ENSG000001185150.018901839 1.479761374 10.75364976 9.273888386 209090_s_at SH3GLB1ENSG00000097033 0.018901839 0.961400759 9.96248528 9.001084521 225171_atARHGAP18 ENSG00000146376 0.018901839 1.537074864 8.677922388 7.140847525204517_at PPIC ENSG00000168938 0.018901839 1.458339897 7.8740588216.415718925 213923_at RAP2B ENSG00000181467 0.018901839 1.2413750110.18514033 8.943765324 201590_x_at ANXA2 ENSG00000182718 0.0189018391.222362695 12.76741798 11.54505528 202202_s_at LAMA4 ENSG000001127690.018901839 1.095301757 9.350315162 8.255013405 218718_at PDGFCENSG00000145431 0.018921376 2.106384599 7.63389478 5.5275101811553541_at LMX1A ENSG00000162761 0.018921376 −0.477745764 4.7297052015.207450965 2061414_s_at ASAP2 ENSG00000151693 0.018921376 1.4747716946.713855258 5.239083564 1553178_a_at SSTR3 ENSG00000183473 0.019065055−0.49695403 6.605956381 7.10291041 212169_at FKBP9 ENSG000001226420.019065055 1.110752419 8.896737181 7.785984761 209348_s_at MAFENSG00000178573 0.019065055 2.155786041 8.892163605 6.736377564202011_at TJP1 ENSG00000104067 0.019266989 2.093652215 8.4082393066.314587092 226823_at PHACTR4 ENSG00000204138 0.019506232 0.7884981767.61381437 6.825316194 201375_s_at PPP2CB ENSG00000104695 0.0195062320.883554817 10.00679214 9.123237324 1558289_at RFT1 ENSG000001639330.019506232 −0.356946278 6.437355142 6.794301421 202808_at WBP1LENSG00000166272 0.019506232 0.667279191 9.547031071 8.879751881227911_at ARHGAP28 ENSG00000088756 0.019879747 1.632136074 5.9754035464.343267472 208034_s_at PROZ ENSG00000126231 0.019879747 −0.4131775967.086538428 7.499716024 1553444_a_at C1orf127 ENSG000001752620.019879747 −0.456161699 7.310783447 7.766945146 220077_at CCDC134ENSG00000100147 0.019879747 −0.431568198 7.194190518 7.624758716215756_at LOC730227 NA 0.019879747 −0.466760373 5.640296789 6.107057162206049_at SELP ENSG00000174175 0.019879747 1.710090268 7.2276269825.517536714 202357_s_at CFB ENSG00000243649 0.019879747 1.1573645698.626327441 7.468962872 217497_at TYMP ENSG00000025708 0.0198797470.851614407 8.694768908 7.843154501 204034_at ETHE1 ENSG000001057550.019879747 0.528926484 8.283720657 7.754794174 210139_s_at PMP22ENSG00000109099 0.019879747 1.749405657 9.219437323 7.470031666242226_at LOC100288079 NA 0.019879747 −0.466011928 4.5019059814.967917909 204114_at NID2 ENSG00000087303 0.019879747 1.6354339047.748453279 6.113019374 207159_x_at CRTC1 ENSG00000105662 0.019974794−0.342848645 8.582700549 8.925549194 1564072_at MYH16 ENSG000000020790.020133959 −0.513849511 5.117985644 5.631835155 200878_at EPAS1ENSG00000116016 0.020133959 1.664350584 10.74528693 9.080936347206112_at ANKRD7 ENSG00000106013 0.020139089 −0.584007767 3.6311606334.2151684 202446_s_at PLSCR1 ENSG00000188313 0.020139089 1.4106050099.747770469 8.33716546 221139_s_at CSAD ENSG00000139631 0.0201390891.103365222 6.326659677 5.223294456 244488_at LSM14B ENSG000001496570.020139089 −0.471204404 5.404535566 5.87573997 221012_s_at TRIM8ENSG00000171206 0.020139089 0.902154468 9.733515113 8.8313606451555832_s_at KLF6 ENSG00000067082 0.020139089 1.505090741 10.492756438.987665692 212859_x_at MTIE ENSG00000139089 0.020139089 1.3116378211.29221774 9.98057992 203729_at EMP3 ENSG00000142227 0.0206911311.242611864 10.80078079 9.558168921 243022_at LOC100506631 NA0.020691131 −0.472548595 6.586231468 7.058780063 223630_at C7orf13ENSG00000244291 0.021317074 −0.621418392 6.683076994 7.304495386209238_at STX3 ENSG00000166900 0.021317074 1.047521762 7.8167540186.769232256 207366_at KCNS1 ENSG00000124134 0.021317074 −0.5225569215.734453296 6.257010217 1569532_a_at LCN15 ENSG00000177984 0.021317074−0.463360876 6.730953106 7.194313982 228617_at XAF1 ENSG000001325300.021319587 1.859163345 9.784426104 7.925262758 204436_at PLEKHO2ENSG00000241839 0.02166097 0.814909278 9.412794546 8.597885267208291_s_at TH ENSG00000180176 0.02166097 −0.435400549 5.8493579816.284758531 1555756_a_at CLEC7A ENSG00000172243 0.02166097 1.9487016959.541407089 7.592705395 202381_at ADAM9 ENSG00000168615 0.0222523061.522568908 9.387992162 7.865423254 202291_s_at MGP ENSG000001113410.022611564 2.128960252 11.06083826 8.931878011 239119_at DNAJC3-AS1ENSG00000247400 0.022611564 −0.889794242 6.485868079 7.375662321213056_at FRMD4B ENSG00000114541 0.022611564 1.741374115 6.0232784084.281904293 218162_at OLFML3 ENSG00000116774 0.022611564 1.5508457388.328430141 6.777584404 212845_at SAMD4A ENSG00000020577 0.0226115641.246715477 6.634446869 5.387731392 240185_at LOC100147773 NA0.022611564 −0.498977477 7.370697097 7.869674574 233843_at ZBTB12ENSG00000204366 0.022611564 −0.519742752 7.218271617 7.738014369218541_s_at C8orf4 ENSG00000176907 0.022732168 1.976295335 6.693744344.717449005 1555722_at SCAMPER NA 0.022732168 −0.334308255 3.60431833.938626555 1559005_s_at CNTLN ENSG00000044459 0.022732168 1.3908168746.512894646 5.122077773 218909_at RPS6KC1 ENSG00000136643 0.0227321680.752157812 8.355673576 7.603515764 1553067_a_at GNRHR2 ENSG000002114510.022732168 −0.649001368 7.399753955 8.048755323 226384_at PPAPDC1BENSG00000147535 0.022732168 1.211118387 8.15972622 6.948607833212509_s_at MXRA7 ENSG00000182534 0.022732168 1.467475866 9.7646580558.297182189 225975_at PCDH18 ENSG00000189184 0.023159359 1.7790237717.236967211 5.45794344 201341_at ENC1 ENSG00000171617 0.0234159031.444333682 8.066608054 6.622274373 203324_s_at CAV2 ENSG000001059710.023506064 1.952200967 8.152023753 6.199822786 238898_at LOC101060264NA 0.023506064 −1.193505286 5.871655735 7.065161021 212230_at PPAP2BENSG00000162407 0.023506064 1.816510197 9.071697681 7.255187484218632_at HECTD3 ENSG00000126107 0.023506064 0.736900447 9.6276478838.890747437 212204_at TMEM87A ENSG00000103978 0.023515139 0.8984927899.007547211 8.109054422 226022_at SASH1 ENSG00000111961 0.0235151392.002711158 7.610795761 5.608084603 224166_at SLC25A2 ENSG000001203290.023531188 −0.439944142 4.676270398 5.11621454 242800_at NHSENSG00000188158 0.023677408 1.162711533 6.713331023 5.550619491203477_at COL1SA1 ENSG00000204291 0.023677408 1.614306704 8.4368831956.822576491 200857_s_at NCOR1 ENSG00000141027 0.023677408 0.7091942638.662953014 7.95375875 238239_at WDR27 ENSG00000184465 0.023677408−0.865615668 5.475660628 6.341276295 1562089_at GLYATL1 ENSG000001668400.023677408 −0.494191579 3.390583969 3.884775548 224996_at ASPHENSG00000198363 0.023699601 1.523017401 7.874015884 6.350998483223562_at PARVG ENSG00000138964 0.023699601 1.500914846 9.6698894418.168974594 213353_at ABCA5 ENSG00000154265 0.023699601 0.9962431598.332970994 7.336727836 209593_s_at TOR1B ENSG00000136816 0.0238000850.46611305 7.855147944 7.389034893 207649_at KRT37 ENSG000001084170.023800085 −0.376179216 5.023738968 5.399918184 32626_at SGSHENSG00000181523 0.023800085 0.781709479 9.793809878 9.0121003991559272_at EXOC3L1 ENSG00000179044 0.023800085 −0.4129202 8.1656459948.578566194 234994_at TMEM200A ENSG00000164484 0.023800085 1.6120474236.524547814 4.91250039 1556822_s_at ZNF837 ENSG00000152475 0.023800085−0.480490017 6.346952069 6.857442086 211456_x_at MT1P2 NA 0.0238000851.026714169 11.3370169 10.31030273 215328_at EFR3B ENSG000000847100.023922328 −0.703597987 6.556203567 7.259801553 203501_at CPQENSG00000104324 0.024111993 0.986206289 7.824447671 6.838241383226155_at FAM160B1 ENSG00000151553 0.024111993 0.94991516 8.1618081517.21189299 1552932_at NLRP6 ENSG00000174885 0.024111993 −4.526198846.55831599 7.010935874 1552258_at LINC00152 ENSG00000222041 0.0241244571.12452576 8.139434844 7.014909085 238025_at MLKL ENSG000001684040.02486642 1.215990498 8.756992858 7.54100236 219460_s_at TMEM127ENSG00000135956 0.02486642 0.454625359 8.62922137 8.174596011 225522_atAAK1 ENSG00000115977 0.02486642 1.172801595 8.65290817 7.480106575217757_at A2M ENSG00000175899 0.024980362 1.576462299 12.0289412710.45247897 223168_at RHOU ENSG00000116574 0.025426902 1.5603849187.215568938 5.655184019 1561615_s_at SLC8A1 ENSG00000183023 0.0258077591.56503616 8.855136737 7.290100577 203758_at CTSO ENSG000002560430.02606631 1.156055866 9.31162358 8.155567714 226552_at IER5LENSG00000188483 0.026467277 0.93672703 7.611941271 6.675214241202766_s_at FBN1 ENSG00000166147 0.027121311 1.374537951 7.7453624286.370824476 225629_s_at ZBTB4 ENSG00000174282 0.027121311 1.0197460139.543580585 8.523834572 212136_at ATP2B4 ENSG00000058668 0.0272826551.526692329 8.833219126 7.306526797 1555881_s_at LZTS2 ENSG000001078160.027517178 0.440221226 7.841075386 7.400854161 57715_at CALHM2ENSG00000138172 0.027517178 0.696007379 8.099815478 7.403808099226601_at SLC30A7 ENSG00000162695 0.027517178 0.937218503 8.3389677317.401749228 217890_s_at PARVA ENSG00000197702 0.027517178 1.5638317849.16028565 7.596453867 207624_s_at RPGR ENSG00000156313 0.0275718380.526289635 7.293504241 6.767214606 212372_at MYH10 ENSG000001330260.027571838 1.055713787 8.323251043 7.267537256 226820_at ZNF362ENSG00000160094 0.027571838 0.806241318 8.807479051 8.001237733202551_s_at CRIM1 ENSG00000150938 0.027571838 1.425695658 8.9476739517.521978294 208030_s_at ADD1 ENSG00000087274 0.027642759 0.5846549989.931156175 9.346501177 206618_at IL18R1 ENSG00000115604 0.0276427591.481537358 7.518533037 6.03699568 201212_at LGMN ENSG000001006000.027659186 2.066812025 10.1698232 8.103011174 208782_at FSTL1ENSG00000163430 0.027736606 1.32524447 10.08689397 8.761649497 209191_atTUBB6 ENSG00000176014 0.027736606 1.657527449 9.832241239 8.17471379206875_s_at SLK ENSG00000065613 0.027736606 1.064373439 8.0577170656.993343627 212990_at SYNJ1 ENSG00000159082 0.027736606 1.0442603817.114954309 6.070693928 204193_at CHKB ENSG00000100288 0.0277366060.899813254 9.518634166 8.618820912 203243_s_at PDLIM5 ENSG000001631100.028029546 1.142844616 7.842659274 6.699814657 227554_at MAGI2-AS3ENSG00000234456 0.028029546 1.583516525 7.049678455 5.46616193 224616_atDYNC1LI2 ENSG00000135720 0.028029546 0.795711906 10.00717568 9.211463776218901_at PLSCR4 ENSG00000114698 0.028186238 1.641200848 5.9386065944.297405747 209050_s_at RALGDS ENSG00000160271 0.028198657 0.8301435239.509798483 8.67965496 209472_at CCBL2 ENSG00000137944 0.0281986570.791465989 9.348801739 8.55733575 227542_at SOCS6 ENSG000001706770.028198657 1.310031965 6.680388823 5.370356858 204039_at CEBPAENSG00000245848 0.028198657 0.929871866 8.572792639 7.642920773212586_at CAST ENSG00000153113 0.028198657 0.741294527 9.2047739288.463479401 201280_s_at DAB2 ENSG00000153071 0.028198657 1.779780798.603166646 6.823385856 201599_at OAT ENSG00000065154 0.0281986570.889981447 9.474237119 8.584255672 225334_at C10orf32 ENSG000001662750.028198657 0.781438768 8.253485336 7.472046568 201334_s_at ARHGEF12ENSG00000196914 0.028226747 1.120752315 9.211231463 8.090479148229041_s_at ITGB2-AS1 ENSG00000227039 0.028919999 1.8343050859.515397779 7.681092694 212124_at ZMIZ1 ENSG00000108175 0.0289199991.472001753 10.25152688 8.779525132 204863_s_at IL6ST ENSG000001343520.028919999 1.145080811 9.161299338 8.016218527 215235_at SPTAN1ENSG00000197694 0.028919999 0.687712354 10.61620713 9.928494779212606_at WDFY3 ENSG00000163625 0.028919999 1.687587613 6.8402722875.152684674 212601_at ZZEF1 ENSG00000074755 0.028919999 0.4622512528.027308146 7.565056894 228577_x_at ODF2L ENSG00000122417 0.0289199990.928335466 7.134280411 6.205944945 227776_at ACER3 ENSG000000781240.028919999 1.179421743 7.521437369 6.342015626 201146_at NFE2L2ENSG00000116044 0.028919999 0.970559163 10.2023661 9.231806934 214807_atLOC100509635 NA 0.028919999 1.839892443 8.320892858 6.481000416201185_at HTRA1 ENSG00000166033 0.028919999 1.815072013 9.7504663787.935394366 209120_at NR2F2 ENSG00000185551 0.029112343 2.1914356368.372704969 6.181269333 226021_at RDH10 ENSG00000121039 0.0291123431.181075712 6.837596657 5.656520945 224480_s_at AGPAT9 ENSG000001386780.029340633 1.110871028 4.910358231 3.799487203 212077_at CALD1ENSG00000122786 0.029340633 1.724790131 10.17919504 8.454404905204745_x_at MT1G ENSG00000124144 0.029340633 1.041896811 10.903005289.861108467 227930_at AGO4 ENSG00000134698 0.029585591 1.1053520726.925534304 5.820182232 212636_at QKI ENSG00000112531 0.0297108131.378340651 8.509471015 7.131130365 202609_at EPS8 ENSG000001514910.029743118 2.016395991 8.302002557 6.285606566 207791_s_at RAB1AENSG00000138069 0.029761404 0.834242654 9.926540665 9.092298011226377_at NFIC ENSG00000141905 0.029761404 1.124935006 8.7856412297.660706223 212607_at AKT3 ENSG00000117020 0.029761404 1.286136328.86790134 7.58176502 220122_at MCTP1 ENSG00000175471 0.0298079011.579458936 7.121595256 5.54213632 225941_at EIF4E3 ENSG000001634120.029807901 1.364241317 7.790818489 6.426577172 65635_at ENGASEENSG00000167280 0.029836343 0.549126535 9.240446513 8.691319977202897_at SIRPA ENSG00000198053 0.029836343 1.079213131 9.7228421028.643628972 213817_at IRAK3 ENSG00000090376 0.029836343 1.4320001316.594781364 5.162781233 204703_at IFT88 ENSG00000032742 0.0298363430.555626502 7.914095211 7.358468709 201029_s_at CD99 ENSG000000025860.029836343 1.179550753 11.79489029 10.61533954 201105_at LGALS1ENSG00000100097 0.029836343 1.067969519 12.55395514 11.48598563228666_at C15orf38 ENSG00000242498 0.029836343 0.965528767 8.6328634327.667334665 213733_at MYO1F ENSG00000142347 0.029836343 1.2020209239.0479833 7.835962377 225162_at SH3D19 ENSG00000109686 0.0298363431.697719881 6.304495587 4.606775706 221766_s_at FAM46A ENSG000001127730.030025868 1.307438215 9.102394105 7.79495589 235256_s_at GALMENSG00000143891 0.030025868 1.3208648 7.939207095 6.618342295 201417_atSOX4 ENSG00000124766 0.030025868 1.094353867 7.314555393 6.220201526201963_at ACSL1 ENSG00000151726 0.030025868 1.026257459 9.4812845788.455027119 218983_at C1RL ENSG00000139178 0.030025868 1.0535411586.970689021 5.917147863 225442_at DDR2 ENSG00000162733 0.0300258681.204158025 8.120903012 6.916744987 225128_at KDELC2 ENSG000001782020.030088928 0.839868955 7.886197408 7.046328453 225913_at PEAK1 NA0.030088928 0.877481347 8.926047545 8.048566198 238477_at KIF1CENSG00000129250 0.030088928 0.514313913 6.616651948 6.1023380351557236_at APOL6 ENSG00000221963 0.030333182 1.353018745 6.5883349215.235316176 224764_at ARHGAP21 ENSG00000126775 0.030504136 0.726254828.341027574 7.614772751 204568_at ATG14 ENSG00000189171 0.0305041360.68255677 7.833224815 7.150668045 202598_at S100A13 ENSG000001717290.030504136 0.905469594 10.25862756 9.353157962 218815_s_at TMEM51ENSG00000118508 0.030529954 0.821120093 9.101393989 8.280273897204214_s_at RAB32 ENSG00000165914 0.030529954 0.974779135 8.2060923467.231313211 226152_at TTC7B ENSG00000172575 0.030555177 1.2258261797.058997136 5.833170957 205590_at RASGRP1 ENSG00000173482 0.0305551771.811511239 10.05801133 8.246500094 1555579_s_at PTPRM ENSG000001720590.030555177 1.133321622 7.834017042 6.70069542 218486_at KLF11ENSG00000157240 0.030555177 1.276283669 7.737115935 6.460832266204451_at FZD1 ENSG00000172059 0.030555177 1.280052899 7.2415743465.961521446 226186_at TMOD2 ENSG00000157240 0.030555177 1.3625461776.78422602 5.421679843 225288_at COL27A1 ENSG00000196739 0.0306910531.40544216 7.835001659 6.429559499 225163_at FRMD4A ENSG000001514740.030947129 1.137531712 7.41162528 6.274093568 221541_at CRISPLD2ENSG00000103196 0.030947129 1.757392292 8.718881123 6.961488831230480_at PIWIL4 ENSG00000134627 0.030947129 0.657514674 6.1122143455.45469967 227444_at ARMCX4 ENSG00000196440 0.030947129 0.9769799636.028166519 5.051186556 218285_s_at BDH2 ENSG00000164039 0.0309471290.724767228 8.942667027 8.217899799 209687_at CXCL12 ENSG000001075620.030947129 2.225058448 9.716134003 7.491075555 203261_at DCTN6ENSG00000104671 0.030947129 0.806565337 10.35688135 9.550316016227001_at NIPAL2 ENSG00000104361 0.030947129 1.385419946 8.2116062536.826186308 213119_at SLC36A1 ENSG00000123643 0.030947129 0.5276490118.188390174 7.660741163 201089_at ATP6V1B2 ENSG00000147416 0.0309471290.97966903 10.05201136 9.072342335 228937_at LACC1 ENSG000001796300.030947129 1.434772368 7.870868743 6.436096375 219666_at MS4A6AENSG00000110077 0.031011469 2.158907191 10.17588351 8.016976319209160_at AKR1C3 ENSG00000196139 0.031011469 1.558340801 6.7025496335.144208832 203688_at PKD2 ENSG00000118762 0.031011469 1.224663978.101780908 6.877116938 209379_s_at CCSER2 ENSG00000107771 0.0310114690.895302988 6.749214848 5.85391186 202973_x_at FAM13A ENSG000001386400.031011469 1.509075891 6.614676319 5.105600428 222999_s_at CCNL2ENSG00000221978 0.031011469 0.586307213 9.418617885 8.832310673 32811_atMYO1C ENSG00000197879 0.031087661 0.640476944 9.336456528 8.695979584213737_x_at GOLGA8I ENSG00000153666 0.031114275 1.284101363 9.2207855637.9366842 202351_at ITGAV ENSG00000138448 0.031169046 1.3604089559.310596989 7.950188034 226066_at MITF ENSG00000187098 0.0312030361.394602359 8.259922404 6.865320045 212453_at KIAA1279 ENSG000001989540.031374519 0.701033594 7.66960335 6.968569756 223276_at SMIM3ENSG00000256235 0.031482467 1.057195825 7.313511684 6.256315859 63825_atABHD2 ENSG00000140526 0.031482467 1.051003553 8.787774645 7.736771092203817_at GUCY1B3 ENSG00000061918 0.031482467 1.374252812 7.6776657456.303412934 232090_at DNM3OS ENSG00000230630 0.031482467 1.8766379036.738189882 4.861551979 218292_s_at PRKAG2 ENSG00000106617 0.031629870.737763701 7.332144993 6.594381292 1558173_a_at LUZP1 ENSG000001696410.03162987 0.796546664 9.005566311 8.209019647 201438_at COL6A3ENSG00000163359 0.03162987 1.673097599 11.52000403 9.846906433 235458_atHAVCR2 ENSG00000135077 0.03162987 1.567140584 9.031225144 7.46408456223393_s_at TSHZ3 ENSG00000121297 0.03162987 1.323992867 7.6079052956.283912428 215706_x_at ZYX ENSG00000159840 0.031657402 0.87736255310.7162578 9.838895242 219315_s_at TMEM204 ENSG00000131634 0.0317995650.945133516 7.656936821 6.711803305 201296_s_at WSB1 ENSG000001094060.031799565 1.262242726 10.19943828 8.937195558 232231_at RUNX2ENSG00000124813 0.031799565 2.284394978 8.680094375 6.395699398226225_at MCC ENSG00000171444 0.031799565 1.796214442 5.4909047963.694690354 214660_at ITGA1 ENSG00000213949 0.031799565 0.9359118594.662646523 3.726734663 216903_s_at MICU1 ENSG00000107745 0.0317995650.517945824 8.82526293 8.307317106 215111_s_at TSC22D1 ENSG000001028040.031799565 1.489649253 9.321974172 7.832324919 200782_at ANXA5ENSG00000164111 0.031799565 0.961354796 10.84305118 9.881696385226771_at ATP8B2 ENSG00000143515 0.031799565 1.091181637 8.2089039187.117722281 212185_x_at MT2A ENSG00000124148 0.031799565 1.01464093412.3668934 11.35225247 200986_at SERPING1 ENSG00000149131 0.0319707061.239835886 10.45704492 9.217209036 221269_s_at SH3BGRL3 ENSG000001426690.031970706 0.564410347 11.47106325 10.9066529 202081_at IER2ENSG00000160888 0.031970706 1.223949737 10.27326737 9.049317631206995_x_at SCARF1 ENSG00000074660 0.0324388 0.731394685 6.4931930875.761798402 204963_at SSPN ENSG00000123096 0.032493399 1.9774021157.971609463 5.994207348 202192_s_at GAS7 ENSG00000007237 0.0326885331.055406528 9.145390855 8.089984326 224747_at UBE2Q2 ENSG000001403670.032688533 1.004434491 8.252426793 7.247992302 202136_at ZMYND11ENSG00000015171 0.032688533 1.001702173 9.778629696 8.776927523209970_x_at CASP1 ENSG00000137752 0.032709967 1.260485478 9.1494747027.888989224 234987_at SAMHD1 ENSG00000101347 0.032726724 1.4165041419.200321126 7.783816985 205173_x_at CD58 ENSG00000116815 0.0327267241.604544482 9.908500357 8.303955875 229732_at ZNF823 ENSG000001979330.032726724 0.521251726 4.981580656 4.46032893 37408_at MRC2ENSG00000011028 0.032726724 0.976917275 9.119459522 8.142542247208922_s_at NXF1 ENSG00000162231 0.032726724 0.716558245 10.108966569.392408317 200766_at CTSD ENSG00000117984 0.032726724 1.03164944111.05559476 10.02394532 209129_at TRIP6 ENSG00000087077 0.0327267240.614395443 8.270124739 7.655729295 228728_at CPED1 ENSG000001060340.032726724 1.325706695 6.216332514 4.890625819 223028_s_at SNX9ENSG00000130340 0.032726724 1.546959073 9.600897425 8.053938352214464_at CDC42BPA ENSG00000143776 0.032726724 1.59035691 8.711909477.12155256 204059_s_at ME1 ENSG00000065833 0.032726724 2.1309537817.883910609 5.752956829 202481_at DHRS3 ENSG00000162496 0.0327267241.355717458 9.373900183 8.018182725 201426_s_at VIM ENSG000000260250.032726724 0.861969983 13.16643703 12.30446705 214177_s_at PBXIP1ENSG00000163346 0.032726724 0.643944864 8.558973921 7.915029058218793_s_at SCML1 ENSG00000047634 0.032726724 1.794930413 7.3483712085.553440795 201163_s_at IGFBP7 ENSG00000163453 0.032726724 1.27728909911.02178563 9.744496534 225406_at TWSG1 ENSG00000128791 0.0327267241.015495797 8.499218476 7.486722679 209071_s_at RGS5 ENSG000001432480.032726724 1.999256143 9.334305908 7.335049765 204206_at MNTENSG00000070444 0.032726724 0.454316598 8.034279619 7.579963021226026_at DIRC2 ENSG00000138463 0.032726724 1.212593407 8.3495612567.136967849 214683_s_at CLK1 ENSG00000013441 0.032726724 0.92150932810.05348313 9.131973801 218095_s_at TMEM165 ENSG00000134851 0.0327267240.788171748 10.38714798 9.598976234 219316_s_at FLVCR2 ENSG000001196860.032726724 0.85580157 7.371184456 6.515382886 226763_at SESTD1ENSG00000187231 0.032726724 1.059647685 9.5497248 8.490077115 227361_atHS3ST3B1 ENSG00000125430 0.032726724 1.522718422 7.752502237 6.229783816205248_at DOPEY2 ENSG00000142197 0.032726724 0.619808007 7.1783748896.558566882 211026_s_at MGLL ENSG00000074416 0.032726724 1.346260579.704250583 8.357990013 212224_at ALDH1A1 ENSG00000165092 0.0327267242.327986623 9.644018097 7.316031474 201215_at PLS3 ENSG000001020240.032726724 1.846069002 7.903700354 6.057631352 218432_at FBXO3ENSG00000110429 0.032726724 0.969202811 6.759587278 5.790384467212428_at KIAA0368 ENSG00000136813 0.032726724 0.502712224 8.8809604648.37824824 203394_s_at HES1 ENSG00000114315 0.032726724 1.180525459.074966195 7.894440745 235125_x_at FAM73A ENSG00000180488 0.0327267240.78900753 6.551390988 5.762383458 224690_at FAM210B ENSG000001240980.032726724 1.21859774 8.947455594 7.728857855 219991_at SLC2A9ENSG00000109667 0.032726724 0.745206521 7.42728002 6.6820735 214560_atFPR3 ENSG00000187474 0.032726724 1.552547402 10.11158701 8.559039603210946_at PPAP2A ENSG00000067113 0.032726724 0.869426384 8.482120437.612694046 210817_s_at CALCOCO2 ENSG00000136436 0.032726724 0.90107212210.04861929 9.147547173 208636_at ACTN1 ENSG00000072110 0.0327267241.492130835 9.059966788 7.567835952 1561226_at XCR1 ENSG000001735780.032726724 0.928038272 4.98061814 4.052579867 229256_at PGM2L1ENSG00000165434 0.032726724 0.950253856 6.806744083 5.856490226228131_at ERCC1 ENSG00000012061 0.032726724 0.698680629 8.6443777177.945697089 209310_s_at CASP4 ENSG00000196954 0.032735931 0.91038938210.59028021 9.679890826 218729_at LXN ENSG00000079257 0.0327359311.373435682 9.36297787 7.989542188 227274_at SYNJ2BP ENSG000002134630.032735931 0.945655293 8.969654087 8.023998795 219147_s_at NMRK1ENSG00000106733 0.032835037 1.031303038 8.134786202 7.103483164205083_at AOX1 ENSG00000138356 0.032835037 1.344757535 6.3464686155.00171108 209109_s_at TSPAN6 ENSG00000000003 0.032869735 1.3163026167.197532473 5.881229857 225303_at KIRREL ENSG00000183853 0.0328697351.284466775 7.658036153 6.373569378 225185_at MRAS ENSG000001581860.032869735 1.037700745 7.834458987 6.796758242 203716_s_at DPP4ENSG00000197635 0.032869735 1.50992049 8.788771757 7.278851267 204342_atSLC25A24 ENSG00000085491 0.032869735 0.999800872 8.623812513 7.624011641202948_at IL1R1 ENSG00000115594 0.033187995 1.749785268 8.5840527136.834267445 212511_at PICALM ENSG00000073921 0.033187995 0.7422532856.915631282 6.173377997 214429_at MTMR6 ENSG00000139505 0.0334655070.769730363 8.954554788 8.184824425 214021_x_at ITGB5 ENSG000000827810.033488347 1.43597723 6.631668819 5.19569159 227624_at TET2ENSG00000168769 0.033488347 1.07690976 7.558846267 6.481936507 225093_atUTRN ENSG00000152818 0.033488347 1.565715389 10.04128739 8.475571999227379_at MBOAT1 ENSG00000172197 0.033637219 1.226714416 7.1977268555.971012439 213139_at SNAI2 ENSG00000019549 0.033800859 1.5495816796.953320081 5.403738401 212099_at RHOB ENSG00000143878 0.0338008591.563197657 9.851472658 8.288275001 204894_s_at AOC3 ENSG000001314710.033800859 1.488715186 6.950874216 5.46215903 219432_at EVCENSG00000072840 0.033800859 0.973495437 7.657380766 6.683885329 55065_atMARK4 ENSG00000007047 0.033800859 0.450131769 7.655069099 7.204937331226353_at SPPL2A ENSG00000138600 0.034000797 1.086036284 9.824237518.738201226 216598_s_at CCL2 ENSG00000108691 0.034000797 1.57410032711.80437366 10.23027333 226568_at FAM102B ENSG00000162636 0.0340007971.19493473 7.320320998 6.125386268 218764_at PRKCH ENSG000000270750.034090749 1.324224837 8.842467348 7.518242511 225984_at PRKAA1ENSG00000132356 0.034117995 0.761625478 6.863441712 6.101816234201542_at SAR1A ENSG00000079332 0.034117995 0.735645671 9.7724311339.036785462 203455_s_at SAT1 ENSG00000130066 0.034117995 1.31652001911.13299333 9.816473307 225922_at FNIP2 ENSG00000052795 0.0341179951.519527523 8.166224411 6.646696888 218665_at FZD4 ENSG000001748040.034117995 1.021163189 7.416230764 6.395067575 221666_s_at PYCARDENSG00000103490 0.034190831 0.606108157 9.397235781 8.791127624201058_s_at MYL9 ENSG00000101335 0.034190831 1.2676991 10.376271989.108572878 203397_s_at GALNT3 ENSG00000115339 0.034190831 1.3066403055.45104883 4.144408525 222453_at CYBRD1 ENSG00000071967 0.0341908311.315727811 9.001391772 7.685663961 208146_s_at CPVL ENSG000001060660.034190831 1.943264679 9.534937034 7.591672354 227334_at USP54ENSG00000166348 0.034190831 0.595004786 7.632456518 7.037451732226534_at KITLG ENSG00000049130 0.034190831 1.687120279 6.5048084994.81768822 229120_s_at CDC42SE1 ENSG00000197622 0.034190831 1.0261208439.039741792 8.013620949 225066_at PPP2R2D ENSG00000175470 0.0341908310.410023152 6.51512502 6.105101868 211977_at GPR107 ENSG000001483580.034190831 0.41506351 7.323330309 6.908266799 217967_s_at FAM129AENSG00000135842 0.034190831 1.631617618 9.361851904 7.730234286207705_s_at NINL ENSG00000101004 0.034190831 0.458032479 7.4692716827.011239203 230029_x_at UBR3 ENSG00000144357 0.034212391 0.7132327417.406813979 6.693581237 227236_at TSPAN2 ENSG00000134198 0.0342400861.160525883 6.827257615 5.666731733 202510_s_at TNFAIP2 ENSG000001852150.034240086 1.611311545 10.98695296 9.375641416 202450_s_at CTSKENSG00000143387 0.034333589 2.058768294 10.34330275 8.284534455226395_at HOOK3 ENSG00000168172 0.034360811 0.907384172 9.0997328028.192348631 219403_s_at HPSE ENSG00000173083 0.034374363 1.2733774917.073411349 5.800033858 227623_at CACNA2D1 ENSG00000153956 0.0344013481.509374159 5.523191348 4.013817189 202239_at PARP4 ENSG000001026990.034401348 0.920213526 9.568361079 8.648147553 204646_at DPYDENSG00000188641 0.034480931 1.716538106 8.184742 6.468203894 209335_atDCN ENSG00000011465 0.034606801 2.0562205 8.106748111 6.050527611202341_s_at TRIM2 ENSG00000109654 0.034606801 1.154998273 7.6826783126.527680038 203386_at TBC1D4 ENSG00000136111 0.034611968 1.598635569.927925002 8.329289442 202465_at PCOLCE ENSG00000106333 0.0346872271.110793856 9.858341328 8.747547472 218501_at ARGHEF3 ENSG000001639470.034710054 1.211901006 9.345778775 8.433877769 203935_at ACVR1ENSG00000115170 0.034710054 0.929748525 7.592939572 6.663191047227726_at RNF166 ENSG00000158717 0.034778201 0.765255386 6.4902418975.724986511 225351_at FAM45A ENSG00000119979 0.034778201 0.7126870227.985558444 7.272871422 209967_s_at CREM ENSG00000095794 0.0347782011.498708212 8.008162888 6.509454676 217767_at C3 ENSG000001257300.034901896 1.610302964 11.06255643 9.452253469 202377_at LEPROTENSG00000213625 0.034901896 0.958758279 8.927718442 7.968960164212067_s_at C1R ENSG00000159403 0.034901896 1.095883775 10.977297789.881414002 206461_x_at MT1H ENSG00000205358 0.034906504 0.93747984810.94110484 10.00362499 212651_at RHOBTB1 ENSG00000072422 0.0349204351.278051787 5.30325947 4.025207683 213077_at YTHDC2 ENSG000000471880.034920435 1.082274718 7.160912963 6.078638245 238617_at KIF26BENSG00000162849 0.034920435 1.816726723 7.548086863 5.73136014 201540_atFHL1 ENSG00000022267 0.034920435 2.090914464 8.481468308 6.390553844227325_at PRR24 ENSG00000257704 0.034920435 0.590098253 7.8239378357.233839582 208093_s_at NDEL1 ENSG00000166579 0.034947401 0.7410348388.576080766 7.835045928 202006_at PTPN12 ENSG00000127947 0.0350385571.018262804 9.540273742 8.522010938 209216_at WDR45 ENSG000001969980.035038557 0.696795004 8.826888223 8.130093219 225782_at MSRB3ENSG00000174099 0.035038557 1.444375496 6.51471588 5.070340384 200602_atAPP ENSG00000142912 0.035038557 1.325930012 9.055534642 7.729604631226939_at CPEB2 ENSG00000137449 0.035264082 1.226498712 7.6116243876.385125675 218986_s_at DDX60 ENSG00000137628 0.035316356 1.4860213718.318531076 6.832509705 203139_at DAPK1 ENSG00000196730 0.0353163561.707948936 8.912548269 7.204599333 213764_s_at MFAP5 ENSG000001976140.035434896 1.297982185 5.790529452 4.492547267 202565_s_at SVILENSG00000197321 0.035639458 1.389051153 8.635444721 7.246393568210968_s_at RTN4 ENSG00000115310 0.035770121 0.829593112 10.696532499.866939383 225562_at RASA3 ENSG00000185989 0.035779896 0.9721275399.062084532 8.089956993 218454_at PLBD1 ENSG00000121316 0.035786371.441982401 10.25391754 8.81193514 209467_s_at MKNK1 ENSG000000792770.035868055 0.783294393 8.294847035 7.511552642 226869_at MEGF6ENSG00000162591 0.035950269 1.265043406 7.859101342 6.594057936221569_at AHI1 ENSG00000135541 0.035950269 1.076140591 7.7936520986.717511506 1569157_s_at ZNF846 ENSG00000196605 0.035950269 0.7746233336.057018085 5.282394752 218132_s_at TSEN34 ENSG00000170892 0.0359502690.438866613 8.237398535 7.798531921 201591_s_at NISCH ENSG000000103220.036417437 0.405648171 8.996513107 8.590864936 227098_at DUSP18ENSG00000167065 0.036417437 0.482163643 7.203923142 6.721759499203910_at ARHGAP29 ENSG00000137962 0.036417437 1.513169879 7.3363413565.823171477 1555847_a_at LOC284454 NA 0.036417437 0.9290134259.021958303 8.092944878 241353_s_at LOC100507507 NA 0.0364174370.563123987 6.938191846 6.375067858 202225_at CRK ENSG000001671930.036417437 0.76604843 9.380487824 8.614439395 212915_at PDZRN3ENSG00000121440 0.036490985 1.312579319 6.719045192 5.406465873202920_at ANK2 ENSG00000145362 0.036490985 1.463394123 8.124628236.661234107 235391_at FAM92A1 ENSG00000188343 0.036548329 0.6211361797.223438844 6.602302665 224906_at ANO6 ENSG00000177119 0.0366753130.877112362 8.66468344 7.787571078 227087_at INPP4A ENSG000000409330.036675313 1.023789448 8.031874294 7.005084846 225931_s_at RNF213ENSG00000173821 0.036802205 1.10725232 9.749178104 8.641925784 212690_atDDHD2 ENSG00000085788 0.036831284 0.878356205 9.176866822 8.298510616209003_at SLC25A11 ENSG00000108528 0.036890888 0.43772317 7.9546672227.516944052 202206_at ARL4C ENSG00000188042 0.036890888 1.3898051179.321386817 7.9315817 232000_at TTC39B ENSG00000155158 0.0370684781.356512637 4.978732932 3.622220295 225386_s_at HNRPLL NA 0.0370684781.459395359 9.121601553 7.662206194 226409_at TBC1D20 ENSG000001258750.037068478 0.505585753 8.965323908 8.459738154 204066_s_at AGAP1ENSG00000157985 0.037087501 1.078941551 6.075080058 4.996138507212441_at KIAA0232 ENSG00000170871 0.037087501 0.590210466 8.6067858968.01657543 225726_s_at PLEKHH1 ENSG00000054690 0.037087501 0.9526951065.964957706 5.0122626 232094_at KATNBL1 ENSG00000134152 0.0370875010.5971703 7.264443135 6.667272835 225604_s_at GLIPR2 ENSG000001226940.037323559 0.853910711 7.844159209 6.990248499 205225_at ESR1ENSG00000091831 0.037323559 1.382468278 6.467921229 5.085452951218838_s_at TTC31 ENSG00000115282 0.037323559 0.672650224 8.5241584797.851508256 227961_at CTSB ENSG00000164733 0.037323559 1.33813958510.24117448 8.903034892 1558041_a_at KIAA0895L ENSG000001961230.037412554 0.876742459 7.925106663 7.048364204 209540_at IGF1ENSG00000017427 0.037412554 1.522509458 8.256633376 6.734123918203651_at ZFYVE16 ENSG00000039319 0.037412554 1.025141601 8.5274841217.502342519 224900_at ANKFY1 ENSG00000185722 0.037546087 0.5329529568.581470479 8.048517523 223441_at SLC17A5 ENSG00000119899 0.0376271910.645005952 6.824616025 6.179610072 204294_at AMT ENSG000001450200.037627191 0.399434215 8.335213696 7.935779481 204040_at RNF144AENSG00000151692 0.037681586 1.481347774 6.933003595 5.451655821225272_at SAT2 ENSG00000141504 0.037706134 0.618612094 9.0781505538.459538459 204464_s_at EDNRA ENSG00000151617 0.037706134 1.4248340747.176770385 8.751936311 205011_at VWA5A ENSG00000110002 0.0377061341.501068828 8.178126937 6.677058109 212765_at CAMSAP2 ENSG000001182000.037713812 1.070277586 7.585165033 6.514887447 212624_s_at CHN1ENSG00000128656 0.037754756 1.199366569 8.339419696 7.140053127209213_at CBR1 ENSG00000159228 0.037828214 0.716339962 9.3781756668.661835705 207738_s_at NCKAP1 ENSG00000061676 0.037828214 1.7420168075.909031575 4.167014768 206856_at LILRB5 ENSG00000105609 0.0379500571.58731928 8.757091921 7.169772641 200697_at HK1 ENSG000001565150.03798879 0.497080421 10.98016503 10.48308461 219134_at ELTD1ENSG00000162618 0.038039799 1.633116993 7.99727279 6.364155796222294_s_at RAB27A ENSG00000069974 0.038154279 1.512875635 7.2273726855.71449705 201057_s_at GOLGB1 ENSG00000173230 0.038450193 0.6396180569.22083416 8.581216104 218017_s_at HGSNAT ENSG00000165102 0.0385665611.101893048 8.583362968 7.48146992 226905_at FAM101B ENSG000001836880.038659566 1.355638698 8.83238214 7.476743442 226616_s_at NDUFV3ENSG00000160194 0.038671508 0.66206984 10.46600414 9.803934298215127_s_at RBMS1 ENSG00000153250 0.038707721 0.985761408 9.0601460358.074384626 212373_at FEM1B ENSG00000169018 0.03889702 0.9618686688.42816521 7.466296542 222750_s_at SRD5A3 ENSG00000128039 0.038897020.762605382 8.2518174 7.489212018 236006_s_at AKAP10 ENSG000001085990.069007321 0.655037688 7.858287091 7.173249402 224733_at CMTM3ENSG00000140931 0.039181923 0.690269684 9.982739003 9.292469319204981_at SLC22A18 ENSG00000110628 0.039181923 0.561183888 0.5611838887.028755911 223077_at TMOD3 ENSG00000138594 0.039239917 1.0922066477.964720713 6.872514066 209686_at S100B ENSG00000160307 0.0392414750.901290569 6.761868136 5.860577567 225325_at MFSD6 ENSG000001516900.039241475 0.839407884 8.69192971 7.852521826 205236_x_at SOD3ENSG00000109610 0.03957993 0.891900627 8.45163302 7.559732393 228220_atFCHO2 ENSG00000157107 0.03957993 1.563762465 8.795856173 7.232093708205904_at MICA ENSG00000204520 0.03957993 0.427228475 7.6847538877.257525412 226777_at ADAM12 ENSG00000148848 0.03957993 1.9432470657.771445066 5.828198001 213618_at ARAP2 ENSG00000047365 0.039579931.028082071 7.620559319 6.592477248 205624_at CPA3 ENSG000001637510.03957993 2.151198872 6.492961642 4.34176277 215268_at KIAA0754ENSG00000255103 0.03957993 0.809104773 6.285140538 5.476035765203672_x_at TPMT ENSG00000137364 0.03957993 0.554375735 9.6233902679.069014532 1555229_a_at C1S ENSG00000182326 0.03957993 1.56283327110.46271064 8.899877365 203855_at WDR47 ENSG00000085433 0.039579930.715002164 7.128000627 6.412998464 207072_at IL18RAP ENSG000001156070.03957993 0.981690585 7.548943432 6.567252847 221935_s_at EOGTENSG00000163378 0.03960808 0.83587661 7.127103969 6.291227359203232_s_at ATXN1 ENSG00000124788 0.03960808 1.486472653 8.2938231166.807350464 202096_s_at TSPO ENSG00000100300 0.039769597 0.6186136059.561862207 8.942972602 224813_at WASL ENSG00000106299 0.0397695970.810234478 8.822272437 8.012037959 213455_at FAM114A1 ENSG000001977120.039797292 0.841637956 7.947071796 7.10543384 226873_at FAM63BENSG00000128923 0.039877715 0.781681687 7.054055786 6.2723740991554503_a_at OSCAR ENSG00000170909 0.040082873 0.481594381 6.6529825946.171388213 206118_at STAT4 ENSG00000138378 0.040381182 1.6428433427.76374389 6.120900548 210970_s_at IBTK ENSG00000005700 0.0405432890.753886475 8.260872375 7.506985901 227113_at ADHFE1 ENSG000001475760.040543289 0.706136194 8.382822434 7.67668624 202949_s_at FHL2ENSG00000115641 0.040593602 1.403182627 7.613598294 6.210415667225579_at PQLC3 ENSG00000162976 0.040596862 1.113667847 9.5378725478.4242047 235291_s_at FLJ32255 NA 0.040715697 1.119695897 7.8673140726.747618175 203939_at NT5E ENSG00000135318 0.040733387 0.8061792487.42523104 6.619051792 214274_s_at ACAA1 ENSG00000060971 0.0407937180.502419076 9.465451705 8.963032628 204046_at PLCB2 ENSG000001378410.040802463 0.533783551 8.533797162 8.000013611 202392_s_at PISDENSG00000241878 0.041073186 0.356364153 8.566583027 8.210218874218326_s_at LGR4 ENSG00000205213 0.041073186 1.255121429 5.0221099263.766988497 229119_s_at ZSWIM7 ENSG00000214941 0.041073186 1.0247863147.910530196 6.885743882 206491_s_at NAPA ENSG00000105402 0.0414146470.495436416 9.333764247 8.838327831 227450_at ERP27 ENSG000001390550.041414647 0.966196682 6.328914416 5.362717734 200866_s_at PSAPENSG00000197746 0.041414647 1.085359838 11.69848738 10.61312755200720_s_at ACTR1A ENSG00000138107 0.041414647 0.496753402 8.8248616768.328108274 232064_at FER ENSG00000151422 0.041414647 0.6560545947.136386009 6.480331415 217922_at MAN1A2 ENSG00000198162 0.041445040.69736844 8.202283201 7.504914761 201944_at HEXB ENSG000000498600.041569794 1.010944746 11.59320288 10.58225814 210986_s_at TPM1ENSG00000140416 0.041569794 1.650337469 9.944608224 8.294270755227568_at HECTD2 ENSG00000165338 0.041569794 1.119931753 6.6850608855.565129131 200645_at GABARAP ENSG00000170296 0.041569794 0.63174734211.38104358 10.74929624 219892_at TM6SF1 ENSG00000136404 0.0415697941.518719736 7.818958694 6.300238959 222431_at SPIN1 ENSG000001067230.041569794 0.70282485 9.186280228 8.483455378 203665_at HMOX1ENSG00000100292 0.041569794 1.019908548 9.506813677 8.486905129202506_at SSFA2 ENSG00000138434 0.041569794 0.947553911 8.0184714737.070917562 221899_at N4BP2L2 ENSG00000244754 0.041569794 0.8653352699.046774211 8.181438942 203668_at MAN2C1 ENSG00000140400 0.0416902060.633916604 8.663669977 8.029753373 206295_at IL18 ENSG000001507820.041916833 1.292174393 9.298735781 8.006561388 228152_s_at DDX60LENSG00000181381 0.041916833 1.421343576 7.853791688 6.432448112228341_at NUDT16 ENSG00000198585 0.041916833 0.813285601 6.7076018465.894316245 218164_at SPATA20 ENSG00000006282 0.041916833 0.5879295929.02333374 8.435404148 227070_at GLT8D2 ENSG00000120820 0.0419168331.757351115 5.840317565 4.082966449 213083_at SLC35D2 ENSG000001309580.041916833 0.829365427 7.315854336 6.486488909 224772_at NAV1ENSG00000134369 0.041916833 1.051478872 7.602145754 6.550666882229287_at PCNX ENSG00000100731 0.041916833 0.943930482 7.5662015476.622271065 201200_at CREG1 ENSG00000143162 0.041916833 1.05815544511.10068635 10.0425309 229450_at IFIT3 ENSG00000119917 0.0419168331.6631975 9.084234826 7.421037327 228249_at C11orf74 ENSG000001663520.041916833 0.848798181 5.174338696 4.325540515 38487_at STAB1ENSG00000010327 0.04205946 1.090580398 9.310990038 8.22040964 202974_atMPP1 ENSG00000130830 0.04205946 1.062976134 9.614559777 8.551583643226510_at HEATR5A ENSG00000129493 0.04205946 0.7510398 7.259605896.50872079 228282_at MFSD8 ENSG00000164073 0.04205946 0.8192732047.582661234 6.763388029 203675_at NUCB2 ENSG00000070081 0.042059460.905774662 9.751698376 8.845923714 228384_s_at PYROXD2 ENSG000001199430.04205946 0.304011115 6.385890727 6.081879612 229367_s_at GIMAP6ENSG00000133561 0.04205946 1.409013647 8.888667615 7.479653968 218309_atCAMK2N1 ENSG00000162545 0.04205946 1.260533336 7.868836571 6.60830323534726_at CACNB3 ENSG00000167535 0.04205946 0.413630799 6.9346170876.520986288 212670_at ELN ENSG00000049540 0.04205946 1.2311529278.81370025 7.582547323 229800_at DCLK1 ENSG00000133083 0.042059461.498592436 6.412070979 4.913478542 201975_at CLIP1 ENSG000001307790.042246192 1.028511221 8.482482941 7.453971719 224413_s_at TM2D2ENSG00000169490 0.042247538 0.61300573 9.024042453 8.411036723 204011_atSPRY2 ENSG00000136158 0.042331876 1.318852631 7.198128454 5.879275822235033_at NPEPL1 ENSG00000215440 0.042331876 0.763205701 5.8905852295.127379527 228348_at LINS ENSG00000140471 0.042350925 0.8898302338.824668316 7.934838083 227628_at GPX8 ENSG00000164294 0.0423510941.180447997 6.970795245 5.790347248 1557112_a_at VPS53 ENSG000001412520.042351094 0.518032516 7.975808016 7.4577755 228071_at GIMAP7ENSG00000179144 0.042351094 1.647364043 8.992108891 7.344744848209264_s_at TSPAN4 ENSG00000214063 0.042351094 0.681754755 9.0066995758.32494482 208892_s_at DUSP6 ENSG00000139318 0.042351094 1.2289738177.992040123 6.763066305 201315_x_at IFITM2 ENSG00000185201 0.0423510940.739392199 11.67358479 10.9341926 222802_at EDN1 ENSG000000784010.042351094 1.460541762 6.322746092 4.86220433 1553395_a_at CD200R1ENSG00000163606 0.042351094 1.256910265 6.464778546 5.207868281226399_at DNAJB14 ENSG00000164031 0.042351094 0.849947729 8.1628842947.312936565 226490_at NHSL1 ENSG00000135540 0.042351094 1.1946658587.117630828 5.92296497 222513_s_at SORBS1 ENSG00000095637 0.0423510941.325460985 8.112293431 6.786832446 218705_s_at SNX24 ENSG000000646520.042351094 0.90943161 7.531422028 6.621990418 226837_at SPRED1ENSG00000166068 0.042351094 1.212871192 7.561561543 6.348690351225338_at ZYG11B ENSG00000162378 0.042351094 0.624478143 7.3137898746.689311731 204955_at SRPX ENSG00000101955 0.042351094 1.7691767497.330012241 5.560835493 210840_s_at IQGAP1 ENSG00000140575 0.0423510940.815667827 10.6038101 9.788142278 201494_at PRCP ENSG000001375090.042351094 0.880611665 10.84225026 9.961638596 204415_at IFI6ENSG00000126709 0.042351094 1.113083585 9.36647792 8.253394336209290_s_at NFIB ENSG00000147862 0.042351094 1.655774494 8.409196346.753421846 221474_at MYL12B ENSG00000118680 0.042419604 0.58613110110.97279348 10.38666238 235747_at SLC25A16 ENSG00000122912 0.0424196040.546049363 7.042744928 6.496695565 201924_at AFF1 ENSG000001724930.042419604 0.952063778 10.2416206 9.289556827 218045_x_at PTMSENSG00000159335 0.042596049 0.607162357 9.924387924 9.317225567213943_at TWIST1 ENSG00000122691 0.042596049 1.16873421 7.2719380176.103203807 226752_at FAM174A ENSG00000174132 0.042596049 0.928716315.776448605 4.847732296 201876_at PON2 ENSG00000105854 0.0427197681.187571081 9.054738216 7.867167135 1554240_a_at ITGAL ENSG000000058440.042881947 1.302505376 9.317162745 8.014657369 203989_x_at F2RENSG00000181104 0.042891128 1.246519921 7.440038684 6.193518762226425_at CLIP4 ENSG00000115295 0.042891128 1.499860122 7.7833280816.28346796 200762_at DPYSL2 ENSG00000092964 0.042891128 1.1591717939.328123535 8.168951742 223681_s_at INADL ENSG00000132849 0.0428911281.250998756 6.181876637 4.930877881 211986_at AHNAK ENSG000001249420.042891128 1.334146601 11.47855827 10.14441167 204112_s_at HNMTENSG00000150540 0.042891128 1.303474995 8.681932953 7.378457958235360_at PLEKHM3 ENSG00000178385 0.042891128 0.436326441 7.4810775737.044751132 209276_s_at GLRX ENSG00000173221 0.042939851 1.15335276810.46513253 9.311779765 226113_at ZNF436 ENSG00000125945 0.0429507470.967635125 7.934452645 6.96681752 201694_at EGR1 ENSG000001207380.04303339 2.356208235 9.680723259 7.324515023 204417_at GALCENSG00000054983 0.04303339 1.18197166 9.186049316 8.004077656211178_s_at PSTPIP1 ENSG00000140368 0.043103445 0.558040078 8.7643749998.206334921 203088_at FBLN5 ENSG00000140092 0.043103445 1.574610418.128331591 6.553721182 218450_at HEBP1 ENSG00000013583 0.0431034450.756321096 8.459513001 7.703191905 210113_s_at NLRP1 ENSG000000915920.043127824 0.654465183 7.398936818 6.744471635 225673_at MYADMENSG00000179820 0.043127824 1.185973479 9.460657173 8.274683693 31874_atGAS2L1 ENSG00000185340 0.043127824 0.959125758 7.063627768 6.10450201222597_at SNAP29 ENSG00000099940 0.043127824 0.523137969 8.6822694288.159131459 226279_at PRSS23 ENSG00000150687 0.043152778 1.360436717.67513518 6.31469847 235570_at RBMS3 ENSG00000144642 0.0431527781.782327906 7.335632998 5.553305092 214830_at SLC38A6 ENSG000001399740.043249838 1.276930786 7.341342657 6.064411871 201366_at ANXA7ENSG00000138279 0.043259906 0.763011677 8.850377121 8.087365443203179_at GALT ENSG00000213930 0.043316491 0.410171519 8.833284448.423112921 225919_s_at C9orf72 ENSG00000147894 0.04347548 0.8552519088.181409697 7.326157789 36711_at MAFF ENSG00000185022 0.043475481.042386023 5.605979018 4.563592995 205174_s_at QPCT ENSG000001158280.043531412 1.261724497 8.418598958 7.156874461 225032_at FNDC3BENSG00000075420 0.043656579 1.148111719 9.960617367 8.542505648225283_at ARRDC4 ENSG00000140450 0.043675035 1.263277402 6.9194181595.656140757 212820_at DMXL2 ENSG00000104093 0.043693329 1.7237552859.098753998 7.374998712 202411_at IFI27 ENSG00000165949 0.0436933291.419904538 10.65301374 9.233109201 201444_s_at ATP6AP2 ENSG000001822200.043693329 0.848128217 9.927790973 9.079662756 212209_at MED13LENSG00000123066 0.043693329 0.718689048 7.683203365 6.964514318228082_at CLMP ENSG00000166250 0.043693329 0.811085985 8.0193609237.208274938 201579_at FAT1 ENSG00000083857 0.043693329 1.1996966026.984437994 5.784741393 201050_at PLD3 ENSG00000105223 0.0437386750.872712957 11.22150754 10.34879458 205726_at DIAPH2 ENSG000001472020.043865363 0.824323825 7.524441934 6.700118109 212717_at PLEKHM1ENSG00000225190 0.04386943 0.350082673 8.468551352 8.118468679202827_s_at MMP14 ENSG00000157227 0.043950069 1.093430274 9.7027379548.60930768 201594_s_at PPP4R1 ENSG00000154845 0.043950069 0.818039389.27411864 8.456079261 203460_s_at PSEN1 ENSG00000080815 0.0439500690.81390235 8.845796903 8.031894553 221840_at PTPRE ENSG000001323340.044016553 1.294850625 8.885637792 7.590787167 203410_at AP3M2ENSG00000070718 0.044042681 0.768339069 7.036583 6.268243931 226582_atLOC400043 NA 0.044042681 0.869479209 6.73443097 5.864951761 209600_s_atACOX1 ENSG00000161533 0.044042681 0.648332519 8.512058318 7.863725799221814_at GPR124 ENSG00000020181 0.044042681 1.095880575 8.4886476757.3927671 230836_at ST8SIA4 ENSG00000113532 0.044042681 1.0174978077.57919038 6.561692573 204270_at SKI ENSG00000157933 0.0440426810.896035069 9.220481497 8.324446427 200872_at S100A10 ENSG000001977470.044042681 0.862231392 12.14558315 11.28335176 219761_at CLEC1AENSG00000150048 0.044042681 1.291289338 6.704345965 5.413056627212708_at MSL1 ENSG00000188895 0.044042681 0.856069768 9.5297262228.673656454 204326_x_at MT1X ENSG00000187193 0.044070216 1.00172934210.8648548 9.863125458 241392_at TMEM39A ENSG00000176142 0.0440702160.341471009 6.928601856 6.587130847 205771_s_at AKAP7 ENSG000001185070.044070216 0.731995834 6.526724778 5.794728944 206227_at CILPENSG00000138615 0.044070216 2.257502766 8.735997724 6.478494958204158_s_at TCIRG1 ENSG00000110719 0.044070216 0.593079771 9.5971571249.004077354 212948_at CAMTA2 ENSG00000108509 0.044070216 0.5383882119.486336458 8.947948247 218241_at GOLGA5 ENSG00000066455 0.0440783550.503478348 7.912463839 7.408985491 203042_at LAMP2 ENSG000000058930.044078355 1.386613769 9.189891489 7.80327772 223264_at MESDC1ENSG00000140406 0.044215499 0.658578285 8.66869473 8.010116444 243141_atSGMS2 ENSG00000164023 0.044312646 1.085634594 5.816519276 4.730884682212513_s_at USP33 ENSG00000077254 0.044312646 0.869205809 8.9106011558.041395346 44111_at VPS33B ENSG00000184056 0.044312646 0.718529387.769682095 7.051152715 203044_at CHSY1 ENSG00000131873 0.0447780870.860312924 9.374891415 8.514578491 201133_s_at PJA2 ENSG000001989610.045063391 0.928851445 8.789327346 7.860475902 238478_at BNC2ENSG00000173068 0.04510855 1.581928937 6.500666236 4.918737299207121_s_at MAPK6 ENSG00000069956 0.045216957 0.971961406 9.2503253098.278363904 226757_at IFIT2 ENSG00000119922 0.045216957 1.2581632877.398381051 6.140217764 224929_at TMEM173 ENSG00000184584 0.0452169570.976901806 8.795661513 7.818759707 219013_at GALNT11 ENSG000001782340.045216957 0.624765223 8.111616397 7.486851174 203732_at TRIP4ENSG00000103671 0.045216957 0.534991672 8.282763586 7.747771914206991_s_at CCR5 ENSG00000160791 0.045321132 1.498899795 8.8071957297.308295934 212192_at KCTD12 ENSG00000179695 0.045321132 1.24111196911.04261631 9.801504337 212071_s_at SPTBN1 ENSG00000115306 0.0453890851.148298747 10.50838671 9.360087962 204194_at BACH1 ENSG000001562730.045389085 0.684495403 7.331339629 6.646844226 213469_at PGAP1ENSG00000197121 0.045389085 0.801387927 4.677932308 3.876544381207173_x_at CDH11 ENSG00000140937 0.045389085 1.855491998 9.1120926597.256600661 202020_s_at LANCL1 ENSG00000115365 0.045389085 0.722589439.184946138 8.462356708 201384_s_at NBR1 ENSG00000188554 0.0456224030.69719383 9.452833592 8.755639763 213004_at ANGPTL2 ENSG000001368590.045650379 1.488271363 9.435206476 7.946935113 203310_at STXBP3ENSG00000116266 0.045775429 0.770798736 7.72163929 6.950840554 212239_atPIK3R1 ENSG00000145675 0.045775429 0.737750823 9.025386358 8.287635535225864_at FAM84B ENSG00000168672 0.045775429 1.677914651 6.1942313054.516316654 218679_s_at VPS28 ENSG00000160948 0.045809883 0.3909078549.961259817 9.300351963 211964_at COL4A2 ENSG00000134871 0.0458568541.232811948 10.70556132 9.472749367 212501_at CEBPB ENSG000001722160.045856854 0.738238476 10.55473241 9.816493929 215596_s_at LTN1ENSG00000198862 0.045856854 0.600695092 9.12314625 8.522451158 235306_atGIMAP8 ENSG00000171115 0.045948778 1.141523234 7.866981655 6.725458421213746_s_at FLNA ENSG00000196924 0.045983205 0.670976446 10.554530249.883553792 200982_s_at ANXA6 ENSG00000197043 0.045983205 0.9677565449.852305278 8.884548734 227029_at FAM177A1 ENSG00000151327 0.0460433330.833008817 6.455041674 5.622032856 225695_at SLC35F6 ENSG000002136990.046225372 0.724610376 9.024413478 8.299803103 230263_s_at DOCK5ENSG00000147459 0.046636223 0.984168534 5.975225342 4.991056808219860_at LY6G5C ENSG00000204428 0.046660118 0.498836907 6.3197731045.820936197 216620_s_at ARHGEF10 ENSG00000104728 0.046660118 1.0059163838.01557698 7.009660598 209298_s_at ITSN1 ENSG00000205726 0.0467115921.277202537 5.88081823 4.603615693 219383_at PRR5L ENSG000001353620.046711592 0.874143565 4.475309631 3.601166066 218204_s_at FYCO1ENSG00000163820 0.046711592 0.475324889 7.841059718 7.36573483212637_s_at WWP1 ENSG00000123124 0.046711592 0.922349431 7.4113092236.488959792 200784_s_at LRP1 ENSG00000123384 0.046711592 0.83546940910.71172473 9.876255321 202668_at EFNB2 ENSG00000125266 0.0467115921.300618622 7.729295355 6.428676733 211926_s_at MYH9 ENSG000001003450.046850713 0.514027812 10.37283665 9.85880884 207181_s_at CASP7ENSG00000165806 0.046856444 0.877318568 8.172928021 7.295609453203940_s_at VASH1 ENSG00000071246 0.046903847 0.759053043 8.9935674898.234514446 225046_at LOC389831 NA 0.046903847 1.209299028 9.5027442988.29344527 229699_at LOC100129550 NA 0.046903847 0.787522797 7.2521246576.46460186 1555997_s_at IGFBP5 ENSG00000115461 0.046903847 2.0893027379.039541189 6.950238452 221858_at TBC1D12 ENSG00000108239 0.0469038470.975449344 6.730088898 5.754639554 202123_s_at ABL1 ENSG000000970070.046903847 0.535932838 8.956464172 8.420531334 209189_at FOSENSG00000170345 0.046903847 2.311395259 8.928569361 6.617174102231697_s_at VMP1 ENSG00000062716 0.046903847 1.337676729 9.3382487588.000572029 231823_s_at SH3PXD2B ENSG00000174705 0.046907121 1.3421905978.749657487 7.40746689 226917_s_at ANAPC4 ENSG00000053900 0.0469071210.7157989 9.420943217 8.705144317 213135_at TIAM1 ENSG000001562990.046959774 1.432495967 8.128730835 6.692234868 222793_at DDX58ENSG00000107201 0.046959774 0.793030854 6.897065298 6.104034445235059_at RAB12 ENSG00000206418 0.047160578 0.736169692 8.2884550577.552285365 213364_s_at SNX1 ENSG00000028528 0.047357556 0.9413215517.632325883 6.691004333 213194_at ROBO1 ENSG00000169855 0.0473575561.202364784 8.299204466 7.096839682 223434_at GBP3 ENSG000001172260.047368037 1.767006321 8.155929476 6.388923155 201464_x_at JUNENSG00000177606 0.047576751 1.411647741 9.379205572 7.967557831228325_at KIAA0146 NA 0.047576751 1.637115768 6.87876789 5.241652122226639_at SFT2D3 ENSG00000173349 0.047769829 0.402970073 7.4722420137.06927194 204204_at SLC31A2 ENSG00000136867 0.04778455 1.0781469637.858561834 6.78041487 213659_at ZNF75D ENSG00000186376 0.047784550.665495605 7.859603651 7.194108047 219165_at PDLIM2 ENSG000001209130.047788444 0.537830248 8.659828829 8.12199858 202704_at TOB1ENSG00000141232 0.047841124 1.157733162 7.864872509 6.707139347201059_at CTTN ENSG00000085733 0.047841124 1.132979997 8.1268289796.993848982 208626_s_at VAT1 ENSG00000108828 0.047842986 0.9455256810.23981289 9.294287208 224285_at GPR174 ENSG00000147138 0.0478864521.19745705 7.961716488 6.764259438 202746_at ITM2A ENSG000000785960.047974392 1.756296873 8.555659235 6.799362362 1557749_at EHBP1L1ENSG00000173442 0.047976051 1.300818836 7.376097806 6.07527897 208671_atSERINC1 ENSG00000111897 0.047976051 0.972609476 8.578870199 7.606260723235199_at RNF125 ENSG00000101695 0.048038754 1.064207451 7.0656920156.001484564 236565_s_at LARP6 ENSG00000166173 0.048102844 0.6843003875.230392066 4.546091679 204575_s_at MMP19 ENSG00000123342 0.0481028440.946555962 7.578626866 6.632070904 221653_x_at APOL2 ENSG000001283350.048102844 0.588583201 10.11616798 9.527584778 224804_s_at FAM219BENSG00000178761 0.048102844 0.651562841 8.895175581 8.24361274 202820_atAHR ENSG00000106546 0.048164884 1.191425195 8.433260381 7.241835186204082_at PBX3 ENSG00000167081 0.048164884 0.63580907 8.5767764577.940967387 218109_s_at MFSD1 ENSG00000118855 0.048304996 1.13967330210.13940908 8.999735777 231897_at PTGR1 ENSG00000106853 0.0483049961.154891244 7.789450843 6.634559598 205786_s_at ITGAM ENSG000001698960.048305577 1.137807787 8.121972126 6.984164339 203510_at METENSG00000105976 0.048305577 1.650209197 7.842578732 6.192369534224896_s_at TTL ENSG00000114999 0.048305577 0.56036721 8.8104420428.250074832 232645_at LOC153684 NA 0.048305577 0.888956991 7.1598783186.270921327 226576_at ARHGAP26 ENSG00000145819 0.048305577 0.8225881926.112705611 5.290117419 219191_s_at BIN2 ENSG00000110934 0.0483055771.097818549 9.34065692 8.242838371 214853_s_at SHC1 ENSG000001606910.048305577 0.580661886 10.02587289 9.445211 224358_s_at MS4A7ENSG00000166927 0.048314327 2.066880998 8.506524406 6.439643408209164_s_at CYB561 ENSG00000008283 0.04855986 0.862673302 8.3347740987.472100797 222175_s_at MED15 ENSG00000099917 0.04855986 0.4451901499.603400247 9.158210098 219469_at DYNC2H1 ENSG00000187240 0.0485697920.659598577 6.555849742 5.896251165 226143_at RAI1 ENSG000001085570.048569792 1.208393363 8.541447862 7.333054499 212681_at EPB41L3ENSG00000082397 0.048619009 1.347291945 8.071548526 6.724256581215784_at CD1E ENSG00000158488 0.048710337 1.145368323 5.4482609244.302892601 211161_s_at COL3A1 ENSG00000168542 0.048710337 2.02946626111.58325522 9.553788957 209906_at C3AR1 ENSG00000171860 0.0488100091.181583182 9.98497067 8.803387488 200625_s_at CAP1 ENSG000001312360.048951883 0.838593198 11.78722536 10.94863217 209550_at NDNENSG00000182636 0.048952014 0.889205149 8.585921026 7.696715877214039_s_at LAPTM4B ENSG00000104341 0.048974372 1.662825915 7.8822235056.21939759 209356_x_at EFEMP2 ENSG00000172638 0.049063503 0.7587052078.0078881 7.249182893 207276_at CDR1 ENSG00000184258 0.0491779211.892594551 9.606611577 7.714017027 209955_s_at FAP ENSG000000780980.049177921 1.477706269 8.251596445 6.773890176 226844_at MOB3BENSG00000120162 0.049203301 1.163764789 6.922109848 5.758345059222468_at KIAA0319L ENSG00000142687 0.049203301 0.30117243 8.2030363137.901863883 226056_at ARHGAP31 ENSG00000031081 0.049246985 0.7875161528.433132327 7.645616175 226695_at PRRX1 ENSG00000116132 0.0493162221.762734658 9.803780005 8.041045346 204844_at ENPEP ENSG000001387920.049441905 0.659515691 4.49151479 3.831999099 200612_s_at AP2B1ENSG00000006125 0.049441905 0.595747097 8.555795692 7.960048594200923_at LGALS3BP ENSG00000108679 0.049441905 0.921133422 10.073622459.152489033 208074_s_at AP2S1 ENSG00000042753 0.049593197 0.5957932810.51238698 9.9165937 200897_s_at PALLD ENSG00000129116 0.0495986261.601894471 9.526128512 7.924234041 209667_at CES2 ENSG000001728310.049598626 0.512790855 8.055153847 7.542362992 225785_at REEP3ENSG00000165476 0.049648667 1.112993317 7.249649028 6.136655711227265_at FGL2 ENSG00000127951 0.049648667 1.768021672 9.4642030467.696181374 226679_at SLC26A11 ENSG00000181045 0.049648667 1.3774826758.622059873 7.244577198 202441_at ERLIN1 ENSG00000107566 0.0496908360.585414195 8.619248306 8.033834111 227758_at RERG ENSG000001345330.049697612 1.130937723 5.789853181 4.658915458 204036_at LPAR1ENSG00000198121 0.049813564 1.444039399 6.674595378 5.230555979225755_at KLHDC8B ENSG00000185909 0.049849481 0.85120088 8.005692227.15449134 209571_at CIR1 ENSG00000138433 0.049849481 0.3762686648.299113302 7.922844638 210184_at ITGAX ENSG00000140678 0.0498533471.112779508 8.872883821 7.760104313 217940_s_at CARKD ENSG000002139950.049853347 0.480686702 8.908728186 8.428041484 212993_at NACC2ENSG00000148411 0.050114999 1.114936871 7.888031769 6.7730678991562876_s_at LOC541471 NA 0.050218071 0.682562423 3.6036775062.921115083 242268_at CELF2 ENSG00000048740 0.050218071 1.5536681297.210053313 5.656385183 213125_at OLFML2B ENSG00000162745 0.0502180710.787465426 8.741575545 7.654110119 221257_x_at FBXO38 ENSG000001458680.050300966 0.597625209 7.698194987 7.100569778 236782_at SAMD3ENSG00000164483 0.050399558 1.072740707 7.590990221 6.5182495141554690_a_at TACC1 ENSG00000147526 0.050505576 1.079368013 9.7003348448.620966831 203431_s_at ARHGAP32 ENSG00000134909 0.050518588 1.2383398666.793820795 5.555480928 226711_at FOXN2 ENSG00000170802 0.0506355830.937101457 9.838675692 8.901574235 203562_at FEZ1 ENSG000001495570.050635583 1.424636375 7.169090802 5.744454428 201508_at IGFBP4ENSG00000141753 0.050635583 1.218153348 10.95048091 9.732327564209933_s_at CD300A ENSG00000167851 0.050635583 1.063950828 8.6535998647.589649035 226751_at CNRIP1 ENSG00000119868 0.05098315 1.0463665867.446206604 6.399840018 203303_at DYNLT3 ENSG00000165169 0.050983150.838978072 9.479702344 8.640724272 1556698_a_at GPRIN3 ENSG000001854770.05098315 1.215337617 6.331782061 5.116444444 223454_at CXCL16ENSG00000161921 0.05098315 0.987094685 9.755064685 8.76797 202032_s_atMAN2A2 ENSG00000196547 0.05098315 0.885891887 9.56468737 8.678795483205779_at RAMP2 ENSG00000131477 0.051156378 0.933822492 8.4836546727.54983218 209110_s_at RGL2 ENSG00000237441 0.051156378 0.6625429448.743821756 8.081278812 209935_at ATP2C1 ENSG00000017260 0.0511563780.657015693 6.368275466 5.711259774 214453_s_at IFI44 ENSG000001379650.051156378 1.633185311 9.486683614 7.853498302 201063_at RCN1ENSG00000049449 0.051233232 0.702809737 9.216222535 8.513412798213222_at PLCB1 ENSG00000182621 0.051361434 0.700475436 5.5359798873.835504451 201069_at MMP2 ENSG00000087245 0.051361434 1.69135381810.01928343 8.327929615 200661_at CTSA ENSG00000064601 0.0513614340.720607027 10.64337094 9.922763911 213258_at TFPI ENSG000000034360.051378943 1.419437821 8.029849535 6.610411714 225414_at RNF149ENSG00000163162 0.05142224 0.804672421 9.112269744 8.307597324 219397_atCOQ10B ENSG00000115520 0.05142224 0.654479835 7.359951703 6.705471868222127_s_at EXOC1 ENSG00000090989 0.051602523 0.754363501 9.7463039288.991940427 223220_s_at PARP9 ENSG00000138496 0.051602523 0.9799493219.260981734 8.281032413 213422_s_at MXRA8 ENSG00000162576 0.0516025231.242243727 8.999253285 7.757009558 203153_at IFIT1 ENSG000001857450.051753444 1.528926589 7.71997217 6.191045582 202100_at RALBENSG00000144118 0.051843475 0.671402473 8.880755781 8.209353307224895_at YAP1 ENSG00000137693 0.051946417 1.490945911 7.4740627595.983116848 201368_at ZFP36L2 ENSG00000152518 0.052319048 0.96471178710.56868804 9.603976254 212027_at RBM25 ENSG00000119707 0.0523840810.678190641 9.494823888 8.816633247 221942_s_at GUCY1A3 ENSG000001641160.052439589 1.367770663 7.987538556 6.619767893 213800_at CFHENSG00000000971 0.052439589 1.232285055 7.757236819 6.5249507641554999_at RASGEF1B ENSG00000138670 0.052613981 1.417397531 6.3414974044.924099873 218606_at ZDHHC7 ENSG00000153786 0.052736978 0.3905379118.928963607 8.538425696 204083_s_at TPM2 ENSG00000198467 0.0527938881.005641012 10.06504289 9.059401879 1553955_at PPP1R21 ENSG000001628690.052932924 0.83883015 8.379910468 7.541080318 228083_at CACNA2D4ENSG00000151062 0.052932924 0.833099044 7.25294855 6.419849507 227304_atSMCR8 ENSG00000176994 0.052932924 0.799991418 8.377826966 7.577835548225710_at GNB4 ENSG00000114450 0.052932924 1.087540407 8.3930345027.305494096 204154_at CDO1 ENSG00000129596 0.052932924 1.1929186065.120926441 3.928007836 228318_s_at CRIPAK ENSG00000179979 0.053008060.531106343 6.682490506 6.151384164 227013_at LATS2 ENSG000001504570.05300806 1.10106835 7.79320732 6.692138971 1558692_at C1orf85ENSG00000198715 0.053110207 0.572438959 5.400511953 4.828072994213238_at ATP10D ENSG00000145246 0.053110207 1.051038069 8.6157304477.564692379 201850_at CAPG ENSG00000042493 0.053135419 0.80938390410.75410257 9.944718664 209717_at EVI5 ENSG00000067208 0.0531403720.711449575 7.081763345 6.37031377 227388_at TUSC1 ENSG000001986800.053261035 1.564367321 8.139272536 6.574905215 200771_at LAMC1ENSG00000135862 0.053546476 0.885804076 8.418291529 7.532487453229055_at GPR68 ENSG00000119714 0.053546476 0.837700456 9.2260907788.388390321 200927_s_at RAB14 ENSG00000119396 0.053623502 0.5226401228.220465934 7.697825812 225447_at GPD2 ENSG00000115159 0.0536235020.967759668 8.485215298 7.51745563 225525_at KIAA1671 ENSG000001970770.053800235 1.446748208 7.312947558 5.866199349 209649_at STAM2ENSG00000115145 0.053803885 0.757498312 7.629711981 6.872213668219492_at CHIC2 ENSG00000109220 0.054091605 0.67290252 8.386461887.71355936 1560060_s_at VPS37C ENSG00000167987 0.054133103 0.557570338.463033953 7.905463623 217947_at CMTM6 ENSG00000091317 0.0541716370.70230484 10.47748323 9.775178387 219078_at GPATCH2 ENSG000000929780.054197198 0.95185617 7.045735811 6.093879641 203854_at CFIENSG00000205403 0.05429229 1.205739531 6.704059047 5.498319516209637_s_at RGS12 ENSG00000159788 0.054327713 0.502100289 7.5159775377.013877248 202252_at RAB13 ENSG00000143545 0.05435009 0.9137575319.579585924 8.665828393 227373_at ATXN1L ENSG00000224470 0.054350090.759716522 8.404084446 7.644367924 207469_s_at PIR ENSG000000878420.054460455 0.663778954 6.265059241 5.601280287 212543_at AIM1ENSG00000112297 0.054463686 0.788119117 9.682280231 8.894161115208983_s_at PECAM1 NA 0.054523626 1.305077039 10.69253504 9.387459226438_at SNTB1 ENSG00000172164 0.054649274 0.809609573 6.9539421866.144332613 201567_s_at GOLGA4 ENSG00000144674 0.054736968 0.5440613018.834091632 8.290030331 204520_x_at BRD1 ENSG00000100425 0.054845990.438369852 9.008739811 8.570369959 217828_at SLTM ENSG000001377760.05484599 0.830702603 8.864809369 8.034106766 224689_at MANBALENSG00000101363 0.05484599 0.340215626 9.457076055 9.11686043 219157_atKLHL2 ENSG00000109466 0.054892546 0.636752761 8.271660585 7.634907824232024_at GIMAP2 ENSG00000106560 0.055019604 1.162132159 7.5937427296.431610571 219087_at ASPN ENSG00000106819 0.05508081 1.8444310577.912112086 6.06768103 213010_at PRKCDBP ENSG00000170955 0.055080810.666737424 7.157466 6.490728576 219570_at KIF168 ENSG000000891770.05508081 0.939524718 6.792995577 5.853470859 214066_x_at NPR2ENSG00000159899 0.05508081 0.499560523 7.871514788 7.371954265 228372_atC10orf128 ENSG00000204161 0.05508081 1.228253425 8.331788019 7.103534595230276_at FAM49A ENSG00000197872 0.05508081 1.286488945 6.312939665.026450715 203002_at AMOTL2 ENSG00000114019 0.05508081 1.3811704987.607053309 6.225882812 225688_s_at PHLDB2 ENSG00000144824 0.055080811.642110715 7.415101954 5.773291239 1553678_a_at ITGB1 ENSG000001500930.05508081 0.762328098 9.60484688 8.842518782 203476_at TPBGENSG00000146242 0.05508081 1.402870201 8.397859019 6.994988818201180_s_at GNAI3 ENSG00000065135 0.05508081 0.716484855 9.7535428629.037058006 220141_at C11orf63 ENSG00000109944 0.05508081 0.5302890665.631726383 5.101437317 227923_at SHANK3 ENSG00000251322 0.055080811.175626141 7.738817565 6.563191424 235334_at ST6GALNAC3 ENSG000001840050.05508081 0.832570926 5.744060873 4.911489947 235411_at PGBD1ENSG00000137338 0.05508081 0.454906286 5.741778418 5.286872132216689_x_at ARHGAP1 ENSG00000175220 0.055086404 0.521010788 9.7475258699.226515081 202932_at YES1 ENSG00000176105 0.055086404 1.2124044556.259729591 5.047325136 212293_at HIPK1 ENSG00000163349 0.0550947730.690816647 7.914422373 7.223605727 225618_at ARHGAP27 ENSG000001593140.055334195 0.473020908 7.935836992 7.462816084 201242_s_at ATP1B1ENSG00000143153 0.055334195 1.283149532 7.126474102 5.84332457 203583_atUNC50 ENSG00000115446 0.055334195 0.452783056 8.989706349 8.5369232921557938_s_at PTRF ENSG00000177469 0.055334195 0.894352142 8.2613996617.367047519 242321_at PTPN14 ENSG00000152104 0.055341667 1.3269816855.787995241 4.461013556 212950_at GPR116 ENSG00000069122 0.0553416671.466287536 6.762014415 5.295726879 205638_at AOAH ENSG000001362500.055341667 0.654520054 9.612122833 8.957602778 223209_s_at VIMPENSG00000131871 0.055341667 0.83813242 9.523564232 8.685431812208131_s_at PTGIS ENSG00000124212 0.055389281 1.321200027 7.4909399276.1697399 227833_s_at MBD6 ENSG00000166987 0.055396564 0.75192264910.51819974 9.766277089 208991_at STAT3 ENSG00000168610 0.0553965640.946587005 9.530424681 8.583837676 216361_s_at KAT6A ENSG000000831680.055396564 0.651745657 7.927871972 7.276126315 1554106_at NBEAL1ENSG00000144426 0.055396564 0.661916069 7.462248226 6.800332157209357_at CITED2 ENSG00000164442 0.055396564 1.232382537 9.3034945718.071112033 53720_at C19orf66 ENSG00000130813 0.055431756 0.9673750929.679981688 8.712606595 228964_at PRDM1 ENSG00000057657 0.0554317561.955052921 9.250667771 7.295614851 228624_at TMEM144 ENSG000001641240.055512399 0.888115651 6.82051307 5.932397419 225626_at PAG1ENSG00000076641 0.055625052 1.648320718 9.726492347 8.07817163 225885_atEEA1 ENSG00000102189 0.055625052 0.727821543 7.739962682 7.012141139236172_at LTB4R ENSG00000213903 0.055654381 1.08404573 7.387480536.3034348 201953_at CIB1 ENSG00000185043 0.055677119 0.7092541739.414667247 8.705413075 213069_at HEG1 ENSG00000173706 0.0556771191.058297106 9.011754037 7.953456931 226885_at RNF217 ENSG000001463730.055687877 1.507951738 5.917910835 4.409959097 203038_at PTPRKENSG00000152894 0.055687877 1.549533171 8.029702811 6.48016964240703_s_at HERC1 ENSG00000103657 0.055700396 0.961787237 6.4452778765.48349064 221641_s_at ACOT9 ENSG00000123130 0.055791741 0.5924097279.037040731 8.444631004 210845_s_at PLAUR ENSG00000011422 0.0558132140.996379681 8.86607143 7.869691749 212097_at CAV1 ENSG000001059740.055813214 1.72714647 8.888796375 7.161649906 243198_at TEX9ENSG00000151575 0.055813214 1.558466496 6.115528068 4.557061571204122_at TYROBP ENSG00000011600 0.055813214 1.153345531 11.4899567410.33661121 226343_at DPP8 ENSG00000074603 0.055813214 0.6675676688.292781672 7.625214004 205715_at BST1 ENSG00000109743 0.0560958760.344955791 7.18626587 6.841310079 211980_at COL4A1 ENSG000001874980.056095876 1.223646645 10.90017588 9.676529238 213572_s_at SERPINB1ENSG00000021355 0.056095876 0.852583509 9.447180216 8.594596707209047_at AQP1 ENSG00000240583 0.056095876 1.711689396 8.7671807817.055491386 214077_x_at MEIS3P1 ENSG00000179277 0.056095876 0.9245863938.655448343 7.730861949 202946_s_at BTBD3 ENSG00000132640 0.0562816651.008164542 5.025902254 4.017737712 242953_at ZNF234 ENSG000002630020.056315736 0.863642317 6.410969189 5.547326872 218380_at LOC728392 NA0.056642523 0.659862844 8.050295783 7.390432938 215000_s_at FEZ2ENSG00000171055 0.056642523 0.895521867 9.749836768 8.854314901229238_at C17orf97 ENSG00000187624 0.056642523 0.793626222 7.0268576546.233231432 219700_at PLXDC1 ENSG00000161381 0.056642523 1.3037292957.282377392 5.978648097 202432_at PPP3CB ENSG00000107758 0.0568554690.594665801 8.654289616 8.059623814 1558711_at FAM13A-AS1ENSG00000248019 0.05685832 0.663485851 6.443455817 5.779969966 202304_atFNDC3A ENSG00000102531 0.05685832 0.958277594 8.951196819 7.992919225213429_at BICC1 ENSG00000122870 0.05685832 1.455435599 5.9114366674.456001068 203388_at ARRB2 ENSG00000141480 0.05685832 0.7900370348.830550615 8.040513531 205140_at FPGT ENSG00000254685 0.0568628680.746130122 7.424392378 6.678262256 226594_at ENTPD5 ENSG000001870970.056942273 0.5571412 7.32471655 6.767575351 219506_at C1orf54ENSG00000118292 0.056942273 1.14432295 10.50282075 9.358497804209230_s_at NUPR1 ENSG00000176046 0.056996975 1.108100553 11.1284391710.02033862 205498_at GHR ENSG00000112964 0.057095384 1.3991555125.181886139 3.782730626 probeset Chromosome chrom_band gene_description228754_at 3 p25.1 solute carrier family 6 [neurotransmitter transporter,taurine), member 6 [Source: HGNC Symbol; Acc: 11052] 238327_at 22 q13.33outer dense fiber of sperm tails 3B [Source: HGNC Symbol, Acc: 34388]208683_at 1 q41 calpain 2, (m/ll) large subunit [Source: HGNC Symbol;Acc: 1479] 218648_at 15 q26.1 CREB regulated transcription coactivator 3[Source: HGNC Symbol; Acc: 26148] 225146_at 9 p13.3 family with sequencesimilarity 219, member A [Source: HGNC Symbol; Acc: 19920] 218589_at 13q14.2 lysophosphatidic acid receptor 6 [Source: HGNC Symbol; Acc: 15520]217762_s_at 18 p11.22 RAB31, member RAS oncogene family [Source: HGNCSymbol; Acc: 9771] 201506_at 5 q31.1 transforming growth factor,beta-induced, 65 kDa [Source: HGNC Symbol; Acc: 11771] 224862_at 9 q21.2guanine nucleotide binding protein (G protein), q polypeptide [Source:HGNC Symbol; Acc: 4390] 201425_at 12 q24.12 aldehyde dehydrogenase 2family (mitochondrial) [Source: HGNC Symbol; Acc: 404] 1555851_s_at 19q13.33 selenoprotein W, 1 [Source: HGNC Symbol; Acc: 10752] 205241_at 22q13.33 SCO2 cytochrome c oxidase assembly protein [Source: HGNC Symbol;Acc: 10604] 218552_at 1 p32.3 enoyl CoA hydratase domain containing 2[Source: HGNC Symbol; Acc: 23408] 55662_at 10 q24.32 chromsome 10 openreading frame 76 [Source: HGNC Symbol; Acc: 25788] 204773_at 9 p13.3interleukin 11 receptor, alpha [Source: HGNC Symbol; Acc: 5967]202600_s_at 21 q21.1 nuclear receptor interacting protein 1 [Source:HGNC Symbol; Acc: 8001] 221802_s_at 10 q25.3 KIAA1598 [Source: HGNCSymbol; Acc: 29319] 226000_at 1 p13.2 CTTNBP2 N-terminal like [Source:HGNC Symbol; Acc: 25330] 222484_s_at 5 q31.1 chemokine (C-X-C motif)ligand 14 [Source: HGNC Symbol; Acc: 10640] 201012_at 9 q21.13 annexinA1 [Source: HGNC Symbol; Acc: 533] 218854_at 6 q22.1 dermatan sulfateepimerase [Source: HGNC Symbol; Acc: 21144] 214040_s_at 9 q33.2 gelsolin[Source: HGNC Symbol; Acc: 4620] 201302_at 2 p13.3 annexin A4 [Source:HGNC Symbol; Acc: 542] 208923_at 15 q11.2 cytoplasmic FMR1 interactingprotein 1 [Source: HGNC Symbol; Acc: 13759] 224414_s_at 5 p13.1 caspaserecruitment domain family, member 6 [Source: HGNC Symbol; Acc: 16394]205945_at 1 q21.3 interleukin 6 receptor [Source: HGNC Symbol; Acc:6019] 200765_x_at 5 q31.2 catenin (cadherin-associated protein), alpha1, 102 kDa [Source: HGNC Symbol; Acc: 2509] 230325_at NA NA NA 223228_at22 q13.31 leucine zipper, down-regulated in cancer 1-like [Source: HGNCSymbol; Acc: 13343] 225842_at 12 q21.2 pleckstrin homology-like domain,family A, member 1 [Source: HGNC Symbol; Acc: 8933] 201348_at 5 q33.1glutathione peroxidase 3 (plasma) [Source: HGNC Symbol; Acc: 4555]219885_at 17 q12 schlafen family member 12 [Source: HGNC Symbol; Acc:25500] 212830_at 9 q33.2 multiple EGF-like domains 9 [Source: HGNCSymbol; Acc: 3234] 231463_at 17 q21.31 cyclin N-terminal domaincontaining 1 [Source: HGNC Symbol; Acc: 26847] 202687_s_at 3 q26.31tumor necrosis factor (ligand) superfamily, member 10 [Source: HGNCSymbol; Acc: 11925] 217731_s_at 13 q14.2 integral membrane protein 2B[Source: HGNC Symbol; Acc: 6174] 218694_at X q22.1 armadillo repeatcontaining, X-linked 1 [Source: HGNC Symbol; Acc: 18073] 1558844_at NANA NA 202944_at 22 q13.2 N-acetylgalactosaminidase, alpha-[Source: HGNCSymbol; Acc: 7631] 212522_at 15 q25.3 phosphodiesterase 8A [Source: HGNCSymbol; Acc: 8793] 226247_at 10 q26.13 pleckstrin homology domaincontaining, family A (phophoinositide binding specific) member 1[Source: HGNC Symbol; Acc: 14335] 243423_at 5 q33.1 TNFAIP3 interactingprotein 1 [Source: HGNC Symbol; Acc: 16903] 229074_at 15 q15.1 EH-domaincontaining 4 [Source: HGNC Symbol; Acc: 3245] 1559507_at NA NA NA222154_s_at 2 q33.1 spermatogenesis associated, serine-rich 2-like[Source: HGNC Symbol; Acc: 24574] 200710_at 17 p13.1 acyl-CoAdehydrogenase, very long chain [Source: HGNC Symbol; Acc: 92] 228791_atNA NA NA 208634_s_at 1 p34.3 microtubule-actin crosslinking factor 1[Source: HGNC Symbol; Acc: 13664] 242487_at 1 p32.3 coiled-coil and C2domain 1B [Source: HGNC Symbol; Acc: 29386] 218559_s_at 20 q12 v-mafavian musculoaponeurotic fibrosarcoma oncogene homolog B [Source: HGNCSymbol; Acc: 6408] 201360_at 20 p11.21 cystatin C [Source: HGNC Symbol;Acc: 2475] extracellular matrix protein 2, female organ and adipocytespecific 206101_at 9 q22.31 [Source: HGNC Symbol; Acc: 3154] 218004_at 1p35.1 BSD domain containing 1 [Source: HGNC Symbol; Acc: 25501] 36129_at17 p13.3 small G protein signaling modulator 2 [Source: HGNC Symbol;Acc: 29026] 227889_at 16 q12.2 lysophosphatidylcholine acyltransferase 2[Source: HGNC Symbol; Acc: 26032] 229378_at 10 q21.3 storkhead box 1[Source: HGNC Symbol; Acc: 23508] 218043_s_at 3 p24.1 5-azactidineinduced 2 [Source: HGNC Symbol; Acc: 24002] 218066_at 5 p15.33 solutecarrier family 12 (potassium/chloride transporters), member 7 [Source:HGNC Symbol; Acc: 10915] 58780_s_at 14 q11.2 Rho guanine nucleotideexchange factor (GEF) 40 [Source: HGNC Symbol; Acc: 25516] 200660_at 1q21.3 S100 calcium binding protein A11 [Source: HGNC Symbol; Acc: 10488]207965_at 10 q22.1 neurogenin 3 [Source: HGNC Symbol; Acc: 13806]212907_at 1 q32.3 solute carrier family 30 (zinc transporter), member 1[Source: HGNC Symbol; Acc: 11012] 208999_at 5 q31.1 septin 8 [Source:HGNC Symbol; Acc: 16511] 208949_s_at 14 q22.3 lectin,galactoside-binding, soluble, 3 [Source: HGNC Symbol; Acc: 6563]218311_at 2 p22.1 mitogen-activated protein kinase kinase kinase kinase3 [Source: HGNC Symbol; Acc: 6865] 203518_at 1 q42.3 lysosomaltrafficking regulator [Source: HGNC Symbol; Acc: 1968] 1552349_a_at 16p13.3 protease, serine, 33 [Source: HGNC Symbol; Acc: 30405] 1566134_at16 p13.2 calcium regulated heat stable protein 1, 24 kDa [Source: HGNCSymbol; Acc: 17150] 204137_at 1 q42.3 G protein-coupled receptor 137B[Source: HGNC Symbol; Acc: 11862] 222217_s_at 1 q21.3 solute carrierfamily 27 (fatty acid transporter), member 3 [Source: HGNC Symbol; Acc:10997] 201505_at 7 q31.1 laminin, beta 1 [Source: HGNC Symbol; Acc:6486] 206602_s_at 2 q31.1 homeobox D3 [Source: HGNC Symbol; Acc: 5137]217728_at 1 q21.3 S100 calcium binding protein A6 [Source: HGNC Symbol;Acc: 10496] 225483_at 11 q25 vacoular protein sorting 26 homolog B (S.pombe) [Source: HGNC Symbol; Acc: 28119] 202686_s_at 19 q13.2 AXLreceptor tyrosine kinase [Source: HGNC Symbol; Acc: 905] 236374_at 5q23.2 cortexin 3 [Source: HGNC Symbol; Acc: 31110] 227276_at 10 p12.31plexin domain containing 2 [Source: HGNC Symbol; Acc: 21013] 228185_at10 p11.1 zinc finger protein 25 [Source: HGNC Symbol; Acc: 13043]217892_s_at 12 q13.12 LIM domain and actin binding 1 [Source: HGNCSymbol; Acc: 24636] 202727_s_at 6 q23.3 interferon gamma receptor 1[Source: HGNC Symbol; Acc: 5439] 1560963_a_at NA NA NA 1553837_at 12q24.33 phosphoglycerate mutase family member 5 [Source: HGNC Symbol;Acc: 28763] 1554763_at X q21.1 ubiquitin-conjugating enzyme E2DN-terminal like (pseudogene) [Source: HGNC Symbol; Acc: 28656]212112_s_at 1 p35.3 syntaxin 12 [Source: HGNC Symbol; Acc: 11430]203789_s_at 7 q21.11 sema domain, immunoglobulin domain (lg), shortbasic domain, secreted, (semaphorin), 3C [Source: HGNC Symbol; Acc:10725] 200677_at 21 q22.3 pituitary tumor-transforming 1 interactingprotein [Source: HGNC Symbol; Acc: 13524] 222876_s_at 17 q11.2 ArfGAPwith dual PH domains 2 [Source: HGNC Symbol; Acc: 16487] 210145_at 1q31.1 phospholipase A2, group IVA (cytosolic, calcium-dependent)[Source: HGNC Symbol; Acc: 9035] 208109_s_at NA NA NA 209651_at 16 p11.2transforming growth factor beta 1 induced transcript 1 [Source: HGNCSymbol; Acc: 11767] 212698_s_at 2 q13 septin 10 [Source: HGNC Symbol;Acc: 14349] 212526_at 13 q13.3 spastic paraplegia 20 (Troyer syndrome)[Source: HGNC Symbol; Acc: 18514] 209684_at 20 p11.23 Ras and Rabinteractor 2 [Source: HGNC Symbol; Acc: 18750] 223204_at 4 q32.1 familywith sequence similarity 198, member B [Source: HGNC Symbol; Acc: 25312]200673_at 2 p24.1 lysosomal protein transmembrane 4 alpha [Source: HGNCSymbol; Acc: 6924] 219840_s_at 14 q32.13 T-cell leukemia/lymphoma 6(non-protein coding) [Source: HGNC Symbol; Acc: 13463] 222896_at 19p13.11 transmembrane protein 38A [Source: HGNC Symbol; Acc: 28462]205688_at 16 p13.3 transcription factor AP-4 (activating enhancerbinding protein 4) [Source: HGNC Symbol; Acc: 11745] 225384_at 1 p31.3dedicator of cytokinesis 7 [Source: HGNC Symbol; Acc: 19190]1557021_s_at NA NA NA 209210_s_at 14 q22.1 fermitin family member 2[Source: HGNC Symbol; Acc: 15767] 201798_s_at 10 q23.33 myoferlin[Source: HGNC Symbol; Acc: 3656] 225949_at 8 q24.3 nuclear receptorbinding protein 2 [Source: HGNC Symbol; Acc: 19339] 208924_at 1 p32.3ring finger protein 11 [Source: HGNC Symbol; Acc: 10056] 209004_s_at 4p15.32 F-box and leucine-rich repeat protein 5 [Source: HGNC Symbol;Acc: 13602] 237880_at NA NA NA 226743_at 17 q12 schlafen family member11 [Source: HGNC Symbol; Acc: 26633] 228573_at 4 q21.21 anthrax toxinreceptor 2 [Source: HGNC Symbol; Acc: 21732] 222065_s_at 17 p11.2flightless I homolog (Drosophila) [Source: HGNC Symbol; Acc: 3750]210450_at 14 q32.33 immunoglobulin heavy variable 5-78 (pseudogene)[Source: HGNC Symbol; Acc: 5660] 212989_at 10 q11.23 sphingomyelinsynthase 1 [Source: HGNC Symbol; Acc: 29799] 202228_s_at 15 q24.1neuroplastin [Source: HGNC Symbol; Acc: 17867] 227761_at 15 q21.2 myosinVA (heavy chain 12, myoxin) [Source: HGNC Symbol; Acc: 7602] 202133_at 3q25.1 WW domain containing transcription regulator 1 [Source: HGNCSymbol; Acc: 24042] 209960_at 7 q21.11 hepatocyte growth factor(hepapoietin A; scatter factor) [Source: HGNC Symbol; Acc: 4893]212203_x_at 11 p15.5 interferon induced transmembrane protein 3 [Source:HGNC Symbol; Acc: 5414] 212158_at 8 q22.1 syndecan 2 [Source: HGNCSymbol; Acc: 10659] 224797_at 5 q14.3 arrestin domain containing 3[Source: HGNC Symbol; Acc: 29263] 203124_s_at 12 q13.12 solute carrierfamily 11 (proton-coupled divalent metal ion transporters), member 2[Source: HGNC Symbol; Acc: 10908] 1570336_at 3 q29 3-hydroxybutyratedehydrogenase, type 1 [Source: HGNC Symbol; Acc: 1027] 1553034_at 1 q43serologically defined colon cancer antigen 8 [Source: HGNC Symbol; Acc:10671] 219076_s_at 12 q24.33 peroxisomal membrane protein 2, 22 kDa[Source: HGNC Symbol; Acc: 9716] 230467_at 1 p36.33 transmembraneprotein 52 [Source: HGNC Symbol; Acc: 27916] 226111_s_at 12 q13.13 zincfinger protein 385A [Source: HGNC Symbol; Acc: 17521] 231579_s_at 17q25.3 TIMP metallopeptidase inhibitor 2 [Source: HGNC Symbol; Acc:11821] 202007_at 1 q42.3 nidogen 1 [Source: HGNC Symbol; Acc: 7821]207689_at 11 q13.2 T-box 10 [Source: HGNC Symbol; Acc: 11593]201681_s_at 10 q22.3 discs, large homolog 5 (Drosophila) [Source: HGNCSymbol; Acc: 2904] 212761_at 10 q25.2 transcription factor 7-like 2(T-cell specific, HMG-box) [Source: HGNC Symbol; Acc: 11641] 224983_at 4q21.1 scavenger receptor class B, member 2 [Source: HGNC Symbol; Acc:1665] 218706_s_at 5 q23.2 GRAM domain containing 3 [Source: HGNC Symbol;Acc: 24911] 210165_at 16 p13.3 deoxyribonucleoase I [Source: HGNCSymbol; Acc: 2956] 203595_s_at 10 q23.31 interferon-induced protein withtetratricopeptide repeats 5 [Source: HGNC Symbol; Acc: 13328] 1558431_at16 p13.3 NHL repeat containing 4 [Source: HGNC Symbol; Acc: 26700]225133_at 4 p14 Kruppel-like factor 3 (basic) [Source: HGNC Symbol; Acc:16516] 210122_at 16 p13.13 protamine 2 [Source: HGNC Symbol; Acc: 9448]204396_s_at 10 q26.11 G protein-coupled receptor kinase 5 [Source: HGNCSymbol; Acc: 4544] 1569270_at NA NA NA 210105_s_at 6 q21 FYN oncogenerelated to SRC, FGR, YES [Source: HGNC Symbol; Acc: 4037] 201218_at 10q26.13 C-terminal bidning protein 2 [Source: HGNC Symbol; Acc: 2495]203973_s_at 8 q11.21 CCAAT/enhancer binding protein (C/EBP), delta[Source: HGNC Symbol; Acc: 1835] 243038_at 2 q23.3 PNA binding motifprotein 43 [Source: HGNC Symbol; Acc: 24790] 212667_at 5 q33.1 secretedprotein, acidic, cysteine-rich (osteonectin) [Source: HGNC Symbol; Acc:11219] 209341_s_at 8 p11.21 inhibitor of kappa light polypeptide geneenhancer in B-cells, kinase beta [Source: HGNC Symbol; Acc: 5960]232781_at 1 q25.2 LIM homeobox 4 [Source: HGNC Symbol; Acc: 21734]202336_s_at 5 q21.1 peptidylglycine alpha-amidating monooxygenase[Source: HGNC Symbol; Acc: 8596] 216151_x_at 1 p36.12 chymotrypsin-likeelastase family, member 38 [Source: HGNC Symbol; Acc: 15945] 1553780_at14 q32.33 long intergenic non-protein coding RNA 638 [Source: HGNCSymbol; Acc: 28325] 212298_at 10 p11.22 neuropilin 1 [Source: HGNCSymbol; Acc: 8004] 1564386_at 9 q31.3 thioredoxin domain containing 8(spermatozoa) [Source: HGNC Symbol; Acc: 31454] 221773_at 12 q23.1 ELK3,ETS-domain protein (SRF accessory protein 2) [Source: HGNC Symbol; Acc:3325] 207116_s_at 19 q13.12 glyceraldehyde-3-phosphate dehydrogenase,spermatogenic [Source: HGNC Symbol; Acc: 24864] 208816_x_at 9 p13.3annexin A2 pseudogene 2 [Source: HGNC Symbol; Acc: 539] 225188_at 2q33.2 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1[Source: HGNC Symbol; Acc: 14436] 1552564_at NA NA NA 212779_at 4 q27KIAA1109 [Source: HGNC Symbol; Acc: 26953] 221748_s_at 2 q35 tensin 1[Source: HGNC Symbol; Acc: 11973] 1552811_at 16 p13.3 WAP,follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1[Source: HGNC Symbol; Acc: 30912] 244543_s_at 12 q13.12 BCDIN3Dantisense RNA 1 [Source: HGNC Symbol; Acc: 44113] 1555124_at NA NA NA213379_at 4 q21.23 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase[Source: HGNC Symbol; Acc: 25223] 211684_s_at 2 q31.1 dynein,cystoplasmic 1, intermediate chain 2 [Source: HGNC Symbol; Acc: 2964]201739_at 6 q23.2 serum/glucocorticoid regulated kinase 1 [Source: HGNCSymbol; Acc: 10810] 209090_s_at 1 p22.3 SH3-domain GRB2-like endophilinB1 [Source: HGNC Symbol; Acc: 10833] 225171_at 6 q22.33 Rho GTPaseactivating protein 18 [Source: HGNC Symbol; Acc: 21035] 204517_at 5q23.2 peptidylprolyl isomerase C (cyclophilin C) [Source: HGNC Symbol;Acc: 9256] 213923_at 3 q25.2 RAP2B, member of RAS oncogene family[Source: HGNC Symbol; Acc: 9862] 201590_x_at 15 q22.2 annexin A2[Source: HGNC Symbol; Acc: 537] 202202_s_at 6 q21 laminin, alpha 4[Source: HGNC Symbol; Acc: 6484] 218718_at 4 q32.1 platelet derivedgrowth factor C [Source: HGNC Symbol; Acc: 8801] 1553541_at 1 q23.3 LIMhomeobox transcription factor 1, alpha [Source: HGNC Symbol; Acc: 6653]2061414_s_at 2 p25.1 ArfGAP with SH3 domain, ankyrin repeat and PHdomain 2 [Source: HGNC Symbol; Acc: 2721] 1553178_a_at 22 q13.1somatostatin receptor 3 [Source: HGNC Symbol; Acc: 11332] 212169_at 7p14.3 FK506 binding protein 9, 63 kDa [Source: HGNC Symbol; Acc: 3725]209348_s_at 16 q23.2 v-maf avian musculoaponeurotic fibrosarcomaoncogene homolog [Source: HGNC Symbol; Acc: 6776] 202011_at 15 q13.1tight junction protein 1 [Source: HGNC Symbol; Acc: 11827] 226823_at 1p35.3 phosphatase and actin regulator 4 [Source: HGNC Symbol; Acc:25793] 201375_s_at 8 p12 protein phosphatase 2, catalytic subunit, betaisozyme [Source: HGNC Symbol; Acc: 9300] 1558289_at 3 p21.1 RFT1 homolog(S. cerevisiae) [Source: HGNC Symbol; Acc: 30220] 202808_at 10 q24.32 WWdomain binding protein 1-like [Source: HGNC Symbol; Acc: 23510]227911_at 18 p11.31 Rho GTPase activating protein 28 [Source: HGNCSymbol; Acc: 25509] 208034_s_at 13 q34 protein Z, vitamin K-dependentplasma glycoprotein [Source: HGNC Symbol; Acc: 9460] 1553444_a_at 1p36.22 chromosome 1 open reading frame 127 [Source: HGNC Symbol; Acc:26730] 220077_at 22 q13.2 coiled-coil domain containing 134 [Source:HGNC Symbol; Acc: 26185] 215756_at NA NA NA 206049_at 1 q24.2 selectin P(granule membrane protein 140 kDa, antigen CD62) [Source: HGNC Symbol;Acc: 10721] 202357_s_at 6 p21.33 complement factor B [Source: HGNCSymbol; Acc: 1037] 217497_at 22 q13.33 thymidine phosphorylase [Source:HGNC Symbol; Acc: 3148] 204034_at 19 q13.31 ethylmalonic encephalopathy1 [Source: HGNC Symbol; Acc: 23287] 210139_s_at 17 p12 peripheral myelinprotein 22 [Source: HGNC Symbol; Acc: 9118] 242226_at NA NA NA 204114_at14 q22.1 nidogen 2 (osteonidogen) [Source: HGNC Symbol; Acc: 13389]207159_x_at 19 p13.11 CREB regulated transcription coactivator 1[Source: HGNC Symbol; Acc: 16062] 1564072_at 7 q22.1 myosin, heavy chain16 pseudogene [Source: HGNC Symbol; Acc: 31038] 200878_at 2 p21endothelial PAS domain protein 1 [Source: HGNC Symbol; Acc: 3374]206112_at 7 q31.31 ankyrin repeat domain 7 [Source: HGNC Symbol; Acc:18588] 202446_s_at 3 q24 phospholipid scramblase 1 [Source: HGNC Symbol;Acc: 9092] 221139_s_at 12 q13.13 cysteine sulfinic acid decarboxylase[Source: HGNC Symbol; Acc: 18966] 244488_at 20 q13.33 LSM14B, SCD6homolog B (S. cerevisiae) [Source: HGNC Symbol; Acc: 15887] 221012_s_at10 q13.33 tripartite motif containing 8 [Source: HGNC Symbol; Acc:15579] 1555832_s_at 10 p15.1 Kruppel-like factor 6 [Source: HGNC Symbol;Acc: 2235] 212859_x_at 16 q12.2 metallothionein 1E [Source: HGNC Symbol;Acc: 7397] 203729_at 19 q13.33 epithelial membrane protein 3 [Source:HGNC Symbol; Acc: 3335] 243022_at NA NA NA 223630_at 7 q36.3 chromosome7 open reading frame 13 [Source: HGNC Symbol; Acc: 17126] 209238_at 11q12.1 syntaxin 3 [Source: HGNC Symbol; Acc: 11438] 207366_at 20 q13.12potassium voltage-gated channel, delayed-rectifier, subfamily S, member1 [Source: HGNC Symbol; Acc: 6300] 1569532_a_at 9 q34.3 lipocalin 15[Source: HGNC Symbol; Acc: 33777] 228617_at 17 p13.1 XIAP associatedfactor 1 [Source: HGNC Symbol; Acc: 30932] 204436_at 15 q22.31pleckstrin homology domain containing. family O member 2 [Source: HGNCSymbol; Acc: 30026] 208291_s_at 11 p15.5 tyrosine hydroxylase [Source:HGNC Symbol; Acc: 11782] 1555756_a_at 12 p13.2 C-type lectin domainfamily 7, member A [Source: HGNC Symbol; Acc: 14558] 202381_at 8 p11.22ADAM metallopeptidase domain 9 [Source: HGNC Symbol; Acc: 216]202291_s_at 12 p12.3 matrix Gla protein [Source: HGNC Symbol; Acc: 7060]239119_at 13 q32.1 DNAJC3 antisense RNA 1 (head to head) [Source: HGNCSymbol; Acc: 39808] 213056_at 3 p14.1 FERM domain containing 4B [Source:HGNC Symbol; Acc: 24886] 218162_at 1 p13.2 olfactomedin-like 3 [Source:HGNC Symbol; Acc: 24956] 212845_at 14 q22.2 sterile alpha motif domaincontaining 4A [Source: HGNC Symbol; Acc: 23023] 240185_at NA NA NA233843_at 6 p21.33 zinc finger and BTB domain containing 12 [Source:HGNC Symbol; Acc: 19066] 218541_s_at 8 p11.21 chromosome 8 open readingframe 4 [Source: HGNC Symbol; Acc: 1357] 1555722_at NA NA NA1559005_s_at 9 p22.2 centlein, centrosomal protein [Source: HGNC Symbol;Acc: 23432] 218909_at 1 q32.3 ribosomal protein S6 kinase, 52 kDa,polypeptide 1 [Source: HGNC Symbol; Acc: 10439] 1553067_a_at 1 q21.1gonadotropin-releasing hormone (type 2) receptor 2 [Source: HGNC Symbol;Acc: 16341] 226384_at 8 p11.23 phosphatidic acid phosphatase type 2domain containing 1B [Source: HGNC Symbol; Acc: 25026] 212509_s_at 17q25.1 matrix-remodelling associated 7 [Source: HGNC Symbol; Acc: 7541]225975_at 4 q28.3 protocadherin 18 [Source: HGNC Symbol; Acc: 14268]201341_at 5 q13.3 ectodermal-neural cortex 1 (with BTB domain) [Source:HGNC Symbol; Acc: 3345] 203324_s_at 7 q31.2 caveolin 2 [Source: HGNCSymbol; Acc: 1528] 238898_at NA NA NA 212230_at 1 p32.2 phosphatidicacid phosphatase type 2B [Source: HGNC Symbol; Acc: 9229] 218632_at 1p34.1 HECT domain containing E3 ubiquitin protein ligase 3 [Source: HGNCSymbol; Acc: 26117] 212204_at 15 q15.1 trasnmembrane protein 87A[Source: HGNC Symbol; Acc: 24522] 226022_at 6 q24.3 SAM and SH3 domaincontaining 1 [Source: HGNC Symbol; Acc: 19182] 224166_at 5 q31.3 solutecarrier family 25 (mitochondrial carrier; ornithine transporter) member3 [Source: HGNC Symbol; Acc: 22921] 242800_at X p22.13 Nance-Horansyndrome (congenital cataracts and dental anomalies) [Source: HGNCSymbol; Acc: 7820] 203477_at 9 q22.33 collagen, type XV, alpha 1[Source: HGNC Symbol; Acc: 2192] 200857_s_at 17 p11.2 nuclear receptorcorepressor 1 [Source: HGNC Symbol; Acc: 7672] 238239_at 6 q27 WD repeatdomain 27 [Source: HGNC Symbol; Acc: 21248] 1562089_at 11 q12.1glycine-N-acyltransferace-like 1 [Source: HGNC Symbol; Acc: 30519]224996_at 8 q12.3 aspartate beta-hydroxylase [Source: HGNC Symbol; Acc:757] 223562_at 22 q13.31 parvin, gamma [Source: HGNC Symbol; Acc: 14654]213353_at 17 q24.3 ATP-binding cassette, sub-family A (ABC1), member 5[Source: HGNC Symbol; Acc: 35] 209593_s_at 9 q34.11 torsin family 1,member B (torsin B) [Source: HGNC Symbol; Acc: 11995] 207649_at 17 q21.2keratin 37 [Source: HGNC Symbol; Acc: 6455] 32626_at 17 q25.3N-sulfoglucosamine sulfohydrolase [Source: HGNC Symbol; Acc: 10818]1559272_at 16 q22.1 exocyst complex component 3-like 1 [Source: HGNCSymbol; Acc: 27540] 234994_at 6 q23.1 transmembrane protein 200A[Source: HGNC Symbol; Acc: 21075] 1556822_s_at 19 q13.43 zinc fingerprotein 837 [Source: HGNC Symbol; Acc: 25164] 211456_x_at NA NA NA215328_at 2 p23.3 EFR3 homolog B (S. cerevisiae) [Source: HGNC Symbol;Acc: 29155] 203501_at 8 q22.1 carboxypeptidase Q [Source: HGNC Symbol;Acc: 16910] 226155_at 10 q25.3 family with sequence similarity 160,member B1 [Source: HGNC Symbol; Acc: 29320] 1552932_at 11 p15.5 NLRfamily, pyrin domain containing 6 [Source: HGNC Symbol; Acc: 22944]1552258_at 2 p11.2 long intergenic non-protein coding RNA 152 [Source:HGNC Symbol; Acc: 28717] 238025_at 16 q23.1 mixed lineage kinasedomain-like [Source: HGNC Symbol; Acc: 26617] 219460_s_at 2 q11.2transmembrane protein 127 [Source: HGNC Symbol; Acc: 26038] 225522_at 2p13.3 AP2 associated kinase 1 [Source: HGNC Symbol; Acc: 19679]217757_at 12 p13.31 alpha-2-macroglobulin [Source: HGNC Symbol; Acc: 7]223168_at 1 q42.13 ras homolog family member U [Source: HGNC Symbol;Acc: 17794] 1561615_s_at 2 p22.1 solute carrier family 8 (sodium/calciumexchanger), member 1 [Source: HGNC Symbol; Acc: 11068] 203758_at 4 q32.1cathepsin O [Source: HGNC Symbol; Acc: 2542] 226552_at 9 q34.11immediately response 5-like [Source: HGNC Symbol; Acc: 23679]202766_s_at 15 q21.1 fibrillin 1 [Source: HGNC Symbol; Acc: 3603]225629_s_at 17 p13.1 zinc finger and BTB domain containing 4 [Source:HGNC Symbol; Acc: 23847] 212136_at 1 q32.1 ATPase, Ca 

 transporting, plasma membrane 4 [Source: HGNC Symbol; Acc: 817]1555881_s_at 10 q24.31 leucine zipper, putative tumor suppressor 2[Source: HGNC Symbol; Acc: 29381] 57715_at 10 q24.33 calcium homeostasismodulator 2 [Source: HGNC Symbol; Acc: 23493] 226601_at 1 p21.2 solutecarrier family 30 (zinc transporter), membrane 7 [Source: HGNC Symbol;Acc: 19306] 217890_s_at 11 p15.3 parvin, alpha [Source: HGNC Symbol;Acc: 14652] 207624_s_at X p11.4 retinitis pigmentosa GTPase regulator[Source: HGNC Symbol; Acc: 10295] 212372_at 17 p13.1 myosin, heavy chain10, non-muscle [Source: HGNC Symbol; Acc: 7568] 226820_at 1 p35.1 zincfinger protein 362 [Source: HGNC Symbol; Acc: 18079] 202551_s_at 2 p22.3cysteine rich transmembrane BMP regulator 1 (chordin-like) [Source: HGNCSymbol; Acc: 2359] 208030_s_at 4 p16.3 adducin 1 (alpha) [Source: HGNCSymbol; Acc: 243] 206618_at 2 q12.1 interleukin 18 receptor 1 [Source:HGNC Symbol; Acc: 5988] 201212_at 14 q32.12 legumain [Source: HGNCSymbol; Acc: 9472] 208782_at 3 q13.33 follistatin-like 1 [Source: HGNCSymbol; Acc: 3972] 209191_at 18 p11.21 tubulin, beta 6 class V [Source:HGNC Symbol; Acc: 20776] 206875_s_at 10 q24.33 STE20-like kinase[Source: HGNC Symbol; Acc: 11088] 212990_at 21 q22.11 synaptojanin 1[Source: HGNC Symbol; Acc: 11503] 204193_at 22 q13.33 choline kinasebeta [Source: HGNC Symbol; Acc: 1938] 203243_s_at 4 q22.3 PD2 and LIMdomain 5 [Source: HGNC Symbol; Acc: 17468] 227554_at 7 q21.11 MAGI2antisense RNA 3 [Source: HGNC Symbol; Acc: 40862] 224616_at 16 q22.1dynein, cytoplasmic 1, light intermediate chain 2 [Source: HGNC Symbol;Acc: 2966] 218901_at 3 q24 phospholipid scramble 4 [Source: HGNC Symbol;Acc: 16497] 209050_s_at 9 q34.2 ral guanine nucleotide dissociationstimulator [Source: HGNC Symbol; Acc: 9842] 209472_at 1 p22.2 cysteineconjugate-beta lyase 2 [Source: HGNC Symbol; Acc: 33238] 227542_at 18q22.2 suppressor of cytokine signaling 6 [Source: HGNC Symbol; Acc:16833] 204039_at 19 q13.11 CCAAT/enhancer binding protein (C/EBP), alpha[Source: HGNC Symbol; Acc: 1833] 212586_at 5 q15 calpastatin [Source:HGNC Symbol; Acc: 1515] 201280_s_at 5 p13.1 Dab, mitogen-responsivephosphoprotein, homolog 2 (Drosophila) [Source: HGNC Symbol; Acc: 2662]201599_at 10 q26.13 ornithine aminotransferase [Source: HGNC Symbol;Acc: 8091] 225334_at 10 q24.32 chromosome 10 open reading frame 32[Source: HGNC Symbol; Acc: 23516] 201334_s_at 11 q23.3 Rho guaninenucleotide exchange factor (GEF) 12 [Source: HGNC Symbol; Acc: 14193]229041_s_at 21 q22.3 ITGB2 antisense RNA 1 [Source: HGNC Symbol; Acc:44304] 212124_at 10 q22.3 zinc finger, MIZ-type containing 1 [Source:HGNC Symbol; Acc: 16493] 204863_s_at 5 q11.2 interleukin 6 signaltransducer (gp130, oncostatin M receptor) [Source: HGNC Symbol; Acc:6021] 215235_at 9 q34.11 spectrim, alpha, non-erythrocytic 1 [Source:HGNC Symbol; Acc: 11273] 212606_at 4 q21.23 WD repeat and FYVE domaincontaining 3 [Source: HGNC Symbol; Acc: 20751] 212601_at 17 p13.2 zincfinger, ZZ-type with EF-hand domain 1 [Source: HGNC Symbol; Acc: 29027]228577_x_at 1 p22.3 outer dense fiber of sperm tails 2-like [Source:HGNC Symbol; Acc: 29225] 227776_at 11 q13.5 alkaline ceramidase 3[Source: HGNC Symbol; Acc: 16066] 201146_at 2 q31.2 nuclear factor(erythroid-derived 2)-like 2 [Source: HGNC Symbol; Acc: 7782] 214807_atNA NA NA 201185_at 10 q26.13 HtrA serine peptidase 1 [Source: HGNCSymbol; Acc: 9476] 209120_at 15 q26.2 nuclear receptor subfamily 2,group F, member 2 [Source: HGNC Symbol; Acc: 7976] 226021_at 8 q21.11retinol dehydrogenase 10 (all-trans) [Source: HGNC Symbol; Acc: 19975]224480_s_at 4 q21.23 1-acylglycerol-3-phosphate O-acyltransferase 9[Source: HGNC Symbol; Acc: 28157] 212077_at 7 q33 caldesmon 1 [Source:HGNC Symbol; Acc: 1441] 204745_x_at 16 q13 metallothionein 1G [Source:HGNC Symbol; Acc: 7399] 227930_at 1 p34.3 argonaute RISC catalyticcomponent 4 [Source: HGNC Symbol; Acc: 18424] 212636_at 6 q26 QKI, KHdomain containing, RNA binding [Source: HGNC Symbol; Acc: 21100]202609_at 12 p12.3 epidermal growth factor receptor pathway substrate 8[Source: HGNC Symbol; Acc: 3420] 207791_s_at 2 p14 RAB1A, member RASoncogene family [Source: HGNC Symbol; Acc: 9758] 226377_at 19 p13.3nuclear factor I/C (CCAAT-binding transcription factor) [Source: HGNCSymbol; Acc: 7786] 212607_at 1 q44 v-akt murine thymoma viral oncogenehomolog 3 [Source: HGNC Symbol; Acc: 393] 220122_at 5 q15 multiple C2domains, transmembrane 1 [Source: HGNC Symbol; Acc: 26183] 225941_at 3p13 eukaryotic translation initiation factor 4E family member 3 [Source:HGNC Symbol; Acc: 31837] 65635_at 17 q25.3endo-beta-N-acetylglucosaminidase [Source: HGNC Symbol; Acc: 24622]202897_at 20 p13 signal-regulatory protein alpha [Source: HGNC Symbol;Acc: 9662] 213817_at 12 q14.3 interleukin-1 receptor-associated kinase 3[Source: HGNC Symbol; Acc: 17020] 204703_at 13 q12.11 intraflagellartransport 88 homolog (Chlamydomonas) [Source: HGNC Symbol; Acc: 20606]201029_s_at X p22.33 CD99 molecule [Source: HGNC Symbol; Acc: 7032]201105_at 22 q13.1 lectin, galactoside-binding, soluble, 1 [Source: HGNCSymbol; Acc: 6561] 228666_at 15 q26.1 chromosome 15 open reading frame38 [Source: HGNC Symbol; Acc: 28782] 213733_at 19 p13.2 myosin IF[Source: HGNC Symbol; Acc: 7600] 225162_at 4 q31.3 SH3 domain containing19 [Source: HGNC Symbol; Acc: 30418] 221766_s_at 6 q14.1 family withsequence similarity 46, member A [Source: HGNC Symbol; Acc: 18345]235256_s_at 2 p22.1 galactose mutarotase (aldose 1-epimerase) [Source:HGNC Symbol; Acc: 24063] 201417_at 6 p22.3 SRY (sex determining regionY)-box 4 [Source: HGNC Symbol; Acc: 11200] 201963_at 4 q35.1 acyl-CoAsynthetase long-chain family member 1 [Source: HGNC Symbol; Acc: 3569]218983_at 12 p13.31 complement component 1, r subcomponent-like [Source:HGNC Symbol; Acc: 21265] 225442_at 1 q23.3 discoidin domain receptortyrosine kinase 2 [Source: HGNC Symbol; Acc: 2731] 225128_at 11 q22.3KDEL (Lys-Asp-Glu-Leu) containing 2 [Source: HGNC Symbol; Acc: 28496]225913_at NA NA NA 238477_at 17 p13.2 kinesin family member 1C [Source:HGNC Symbol; Acc: 6317] 1557236_at 22 q12.3 apolipoprotein L, 6 [Source:HGNC Symbol; Acc: 14870] 224764_at 10 p12.1 Rho GTPase activatingprotein 21 [Source: HGNC Symbol; Acc: 23725] 204568_at 14 q22.3autophagy related 14 [Source: HGNC Symbol; Acc: 19962] 202598_at 1 q21.3S100 calcium binding protein A13 [Source: HGNC Symbol; Acc: 10490]218815_s_at 1 p36.21 transmembrane protein 51 [Source: HGNC Symbol; Acc:25483] 204214_s_at 6 q24.3 RAB32, member RAS oncogene family [Source:HGNC Symbol; Acc: 9772] 226152_at 14 q32.11 tetratricopeptide repeatdomain 7B [Source: HGNC Symbol; Acc: 19858] 205590_at 15 q14 RAS guanylreleasing protein 1 (calcium and DAG-regulated) [Source: HGNC Symbol;Acc: 9878] 1555579_s_at 18 p11.23 protein tyrosine phosphatase, receptortype, M [Source: HGNC Symbol; Acc: 9675] 218486_at 2 p25.1Kruppel-factor 11 [Source: HGNC Symbol; Acc: 11811] 204451_at 7 q21.13frizzled family receptor 1 [Source: HGNC Symbol; Acc: 4038] 226186_at 15q21.2 tropomodulin 2 (neuronal) [Source: HGNC Symbol; Acc: 11872]225288_at 9 q32 collagen, type XXVII, alpha 1 [Source: HGNC Symbol; Acc:22986] 225163_at 10 p13 FERM domain containing 4A [Source: HGNC Symbol;Acc: 25491] 221541_at 16 q24.3 cystein-rich secretary protein LCCLdomain containing 2 [Source: HGNC Symbol; Acc: 25248] 230480_at 11 q21piwi-like RNA-mediated gene silencing 4 [Source: HGNC Symbol; Acc:18444] 227444_at X q22.1 armadillo repeat containing, X-linked 4[Source: HGNC Symbol; Acc: 28615] 218285_s_at 4 q24 3-hydroxybutyratedehydrogenase, type 2 [Source: HGNC Symbol; Acc: 32389] 209687_at 10q11.21 chemokine (C-X-C motif) ligand 12 [Source: HGNC Symbol; Acc:10672] 203261_at 8 p12 dynactin 6 [Source: HGNC Symbol; Acc: 16964]227001_at 8 q22.2 NIPA-like domain containing 2 [Source: HGNC Symbol;Acc: 25854] 213119_at 5 q33.1 solute carrier family 36 (proton/aminoacid symporter), member 1 [Source: HGNC Symbol; Acc: 18761] 201089_at 8p21.3 ATPase, H transporting, lysosomal 56/58 kDa, V1 subunit B2[Source: HGNC Symbol; Acc: 854] 228937_at 13 q14.11 laccase (multicopperoxidoreductase) domain containing 1 [Source: HGNC Symbol; Acc: 26789]219666_at 11 q12.2 membrane-spanning 4-domains, subfamily A, member 6A[Source: HGNC Symbol; Acc: 13375] 209160_at 10 p15.1 aldo-keto reductasefamily 1, member C3 [Source: HGNC Symbol; Acc: 386] 203688_at 4 q22.1polycystic kidney disease 2 (autosomal dominant) [Source: HGNC Symbol;Acc: 9009] 209379_s_at 10 q23.1 coiled-coil serine-rich protein 2[Source: HGNC Symbol; Acc: 29197] 202973_x_at 4 q22.1 family withsequence similarity 13, member A [Source: HGNC Symbol; Acc: 19367]222999_s_at 1 p36.33 cyclin L2 [Source: HGNC Symbol; Acc: 20570]32811_at 17 p13.3 myosin IC [Source: HGNC Symbol; Acc: 7597 213737_x_at15 q11.2 golgin A8 family, member I [Source: HGNC Symbol; Acc: 26660]202351_at 2 q32.1 integrin, alpha V [Source: HGNC Symbol; Acc: 6150]226066_at 3 p14.1 microphthalmia-associated transcription factor[Source: HGNC Symbol; Acc: 7105] 212453_at 10 q22.1 KIAA1279 [Source:HGNC Symbol; Acc: 23419] 223276_at 5 q33.1 small integral membraneprotein 3 [Source: HGNC Symbol; Acc: 30248] 63825_at 15 q26.1abhydrolase domain containing 2 [Source: HGNC Symbol; Acc: 18717]203817_at 4 q32.1 guanylate cyclase 1, soluble, beta 3 [Source: HGNCSymbol; Acc: 4687] 232090_at 1 q24.3 DNM3 opposite strand/antisense RNA[Source: HGNC Symbol; Acc: 41228] 218292_s_at 7 q36.1 protein kinase,AMP-activated, gamma 2 non-catalytic subunit [Source: HGNC Symbol; Acc:9386] 1558173_a_at 1 p36.12 leucine zipper protein 1 [Source: HGNCSymbol; Acc: 14985] 201438_at 2 q37.3 collagen, type VI, alpha 3[Source: HGNC Symbol; Acc: 2213] 235458_at 5 q33.3 hepatitis A viruscellular receptor 2 [Source: HGNC Symbol; Acc: 18437] 223393_s_at 19 q12teashirt zinc finger homeobox 3 [Source: HGNC Symbol; Acc: 30700]215706_x_at 7 q34 zyxin [Source: HGNC Symbol; Acc: 13200] 219315_s_at 16p13.3 transmembrane protein 204 [Source: HGNC Symbol; Acc: 14158]201296_s_at 17 q11.1 WD repeat and SOCS box containing 1 [Source: HGNCSymbol; Acc: 19221] 232231_at 6 p21.1 runt-related transcription factor2 [Source: HGNC Symbol; Acc: 10472] 226225_at 5 q22.2 mutated incolorectal cancers [Source: HGNC Symbol; Acc: 6935] 214660_at 5 q11.2integrin, alpha 1 [Source: HGNC Symbol; Acc: 6134] 216903_s_at 10 q22.1mitochondrial calcium uptake 1 [Source: HGNC Symbol; Acc: 1530]215111_s_at 13 q14.11 TSC22 domain family, member 1 [Source: HGNCSymbol; Acc: 16826] 200782_at 4 q27 annexin A5 [Source: HGNC Symbol;Acc: 543] 226771_at 1 q21.3 ATPase, aminophospholipid transporter, classI, type 8B, member 2 [Source: HGNC Symbol; Acc: 13534] 212185_x_at 16q12.2 metallothionein 2A [Source: HGNC Symbol; Acc: 7406] 200986_at 11q12.1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1[Source: HGNC Symbol; Acc: 1228] 221269_s_at 1 p36.11 SH3 domain bindingglutamic acid-rich protein like 3 [Source: HGNC Symbol; Acc: 15568]202081_at 19 p13.2 immediate early response 2 [Source: HGNC Symbol; Acc:28871] 206995_x_at 17 p13.3 scavenger receptor class F, member 1[Source: HGNC Symbol; Acc: 16820] 204963_at 12 p12.1 sarcospan [Source:HGNC Symbol; Acc: 11322] 202192_s_at 17 p13.1 growth arrest-specific 7[Source: HGNC Symbol; Acc: 4169] 224747_at 15 q24.2ubiquitin-conjugating enzyme E2Q family member 2 [Source: HGNC Symbol;Acc: 19248] 202136_at 10 p15.3 zinc finger, MYND-type containing 11[Source: HGNC Symbol; Acc: 16966] 209970_x_at 11 q22.3 caspase 1,apoptosis-related cysteine peptidase [Source: HGNC Symbol; Acc: 1499]234987_at 20 q11.23 SAM domain and HD domain 1 [Source: HGNC Symbol;Acc: 15925] 205173_x_at 1 p13.1 CD58 molecule [Source: HGNC Symbol; Acc:1688] 229732_at 19 p13.2 zinc finger protein 823 [Source: HGNC Symbol;Acc: 30936] 37408_at 17 q23.2 mannose receptor, C type 2 [Source: HGNCSymbol; Acc: 16875] 208922_s_at 11 q12.3 nuclear RNA export factor 1[Source: HGNC Symbol; Acc: 8071] 200766_at 11 p15.5 cathepsin D [Source:HGNC Symbol; Acc: 2529] 209129_at 7 q22.1 thyroid hormone receptorinteractor 6 [Source: HGNC Symbol; Acc: 12311] 228728_at 7 q31.31cadherin-like and PC-esterase domain containing 1 [Source: HGNC Symbol;Acc: 26159] 223028_s_at 6 q25.3 sorting nexin 9 [Source: HGNC Symbol;Acc: 14973] 214464_at 1 q42.13 CDC42 binding protein kinase alpha(DMPK-like) [Source: HGNC Symbol; Acc: 1737] 204059_s_at 6 q14.2 malicenzyme 1, NADP( )-dependent, cytosolic [Source: HGNC Symbol; Acc: 6983]202481_at 1 p36.22 dehydrogenase/reductase (SDR family) member 3[Source: HGNC Symbol; Acc: 17693] 201426_s_at 10 p13 vimentin [Source:HGNC Symbol; Acc: 12692] 214177_s_at 1 q21.3 pre-B-cell leukemiahomeobox interacting protein 1 [Source: HGNC Symbol; Acc: 21199]218793_s_at X p22.13 sex comb on midleg-like 1 (Drosophila) [Source:HGNC Symbol; Acc: 10580] 201163_s_at 4 q12 insulin-like growth factorbinding protein 7 [Source: HGNC Symbol; Acc: 5476] 225406_at 18 p11.22twisted gastrulation homolog 1 (Drosophila) [Source: HGNC Symbol; Acc:12429] 209071_s_at 1 q23.3 regulator of G-protein signaling 5 [Source:HGNC Symbol; Acc: 10001] 204206_at 17 p13.3 MNT, MAX dimerizationprotein [Source: HGNC Symbol; Acc: 7188] 226026_at 3 q21.1 disrupted inrenal carcinoma 2 [Source: HGNC Symbol; Acc: 16628] 214683_s_at 2 q33.1CDC-like kinase 1 [Source: HGNC Symbol; Acc: 2068] 218095_s_at 4 q12transmembrane protein 165 [Source: HGNC Symbol; Acc: 30760] 219316_s_at14 q24.3 feline leukemia virus subgroup C cellular receptor family,member 2 [Source: HGNC Symbol; Acc: 20105] 226763_at 2 q31.2 SEC14 andspectrin domains 1 [Source: HGNC Symbol; Acc: 18379] 227361_at 17 p12heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 [Source: HGNCSymbol; Acc: 5198] 205248_at 21 q22.12 dopey family member 2 [Source:HGNC Symbol; Acc: 1291] 211026_s_at 3 q21.3 monoglyceride lipase[Source: HGNC Symbol; Acc: 17038] 212224_at 9 q21.13 aldehydedehydrogenase 1 family, member A1 [Source: HGNC Symbol; Acc: 402]201215_at X q23 plastin 3 [Source: HGNC Symbol; Acc: 9091] 218432_at 11p13 F-box protein 3 [Source: HGNC Symbol; Acc: 13582] 212428_at 9 q31.3KIAA0368 [Source: HGNC Symbol; Acc: 29020] 203394_s_at 3 q29 hairy andenhancer of split 1, (Drosophila) [Source: HGNC Symbol; Acc: 5192]235125_x_at 1 p31.1 family with sequence similarity 73, member A[Source: HGNC Symbol; Acc: 24741] 224690_at 20 q13.2 family withsequence similarity 210, member B [Source: HGNC Symbol; Acc: 16102]219991_at 4 p16.1 solute carrier family 2 (facilitated glucosetransporter), member 9 [Source: HGNC Symbol; Acc: 13446] 214560_at 19q13.41 formyl peptide receptor 3 [Source: HGNC Symbol; Acc: 3828]210946_at 5 q11.2 phosphatidic acid phosphatase type 2A [Source: HGNCSymbol; Acc: 9228] 210817_s_at 17 q21.32 calcium binding and coiled-coildomain 2 [Source: HGNC Symbol; Acc: 29912] 208636_at 14 q24.1 actinin,alpha 1 [Source: HGNC Symbol; Acc: 163] 1561226_at 3 p21.31 chemokine (Cmotif) receptor 1 [Source: HGNC Symbol; Acc: 1625] 229256_at 11 q13.4phosphoglucomutase 2-like 1 [Source: HGNC Symbol; Acc: 20898] 228131_at19 q13.32 excision repair cross-complementing rodent repair deficiency,complementation group 1 (includes overlapping antisense sequence)[Source: HGNC Symbol; Acc: 3433] 209310_s_at 11 q22.3 caspase 4,apoptosis-related cysteine peptidase [Source: HGNC Symbol; Acc: 1505]218729_at 3 q25.32 latexin [Source: HGNC Symbol; Acc: 13347] 227274_at14 q24.2 synaptojanin 2 binding protein [Source: HGNC Symbol; Acc:18955] 219147_s_at 9 q21.13 nicotinamide riboside kinase 1 [Source: HGNCSymbol; Acc: 26057] 205083_at 2 q33.1 aldehyde oxidase 1 [Source: HGNCSymbol; Acc: 553] 209109_s_at X q22.1 tetraspanin 6 [Source: HGNCSymbol; Acc: 11858] 225303_at 1 q23.1 kin of IRRE like (Drosophila)[Source: HGNC Symbol; Acc: 15734] 225185_at 3 q22.3 muscle RAS oncogenehomolog [Source: HGNC Symbol; Acc: 7227] 203716_s_at 2 q24.2dipeptidyl-peptidase 4 [Source: HGNC Symbol; Acc: 3009] 204342_at 1p13.3 solute carrier family 25 (mitochondrial carrier; phosphatecarrier), member 24 [Source: HGNC Symbol; Acc: 20662] 202948_at 2 q11.2interleukin 1 receptor, type I [Source: HGNC Symbol; Acc: 5993]212511_at 11 q14.2 phosphatidylinositol binding clathrin assemblyprotein [Source: HGNC Symbol; Acc: 15514] 214429_at 13 q12.13myotubularin related protein 6 [Source: HGNC Symbol; Acc: 7453]214021_x_at 3 q21.2 integrin, beta 5 [Source: HGNC Symbol; Acc: 6160]227624_at 4 q24 tet methylcytosine dioxygenase 2 [Source: HGNC Symbol;Acc: 25941] 225093_at 6 q24.2 utrophin [Source: HGNC Symbol; Acc: 12635]227379_at 6 p22.3 membrane bound O-acyltransferase domain containing 1[Source: HGNC Symbol; Acc: 21579] 213139_at 8 q11.21 snail family zincFinger 2 [Source: HGNC Symbol; Acc: 11094] 212099_at 2 p24.1 ras homologfamily member B [Source: HGNC Symbol; Acc: 668] 204894_s_at 17 q21.31amine oxidase, copper containing 3 [Source: HGNC Symbol; Acc: 550]219432_at 4 p16.2 Ellis van Creveld syndrome [Source: HGNC Symbol; Acc:3497] 55065_at 19 q13.32 MAP/microtobule affinity-regulating kinase 4[Source: HGNC Symbol; Acc: 13538] 226353_at 15 q21.2 signal peptidepeptidase like 2A [Source: HGNC Symbol; Acc: 30227] 216598_s_at 17 q12chemokine (C-C motif) ligand 2 [Source: HGNC Symbol; Acc: 10618]226568_at 1 p13.3 family with sequence similarity 102, member B [Source:HGNC Symbol; Acc: 27637] 218764_at 14 q23.1 protein kinase C, eta[Source: HGNC Symbol; Acc: 9403] 225984_at 5 p13.1 protein kinase,AMP-activated, alpha 1 catalytic subunit [Source: HGNC Symbol; Acc:9376] 201542_at 10 q22.1 SAR1 homolog A (S. cerevisiae) [Source: HGNCSymbol; Acc: 10534] 203455_s_at X p22.11 spermidine/spermineN1-acetyltransferase 1 [Source: HGNC Symbol; Acc: 10540] 225922_at 4q32.1 folliculin interacting protein 2 [Source: HGNC Symbol; Acc: 29280]218665_at 11 q14.2 frizzled family receptor 4 [Source: HGNC Symbol; Acc:4042] 221666_s_at 16 p11.2 PYD and CARD domain containing [Source: HGNCSymbol; Acc: 16608] 201058_s_at 20 q11.23 myosin, light chain 9,regulatory [Source: HGNC Symbol; Acc: 15754] 203397_s_at 2 q24.3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) [Source: HGNC Symbol; Acc:4125] 222453_at 2 q31.1 cytochrome b reductase 1 [Source: HGNC Symbol;Acc: 20797] 208146_s_at 7 p14.3 carboxypeptidase, vitellogenic-like[Source: HGNC Symbol; Acc: 14399] 227334_at 10 q22.2 ubiquitin specificpeptidase 54 [Source: HGNC Symbol; Acc: 23513] 226534_at 12 q21.32 KITligand [Source: HGNC Symbol; Acc: 6343] 229120_s_at 1 q21.3 CDC42 smalleffector 1 [Source: HGNC Symbol; Acc: 17719] 225066_at 10 q26.3 proteinphosphatase 2, regulatory subunit B, delta [Source: HGNC Symbol; Acc:23732] 211977_at 9 q34.11 G protein-coupled receptor 107 [Source: HGNCSymbol; Acc: 17830] 217967_s_at 1 q25.3 family with sequence similarity129, member A [Source: HGNC Symbol; Acc: 16784] 207705_s_at 20 p11.21ninein-like [Source: HGNC Symbol; Acc: 29163] 230029_x_at 2 q31.1ubiquitin protein ligase E3 component n-recognin 3 (putative) [Source:HGNC Symbol; Acc: 30467] 227236_at 1 p13.2 tetraspanin 2 [Source: HGNCSymbol; Acc: 20659] 202510_s_at 14 q32.32 tumor necrosis factor,alpha-induced protein 2 [Source: HGNC Symbol; Acc: 11895] 202450_s_at 1q21.3 cathepsin K [Source: HGNC Symbol; Acc: 2536] 226395_at 8 p11.21hook homolog 3 (Drosophila) [Source: HGNC Symbol; Acc: 23576]219403_s_at 4 q21.23 heparanase [Source: HGNC Symbol; Acc: 5164]227623_at 7 q21.11 calcium channel, voltage-dependent, alpha 2/deltasubunit 1 [Source: HGNC Symbol; Acc: 1399] 202239_at 13 q12.12 poly(ADP-ribose) polymerase family, member 4 [Source: HGNC Symbol; Acc: 271]204646_at 1 p21.3 dihydropyrimidine dehydrogenase [Source: HGNC Symbol;Acc: 3012] 209335_at 12 q21.33 decorin [Source: HGNC Symbol; Acc: 2705]202341_s_at 4 q31.3 tripartite motif containing 2 [Source: HGNC Symbol;Acc: 15974] 203386_at 13 q22.2 TBC1 domain family, member 4 [Source:HGNC Symbol; Acc: 19165] 202465_at 7 q22.1 procollagen C-endopeptidaseenhancer [Source: HGNC Symbol; Acc: 8738] 218501_at 3 p14.3 Rho guaninenucleotide exchange factor (GEF) 3 [Source: HGNC Symbol; Acc: 683]203935_at 2 q24.1 activin A receptor, type I [Source: HGNC Symbol; Acc:171] 227726_at 16 q24.3 ring finger protein 166 [Source: HGNC Symbol;Acc: 28856] 225351_at 10 q26.11 family with sequence similarity 45,member A [Source: HGNC Symbol; Acc: 31793] 209967_s_at 10 p11.21 cAMPresponsive element modulator [Source: HGNC Symbol; Acc: 2352] 217767_at19 p13.3 complement component 3 [Source: HGNC Symbol; Acc: 1318]202377_at 1 p31.3 leptin receptor overlapping transcript [Source: HGNCSymbol; Acc: 29447] 212067_s_at 12 p13.31 complement component 1, rsubcomponent [Source: HGNC Symbol; Acc: 1246] 206461_x_at 16 q13metallothionein 1H [Source: HGNC Symbol; Acc: 7400] 212651_at 10 q21.2Rho-related BTB domain containing 1 [Source: HGNC Symbol; Acc: 18738]213077_at 5 q22.2 YTH domain containing 2 [Source: HGNC Symbol; Acc:24721] 238617_at 1 q44 kinesin family member 26B [Source: HGNC Symbol;Acc: 25484] 201540_at X q26.3 four and a half LIM domains 1 [Source:HGNC Symbol; Acc: 3702] 227325_at 19 q13.32 proline rich 24 [Source:HGNC Symbol; Acc: 27406] 208093_s_at 17 p13.1 nudE nuclear distributionE homolog (A. nidulans)-like 1 [Source: HGNC Symbol; Acc: 17620]202006_at 7 q11.23 protein tyrosine phosphatase, non-receptor type 12[Source: HGNC Symbol; Acc: 9645] 209216_at X p11.23 WD repeat domain 45[Source: HGNC Symbol; Acc: 28912] 225782_at 12 q14.3 methioninesulfoxide reductase B3 [Source: HGNC Symbol; Acc: 27375] 200602_at 21q21.3 amyloid beta (A4) precursor protein [Source: HGNC Symbol; Acc:620] 226939_at 4 p15.33 cytoplasmic polyadenylation element bindingprotein 2 [Source: HGNC Symbol; Acc: 21745] 218986_s_at 4 q32.3 DEAD(Asp-Glu-Ala-Asp) box polypeptide 60 [Source: HGNC Symbol; Acc: 25942]203139_at 9 q21.33 death-asscosiated protein kinase 1 [Source: HGNCSymbol; Acc: 2674] 213764_s_at 12 p13.31 microfibrillar associatedprotein 5 [Source: HGNC Symbol; Acc: 29673] 202565_s_at 10 p11.23supervillin [Source: HGNC Symbol; Acc: 11480] 210968_s_at 2 p16.1reticulon 4 [Source: HGNC Symbol; Acc: 14085] 225562_at 13 q34 RAS p21protein activator 3 [Source: HGNC Symbol; Acc: 20331] 218454_at 12 p13.1phospholipase B domain containing 1 [Source: HGNC Symbol; Acc: 26215]209467_s_at 1 p33 MAP kinase interacting serine/threonine kinase 1[Source: HGNC Symbol; Acc: 7110] 226869_at 1 p36.32 multipleEGF-like-domains 6 [Source: HGNC Symbol; Acc: 3232] 221569_at 6 q23.3Abelson helper integration site 1 [Source: HGNC Symbol; Acc: 21575]1569157_s_at 19 p13.2 zinc finger protein 846 [Source: HGNC Symbol; Acc:27260] 218132_s_at 19 q13.42 tRNA splicing endonuclease 34 homolog (S.cerevisiae) [Source: HGNC Symbol; Acc: 15506] 201591_s_at 3 p21.1nischarin [Source: HGNC Symbol; Acc: 18006] 227098_at 22 q12.2 dualspecificity phosphatase 18 [Source: HGNC Symbol; Acc: 18484] 203910_at 1p21.3 Rho GTPase activating protein 29 [Source: HGNC Symbol; Acc: 30207]1555847_a_at NA NA NA 241353_s_at NA NA NA 202225_at 17 p13.3 v-crkavian sarcoma virus CT10 oncogene homolog [Source: HGNC Symbol; Acc:2362] 212915_at 3 p13 PDZ domain containing ring finger 3 [Source: HGNCSymbol; Acc: 17704] 202920_at 4 q25 ankyrin 2, neuronal [Source: HGNCSymbol; Acc: 493] 235391_at 8 q22.1 family with sequence similarity 92,member A1 [Source: HGNC Symbol; Acc: 30452] 224906_at 12 q12 anoctamin 6[Source: HGNC Symbol; Acc: 25240] 227087_at 2 q11.2 inositolpolyphosphate-4-phosphatase, type I, 107 kDa [Source: HGNC Symbol; Acc:6074] 225931_s_at 17 q25.3 ring finger protein 213 [Source: HGNC Symbol;Acc: 14539] 212690_at 8 p11.23 DDHD domain containing 2 [Source: HGNCSymbol; Acc: 29106] 209003_at 17 p13.2 solute carrier family 25(mitchondrial carrier; oxoglutarate carrier), member 11 [Source: HGNCSymbol; Acc: 10981] 202206_at 2 q37.1 ADP-ribosylation factor-like 4C[Source: HGNC Symbol; Acc: 698] 232000_at 9 p22.3 tetratricopeptiderepeat domain 39B [Source: HGNC Symbol; Acc: 23704] 225386_s_at NA NA NA226409_at 20 p13 TBC1 domain family, member 20 [Source: HGNC Symbol;Acc: 16133] 204066_s_at 2 q37.2 ArfGAP with GTPase domain, ankyrinrepeat and PH domain 1 [Source: HGNC Symbol; Acc: 16922] 212441_at 4p16.1 KIAA0232 [Source: HGNC Symbol; Acc: 28992] 225726_s_at 14 q24.1pleckstrin homology domain containing, family H (with MyTH4 domain)member 1 [Source: HGNC Symbol; Acc: 17733] 232094_at 15 q14 katanin p80subunit B-like 1 [Source: HGNC Symbol; Acc: 26199] 225604_s_at 9 p13.3GLI pathogenesis-related 2 [Source: HGNC Symbol; Acc: 18007] 205225_at 6q25.1 estrogen receptor 1 [Source: HGNC Symbol; Acc: 3467] 218838_s_at 2p13.1 tetratricopeptide repeat domain 31 [Source: HGNC Symbol; Acc:25759] 227961_at 8 p23.1 cathepsin B [Source: HGNC Symbol; Acc: 2527]1558041_a_at 16 q22.1 KIAA0895-like [Source: HGNC Symbol; Acc: 34408]209540_at 12 q23.2 insulin-like growth factor 1 (somatomedin C) [Source:HGNC Symbol; Acc: 5464] 203651_at 5 q14.1 zinc finger, FYVE domaincontaining 16 [Source: HGNC Symbol; Acc: 20756] 224900_at 17 p13.2ankyrin repeat and FYVE domain containing 1 [Source: HGNC Symbol; Acc:20763] 223441_at 6 q13 solute carrier family 17 (anion/sugartransporter), member 5 [Source: HGNC Symbol; Acc: 10933] 204294_at 3p21.31 aminomethyltransferase [Source: HGNC Symbol; Acc: 473] 204040_at2 p25.2 ring finger protein 144A [Source: HGNC Symbol; Acc: 20457]225272_at 17 p13.1 spermidine/spermine N1-acetyltransferase familymember 2 [Source: HGNC Symbol; Acc: 23160] 204464_s_at 4 q31.22endothelin receptor type A [Source: HGNC Symbol; Acc: 3179] 205011_at 11q24.2 von Willebrand factor A domain containing 5A [Source: HGNC Symbol;Acc: 6658] 212765_at 1 q32.1 calmodulin regulated spectrin-associatedprotein family, member 2 [Source: HGNC Symbol; Acc: 29188] 212624_s_at 2q31.1 chimerin 1 [Source: HGNC Symbol; Acc: 1943] 209213_at 21 q22.12carbonyl reductase 1 [Source: HGNC Symbol; Acc: 1548] 207738_s_at 2q32.1 NCK-associated protein 1 [Source: HGNC Symbol; Acc: 7666]206856_at 19 q13.42 leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 5 [Source: HGNC Symbol; Acc: 6609]200697_at 10 q22.1 hexokinase 1 [Source: HGNC Symbol; Acc: 4922]219134_at 1 p31.1 EGF, latrophilin and seven transmembrane domaincontaining 1 [Source: HGNC Symbol; Acc: 20822] 222294_s_at 15 q21.3RAB27A, member RAS oncogene family [Source: HGNC Symbol; Acc: 9766]201057_s_at 3 q13.33 golgin B1 [Source: HGNC Symbol; Acc: 4429]218017_s_at 8 p11.21 heparan-alpha-glucosaminide N-acetyltransferase[Source: HGNC Symbol; Acc: 26527] 226905_at 17 p13.3 family withsequence similarity 101, member B [Source: HGNC Symbol; Acc: 28705]226616_s_at 21 q22.3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa [Source: HGNC Symbol; Acc: 7719] 215127_s_at 2 q24.2 RNA bindingmotif, single stranded interacting protein 1 [Source: HGNC Symbol; Acc:9907] 212373_at 15 q23 fem-1 homolog b (C. elegans) [Source: HGNCSymbol; Acc: 3649] 222750_s_at 4 q12 steroid 5 alpha-reductase 3[Source: HGNC Symbol; Acc: 25812] 236006_s_at 17 p11.2 A kinase (PRKA)anchor protein 10 [Source: HGNC Symbol; Acc: 368] 224733_at 16 q21CKLF-like MARVEL transmembrane domain containing 3 [Source: HGNC Symbol;Acc: 19174] 204981_at 11 p15.4 solute carrier family 22, member 18[Source: HGNC Symbol; Acc: 10964] 223077_at 15 q21.2 tropomodulin 3(ubiquitous) [Source: HGNC Symbol; Acc: 11873] 209686_at 21 q22.3 S100calcium binding protein B [Source: HGNC Symbol; Acc: 10500] 225325_at 2q32.2 major facilitator superfamily domain containing 6 [Source: HGNCSymbol; Acc: 24711] 205236_x_at 4 p15.2 superoxide dismutase 3,extracellular [Source: HGNC Symbol; Acc: 11181] 228220_at 5 q13.2 FCHdomain only 2 [Source: HGNC Symbol; Acc: 25180] 205904_at 6 p21.33 MHCclass I polypeptide-related sequence A [Source: HGNC Symbol; Acc: 7090]226777_at 10 q26.2 ADAM metallopeptidase domain 12 [Source: HGNC Symbol;Acc: 190] 213618_at 4 p14 ArfGAP with RhoGAP domain, ankyrin repeat andPH domain 2 [Source: HGNC Symbol; Acc: 16924] 205624_at 3 q24carboxypeptidase A3 (mast cell) [Source: HGNC Symbol; Acc: 2298]215268_at 1 p34.3 KIAA0754 [Source: HGNC Symbol; Acc: 29111] 203672_x_at6 p22.3 thiopurine S-methyltransferase [Source: HGNC Symbol; Acc: 12014]1555229_a_at 12 p13.31 complement component 1, s subcomponent [Source:HGNC Symbol; Acc: 1247] 203855_at 1 p13.3 WD repeat domain 47 [Source:HGNC Symbol; Acc: 29141] 207072_at 2 q12.1 interleukin 18 receptoraccessory protein [Source: HGNC Symbol; Acc: 5989] 221935_s_at 3 p14.1EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase[Source: HGNC Symbol; Acc: 28526] 203232_s_at 6 p22.3 ataxin 1 [Source:HGNC Symbol; Acc: 10548] 202096_s_at 22 q13.2 translocator protein (18kDa) [Source: HGNC Symbol; Acc: 1158] 224813_at 7 q31.32 Wiskott-Aldrichsyndrome-like [Source: HGNC Symbol; Acc: 12735] 213455_at 4 p14 familywith sequence similarity 114, member A1 [Source: HGNC Symbol; Acc:25087] 226873_at 15 q21.3 family with sequence similarity 63, member B[Source: HGNC Symbol; Acc: 26954] 1554503_a_at 19 q13.42 osteoclastassociated, immunoglobulin-like receptor [Source: HGNC Symbol; Acc:29960] 206118_at 2 q32.3 signal transducer and activator of transription4 [Source: HGNC Symbol; Acc: 11365] 210970_s_at 6 q14.1 inhibitor ofBruton agammaglobulinemia tyrosine kinase [Source: HGNC Symbol; Acc:17853] 227113_at 8 q13.1 alcohol dehydrogenase, iron containing, 1[Source: HGNC Symbol; Acc: 16354] 202949_s_at 2 q12.2 four and a halfLIM domains 2 [Source: HGNC Symbol; Acc: 3703] 225579_at 2 p25.1 PQ looprepeat containing 3 [Source: HGNC Symbol; Acc: 28503] 235291_s_at NA NANA 203939_at 6 q14.3 5′-nucleotidase, ecto (CD73) [Source: HGNC Symbol;Acc: 8021] 214274_s_at 3 p22.2 acetyl-CoA acyltransferase 1 [Source:HGNC Symbol; Acc: 82] 204046_at 15 q15.1 phospholipase C, beta 2[Source: HGNC Symbol; Acc: 9055] 202392_s_at 22 q12.2 phosphatidylserinedecarboxylase [Source: HGNC Symbol; Acc: 8999] 218326_s_at 11 p14.1leucine-rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol; Acc: 13299] 229119_s_at 17 p12 zinc finger, SWIM-typecontaining 7 [Source: HGNC Symbol; Acc: 26993] 206491_s_at 19 q13.33N-ethylmaleimide-sensitive factor attachment protein, alpha [Source:HGNC Symbol; Acc: 7641] 227450_at 12 p12.3 endoplasmic reticulum protein27 [Source: HGNC Symbol; Acc: 26495] 200866_s_at 10 q22.1 prosaposin[Source: HGNC Symbol; Acc: 9498] 200720_s_at 10 q24.32 ARP1actin-related protein 1 homolog A, centractin alpha (yeast) [Source:HGNC Symbol; Acc: 167] 232064_at 5 q21.3 fer (fps/fes related) tyrosinekinase [Source: HGNC Symbol; Acc: 3655] 217922_at 1 p12 mannosidase,alpha, class 1A, member 2 [Source: HGNC Symbol; Acc: 6822] 201944_at 5q13.3 hexosaminidase B (beta polypeptide) [Source: HGNC Symbol; Acc:4879] 210986_s_at 15 q22.2 tropomyosin 1 (alpha) [Source: HGNC Symbol;Acc: 12010] 227568_at 10 q23.32 HECT domain containing E3 ubiquitinprotein ligase 2 [Source: HGNC Symbol; Acc: 26736] 200645_at 17 p13.1GABA(A) receptor-associated protein [Source: HGNC Symbol; Acc: 4067]219892_at 15 q25.2 transmembrane 6 superfamily member 1 [Source: HGNCSymbol; Acc: 11860] 222431_at 9 q22.1 spindlin 1 [Source: HGNC Symbol;Acc: 11243] 203665_at 22 q12.3 heme oxygenase (decycling) 1 [Source:HGNC Symbol; Acc: 5013] 202506_at 2 q31.3 sperm specific antigen 2[Source: HGNC Symbol; Acc: 11319] 221899_at 13 q13.1 NEDD4 bindingprotein 2-like 2 [Source: HGNC Symbol; Acc: 26916] 203668_at 15 q24.2mannosidase, alpha, class 2C, member 1 [Source: HGNC Symbol; Acc: 6827]206295_at 11 q23.1 interleukin 18 (interferon-gamma-inducing factor)[Source: HGNC Symbol; Acc: 5986] 228152_s_at 4 q32.3 DEAD(Asp-Glu-Ala-Asp) box polypeptide 60-like [Source: HGNC Symbol; Acc:26429] 228341_at 3 q22.1 nudix (nucleoside diphosphate linked moeityX)-type motif 16 [Source: HGNC Symbol; Acc: 26442] 218164_at 17 q21.33spermatogenesis associated 20 [Source: HGNC Symbol; Acc: 26125]227070_at 12 q23.3 glycosyltransferase 8 domain containing 2 [Source:HGNC Symbol; Acc: 24890] 213083_at 9 q22.32 solute carrier family 35(UDP-GlcNAc/UDP-glucose transporter), member D2 [Source: HGNC Symbol;Acc: 20799] 224772_at 1 q32.1 neuron navigator 1 [Source: HGNC Symbol;Acc: 15989] 229287_at 14 q24.2 pecanex homolog (Drosophila) [Source:HGNC Symbol; Acc: 19740] 201200_at 1 q24.2 cellular repressor ofE1A-stimulated genes 1 [Source: HGNC Symbol; Acc: 2351] 229450_at 10q23.31 interferon-induced protein with tetratricopeptide repeats 3[Source: HGNC Symbol; Acc: 5411] 228249_at 11 p12 chromosome 11 openreading frame 74 [Source: HGNC Symbol; Acc: 25142] 38487_at 3 p21.1stabilin 1 [Source: HGNC Symbol; Acc: 18628] 202974_at X q28 membraneprotein, palmitoylated 1, 55 kDa [Source: HGNC Symbol; Acc: 7219]226510_at 14 q12 HEAT repeat containing 5A [Source: HGNC Symbol; Acc:20276] 228282_at 4 q28.2 major facilitator superfamily domain containing8 [Source: HGNC Symbol; Acc: 28486] 203675_at 11 p15.1 nucleobindin 2[Source: HGNC Symbol; Acc: 8044] 228384_s_at 10 q24.2 pyridinenucleotide-disulphide oxidoreductase domain 2 [Source: HGNC Symbol; Acc:23517] 229367_s_at 7 q36.1 GTPase, IMAP family member 6 [Source: HGNCSymbol; Acc: 21918] 218309_at 1 p36.12 calcium/calmodulin-dependentprotein kinase II inhibitor 1 [Source: HGNC Symbol; Acc: 24190] 34726_at12 q13.12 calcium channel, voltage-dependent, beta 3 subunit [Source:HGNC Symbol; Acc: 1403] 212670_at 7 q11.23 elastin [Source: HGNC Symbol;Acc: 3327] 229800_at 13 q13.3 doublecortin-like kinase 1 [Source: HGNCSymbol; Acc: 2700] 201975_at 12 q24.31 CAP-GLY domain containing linkerprotein 1 [Source: HGNC Symbol; Acc: 10461] 224413_s_at 8 p11.22 TM2domain containing 2 [Source: HGNC Symbol; Acc: 24127] 204011_at 13 q31.1sprouty homolog 2 (Drosophila) [Source: HGNC Symbol; Acc: 11270]235033_at 20 q13.32 aminopeptidase-like 1 [Source: HGNC Symbol; Acc:16244] 228348_at 15 q26.3 lines homolog (Drosophila) [Source: HGNCSymbol; Acc: 30922] 227628_at 5 q11.2 glutathione peroxidase 8(putative) [Source: HGNC Symbol; Acc: 33100] 1557112_a_at 17 p13.3vacuolar protein sorting 53 homolog (S. cerevisiae) [Source: HGNCSymbol; Acc: 25608] 228071_at 7 q36.1 GTPase, IMAP family member 7[Source: HGNC Symbol; Acc: 22404] 209264_s_at 11 p15.5 tetraspanin 4[Source: HGNC Symbol; Acc: 11859] 208892_s_at 12 q21.33 dual specificityphophatase 6 [Source: HGNC Symbol; Acc: 3072] 201315_x_at 11 p15.5interferon induced transmembrane protein 2 [Source: HGNC Symbol; Acc:5413] 222802_at 6 p24.1 endothelin 1 [Source: HGNC Symbol; Acc: 3176]1553395_a_at 3 q13.2 CD200 receptor 1 [Source: HGNC Symbol; Acc: 24235]226399_at 4 q23 DnaJ (Hsp40) homolog, subfamily B, member 14 [Source:HGNC Symbol; Acc: 25881] 226490_at 6 q24.1 NHS-like 1 [Source: HGNCSymbol; Acc: 21021] 222513_s_at 10 q24.1 sorbin and SH3 domaincontaining 1 [Source: HGNC Symbol; Acc: 14565] 218705_s_at 5 q23.2sorting nexin 24 [Source: HGNC Symbol; Acc: 21533] 226837_at 15 q14sprouty-related, EVH1 domain containing 1 [Source: HGNC Symbol; Acc:20249] 225338_at 1 p32.3 zyg-11 family member B, cell cycle regulator[Source: HGNC Symbol; Acc: 25820] 204955_at X p11.4 sushi-repeatcontaining protein, X-linked [Source: HGNC Symbol; Acc: 11309]210840_s_at 15 q26.1 IQ motif containing GTPase activating protein 1[Source: HGNC Symbol; Acc: 6110] 201494_at 11 q14.1prolylcarboxypeptidase (angiotensinase C) [Source: HGNC Symbol; Acc:9344] 204415_at 1 p36.11 interferon, alpha-inductible protein 6 [Source:HGNC Symbol; Acc: 4054] 209290_s_at 9 p22.3 nuclear factor I/B [Source:HGNC Symbol; Acc: 7785] 221474_at 18 p11.31 myosin, light chain 12B,regulatory [Source: HGNC Symbol; Acc: 29827] 235747_at 10 q21.3 solutecarrier family 25 (mitochondrial carrier; Graves disease autoantigen),member 16 [Source: HGNC Symbol; Acc: 10986] 201924_at 4 q21.3 AF4/FMR2family, member 1 [Source: HGNC Symbol; Acc: 7135] 218045_x_at 12 p13.31parathymosin [Source: HGNC Symbol; Acc: 9629] 213943_at 7 p21.1 twistbasic helix-loop-helix transcription factor 1 [Source: HGNC Symbol; Acc:12428] 226752_at 5 q21.1 Family with sequence similarity 174, member A[Source: HGNC Symbol; Acc: 24943] 201876_at 7 q21.3 paraoxonase 2[Source: HGNC Symbol; Acc: 9205] 1554240_a_at 16 p11.2 integrin, alpha L(antigen CD11A (p180), lymphocyte function- associated antigen 1; alphapolypeptide) [Source: HGNC Symbol; Acc: 6148] 203989_x_at 5 q13.3coagulation factor II (thrombin) receptor [Source: HGNC Symbol; Acc:3537] 226425_at 2 p23.2 CAP-GLY domain containing linker protein family,member 4 [Source: HGNC Symbol; Acc: 26108] 200762_at 8 p21.2dihydropyrimidinase-like 2 [Source: HGNC Symbol; Acc: 3014] 223681_s_at1 p31.3 InaD-like (Drosophila) [Source: HGNC Symbol; Acc: 28881]211986_at 11 q12.3 AHNAK nucleoprotein [Source: HGNC Symbol; Acc: 347]204112_s_at 2 q22.1 histamine N-methyltransferase [Source: HGNC Symbol;Acc: 5028] 235360_at 2 q33.3 pleckstrin homology domain containing,family M, member 3 [Source: HGNC Symbol; Acc: 34006] 209276_s_at 5 q15glutaredoxin (thioltransferase) [Source: HGNC Symbol; Acc: 4330]226113_at 1 p36.12 zinc finger protein 436 [Source: HGNC Symbol; Acc:20814] 201694_at 5 q31.2 early growth response 1 [Source: HGNC Symbol;Acc: 3238] 204417_at 14 q31.3 galactosylceramidase [Source: HGNC Symbol;Acc: 4115] 211178_s_at 15 q24.3 proline-serine-threonine phosphataseinteracting protein 1 [Source: HGNC Symbol; Acc: 9580] 203088_at 14q32.12 fibulin 5 [Source: HGNC Symbol; Acc: 3602] 218450_at 12 p13.1heme binding protein 1 [Source: HGNC Symbol; Acc: 17176] 210113_s_at 17p13.2 NLR family, pyrin domain containing 1 [Source: HGNC Symbol; Acc:14374] 225673_at 19 q13.42 myeloid-associated differentiation marker[Source: HGNC Symbol; Acc: 7544] 31874_at 22 q12.2 growtharrest-specific 2 like 1 [Source: HGNC Symbol; Acc: 16955] 222597_at 22q11.21 synaptosomal-associated protein, 29 kDa [Source: HGNC Symbol;Acc: 11133] 226279_at 11 q14.2 protease, serine, 23 [Source: HGNCSymbol; Acc: 14370] 235570_at 3 p24.1 RNA binding motif, single strandedinteracting protein 3 [Source: HGNC Symbol; Acc: 13427] 214830_at 14q23.1 solute carrier family 38, member 6 [Source: HGNC Symbol; Acc:19863] 201366_at 10 q22.2 annexin A7 [Source: HGNC Symbol; Acc: 545]203179_at 9 p13.3 galactose-1-phosphate uridylyltransferase [Source:HGNC Symbol; Acc: 4135] 225919_s_at 9 p21.2 chromosome 9 open readingframe 72 [Source: HGNC Symbol; Acc: 28337] 36711_at 22 q13.1 v-maf avianmusculoaponeurotic fibrosarcoma oncogene homolog F [Source: HGNC Symbol;Acc: 6780] 205174_s_at 2 p22.2 glutaminyl-peptide cyclotransferase[Source: HGNC Symbol; Acc: 9753] 225032_at 3 q26.31 fibronectin type IIIdomain containing 3B [Source: HGNC Symbol; Acc: 24670] 225283_at 15q26.2 arrestin domain containing 4 [Source: HGNC Symbol; Acc: 28087]212820_at 15 q21.2 Dmx-like 2 [Source: HGNC Symbol; Acc: 2938] 202411_at14 q32.12 interferon, alpha-inducible protein 27 [Source: HGNC Symbol;Acc: 5397] 201444_s_at X p11.4 ATPase, H transporting, lysosomalaccessory protein 2 [Source: HGNC Symbol; Acc: 18305] 212209_at 12q24.21 mediator complex subunit 13-like [Source: HGNC Symbol; Acc:22962] 228082_at 11 q24.1 CXADR-like membrane protein [Source: HGNCSymbol; Acc: 24039] 201579_at 4 q35.2 FAT atypical cadherin 1 [Source:HGNC Symbol; Acc: 3595] 201050_at 19 q13.2 phospholipase D family,member 3 [Source: HGNC Symbol; Acc: 17158] 205726_at X q21.33diaphanous-related formin 2 [Source: HGNC Symbol; Acc: 2877] 212717_at17 q21.31 pleckstrin homology domain containing, family M (with RUNdomain) member 1 [Source: HGNC Symbol; Acc: 29017] 202827_s_at 14 q11.2matrix metallopeptidase 14 (membrane-inserted) [Source: HGNC Symbol;Acc: 7160] 201594_s_at 18 p11.22 protein phosphatase 4, regulatorysubunit 1 [Source: HGNC Symbol; Acc: 9320] 203460_s_at 14 q24.2presenilin 1 [Source: HGNC Symbol; Acc: 9508] 221840_at 10 q26.2 proteintyrosine phosphatase, receptor type, E [Source: HGNC Symbol; Acc: 9669]203410_at 8 p11.21 adaptor-related protein complex 3, mu 2 subunit[Source: HGNC Symbol; Acc: 570] 226582_at NA NA NA 209600_s_at 17 q25.1acyl-CoA oxidase 1, palmitoyl [Source: HGNC Symbol; Acc: 119] 221814_at8 p11.23 G protein-coupled receptor 124 [Source: HGNC Symbol; Acc:17849] 230836_at 5 q21.1 ST8 alpha-N-acetyl-neuraminidealpha-2,8-sialyltransferase 4 [Source: HGNC Symbol; Acc: 10871]204270_at 1 p36.33 v-ski avian sarcoma viral oncogene homolog [Source:HGNC Symbol; Acc: 10896] 200872_at 1 q21.3 S100 calcium binding proteinA10 [Source: HGNC Symbol; Acc: 10487] 219761_at 12 p13.2 C-type lectindomain family 1, member 1, member A [Source: HGNC Symbol; Acc: 24355]212708_at 17 q21.1 male-specific lethal 1 homolog (Drosophila) [Source:HGNC Symbol; Acc: 27905] 204326_x_at 16 q13 metallothionein 1X [Source:HGNC Symbol; Acc: 7405] 241392_at 3 q13.33 transmembrane protein 39A[Source: HGNC Symbol; Acc: 25600] 205771_s_at 6 q23.2 A kinase (PRKA)anchor protein 7 [Source: HGNC Symbol; Acc: 377] 206227_at 15 q22.31cartilage intermediate layer protein, nucleotide pyrophosphohydrolase[Source: HGNC Symbol; Acc: 1980] 204158_s_at 11 q13.2 T-cell, immuneregulator 1, ATPase, H Transporting, lysosomal V0 subunit A3 [Source:HGNC Symbol; Acc: 11647] 212948_at 17 p13.2 calmodulin bindingtranscription activator 2 [Source: HGNC Symbol; Acc: 18807] 218241_at 14q32.12 golgin A5 [Source: HGNC Symbol; Acc: 4428] 203042_at X q24lysosomal-associated membrane protein 2 [Source: HGNC Symbol; Acc: 6501]223264_at 15 q25.1 mesoderm development candidate 1 [Source: HGNCSymbol; Acc: 13519] 243141_at 4 q25 sphingomyelin synthase 2 [Source:HGNC Symbol; Acc: 28395] 212513_s_at 1 p31.1 ubiquitin specificpeptidase 33 [Source: HGNC Symbol; Acc: 20059] 44111_at 15 q26.1vacuolar protein sorting 33 homolog B (yeast) [Source: HGNC Symbol; Acc:12712] 203044_at 15 q26.3 chondroitin sulfate synthase 1 [Source: HGNCSymbol; Acc: 17198] 201133_s_at 5 q21.3 praja ring finger 2, E3ubiquitin protein ligase [Source: HGNC Symbol; Acc: 17481] 238478_at 9p22.2 basonuclin 2 [Source: HGNC Symbol; Acc: 30988] 207121_s_at 15q21.2 mitogen-activated protein kinase 6 [Source: HGNC Symbol; Acc:3879] 226757_at 10 q23.31 interferon-induced protein withtetratricopeptide repeats 2 [Source: HGNC Symbol; Acc: 5409] 224929_at 5q31.2 transmembrane protein 173 [Source: HGNC Symbol; Acc: 27962]219013_at 7 q36.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) [Source: HGNC Symbol;Acc: 19875] 203732_at 15 q22.31 thyroid hormone receptor interactor 4[Source: HGNC Symbol; Acc: 12310] 206991_s_at 3 p21.31 chemokine (C-Cmotif) receptor 5 (gene/pseudogene) [Source: HGNC Symbol; Acc: 1606]212192_at 13 q22.3 potassium channel tetramerization domain containing12 [Source: HGNC Symbol; Acc: 14678] 212071_s_at 2 p16.2 spectrin, beta,non-erythrocytic 1 [Source: HGNC Symbol; Acc: 11275] 204194_at 21 q21.3BTB and CNC homology 1, basic leucine zipper transcription factor 1[Source: HGNC Symbol; Acc: 935] 213469_at 2 q33.1 post-GPI attachment toproteins 1 [Source: HGNC Symbol; Acc: 25712] 207173_x_at 16 q21 cadherin11, type 2, OB-cadherin (osteoblast) [Source: HGNC Symbol; Acc: 1750]202020_s_at 2 q34 LanC lantibiotic synthetase component C-like 1(bacterial) [Source: HGNC Symbol; Acc: 6508] 201384_s_at 17 q21.31neighbor of BRCA1 gene 1 [Source: HGNC Symbol; Acc: 6746] 213004_at 9q33.3 angiopoietin-like 2 [Source: HGNC Symbol; Acc: 490] 203310_at 1p13.3 syntaxin binding protein 3 [Source: HGNC Symbol; Acc: 11446]212239_at 5 q13.1 phosphoinositide-3-kinase, regulatory subunit 1(alpha) [Source: HGNC Symbol; Acc: 8979] 225864_at 8 q24.21 family withsequence similarity 84, member B [Source: HGNC Symbol; Acc: 24166]218679_s_at 8 q24.3 vacuolar protein sorting 28 homolog (S. cerevisiae)[Source: HGNC Symbol; Acc: 18178] 211964_at 13 q34 collagen, type IV,alpha 2 [Source: HGNC Symbol; Acc: 2203] 212501_at 20 q13.13CCAAT/enhancer binding protein (C/EBP), beta [Source: HGNC Symbol; Acc:1834] 215596_s_at 21 q21.3 listerin E3 ubiquitin protein ligase 1[Source: HGNC Symbol; Acc: 13082] 235306_at 7 q36.1 GTPase, IMAP familymember 8 [Source: HGNC Symbol; Acc: 21792] 213746_s_at X q28 filamin A,alpha [Source: HGNC Symbol; Acc: 3754] 200982_s_at 5 q33.1 annexin A6[Source: HGNC Symbol; Acc: 544] 227029_at 14 q13.2 family with sequencesimilarity 177, member A1 [Source: HGNC Symbol; Acc: 19829] 225695_at 2p23.3 solute carrier family 35, member F6 [Source: HGNC Symbol; Acc:26055] 230263_s_at 8 p21.2 dedicator of cytokinesis 5 [Source: HGNCSymbol; Acc: 23476] 219860_at 6 p21.33 lymphocyte antigen 6 complex,locus G5C [Source: HGNC Symbol; Acc: 13932] 216620_s_at 8 p23.3 Rhoguanine nucleotide exchange factor (GEF) 10 [Source: HGNC Symbol; Acc:14103] 209298_s_at 21 q22.11 intersectin 1 (SH3 domain protein) [Source:HGNC Symbol; Acc: 6183] 219383_at 11 p13 proline rich 5 like [Source:HGNC Symbol; Acc: 25878] 218204_s_at 3 p21.31 FYVE and coiled-coildomain containing 1 [Source: HGNC Symbol; Acc: 14673] 212637_s_at 8q21.3 WW domain containing E3 ubiquitin protein ligase 1 [Source: HGNCSymbol; Acc: 17004] 200784_s_at 12 q13.3 low density lipoproteinreceptor-related protein 1 [Source: HGNC Symbol; Acc: 6692] 202668_at 13q33.3 ephrin-B2 [Source: HGNC Symbol; Acc: 3227] 211926_s_at 22 q12.3myosin, heavy chain 9, non-muscle [Source: HGNC Symbol; Acc: 7579]207181_s_at 10 q25.3 caspase 7, apoptosis-related cysteine peptidase[Source: HGNC Symbol; Acc: 1508] 203940_s_at 14 q24.3 vasohibin 1[Source: HGNC Symbol; Acc: 19964] 225046_at NA NA NA 229699_at NA NA NA1555997_s_at 2 q35 insulin-like growth factor binding protein 5 [Source:HGNC Symbol; Acc: 5474] 221858_at 10 q23.33 TBC1 domain family, member12 [Source: HGNC Symbol; Acc: 29082] 202123_s_at 9 q34.12 c-abl oncogene1, non-receptor tyrosine kinase [Source: HGNC Symbol; Acc: 76] 209189_at14 q24.3 FBJ murine osteosarcoma viral oncogene homolog [Source: HGNCSymbol; Acc: 3796] 231697_s_at 17 q23.1 vacuole membrane protein 1[Source: HGNC Symbol; Acc: 29559] 231823_s_at 5 q35.1 SH3 and PX domains2B [Source: HGNC Symbol; Acc: 29242] 226917_s_at 4 p15.2 anaphasepromoting complex subunit 4 [Source: HGNC Symbol; Acc: 19990] 213135_at21 q22.11 T-cell lymphoma invasion and metastasis 1 [Source: HGNCSymbol; Acc: 11805] 222793_at 9 p21.1 DEAD (Asp-Glu-Ala-Asp) boxpolypeptide 58 [Source: HGNC Symbol; Acc: 19102] 235059_at 18 p11.22RAB12, member RAS oncogene family [Source: HGNC Symbol; Acc: 31332]213364_s_at 15 q22.31 sorting nexin 1 [Source: HGNC Symbol; Acc: 11172]213194_at 3 p12.2 roundabout, axon guidance receptor, homolog 1(Drosophila) [Source: HGNC Symbol; Acc: 10249] 223434_at 1 p22.2guanylate binding protein 3 [Source: HGNC Symbol; Acc: 4184] 201464_x_at1 p32.1 jun proto-oncogene [Source: HGNC Symbol; Acc: 6204] 228325_at NANA NA 226639_at 2 q14.3 SFT2 domain containing 3 [Source: HGNC Symbol;Acc: 28767] 204204_at 9 q32 solute carrier family 31 (coppertransporter), member 2 [Source: HGNC Symbol; Acc: 11017] 213659_at Xq26.3 zinc finger protein 75D [Source: HGNC Symbol; Acc: 13145]219165_at 8 p21.3 PDZ and LIM domain 2 (mystique) [Source: HGNC Symbol;Acc: 13992] 202704_at 17 q21.33 transducer of ERBB2, 1 [Source: HGNCSymbol; Acc: 11979] 201059_at 11 q13.3 cortacin [Source: HGNC Symbol;Acc: 3338] 208626_s_at 17 q21.31 vesicle amine transport protein 1homolog (T. californica) [Source: HGNC Symbol; Acc: 16919] 224285_at Xq21.1 G protein-coupled receptor 174 [Source: HGNC Symbol; Acc: 30245]202746_at X q21.1 integral membrane protein 2A [Source: HGNC Symbol;Acc: 6173] 1557749_at 11 q13.1 EH domain binding protein 1-like 1[Source: HGNC Symbol; Acc: 30682] 208671_at 6 q22.31 serine incorporator1 [Source: HGNC Symbol; Acc: 13464] 235199_at 18 q12.1 ring fingerprotein 125, E3 ubiquitin protein ligase [Source: HGNC Symbol; Acc:21150] 236565_s_at 15 q23 La ribonucleoprotein domain family, member 6[Source: HGNC Symbol; Acc: 24012] 204575_s_at 12 q13.2 matrixmetallopeptidase 19 [Source: HGNC Symbol; Acc: 7165] 221653_x_at 22q12.3 apolipoprotein L, 2 [Source: HGNC Symbol; Acc: 619] 224804_s_at 15q24.1 family with sequence similarity 219, member B [Source: HGNCSymbol; Acc: 24695] 202820_at 7 p21.1 aryl hydrocarbon receptor [Source:HGNC Symbol; Acc: 348] 204082_at 9 q33.3 pre-B-cell leukemia homeobox 3[Source: HGNC Symbol; Acc: 8634] 218109_s_at 3 q25.32 major facilitatorsuperfamily domain containing 1 [Source: HGNC Symbol; Acc: 25874]231897_at 9 q31.3 prostaglandin reductase 1 [Source: HGNC Symbol; Acc:18429] 205786_s_at 16 p11.2 integrin, alpha M (complement component 3receptor 3 subunit) [Source: HGNC Symbol; Acc: 6149] 203510_at 7 q31.2met proto-oncogene [Source: HGNC Symbol; Acc: 7029] 224896_s_at 2 q13tubulin tyrosine ligase [Source: HGNC Symbol; Acc: 21586] 232645_at NANA NA 226576_at 5 q31.3 Rho GTPase activating protein 26 [Source: HGNCSymbol; Acc: 17073] 219191_s_at 12 q13.13 bridging integrator 2 [Source:HGNC Symbol; Acc: 1053] 214853_s_at 1 q21.3 SHC (Src homology 2 domaincontaining) transforming protein 1 [Source: HGNC Symbol; Acc: 10840]224358_s_at 11 q12.2 membrane-spanning 4-domains, subfamily A, member 7[Source: HGNC Symbol; Acc: 13378] 209164_s_at 17 q23.3 cytochrome b561[Source: HGNC Symbol; Acc: 2571] 222175_s_at 22 q11.21 mediator complexsubunit 15 [Source: HGNC Symbol; Acc: 14248] 219469_at 11 q22.3 dynein,cytoplasmic 2, heavy chain 1 [Source: HGNC Symbol; Acc: 2962] 226143_at17 p11.2 retinoic acid induced 1 [Source: HGNC Symbol; Acc: 9834]212681_at 18 p11.31 erythrocyte membrane protein band 4.1-like 3[Source: HGNC Symbol; Acc: 3380] 215784_at 1 q23.1 CD1e molecule[Source: HGNC Symbol; Acc: 1638] 211161_s_at 2 q32.2 collagen, type III,alpha 1 [Source: HGNC Symbol; Acc: 2201] 209906_at 12 p13.31 complementcomponent 3a receptor 1 [Source: HGNC Symbol; Acc: 1319] 200625_s_at 1p34.2 CAP, adenylate cyclase-associated protein 1 (yeast) [Source: HGNCSymbol; Acc: 20040] 209550_at 15 q11.2 necdin, melanoma antigen (MAGE)family member [Source: HGNC Symbol; Acc: 7675] 214039_s_at 8 q22.1lysosomal protein transmembrane 4 beta [Source: HGNC Symbol; Acc: 13646]209356_x_at 11 q13.1 EGF containing fibulin-like extracellular matrixprotein 2 [Source: HGNC Symbol; Acc: 3219] 207276_at X q27.1 cerebellardegeneration-related protein 1, 34 kDa [Source: HGNC Symbol; Acc: 1798]209955_s_at 2 q24.2 fibroblast activation protein, alpha [Source: HGNCSymbol; Acc: 3590] 226844_at 9 p21.2 MOB kinase activator 3B [Source:HGNC Symbol; Acc: 23825] 222468_at 1 p34.3 KIAA0319-like [Source: HGNCSymbol; Acc: 30071] 226056_at 3 q13.33 Rho GTPase activating protein 31[Source: HGNC Symbol; Acc: 29216] 226695_at 1 q24.2 paired relatedhomeobox 1 [Source: HGNC Symbol; Acc: 9142] 204844_at 4 q25 glutamylaminopeptidase (aminopeptidase A) [Source: HGNC Symbol; Acc: 3355]200612_s_at 17 q12 adaptor-related protein complex 2, beta 1 subunit[Source: HGNC Symbol; Acc: 563] 200923_at 17 q25.3 lectin,galactoside-binding soluble, 3 binding protein [Source: HGNC Symbol;Acc: 6564] 208074_s_at 19 q13.32 adaptor-related protein complex 2,sigma 1 subunit [Source: HGNC Symbol; Acc: 565] 200897_s_at 4 q32.3palladin, cytoskeletal associated protein [Source: HGNC Symbol; Acc:17068] 209667_at 16 q22.1 carboxylesterase 2 [Source: HGNC Symbol; Acc:1864] 225785_at 10 q21.3 receptor accessory protein 3 [Source: HGNCSymbol; Acc: 23711] 227265_at 7 q11.23 fibrinogen-like 2 [Source: HGNCSymbol; Acc: 396] 226679_at 17 q25.3 solute carrier family 26, member 11[Source: HGNC Symbol; Acc: 14471] 202441_at 10 q24.31 ER lipid raftassociated 1 [Source: HGNC Symbol; Acc: 16947] 227758_at 12 q12.3RAS-like, estrogen-related, growth inhibitor [Source: HGNC Symbol; Acc:15980] 204036_at 9 q31.3 lysophosphatidic acid receptor 1 [Source: HGNCSymbol; Acc: 3166] 225755_at 3 p21.31 kelch domain containing 8B[Source: HGNC Symbol; Acc: 28557] 209571_at 2 q31.1 corepressorinteracting with RBPJ, 1 [Source: HGNC Symbol; Acc: 24217] 210184_at 16p11.2 integrin, alpha X (complement component 3 receptor 4 subunit)[Source: HGNC Symbol; Acc: 6152] 217940_s_at 13 q34 carbohydrate kinasedomain containing [Source: HGNC Symbol; Acc: 25576] 212993_at 9 q34.3NACC family member 2, BEN and BTB (POZ) domain containing [Source: HGNCSymbol; Acc: 23846] 1562876_s_at NA NA NA 242268_at 10 p14 CUGBP,Elav-like family member 2 [Source: HGNC Symbol; Acc: 2550] 213125_at 1q23.3 olfactomedin-like 2B [Source: HGNC Symbol; Acc: 24558] 221257_x_at5 q32 F-box protein 38 [Source: HGNC Symbol; Acc: 28844] 236782_at 6q23.1 sterile alpha motif domain containing 3 [Source: HGNC Symbol; Acc:21574] 1554690_a_at 8 p11.22 transforming, acidic coiled-coil containingprotein 1 [Source: HGNC Symbol; Acc: 11522] 203431_s_at 11 q24.3 RhoGTPase activating protein 32 [Source: HGNC Symbol; Acc: 17399] 226711_at2 p16.3 forkhead box N2 [Source: HGNC Symbol; Acc: 5281] 203562_at 11q24.2 fasciculation and elongation protein zeta 1 (zygin I) [Source:HGNC Symbol; Acc: 3659] 201508_at 17 q21.2 insulin-like growth factorbinding protein 4 [Source: HGNC Symbol; Acc: 5473] 209933_s_at 17 q25.1CD300a molecule [Source: HGNC Symbol; Acc: 19319] 226751_at 2 p14cannabinoid receptor interacting protein 1 [Source: HGNC Symbol; Acc:24546] 203303_at X p11.4 dynein, light chain, Tctex-type 3 [Source: HGNCSymbol; Acc: 11694] 1556698_a_at 4 q22.1 GPRIN family member 3 [Source:HGNC Symbol; Acc: 27733] 223454_at 17 p13.2 chemokine (C-X-C motif)ligand 16 [Source: HGNC Symbol; Acc: 16642] 202032_s_at 15 q26.1mannosidase, alpha, class 2A, member 2 [Source: HGNC Symbol; Acc: 6825]205779_at 17 q21.31 receptor (G protein-coupled) activity modifyingprotein 2 [Source: HGNC Symbol; Acc: 9844] 209110_s_at 6 p21.32 ralguanine nucleotide dissociation stimulator-like 2 [Source: HGNC Symbol;Acc: 9769] 209935_at 3 q22.1 ATPase, Ca 

 transporting, type 2C, member 1 [Source: HGNC Symbol; Acc: 13211]214453_s_at 1 p31.1 interferon-induced protein 44 [Source: HGNC Symbol;Acc: 16938] 201063_at 11 p13 reticulocalbin 1, EF-band calcium bindingdomain [Source: HGNC Symbol; Acc: 9934] 213222_at 20 p12.3 phospholipaseC, beta 1 (phosphoinositide-specific) [Source: HGNC Symbol; Acc: 15917]201069_at 16 q12.2 matrix metallopeptidase 2 (gelatinase A, 72 kDagelatinase, 72 kDa type IV collagenase) [Source: HGNC Symbol; Acc: 7166]200661_at 20 q13.12 cathepsin A [Source: HGNC Symbol; Acc: 9251]213258_at 2 q32.1 tissue factor pathway inhibitor(lipoprotein-associated coagulation inhibitor) [Source: HGNC Symbol;Acc: 11760] 225414_at 2 q11.2 ring finger protein 149 [Source: HGNCSymbol; Acc: 23137] 219397_at 2 q33.1 coenzyme Q10 homolog B (S.cerevisiae) [Source: HGNC Symbol; Acc: 25819] 222127_s_at 4 q12 exocystcomplex component 1 [Source: HGNC Symbol; Acc: 30380] 223220_s_at 3q21.1 poly (ADP-ribose) polymerase family, member 9 [Source: HGNCSymbol; Acc: 24118] 213422_s_at 1 p36.33 matrix-remodelling associated 8[Source: HGNC Symbol; Acc: 7542] 203153_at 10 q23.31 interferon-inducedprotein with tetratricopeptide repeats 1 [Source: HGNC Symbol; Acc:5407] 202100_at 2 q14.2 v-ral simian leukemia viral oncogene homolog B[Source: HGNC Symbol; Acc: 9840] 224895_at 11 q22.1 Yes-associatedprotein 1 [Source: HGNC Symbol; Acc: 16262] 201368_at 2 p21 ZFP36 ringfinger protein-like 2 [Source: HGNC Symbol; Acc: 1108] 212027_at 14q24.2 RNA binding motif protein 25 [Source: HGNC Symbol; Acc: 23244]221942_s_at 4 q32.1 guanylate cyclase 1, soluble, alpha 3 [Source: HGNCSymbol; Acc: 4685] 213800_at 1 q31.3 complement factor H [Source: HGNCSymbol; Acc: 4883] 1554999_at 4 q21.22 RasGEF domain family, member 1B[Source: HGNC Symbol; Acc: 24881] 218606_at 16 q24.1 zinc finger,DHHC-type containing 7 [Source: HGNC Symbol; Acc: 18459] 204083_s_at 9p13.3 tropomyosin 2 (beta) [Source: HGNC Symbol; Acc: 12011] 1553955_at2 p16.3 protein phosphatase 1, regulatory subunit 21 [Source: HGNCSymbol; Acc: 30595] 228083_at 12 p13.33 calcium channel,voltage-dependent, alpha 2/delta subunit 4 [Source: HGNC Symbol; Acc:20202] 227304_at 17 p11.2 Smith-Magenis syndrome chromosome region,candidate 8 [Source: HGNC Symbol; Acc: 17921] 225710_at 3 q26.33 guaninenucleotide binding protein (G protein), beta polypeptide 4 [Source: HGNCSymbol; Acc: 20731] 204154_at 5 q22.3 cysteine dioxygenase type 1[Source: HGNC Symbol; Acc: 1795] 228318_s_at 4 p16.3 cysteine-rich PAK1inhibitor [Source: HGNC Symbol; Acc: 26619] 227013_at 13 q12.11 largetumor suppressor kinase 2 [Source: HGNC Symbol; Acc: 6515] 1558692_at 1q22 chrmosome 1 open reading frame 85 [Source: HGNC Symbol; Acc: 29436]213238_at 4 p12 ATPase, class V, type 10D [Source: HGNC Symbol; Acc:13549] 201850_at 2 p11.2 capping protein (actin filament), gelsolin-like[Source: HGNC Symbol; Acc: 1474] 209717_at 1 p22.1 ecotropic viralintegration site 5 [Source: HGNC Symbol; Acc: 3501] 227388_at 9 p21.2tumor suppressor candidate 1 [Source: HGNC Symbol; Acc: 31010] 200771_at1 q25.3 laminin, gamma 1 (formerly LAMB2) [Source: HGNC Symbol; Acc:6492] 229055_at 14 q32.11 G protein-coupled receptor 68 [Source: HGNCSymbol; Acc: 4519] 200927_s_at 9 q33.2 RAB14, member RAS oncogene family[Source: HGNC Symbol; Acc: 16524] 225447_at 2 q24.1 glycerol-3-phosphatedehydrogenase 2 (mitochondrial) [Source: HGNC Symbol; Acc: 4456]225525_at 22 q11.23 KIAA1671 [Source: HGNC Symbol; Acc: 29345] 209649_at2 q23.3 signal transducing adaptor molecule (SH3 domain and ITAM motif)2 [Source: HGNC Symbol; Acc: 11358] 219492_at 4 q12 cysteine-richhydrophobic domain 2 [Source: HGNC Symbol; Acc: 1935] 1560060_s_at 11q12.2 vacuolar protein sorting 37 homolog C (S. cerevisiae) [Source:HGNC Symbol; Acc: 26097] 217947_at 3 p22.3 CKLF-like MARVELtransmembrane domain containing 6 [Source: HGNC Symbol; Acc: 19177]219078_at 1 q41 G patch domain containing 2 [Source: HGNC Symbol; Acc:25499] 203854_at 4 q25 complement factor I [Source: HGNC Symbol; Acc:5394] 209637_s_at 4 p16.3 regulator of G-protein signaling 12 [Source:HGNC Symbol; Acc: 9994] 202252_at 1 q21.3 RAB13, member RAS oncogenefamily [Source: HGNC Symbol; Acc: 9762] 227373_at 16 q22.2 ataxin 1-like[Source: HGNC Symbol; Acc: 33279] 207469_s_at X p22.2 pirin(iron-binding nuclear protein) [Source: HGNC Symbol; Acc: 30048]212543_at 6 q21 absent in melanoma 1 [Source: HGNC Symbol; Acc: 356]208983_s_at NA NA NA 226438_at 8 q24.12 syntrophin, beta 1(dystrophin-associated protein A1, 59 kDa, basic component 1) [Source:HGNC Symbol; Acc: 11168] 201567_s_at 3 p22.2 golgin A4 [Source: HGNCSymbol; Acc: 4427] 204520_x_at 22 q13.33 bromodomain containing 1[Source: HGNC Symbol; Acc: 1102] 217828_at 15 q22.1 SAFB-like,transcription modulator [Source: HGNC Symbol; Acc: 20709] 224689_at 20q11.23 mannosidase, beta A, lysosomal-like [Source: HGNC Symbol; Acc:15799] 219157_at 4 q32.3 kelch-like family member 2 [Source: HGNCSymbol; Acc: 6353] 232024_at 7 q36.1 GTPase, IMAP family member 2[Source: HGNC Symbol; Acc: 21789] 219087_at 9 q22.31 asporin [Source:HGNC Symbol; Acc: 14872] 213010_at 11 p15.4 protein kinase C, deltabinding protein [Source: HGNC Symbol; Acc: 9400] 219570_at 20 p12.1kinesin family member 16B [Source: HGNC Symbol; Acc: 15869] 214066_x_at9 p13.3 natriuretic peptide receptor B/guanylate cyclase B(atrionatriuretic peptide receptor B) [Source: HGNC Symbol; Acc: 7944]228372_at 10 q11.23 chromosome 10 open reading frame 128 [Source: HGNCSymbol; Acc: 27274] 230276_at 2 p24.2 family with sequence similarity49, member A [Source: HGNC Symbol; Acc: 25373] 203002_at 3 q22.2angiomotin like 2 [Source: HGNC Symbol; Acc: 17812] 225688_s_at 3 q13.2pleckstrin homology-like domain, family B, member 2 [Source: HGNCSymbol; Acc: 29573] 1553678_a_at 10 p11.22 integrin, beta 1 (fibronectinreceptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [Source:HGNC Symbol; Acc: 6153] 203476_at 6 q14.1 trophoblast glycoprotein[Source: HGNC Symbol; Acc: 12004] 201180_s_at 1 p13.3 guanine nucleotidebinding protein (G protein), alpha inhibiting activity polypeptide 3[Source: HGNC Symbol; Acc: 4387] 220141_at 11 q24.1 chromosome 11 openreading frame 63 [Source: HGNC Symbol; Acc: 26288] 227923_at 22 q13.33SH3 and multiple ankyrin repeat domains 3 [Source: HGNC Symbol; Acc:14294] 235334_at 1 p31.1 ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [Source: HGNCSymbol; Acc: 19343] 235411_at 6 p22.1 piggyBac transposable elementderived 1 [Source: HGNC Symbol; Acc: 19398] 216689_x_at 11 p11.2 RhoGTPase activating protein 1 [Source: HGNC Symbol; Acc: 673] 202932_at 18p11.32 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 [Source: HGNCSymbol; Acc: 12841] 212293_at 1 p13.2 homeodomain interacting proteinkinase 1 [Source: HGNC Symbol; Acc: 19006] 225618_at 17 q21.31 RhoGTPase activating protein 27 [Source: HGNC Symbol; Acc: 31813]201242_s_at 1 q24.2 ATPase, Nasun transporting, beta 1 polypeptide[Source: HGNC Symbol; Acc: 804] 203583_at 2 q11.2 unc-50 homolog (C.elegans) [Source: HGNC Symbol; Acc: 16046] 1557938_s_at 17 q21.2polymerase I and transcript release factor [Source: HGNC Symbol; Acc:9688] 242321_at 1 q41 protein tyrosine phosphatase, non-receptor type 14[Source: HGNC Symbol; Acc: 9647] 212950_at 6 p12.3 G protein-coupledreceptor 116 [Source: HGNC Symbol; Acc: 19030] 205638_at 7 p14.2acyloxyacyl hydrolase (neutrophil) [Source: HGNC Symbol; Acc: 548]223209_s_at 15 q26.3 VCP-interacting membrane protein [Source: HGNCSymbol; Acc: 30396] 208131_s_at 20 q13.13 prostaglandin I2(prostacyclin) synthase [Source: HGNC Symbol; Acc: 9603] 227833_s_at 12q13.3 methyl-CpG binding domain protein 6 [Source: HGNC Symbol; Acc:20445] 208991_at 17 q21.2 signal transducer and activator oftranscription 3 (acute-phase response factor) [Source: HGNC Symbol; Acc:11364] 216361_s_at 8 p11.21 K(lysine) acetyltransferase 6A [Source: HGNCSymbol; Acc: 13013] 1554106_at 2 q33.2 neurobeachin-like 1 [Source: HGNCSymbol; Acc: 20681] 209357_at 6 q24.1 Cbp/p300-interactingtransactivator, with Glu/Asp-rich carboxy- terminal domain, 2 [Source:HGNC Symbol; Acc: 1987] 53720_at 19 p13.2 chromosome 19 open readingframe 66 [Source: HGNC Symbol; Acc: 25649] 228964_at 6 q21 PR domaincontaining 1, with ZNF domain [Source: HGNC Symbol; Acc: 9346] 228624_at4 q32.1 transmembrane protein 144 [Source: HGNC Symbol; Acc: 25633]225626_at 8 q21.13 phosphoprotein associated with glycosphingolipidmicrodomains 1 [Source: HGNC Symbol; Acc: 30043] 225885_at 12 q22 earlyendosome antigen 1 [Source: HGNC Symbol; Acc: 3185] 236172_at 14 q12leukotriene B4 receptor [Source: HGNC Symbol; Acc: 6713] 201953_at 15q26.1 calcium and integrin binding 1 (calmyrin) [Source: HGNC Symbol;Acc: 16920] 213069_at 3 q21.2 heart development protein with EGF-likedomains 1 [Source: HGNC Symbol; Acc: 29227] 226885_at 6 q22.31 ringfnger protein 217 [Source: HGNC Symbol; Acc: 21487] 203038_at 6 q22.33protein tyrosine phosphatase, receptor type, K [Source: HGNC Symbol;Acc: 9674] 240703_s_at 15 q22.31 HECT and RLD domain containing E3ubiquitin protein ligase family membrane 1 [Source: HGNC Symbol; Acc:4867] 221641_s_at X p22.11 acyl-CoA thioesterase 9 [Source: HGNC Symbol;Acc: 17152] 210845_s_at 19 q13.31 plasminogen activator, urokinasereceptor [Source: HGNC Symbol; Acc: 9053] 212097_at 7 q31.2 caveolin 1,caveolae protein, 22 kDa [Source: HGNC Symbol; Acc: 1527] 243198_at 15q21.3 testis expressed 9 [Source: HGNC Symbol; Acc: 29585] 204122_at 19q13.12 TYRO protein tyrosine kinase binding protein [Source: HGNCSymbol; Acc: 12449] 226343_at 15 q22.31 dipeptidyl-peptidase 8 [Source:HGNC Symbol; Acc: 16490] 205715_at 4 p15.32 bone narrow stromal cellantigen 1 [Source: HGNC Symbol; Acc: 1118] 211980_at 13 q34 collagen,type IV, alpha 1 [Source: HGNC Symbol; Acc: 2202] 213572_s_at 6 p25.2serpin peptidase inhibitor, clade B (ovalbumin), member 1 [Source: HGNCSymbol; Acc: 3311] 209047_at 7 p14.3 aquaporin 1 (Colton blood group)[Source: HGNC Symbol; Acc: 633] 214077_x_at 17 p12 Meis homeobox 3pseudogene 1 [Source: HGNC Symbol; Acc: 7002] 202946_s_at 20 p12.2 BTB(POZ) domain containing 3 [Source: HGNC Symbol; Acc: 15854] 242953_at 19q13.31 zinc finger protein 234 [Source: HGNC Symbol; Acc: 13027]218380_at NA NA NA 215000_s_at 2 p22.2 fasciculation and elongationprotein zeta 2 (zygin II) [Source: HGNC Symbol; Acc: 3660] 229238_at 17p13.3 chromosome 17 open reading frame 97 [Source: HGNC Symbol; Acc:33800] 219700_at 17 q12 plexin domain containing 1 [Source: HGNC Symbol;Acc: 20945] 202432_at 10 q22.2 protein phosphatase 3, catalytic subunit,beta isozyme [Source: HGNC Symbol; Acc: 9315] 1558711_at 4 q22.1 FAM13Aantisense RNA 1 [Source: HGNC Symbol; Acc: 19370] 202304_at 13 q14.2fibronectin type III domain containing 3A [Source: HGNC Symbol; Acc:20296] 213429_at 10 q21.1 bicaudal C homolog 1 (Drosophila) [Source:HGNC Symbol; Acc: 19351] 203388_at 17 p13.2 arrestin, beta 2 [Source:HGNC Symbol; Acc: 712] 205140_at 1 p31.1 fucose-1-phosphateguanylyltransferase [Source: HGNC Symbol; Acc: 3825] 226594_at 14 q24.3ectonucleoside triphosphate diphospphohydrolase 5 [Source: HGNC Symbol;Acc: 3367] 219506_at 1 q21.2 chromosome 1 open reading frame 54 [Source:HGNC Symbol; Acc: 26258] 209230_s_at 16 p11.2 nuclear protein,transcriptional regulator, 1 [Source: HGNC Symbol; Acc: 29990] 205498_at5 p13.1 growth hormone receptor [Source: HGNC Symbol; Acc: 4263]

TABLE 4 Chromo- Gene cox.pvalues cox.coefficients ensembl_gene _id someband description CAMTA2 0.00000203 −4.668235881 ENSG00000108509 17 p13.2calmodulin binding transcription activator 2 [Source: HGNC Symbol;Acc:18807] ODF3B 0.00003813 −2.506221601 ENSG00000177989 22 q13.33 outerdense fiber of sperm tails 3B [Source: HGNC Symbol;Acc: 34388] SCO20.00005664 −2.545936327 ENSG00000130489 22 q13.33 SCO2 cytochrome coxidase assembly protein [Source: HGNC Symbol;Acc: 10604] PSTPIP10.00005675 −3.099610719 ENSG00000140368 15 q24.3proline-serine-threonine phosphatase interacting protein 1 [Source: HGNCSymbol;Acc: 9580] ZNF25 0.00006246 −2.650047611 ENSG00000175395 10 p11.1zinc finger protein 25 [Source: HGNC Symbol;Acc: 13043] PHLDA10.00008490 −1.39157215 ENSG00000139289 12 q21.2 pleckstrin homology-likedomain, family A, member 1 [Source: HGNC Symbol;Acc: 8933] LOC1005092050.00008899 3.284490596 NA NA NA NA NINL 0.00009498 −3.750225037ENSG00000101004 20 p11.21 ninein-like [Source: HGNC Symbol;Acc: 29163]IL11RA 0.00011009 −2.428243399 ENSG00000137070 9 p13.3 interleukin 11receptor, alpha [Source: HGNC Symbol;Acc: 5967] IL18RAP 0.00013238−2.002156881 ENSG00000115607 2 q12.1 interleukin 18 receptor accessoryprotein [Source: HGNC Symbol;Acc: 5989] CC2D1B 0.00013484 −3.165981531ENSG00000154222 1 p32.3 coiled-coil and C2 domain containing 1B [Source:HGNC Symbol;Acc: 29386] FAM219A 0.00016883 −2.594263538 ENSG000001649709 p13.3 family with sequence similarity 219, member A [Source: HGNCSymbol;Acc: 19920] IL18R1 0.00019551 −1.244126139 ENSG00000115604 2q12.1 interleukin 18 receptor 1 [Source: HGNC Symbol;Acc: 5988] CASP70.00019755 −1.567912334 ENSG00000165806 10 q25.3 caspase 7,apoptosis-related cysteine peptidase [Source: HGNC Symbol;Acc: 1508] CD50.00022052 −2.463614971 ENSG00000110448 11 q12.2 CD5 molecule [Source:HGNC Symbol;Acc: 1685] COX10 0.00023739 −2.388350273 ENSG00000006695 17p12 cytochrome c oxidase assembly homolog 10 (yeast) [Source: HGNCSymbol;Acc: 2260] LYST 0.00033014 −0.979162015 ENSG00000143669 1 q42.3lysosomal trafficking regulator [Source: HGNC Symbol;Acc: 1968]LOC100507507 0.00036569 −2.223497444 NA NA NA NA TRIP6 0.00037027−2.212398882 ENSG00000087077 7 q22.1 thyroid hormone receptor interactor6 [Source: HGNC Symbol;Acc: 12311] WDR27 0.00037479 2.047182081ENSG00000184465 6 q27 WD repeat domain 27 [Source: HGNC Symbol;Acc:21248] SLFN12 0.00037578 −1.198035184 ENSG00000172123 17 q12 schlafenfamily member 12 [Source: HGNC Symbol;Acc: 25500] TBC1D4 0.00038960−0.865903169 ENSG00000136111 13 q22.2 TBC1 domain family, member 4[Source: HGNC Symbol;Acc: 19165] ACADVL 0.00040722 −1.831475638ENSG00000072778 17 p13.1 acyl-CoA dehydrogenase, very long chain[Source: HGNC Symbol;Acc: 92] PHEX 0.00042337 −1.148081776ENSG00000102174 X p22.11 phosphate regulating endopeptidase homolog,X-linked [Source: HGNC Symbol;Acc: 8918] TOR1B 0.00048257 −2.788588939ENSG00000136816 9 q34.11 torsin family 1, member B (torsin B) [Source:HGNC Symbol;Acc: 11995] KIF26B 0.00050893 −0.820664008 ENSG00000162849 1q44 kinesin family member 26B [Source: HGNC Symbol;Acc: 25484] COQ20.00052599 −2.524800127 ENSG00000173085 4 q21.23 coenzyme Q24-hydroxybenzoate polyprenyltransferase [Source: HGNC Symbol;Acc: 25223]NDUFV3 0.00054696 −2.206346662 ENSG00000160194 21 q22.3 NADHdehydrogenase (ubiquinone) flavoprotein 3, 10 kDa [Source: HGNCSymbol;Acc: 7719] CNTLN 0.00056050 −1.199738102 ENSG00000044459 9 p22.2centlein, centrosornal protein [Source: HGNC Symbol;Acc: 23432] SLC6A60.00056079 −1.66525648 ENSG00000131389 3 p25.1 solute carrier family 6(neurotransmitter transporter, taurine), member 6 [Source: HGNCSymbol;Acc: 11052] TUBG2 0.00057975 −2.766415519 ENSG00000037042 17q21.2 tubulin, gamma 2 [Source: HGNC Symbol;Acc: 12419] LPAR6 0.00059706−0.810738084 ENSG00000139679 13 q14.2 lysophosphatidic acid receptor 6[Source: HGNC Symbol;Acc: 15520] SLC12A7 0.00060983 −1.723437657ENSG00000113504 5 p15.33 solute carrier family 12 (potassium/chloridetransporters), member 7 [Source: HGNC Symbol;Acc: 10915] TYMP 0.00061216−1.832645096 ENSG00000025708 22 q13.33 thymidine phosphorylase [Source:HGNC Symbol;Acc: 3148] TMOD2 0.00062660 −1.291604457 ENSG00000128872 15q21.2 tropomodulin 2 (neuronal) [Source: HGNC Symbol;Acc: 11872] SUN20.00063540 −5.074770677 ENSG00000100242 22 q13.1 Sad1 and UNC84 domaincontaining 2 [Source: HGNC Symbol;Acc: 14210] NRBP2 0.00066284−1.371485291 ENSG00000185189 8 q24.3 nuclear receptor binding protein 2[Source: HGNC Symbol;Acc: 19339] ZSWIM7 0.00067007 −1.458321834ENSG00000214941 17 p12 zinc finger, SWIM-type containing 7 [Source: HGNCSymbol;Acc: 26993] S100B 0.00067297 −1.792059143 ENSG00000160307 21q22.3 S100 calcium binding protein B [Source: HGNC Symbol;Acc: 10500]ITGB2-AS1 0.00067370 −0.863312228 ENSG00000227039 21 q22.3 ITGB2antisense RNA 1 [Source: HGNC Symbol;Acc: 44304] LOC730227 0.000677113.052297063 NA NA NA NA ALLC 0.00070484 1.173487594 ENSG00000151360 2p25.3 allantoicase [Source: HGNC Symbol;Acc: 17377] ECHDC2 0.00074255−1.182987095 ENSG00000121310 1 p32.3 enoyl CoA hydratase domaincontaining 2 [Source: HGNC Symbol;Acc: 23408] VPS26B 0.00076061−1.959803305 ENSG00000151502 11 q25 vacuolar protein sorting 26 homologB (S. pombe) [Source: HGNC Symbol;Acc: 28119] MGC16142 0.000817303.447869406 NA NA NA NA ADAP2 0.00085355 −1.423623909 ENSG00000184060 17q11.2 ArfGAP with dual PH domains 2 [Source: HGNC Symbol;Acc: 16487]TCL6 0.00085843 1.001037623 ENSG00000187621 14 q32.13 T-cellleukemia/lymphoma 6 (non-protein coding) [Source: HGNC Symbol;Acc:13463] IFIT5 0.00086743 −1.127640551 ENSG00000152778 10 q23.31interferon-induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc: 13328] LDOC1L 0.00083004 −1.303614625 ENSG0000018863622 q13.31 leucine zipper, down-regulated in cancer 1-like [Source: HGNCSymbol;Acc: 13343] NUDT16 0.00091516 −1.407527098 ENSG00000198585 3q22.1 nudix (nucleoside diphosphate linked moiety X)-type motif 16[Source: HGNC Symbol;Acc: 26442] FLII 0.00093525 −1.671920539ENSG00000177731 17 p11.2 flightless I homolog (Drosophila) [Source: HGNCSymbol;Acc: 3750] HEXIM1 0.00096902 −1.893455283 ENSG00000186834 17q21.31 hexamethylene bis-acetamide inducible 1 [Source: HGNC Symbol;Acc:24953] SGSM2 0.00099078 −1.460523274 ENSG00000141258 17 p13.3 small Gprotein signaling modulator 2 [Source: HGNC Symbol;Acc: 29026] FXYD20.00100378 −1.494412258 ENSG00000137731 11 q23.3 FXYD domain containingion transport regulator 2 [Source: HGNC Symbol;Acc: 4026] RDH100.00100828 −1.263627433 ENSG00000121039 8 q21.11 retinol dehydrogenase10 (all-trans) [Source: HGNC Symbol;Acc: 19975] RHOBTB2 0.001008521.443814978 ENSG00000008853 8 p21.3 Rho-related BTB domain containing 2[Source: HGNC Symbol;Acc: 18756] PDE8A 0.00103756 −1.366305067ENSG00000073417 15 q25.3 phosphodiesterase 8A [Source: HGNC Symbol;Acc:8793] KIAA1598 0.00106273 −0.883804986 ENSG00000187164 10 q25.3 KIAA1598[Source: HGNC Symbol;Acc: 29319] ACSL1 0.00106684 −1.1398898ENSG00000151726 4 q35.1 acyl-CoA synthetase long-chain family member 1[Source: HGNC Symbol;Acc: 3569] CAPN2 0.00111892 −0.673819472ENSG00000162909 1 q41 calpain 2, (m/ll) large subunit [Source: HGNCSymbol;Acc: 1479] EPM2A 0.00112005 2.042733065 ENSG00000112425 6 q24.3epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)[Source: HGNC Symbol;Acc: 3413] SPG20 0.00112318 −1.345465148ENSG00000133104 13 q13.3 spastic paraplegia 20 (Troyer syndrome)[Source: HGNC Symbol;Acc: 18514] NUDT9P1 0.00113163 1.948144791 NA NA NANA FHOD1 0.00116819 −2.500243302 ENSG00000135723 16 q22.1 forminhomology 2 domain containing 1 [Source: HGNC Symbol;Acc: 17905] OSCAR0.00118671 −2.271018361 ENSG00000170909 19 q13.42 osteoclast associated,immunoglobulin-like receptor [Source: HGNC Symbol;Acc: 29960] ARMCX10.00119573 −1.079753587 ENSG00000126947 X q22.1 armadillo repeatcontaining, X-linked 1 [Source: HGNC Symbol,Acc: 18073] SELP 0.00122190−0.903200375 ENSG00000174175 1 q24.2 selectin P (granule membraneprotein 140 kDa, antigen CD62) [Source: HGNC Symbol;Acc: 10721] CD200R10.00126705 −0.920571979 ENSG00000163606 3 q13.2 CD200 receptor 1[Source: HGNC Symbol;Acc: 24235] PLEKHA7 0.00128422 −1.287862112ENSG00000166689 11 p15.1 pleckstrin homology domain containing, family Amember 7 [Source: HGNC Symbol;Acc: 27049] GNAQ 0.00133109 −0.799757937ENSG00000156052 9 q21.2 guanine nucleotide binding protein (G protein),q polypeptide [Source: HGNC Symbol;Acc: 4390] ZBTB4 0.00135017−1.220347435 ENSG00000174282 17 p13.1 zinc finger and BTB domaincontaining 4 [Source: HGNC Symbol;Acc: 23847] CLEC12A 0.00136635−1.624654383 ENSG00000172322 12 p13.2 C-type lectin domain family 12,member A [Source: HGNC Symbol;Acc: 31713] PTSD 0.00139038 −3.41677807ENSG00000241878 22 p12.2 phosphatidylserine decarboxylase [Source: HGNCSymbol;Acc: 8999] ALDH2 0.00141785 −0.672902178 ENSG00000111275 12q24.12 aldehyde dehydrogenase 2 family (mitochondrial) [Source: HGNCSymbol;Acc: 404] IL6R 0.00142894 −0.755163035 ENSG00000160712 1 p21.3interleukin 6 receptor [Source: HGNC Symbol;Acc: 6019] MRC2 0.00144402−1.526866671 ENSG00000011028 17 q23.2 mannose receptor, C type 2[Source: HGNC Symbol;Acc: 16875] TSEN34 0.00145956 −2.689190004ENSG00000170892 19 q13.42 tRNA splicing endonuclease 34 homolog (S.cerevisiae) [Source: HGNC Symbol;Acc: 15506] GALM 0.00147988−0.995059373 ENSG00000143891 2 p22.1 galactose mutarotase (aldose1-epimerase) [Source: HGNC Symbol;Acc: 24063] EMP3 0.00148006−1.056401849 ENSG00000142227 19 q13.33 epithelial membrane protein 3[Source: HGNC Symbol;Acc: 3335] SAT2 0.00157137 −2.792215867ENSG00000141504 17 p13.1 spermidine/sperrnine N1-acetyltransferasefamily member 2 [Source: HGNC Symbol;Acc: 23160] TTC31 0.00157244−1.63766409 ENSG00000115282 2 p13.1 tetratricopeptide repeat domain 31[Source: HGNC Symbol;Acc: 25759] CES2 0.00159167 −2.024818272ENSG00000172831 16 q22.1 carboxylesterase 2 [Source: HGNC Symbol;Acc:1864] AGPAT9 0.00159441 −1.35239458 ENSG00000138678 4 q21.231-acylglycerol 3 phosphate O-acyltransferase 9 [Source: HGNC Symbol;Acc:28157] RBM43 0.00161986 −1.428737679 ENSG00000184898 2 q23.3 RNA bindingmotif protein 43 [Source: HGNC Symbol;Acc: 24790] CXCL14 0.00162663−0.467340849 ENSG00000145824 5 q31.1 chemokine (C-X-C motif) ligand 14[Source: HGNC Symbol;Acc: 10640] PLEKHA1 0.00167197 −0.919870988ENSG00000107679 10 q26.13 pleckstrin homology domain containing, familyA (phosphoinositide binding specific) member 1 [Source: HGNC Symbol;Acc:14335] SLC35D2 0.00168394 −1.418796477 ENSG00000130958 9 q22.32 solutecarrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2[Source: HGNC Symbol;Acc: 20799] LOC654841 0.00170773 4.303627408 NA NANA NA RFPL3S 0.00171657 −2.35571089 ENSG00000205853 22 q12.3 RFPL3antisense [Source: HGNC Symbol;Acc: 9981] PLCB2 0.00175948 −2.173217301ENSG00000137841 15 q15.1 phospholipase C, beta 2 [Source: HGNCSymbol;Acc: 9055] DPP4 0.00176325 −1.056413733 ENSG00000197635 2 q24.2dipeptidyl-peptidase 4 [Source: HGNC Symbol;Acc: 3009] FAM219B0.00181328 −1.464593174 ENSG00000178761 15 q24.1 family with sequencesimilarity 219, member B [Source: HGNC Symbol;Acc: 24695] TSPAN20.00181539 −1.024722523 ENSG00000134198 1 p13.2 tetraspanin 2 [Source:HGNC Symbol;Acc: 20659] SLC2A4RG 0.00183651 −2.092522041 ENSG0000012552020 q13.33 SLC2A4 regulator [Source: HGNC Symbol;Acc: 15930] TCF7L20.00183773 −1.072368328 ENSG00000148737 10 q25.2 transcription factor7-like 2 (T-cell specific, HMG-box) [Source: HGNC Symbol;Acc: 11641]C10orf76 0.00184603 −1.832924913 ENSG00000120029 10 q24.32 chromosome 10open reading frame 76 [Source: HGNC Symbol;Acc: 25788] NAGA 0.00187105−1.371486854 ENSG00000198951 22 q13.2 N-acetylgalactosaminidase,alpha-[Source: HGNC Symbol;Acc: 7631] RIPK3 0.00190047 −3.462098915ENSG00000129465 14 q12 receptor-interacting serine-threonine kinase 3[Source: HGNC Symbol;Acc: 10021] CD1E 0.00197070 −1.121895164ENSG00000158488 1 q23.1 CD1e molecule [Source: HGNC Symbol;Acc: 1638]HAVCR2 0.00202258 −0.729699479 ENSG00000135077 5 q33.3 hepatitis A viruscellular receptor 2 [Source: HGNC Symbol;Acc: 18437]

From the foregoing, it will be appreciated that, although specificembodiments have been described herein for the purpose of illustration,various modifications may be made without deviating from the spirit andscope of what is provided herein. All of the references referred toabove are incorporated herein by reference in their entireties.

What is claimed is:
 1. A method for predicting the clinical sensitivityof a diffuse large B-cell lymphoma (DLBCL) to treatment withlenalidomide comprising: (a) obtaining a first biological sample from afirst patient having a DLBCL; (b) measuring the level of expression ofone, two, three, four, five or more of the genes identified in Table 3;(c) comparing the level of expression of the one, two, three, four, fiveor more of the genes identified in Table 3 in the first biologicalsample with the level of expression of the same genes in a secondbiological sample from a second patient having a DLBCL, wherein theDLBCL in the second patient is clinically insensitive to lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof, andwherein the differential expression of the one, two, three, four, fiveor more of the genes in the first biological sample relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample indicates that the DLBCL in thefirst patient will be clinical sensitive to treatment with lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof.
 2. Amethod for predicting the clinical sensitivity of a DLBCL to treatmentwith lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof, comprising: (a) obtaining a first biological samplefrom a first patient having a DLBCL; (b) measuring the level ofexpression of one, two, three, four, five or more of the genesidentified in Table 4; (c) comparing the level of expression of the one,two, three, four, five or more of the genes identified in Table 4 in thefirst biological sample with the level of expression of the same genesin a second biological sample from a second patient having a DLBCL,wherein the DLBCL in the second patient is clinically insensitive tolenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof, and wherein the differential expression of the one, two, three,four, five or more of the genes in the first biological sample relativeto the level of expression of the one, two, three, four, five or more ofthe genes in the second biological sample indicates that the DLBCL inthe first patient will be clinical sensitive to treatment withlenalidomide.
 3. A method for predicting the clinical sensitivity of aDLBCL to treatment with lenalidomide, or pharmaceutically acceptablesalts, solvates or isomers thereof, comprising: (a) obtaining a firstbiological sample from a first patient having a DLBCL; (b) measuring thelevel of expression of one, two, three, four, five or more of the genesidentified in Table 1; and (c) comparing the level of expression of theone, two, three, four, five or more of the genes identified in Table 1in the first biological sample with the level of expression of the samegenes in a second biological sample from a second patient having aDLBCL, wherein the DLBCL cancer in the second patient is clinicallyinsensitive to lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, and wherein a higher level of expression ofthe one, two, three, four, five or more of the genes in the firstbiological sample relative to the level of expression of the one, two,three, four, five or more of the genes in the second biological sampleindicates that the DLBCL in the first patient will be clinical sensitiveto treatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof.
 4. A method for predicting the clinicalsensitivity of a DLBCL to treatment with lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof,comprising: (a) obtaining a first biological sample from a first patienthaving a DLBCL; (b) measuring the level of expression of one, two,three, four, five or more of the genes identified in Table 2; and (c)comparing the level of expression of the one, two, three, four, five ormore of the genes identified in Table 2 in the first biological samplewith the level of expression of the same genes in a second biologicalsample is from a second patient having a DLBCL, wherein the DLBCL in thesecond patient is clinically insensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, andwherein a lower level of expression of the one, two, three, four, fiveor more of the genes in the first biological sample relative to thelevel of expression of the one, two, three, four, five or more of thegenes in the second biological sample indicates that the DLBCL in thefirst patient will be clinical sensitive to treatment with lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof.
 5. Amethod for predicting the clinical sensitivity of a DLBCL to treatmentwith lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof, comprising: (a) obtaining a first tumor sample from afirst patient having a DLBCL; (b) measuring the proportion of dendriticcells in the first tumor sample; and (c) comparing the proportion ofdendritic cells in the first tumor sample with the proportion ofdendritic cells in a second tumor sample from a second patient having aDLBCL, wherein the second patient's DLBCL is clinically insensitive totreatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, and wherein a higher proportion ofdendritic cells in the first tumor sample relative the proportion ofdendritic cells in the second tumor sample indicates that the DLBCL inthe first patient will be clinical sensitive to treatment withlenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof.
 6. A methods for predicting the clinical sensitivity of a DLBCLto treatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, comprising: (a) obtaining a first tumorsample from a first patient having a DLBCL; (b) measuring the proportionof plasma cells in the first tumor sample; and (c) comparing theproportion of plasma cells in the first tumor sample with the proportionof plasma cells in a second tumor sample from a second patient having aDLBCL, wherein the second patient's DLBCL is clinically insensitive totreatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, and wherein a higher proportion of plasmacells in the first tumor sample relative the proportion of plasma cellsin the second tumor sample indicates that the DLBCL in the first patientwill be clinical sensitive to treatment with lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof.
 7. Amethod for predicting the clinical sensitivity of a DLBCL to treatmentwith lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof, comprising: (a) obtaining a first biological samplefrom a first patient having a DLBCL (b) measuring the expression of thegenes or a certain subset of genes set forth in Table 1, 2, 3, or 4 inthe first biological sample; and (c) comparing the gene expressionprofile of the genes or subset of genes in the first biological sampleto (i) the gene expression profile of the genes or subset of genes intumor samples from patients having DLBCL which are clinically sensitiveto lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof, and (ii) the gene expression of the genes or subset ofgenes in tumor samples from patients having DLBCL which are clinicallyinsensitive to lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, wherein a gene expression profile for thegenes or subset of genes in the first biological sample similar to thegene expression profile for the genes or subset of genes in tumorsamples from patients having DLBCL which are clinically sensitive tolenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof, indicates that the DLBCL in the first patient will be clinicalsensitive to treatment with lenalidomide, and a gene expression profilefor the genes or subset of genes in first biological sample similar tothe gene expression profile for the genes or subset of genes in tumorsamples from patients having DLBCL which are clinically insensitive tolenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof, indicates that the DLBCL of the first patient will beclinically insensitive to treatment with lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof.
 8. Amethod for predicting the clinical sensitivity of a DLBCL to treatmentwith lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof, comprising: (a) obtaining a first tumor sample from afirst patient having a hematological cancer; (b) measuring theproportion of immune cells in the first tumor sample; and (c) comparingthe proportion of the immune cells in the first tumor sample to (i) theproportion of the same immune cells in tumor samples from patientshaving DLBCL which are clinically sensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, and (ii)the proportion of the same immune cells in tumor samples from patientshaving DLBCL which are clinically insensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, whereina proportion of the immune cells in the first tumor sample similar tothe proportion of the same immune cells in tumor samples from patientshaving DLBCL which are clinically sensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof,indicates that the DLBCL in the first patient will be clinical sensitiveto treatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, and a proportion of the immune cells in thefirst tumor sample similar to the proportion of the same immune cells intumor samples from patients having DLBCL which are clinicallyinsensitive to lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, indicates that the DLBCL in the firstpatient will be clinical insensitive to treatment with lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof.
 9. Amethod for managing or treating a DLBCL comprising: (a) obtaining afirst biological sample from a first patient having a DLBCL; (b)measuring the level of expression of one, two, three, four, five or moreof the genes identified in Table 3; (c) comparing the level ofexpression of the one, two, three, four, five or more of the genesidentified in Table 3 in the first biological sample with the level ofexpression of the same genes in a second biological sample from a secondpatient having a DLBCL, wherein the DLBCL in the second patient isclinically insensitive to lenalidomide, or pharmaceutically acceptablesalts, solvates or isomers thereof; and (d) administering lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof, tothe first patient if the one, two, three, four, five or more of thegenes in the first biological sample are differentially expressedrelative to the level of expression of the one, two, three, four, fiveor more of the genes in the second biological sample.
 10. A method formanaging or treating a DLBCL comprising: (a) obtaining a firstbiological sample from a first patient having a DLBCL; (b) measuring thelevel of expression of one, two, three, four, five or more of the genesidentified in Table 4; (c) comparing the level of expression of the one,two, three, four, five or more of the genes identified in Table 4 in thefirst biological sample with the level of expression of the same genesin a second biological sample from a second patient having a DLBCL,wherein the DLBCL in the second patient is clinically insensitive tolenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof; and (d) administering lenalidomide, or pharmaceuticallyacceptable salts, solvates or isomers thereof to the first patient ifthe one, two, three, four, five or more of the genes in the firstbiological sample are differentially expressed relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample.
 11. A method for managing or treating aDLBCL comprising: (a) obtaining a first biological sample from a firstpatient having a DLBCL; (b) measuring the level of expression of one,two, three, four, five or more of the genes identified in Table 1; (c)comparing the level of expression of the one, two, three, four, five ormore of the genes identified in Table 1 in the first biological samplewith the level of expression of the same genes in a second biologicalsample from a second patient having a DLBCL, wherein the DLBCL in thesecond patient is clinically insensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof; and (d)administering lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, to the first patient if a higher level ofexpression of the one, two, three, four, five or more of the genes inthe first biological sample is measured relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample.
 12. A method for managing or treating aDLBCL comprising: (a) obtaining a first biological sample from a firstpatient having a DLBCL; (b) measuring the level of expression of one,two, three, four, five or more of the genes identified in Table 2; (c)comparing the level of expression of the one, two, three, four, five ormore of the genes identified in Table 2 in the first biological samplewith the level of expression of the same genes in a second biologicalsample is from a second patient having a DLBCL, wherein the DLBCL in thesecond patient is clinically insensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof; and (d)administering lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, to the first patient if a lower level ofexpression of the one, two, three, four, five or more of the genes inthe first biological sample is measured relative to the level ofexpression of the one, two, three, four, five or more of the genes inthe second biological sample.
 13. A method for managing or treating aDLBCL: (a) obtaining a first biological sample from a first patienthaving a DLBCL; (b) measuring the expression of a certain subset ofgenes set forth in Table 1, 2, 3 or 4, or any combination thereof in thefirst biological sample, (c) comparing the gene expression profile ofthe subset of genes in the first biological sample to (i) the geneexpression profile of the subset of genes in tumor samples from patientshaving DLBCL which are clinically sensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, and (ii)the gene expression of the subset of genes in tumor samples frompatients having DLBCL which are clinically insensitive to lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof; and(d) administering lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, to the first patient if: (i) the geneexpression profile for the subset of genes in the first biologicalsample is similar to the gene expression profile for the subset of genesin tumor samples from patients having DLBCL which are clinicallysensitive to lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, and (ii) the gene expression profile forthe subset of genes in first biological sample is not similar to thegene expression profile for the subset of genes in tumor samples frompatients having DLBCL which are clinically insensitive to lenalidomide,or pharmaceutically acceptable salts, solvates or isomers thereof.
 14. Amethod for managing or treating a DLBCL comprising: (a) obtaining afirst tumor sample from a first patient having a DLBCL; (b) measuringthe proportion of dendritic cells in the first tumor sample; (c)comparing the proportion of dendritic cells in the first tumor samplewith the proportion of dendritic cells in a second tumor sample from asecond patient having a DLBCL, wherein the second patient's DLBCL isclinically insensitive to treatment with lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof; and (d)administering lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof, to the first patient if a higher proportionof dendritic cells in the first tumor sample is measured relative theproportion of dendritic cells in the second tumor sample.
 15. A methodfor managing or treating a DLBCL comprising: (a) obtaining a first tumorsample from a first patient having a DLBCL; (b) measuring the proportionof plasma cells in the first tumor sample; (c) comparing the proportionof plasma cells in the first tumor sample with the proportion of plasmacells in a second tumor sample from a second patient having a DLBCL,wherein the second patient's DLBCL is clinically insensitive totreatment with lenalidomide, or pharmaceutically acceptable salts,solvates or isomers thereof; and (d) administering lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, to thefirst patient if a higher proportion of plasma cells in the first tumorsample is measured relative the proportion of plasma cells in the secondtumor sample.
 16. A method for managing or treating a DLBCL comprising:(a) obtaining a first tumor sample from a first patient having a DLBCL;(b) measuring the proportion of immune cells in the first tumor sample;and (c) comparing the proportion of the immune cells in the first tumorsample to (i) the proportion of the same immune cells in tumor samplesfrom patients having DLBCL which are clinically sensitive tolenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof, and (ii) the proportion of the same immune cells in tumorsamples from patients having DLBCL which are clinically insensitive tothe lenalidomide, or pharmaceutically acceptable salts, solvates orisomers thereof; and (d) administering lenalidomide, or pharmaceuticallyacceptable salts, solvates or isomers thereof, to the first patient ifthe proportion of the immune cells in the first tumor sample is (i)similar to the proportion of the same immune cells in tumor samples frompatients having DLBCL which are clinically sensitive to lenalidomide, orpharmaceutically acceptable salts, solvates or isomers thereof, and (ii)not similar to the proportion of the same immune cells in tumor samplesfrom patients having DLBCL which are clinically insensitive to thelenalidomide, or pharmaceutically acceptable salts, solvates or isomersthereof.
 17. The method of any one of claims 1 to 16, wherein the DLBCLis refractory.
 18. The method of any one of claims 1 to 16, wherein theDLBCL is relapsed in the first patient.
 19. The method of any one ofclaims 1 to 16, wherein the DLBCL is a germinal center B-cell-likesubtype.
 20. The method of any one of claims 1 to 16, wherein the DLBCLis an activated B-cell-like subtype.